GO:0070830

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Name tight junction assembly
Categary Process
Go Slim No
Go Link GO:0070830
Unique Molecular Interactions 101
Total Molecular Interactions 154
Total Single Events 951
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tight junction assembly. They are ordered first by their pain relevance and then by number of times they were reported for tight junction assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
2 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
3 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
4 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
5 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
6 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72
7 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
8 INT297316 Negative_regulation of Rock2 Positive_regulation of Cdh1 1 0.01 1.92 0.43
9 INT338044 F2 Positive_regulation of Pard3 1 0.08 0.38 0.4
10 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
11 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
12 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
13 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
14 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
15 INT119333 Binding of Ramp2 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
16 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
17 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
18 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
19 INT274942 Binding of Dlg1 and Ephb6 1 0.05 0 0.25
20 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
21 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
22 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
23 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
24 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
25 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
26 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
27 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
28 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
29 INT194404 Binding of RAMP2 and DCLK3 1 0.07 0 0.22
30 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
31 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
32 INT256985 Binding of Dlg1 and Cd81 1 0.39 0.2 0.17
33 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
34 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
35 INT316482 Il6 Positive_regulation of Cdh1 1 0.03 0.33 0.15
36 INT106994 PARD3 Positive_regulation of PAR4 1 0.21 0.28 0.14
37 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14
38 INT107006 PARD3 Positive_regulation of SPG21 1 0.24 0.29 0.14
39 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
40 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13
41 INT106997 PARD3 Positive_regulation of NR1I2 1 0.19 0.28 0.13
42 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
43 INT354718 Binding of INADL and Myo18a 1 0.00 0.13 0.12
44 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
45 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
46 INT338041 F2r Positive_regulation of Pard3 1 0.15 0.05 0.11
47 INT338048 F2rl3 Positive_regulation of Pard3 1 0.11 0.05 0.11
48 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
49 INT262255 Binding of APC and F2R 1 0.05 3 0.1
50 INT257665 Binding of Nphs1 and Pard3 1 0.39 0.67 0.09
51 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
52 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
53 INT349914 Binding of Cdh1 and Jup 1 0.11 0.47 0.07
54 INT349916 Binding of Ctnnd1 and Cdh1 1 0.17 0.47 0.07
55 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06
56 INT317416 Binding of FN1 and ITGB1 1 0.47 0.69 0.05
57 INT251373 Binding of Cdh2 and Cdh1 1 0.17 0 0.04
58 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
59 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04
60 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04
61 INT251370 Cdh2 Regulation of Gene_expression of Cdh1 1 0.21 0.35 0
62 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
63 INT263726 Binding of Dlg1 and Dlg4 1 0.04 0 0
64 INT256988 Binding of Dlg1 and Rpe 1 0.06 0 0
65 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
66 INT263737 Binding of Dlg1 and Neto1 1 0.07 0 0
67 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
68 INT312318 Binding of Cdh1 and Regulation of Transcription of Prl 1 0.30 0.39 0
69 INT310042 Binding of Cdh1 and Lsr1 1 0.01 0.09 0
70 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
