GO:0070671

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Name response to interleukin-12
Categary Process
Go Slim No
Go Link GO:0070671
Unique Molecular Interactions 71
Total Molecular Interactions 77
Total Single Events 395
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-12. They are ordered first by their pain relevance and then by number of times they were reported for response to interleukin-12. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
2 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
3 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
4 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
5 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
6 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
7 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
8 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
9 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
10 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
11 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
12 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
13 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
14 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
15 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
16 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
17 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
18 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
19 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
20 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
21 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
22 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
23 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
24 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
25 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
26 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11
27 INT169340 Binding of UGT8 and Jak2 1 0.36 0.15 0.11
28 INT273374 Binding of JAK2 and STAT3 1 0.24 0 0.07
29 INT273368 Negative_regulation of Binding of JAK2 and STAT3 1 0.28 0 0.07
30 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 0.27 1.05 0.07
31 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 0.01 0 0.06
32 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
33 INT325769 Binding of EPOR and Positive_regulation of Phosphorylation of JAK2 1 0.66 0 0.06
34 INT273365 JAK2 Regulation of SOCS1 1 0.01 0 0.06
35 INT238117 Positive_regulation of STAT3 Positive_regulation of Gene_expression of JAK2 1 0.11 0 0.05
36 INT238116 STAT3 Positive_regulation of Gene_expression of JAK2 1 0.16 0 0.05
37 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
38 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
39 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
40 INT253578 Csnk2a2 Negative_regulation of Jak2 1 0.09 0 0.03
41 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
42 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
43 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
44 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
45 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
46 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
47 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
48 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
49 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
50 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
51 INT300081 Binding of JAK2 and TYK2 1 0.09 1.13 0
52 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0
53 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0
54 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
55 INT198026 JAK2 Positive_regulation of HCC 1 0.19 1.35 0
56 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0
57 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-12. They are ordered first by their pain relevance and then by number of times they were reported in response to interleukin-12. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
2 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
3 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
4 INT20459 Regulation of Ripk2 5 0.44 0 4.53
5 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
6 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
7 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
8 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
9 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
10 INT113339 Binding of JAK2 6 0.40 5.31 2.4
11 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
12 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
13 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
14 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
15 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
16 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
17 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
18 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
19 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
20 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
21 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
22 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
23 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
24 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
25 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
26 INT169336 Binding of Jak2 2 0.42 1.31 0.93
27 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
28 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
29 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
30 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
31 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
32 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
33 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
34 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
35 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
36 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
37 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
38 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5
39 INT184062 Binding of Jak2 5 0.37 3.13 0.47
40 INT38738 Localization of RIPK2 2 0.68 0.07 0.45
41 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
42 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
43 INT107462 Localization of Jak2 2 0.60 0.78 0.4
44 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
45 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
46 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
47 INT303972 Positive_regulation of Gene_expression of JAK2 2 0.63 1.3 0.24
48 INT201691 Binding of RIPK2 2 0.18 1.51 0.17
49 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
50 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
51 INT240596 Negative_regulation of Gene_expression of RIPK2 1 0.06 0.91 0.15
52 INT136002 Positive_regulation of Gene_expression of RIPK2 1 0.67 0.52 0.15
53 INT278143 Positive_regulation of Negative_regulation of Jak2 1 0.16 0.54 0.11
54 INT312354 Regulation of Gene_expression of JAK2 1 0.25 1.17 0.1
55 INT200792 Regulation of Gene_expression of Jak2 5 0.61 5.69 0.09
56 INT144094 Negative_regulation of Localization of Ripk2 1 0.42 0.49 0.09
57 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08
58 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08
59 INT310747 Regulation of JAK2 2 0.33 1.58 0.05
60 INT238202 Negative_regulation of Localization of JAK2 1 0.09 0 0.05
61 INT238200 Localization of JAK2 1 0.16 0 0.05
62 INT238199 Positive_regulation of Positive_regulation of JAK2 1 0.10 0 0.03
63 INT238196 Negative_regulation of Binding of JAK2 1 0.09 0 0
64 INT202420 Transcription of Jak2 1 0.56 0.91 0
65 INT350506 Protein_catabolism of JAK2 1 0.48 1.55 0
66 INT320539 Negative_regulation of Phosphorylation of JAK2 1 0.26 0.46 0
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