GO:0070741

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Name response to interleukin-6
Categary Process
Go Slim No
Go Link GO:0070741
Unique Molecular Interactions 30
Total Molecular Interactions 50
Total Single Events 288
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-6. They are ordered first by their pain relevance and then by number of times they were reported for response to interleukin-6. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
2 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
3 INT176340 CHI3L1 Positive_regulation of Localization of CSF2 1 0.11 1.86 0.55
4 INT176343 CHI3L1 Positive_regulation of Localization of CSF1 1 0.23 1.86 0.55
5 INT231225 Binding of C1S and SFTPC 1 0.39 1.51 0.43
6 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
7 INT183924 Binding of CHI3L1 and HLA-E 1 0.08 0.9 0.39
8 INT25354 Chi3l1 Negative_regulation of Ptgs1 1 0.00 0.39 0.34
9 INT141109 Sftpa1 Positive_regulation of Mapk1 1 0.77 0.65 0.27
10 INT249831 Binding of CHI3L1 and IL6 1 0.30 2.81 0.26
11 INT249833 Binding of CHI3L1 and GOPC 1 0.06 1.11 0.15
12 INT141110 Negative_regulation of Sftpa1 Positive_regulation of Mapk1 1 0.47 0.31 0.14
13 INT141111 Sftpa1 Positive_regulation of Ptgs2 1 0.64 0.3 0.14
14 INT249829 CHI3L1 Positive_regulation of AKT1 1 0.47 0.69 0.14
15 INT141112 Negative_regulation of Sftpa1 Positive_regulation of Ptgs2 1 0.39 0.31 0.14
16 INT249832 Binding of CHI3L1 and HRASLS 1 0.00 0.85 0.08
17 INT249834 Positive_regulation of IL6 Positive_regulation of CHI3L1 1 0.26 0.89 0.06
18 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03
19 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0
20 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0
21 INT290678 Binding of CHI3L1 and KRTAP19-9P 1 0.08 1.2 0
22 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0
23 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
24 INT269933 Foxa2 Regulation of Gene_expression of Foxj1 1 0.27 0 0
25 INT186449 Binding of SFTPB and SFTPC 1 0.38 0.09 0
26 INT269927 Foxa2 Regulation of Gene_expression of Scgb1a1 1 0.26 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-6. They are ordered first by their pain relevance and then by number of times they were reported in response to interleukin-6. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
2 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43
3 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64
4 INT186456 Gene_expression of SFTPC 2 0.75 11.46 2.38
5 INT158022 Binding of CHI3L1 10 0.43 14.18 1.94
6 INT248321 Regulation of Gene_expression of CHI3L1 2 0.44 10.73 1.64
7 INT124212 Protein_catabolism of CHI3L1 3 0.21 3.48 1.4
8 INT186458 Negative_regulation of SFTPC 11 0.57 8.6 1.29
9 INT145312 Localization of CHI3L1 8 0.78 12.71 1.26
10 INT208974 Negative_regulation of Chi3l1 1 0.01 0.12 1.16
11 INT65734 Regulation of Chi3l1 2 0.06 1.25 1.15
12 INT186461 Gene_expression of SFTPB 10 0.73 8.69 1.09
13 INT102988 Regulation of CHI3L1 5 0.48 7.23 0.86
14 INT124210 Negative_regulation of CHI3L1 7 0.12 4.39 0.85
15 INT182180 Transcription of CHI3L1 1 0.67 1.94 0.82
16 INT179441 Gene_expression of Chi3l1 1 0.02 0 0.81
17 INT186463 Negative_regulation of Gene_expression of SFTPC 2 0.42 4.52 0.75
18 INT231228 Regulation of Gene_expression of SFTPC 1 0.60 3.8 0.73
19 INT186455 Localization of SFTPB 2 0.74 3.24 0.53
20 INT237744 Positive_regulation of Chi3l1 2 0.40 0.58 0.52
21 INT40536 Binding of Chi3l1 1 0.29 0 0.52
22 INT141097 Binding of Sftpa1 1 0.48 1.28 0.47
23 INT352052 Regulation of Positive_regulation of Chi3l1 1 0.05 0.25 0.4
24 INT231232 Negative_regulation of Negative_regulation of SFTPC 1 0.42 2.01 0.37
25 INT186459 Positive_regulation of SFTPC 4 0.45 4.64 0.36
26 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31
27 INT186454 Binding of SFTPB 3 0.35 1.48 0.24
28 INT231231 Regulation of SFTPB 1 0.27 1.47 0.22
29 INT353863 Regulation of Binding of CHI3L1 1 0.07 2.31 0.21
30 INT233856 Regulation of SFTPC 4 0.60 2.25 0.19
31 INT239883 Transcription of SFTPC 3 0.69 1.11 0.18
32 INT239885 Positive_regulation of Transcription of SFTPC 1 0.67 0.44 0.18
33 INT349942 Positive_regulation of Negative_regulation of CHI3L1 1 0.14 0.33 0.18
34 INT231230 Localization of SFTPC 2 0.68 2.06 0.16
35 INT141095 Negative_regulation of Binding of Sftpa1 1 0.42 0.31 0.14
36 INT353862 Positive_regulation of Positive_regulation of CHI3L1 1 0.08 2.51 0.14
37 INT141096 Positive_regulation of Binding of Sftpa1 1 0.50 0.34 0.13
38 INT249838 Regulation of Localization of CHI3L1 1 0.40 0.98 0.07
39 INT212049 Protein_catabolism of SFTPB 1 0.44 0.15 0.04
40 INT186452 Positive_regulation of SFTPB 7 0.47 6.43 0.03
41 INT200834 Positive_regulation of Foxa2 2 0.32 0.08 0
42 INT212050 Negative_regulation of Gene_expression of SFTPB 1 0.32 0.95 0
43 INT141101 Gene_expression of Sftpa1 1 0.77 0.38 0
44 INT186451 Positive_regulation of Negative_regulation of SFTPB 1 0.47 0.52 0
45 INT349943 Negative_regulation of Gene_expression of CHI3L1 1 0.09 0 0
46 INT262045 Phosphorylation of Foxa2 1 0.34 0.08 0
47 INT331624 Transcription of SFTPB 1 0.03 0.48 0
48 INT205997 Regulation of Gene_expression of SFTPB 1 0.44 0.71 0
49 INT262071 Binding of Foxa2 1 0.15 0.68 0
50 INT186462 Binding of SFTPC 1 0.35 0.09 0
51 INT262084 Negative_regulation of Binding of Foxa2 1 0.18 0.23 0
52 INT262125 Negative_regulation of Foxa2 1 0.18 0.08 0
53 INT269888 Gene_expression of Foxa2 1 0.65 0 0
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