71 INT301674 Binding of APC and CD80 1 0.01 0.53 0
72 INT225590 Ncoa6 Regulation of Srf 1 0.08 0.21 0
73 INT257666 Binding of Mgst1 and Pard3 1 0.05 0 0
74 INT338047 Binding of F2r and Pard3 1 0.11 0 0
75 INT195661 Binding of APC and PROC 1 0.23 0.89 0
76 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
77 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
78 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
79 INT312316 Gene_expression of Cdh1 Negative_regulation of Prl 1 0.29 0 0
80 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
81 INT257664 Regulation of Binding of Nphs1 and Pard3 1 0.36 0 0
82 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
83 INT268395 Binding of APC and Kras 1 0.04 1.21 0
84 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0
85 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
86 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
87 INT251372 Cdh1 Regulation of Gene_expression of Cdh2 1 0.21 0.35 0
88 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
89 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
90 INT310039 Binding of Cdh1 and Slc30a4 1 0.04 0.46 0
91 INT235009 Binding of DSG1 and Cdh1 1 0.02 0.87 0
92 INT312317 Cdh1 Regulation of Transcription of Prl 1 0.41 0.39 0
93 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tight junction assembly. They are ordered first by their pain relevance and then by number of times they were reported in tight junction assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
2 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
3 INT105960 Gene_expression of Cdh1 41 0.76 22.28 5.56
4 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
5 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
6 INT63121 Binding of APC 29 0.41 23.02 3.8
7 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77
8 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
9 INT169705 Negative_regulation of Gene_expression of Cdh1 10 0.57 8.8 2.1
10 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
11 INT118511 Gene_expression of Pard3 5 0.57 0.76 1.86
12 INT168602 Negative_regulation of Itgb1 3 0.21 1.29 1.73
13 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
14 INT122103 Negative_regulation of Cdh1 5 0.49 2.05 1.18
15 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
16 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
17 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
18 INT169704 Regulation of Gene_expression of Cdh1 4 0.35 1.75 1.09
19 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
20 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
21 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
22 INT26531 Regulation of Srf 3 0.18 0.62 0.9
23 INT276620 Negative_regulation of Cdh1 7 0.57 6.48 0.86
24 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
25 INT45293 Transcription of Srf 2 0.47 0.79 0.76
26 INT171585 Positive_regulation of INADL 3 0.40 0.61 0.75
27 INT119331 Gene_expression of Ramp2 2 0.60 0.19 0.75
28 INT153565 Gene_expression of PRKCI 1 0.75 0 0.72
29 INT235069 Localization of Cdh1 9 0.74 3.81 0.71
30 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
31 INT57062 Regulation of APC 24 0.58 14.3 0.7
32 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
33 INT189877 Gene_expression of Cdh1 55 0.58 9.36 0.66
34 INT153568 Binding of PRKCI 1 0.36 0 0.6
35 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
36 INT346182 Positive_regulation of Gene_expression of RAMP2 1 0.14 1.51 0.58
37 INT105959 Positive_regulation of Gene_expression of Cdh1 5 0.49 2.65 0.57
38 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
39 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
40 INT301995 Regulation of Cdh1 5 0.44 3.8 0.48
41 INT119326 Positive_regulation of Ramp2 1 0.42 0.2 0.48
42 INT172558 Positive_regulation of Cdh1 11 0.49 8.92 0.42
43 INT346192 Negative_regulation of RAMP2 1 0.12 0.92 0.42
44 INT118243 Transcription of APC 4 0.45 3.33 0.33
45 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
46 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
47 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
48 INT195672 Localization of APC 7 0.74 3.76 0.3
49 INT119325 Binding of Ramp2 1 0.33 0.12 0.29
50 INT319280 Positive_regulation of Dlg1 1 0.45 0.42 0.28
51 INT7610 Localization of Srf 3 0.67 0.98 0.27
52 INT208930 Positive_regulation of Pard3 2 0.33 0.49 0.27
53 INT209224 Binding of Dlg1 3 0.13 0.22 0.23
54 INT234858 Binding of Cdh1 11 0.47 4.58 0.22
55 INT215000 Transcription of Cdh1 4 0.40 1.17 0.22
56 INT225973 Binding of Itgb1 2 0.08 1.1 0.2
57 INT245860 Gene_expression of Itgb1 8 0.42 5.37 0.19
58 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
59 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
60 INT89766 Binding of SRF 1 0.17 0.89 0.15
61 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
62 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
63 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
64 INT222042 Localization of ITGB1 3 0.29 0.72 0.12
65 INT354691 Gene_expression of INADL 1 0.65 0.12 0.11
66 INT229402 Positive_regulation of PARD3 1 0.11 0.8 0.11
67 INT354690 Positive_regulation of Gene_expression of INADL 1 0.49 0.12 0.11
68 INT296622 Positive_regulation of Gene_expression of Cdh1 3 0.52 2.24 0.09
69 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
70 INT296623 Positive_regulation of Cdh1 2 0.35 1.88 0.09
71 INT222603 Negative_regulation of Gene_expression of Ramp2 1 0.09 0 0.09
72 INT276619 Negative_regulation of Transcription of Cdh1 1 0.24 0.57 0.09
73 INT251364 Negative_regulation of Gene_expression of Cdh1 4 0.32 1.02 0.07
74 INT22789 Binding of Srf 1 0.37 0.07 0.07
75 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
76 INT256975 Binding of Dlg1 7 0.36 0 0.06
77 INT190544 Transcription of Srf 1 0.19 0.43 0.06
78 INT190570 Localization of Srf 1 0.20 0.49 0.06
79 INT209184 Regulation of PRKCI 1 0.02 0.06 0.06
80 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
81 INT349912 Negative_regulation of Negative_regulation of Cdh1 1 0.42 1.04 0.05
82 INT189881 Binding of Cdh1 6 0.36 1.24 0.04
83 INT251361 Transcription of Cdh1 1 0.36 0 0.04
84 INT257639 Binding of Pard3 1 0.35 0.4 0.04
85 INT349906 Negative_regulation of Localization of Cdh1 1 0.42 0.37 0.04
86 INT225411 Positive_regulation of Srf 1 0.05 0.27 0.03
87 INT268102 Transcription of SRF 1 0.53 0.85 0.03
88 INT225413 Binding of Srf 1 0.10 0.27 0.03
89 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
90 INT157800 Gene_expression of Srf 2 0.45 0.88 0
91 INT268299 Positive_regulation of Gene_expression of Itgb1 2 0.38 1.37 0
92 INT251359 Regulation of Cdh1 2 0.34 0.47 0
93 INT189878 Localization of Cdh1 2 0.56 0.34 0
94 INT251362 Regulation of Gene_expression of Cdh1 2 0.46 0.4 0
95 INT256961 Regulation of Gene_expression of Dlg1 1 0.33 0 0
96 INT105753 Positive_regulation of Gene_expression of SRF 1 0.01 0.13 0
97 INT225977 Regulation of Binding of Itgb1 1 0.07 0.41 0
98 INT256978 Positive_regulation of Dlg1 1 0.34 0 0
99 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
100 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
101 INT174771 Negative_regulation of INADL 1 0.04 0 0
102 INT256952 Localization of Dlg1 1 0.55 0 0
103 INT189879 Positive_regulation of Binding of Cdh1 1 0.08 0.15 0
104 INT301987 Negative_regulation of Positive_regulation of Cdh1 1 0.07 1.28 0
105 INT312313 Protein_catabolism of Cdh1 1 0.75 0.21 0
106 INT245366 Regulation of Itgb1 1 0.03 0 0
107 INT355317 Negative_regulation of Gene_expression of Itgb1 1 0.20 0.14 0
108 INT349911 Regulation of Negative_regulation of Cdh1 1 0.44 0.23 0
109 INT291604 Binding of ITGB1 1 0.05 0.16 0
110 INT324055 Regulation of Transcription of Cdh1 1 0.09 0.49 0
111 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
112 INT105752 Positive_regulation of SRF 1 0.01 0.13 0
113 INT257646 Positive_regulation of Gene_expression of Pard3 1 0.51 0 0
114 INT337667 Regulation of Transcription of APC 1 0.23 1 0
115 INT189883 Negative_regulation of Localization of Cdh1 1 0.07 0.06 0
116 INT268104 Negative_regulation of Gene_expression of SRF 1 0.38 0.16 0
117 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0
118 INT296611 Positive_regulation of Negative_regulation of Cdh1 1 0.11 0.78 0
119 INT310014 Phosphorylation of Cdh1 1 0.16 0.24 0
120 INT286250 Positive_regulation of RAMP2 1 0.33 0.5 0
121 INT256974 Gene_expression of Dlg1 1 0.50 0.08 0
122 INT280923 Localization of Itgb1 1 0.40 0.72 0
123 INT225408 Negative_regulation of Srf 1 0.05 0.39 0
124 INT301989 Positive_regulation of Binding of Cdh1 1 0.08 0.42 0
125 INT157799 Negative_regulation of Gene_expression of Srf 1 0.18 0.07 0
126 INT349904 Regulation of Localization of Cdh1 1 0.44 0.05 0
127 INT157794 Phosphorylation of Srf 1 0.26 0.07 0
128 INT257653 Negative_regulation of Binding of Pard3 1 0.32 0.07 0
129 INT263679 Transcription of Dlg1 1 0.12 0.07 0
130 INT175647 Regulation of Gene_expression of ITGB1 1 0.01 0.4 0
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