GO:0070857

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Name regulation of bile acid biosynthetic process
Categary Process
Go Slim No
Go Link GO:0070857
Unique Molecular Interactions 102
Total Molecular Interactions 159
Total Single Events 638
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of bile acid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for regulation of bile acid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
3 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
4 INT177269 Binding of CXADR and NR1H4 1 0.04 0 0.58
5 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
6 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
7 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
8 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
9 INT335028 Fgf15 Positive_regulation of Fgfr4 1 0.40 0.31 0.25
10 INT335015 Fgf15 Negative_regulation of Gene_expression of Cyp7a1 1 0.57 0.2 0.24
11 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23
12 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
13 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
14 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
15 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
16 INT229289 FGF19 Negative_regulation of CYP7A1 1 0.26 0.32 0.16
17 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
18 INT278610 CDCA2 Negative_regulation of NR1H4 1 0.01 0.62 0.13
19 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12
20 INT264403 NR1H4 Negative_regulation of IL1R2 1 0.04 0.09 0.12
21 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
22 INT177263 Binding of NR1H4 and FAUP1 1 0.00 0 0.09
23 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
24 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
25 INT177278 Binding of HLA-DRB4 and NR1H4 1 0.02 0 0.08
26 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
27 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
28 INT279416 NR1H4 Regulation of PPARA 1 0.01 0.13 0.08
29 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
30 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
31 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
32 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
33 INT279421 Binding of NR1H4 and MLXIPL 1 0.00 0.27 0.07
34 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
35 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
36 INT177255 Binding of SV2A and NR1H4 1 0.04 0 0.07
37 INT182943 Binding of DR1 and NR1H4 3 0.03 0.14 0.06
38 INT113862 Binding of CA2 and NR1H4 1 0.00 0 0.06
39 INT113861 Binding of CA3 and NR1H4 1 0.00 0 0.06
40 INT177276 Positive_regulation of Binding of CXADR and NR1H4 1 0.04 0 0.05
41 INT177282 Regulation of Binding of CXADR and NR1H4 1 0.02 0 0.05
42 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
43 INT177270 Binding of TNFRSF25 and NR1H4 2 0.02 0.21 0.04
44 INT177272 Binding of ABCB1 and NR1H4 1 0.02 0 0.04
45 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
46 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04
47 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
48 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
49 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
50 INT264382 NR1H4 Positive_regulation of VDR 1 0.04 0.09 0.03
51 INT264396 NR1H4 Positive_regulation of THRA 1 0.01 0.09 0.03
52 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
53 INT182950 Binding of VDR and NR1H4 5 0.03 1.16 0
54 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
55 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
56 INT290033 Binding of PPARD and NR1H4 1 0.01 0.39 0
57 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
58 INT290027 Binding of PPARG and NR1H4 1 0.03 0.39 0
59 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
60 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
61 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
62 INT290029 Binding of INS and NR1H4 1 0.01 0.47 0
63 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
64 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
65 INT183014 Binding of NR1H4 and Dre 1 0.00 0.06 0
66 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
67 INT182955 Positive_regulation of Binding of VDR and NR1H4 1 0.03 0 0
68 INT302303 Binding of NR1H4 and Rdh5 1 0.02 0.11 0
69 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
70 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
71 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
72 INT330956 Binding of TEP1 and NR1H4 1 0.00 1.07 0
73 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
74 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
75 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
76 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
77 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
78 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
79 INT234439 Binding of NR1H4 and HCC 1 0.06 0.82 0
80 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
81 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
82 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
83 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
84 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
85 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
86 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
87 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
88 INT278605 CDCA2 Positive_regulation of NR1H4 1 0.01 0.36 0
89 INT182930 Binding of TNFRSF10B and NR1H4 1 0.02 0 0
90 INT135128 Binding of NR1I2 and NR1H4 1 0.09 0.57 0
91 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
92 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
93 INT182963 Binding of NR1H4 and KCNIP3 1 0.03 0.45 0
94 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
95 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
96 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of bile acid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in regulation of bile acid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
2 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
3 INT132575 Binding of NR1H4 57 0.20 22.06 2.82
4 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45
5 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
6 INT114953 Gene_expression of NR1H4 23 0.29 16.58 2.02
7 INT262117 Negative_regulation of Gene_expression of Cyp7a1 3 0.25 0.91 1.6
8 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
9 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
10 INT135132 Positive_regulation of NR1H4 17 0.30 8.63 1.38
11 INT114961 Positive_regulation of Gene_expression of NR1H4 6 0.16 3.55 1.23
12 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
13 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
14 INT334977 Regulation of Gene_expression of Cyp7a1 2 0.40 0.43 0.94
15 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
16 INT197010 Positive_regulation of CYP7A1 4 0.47 1.75 0.7
17 INT229326 Negative_regulation of CYP7A1 3 0.29 1.03 0.7
18 INT262093 Positive_regulation of Gene_expression of Cyp7a1 2 0.44 0.81 0.55
19 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
20 INT329888 Positive_regulation of Transcription of CYP7A1 1 0.20 0.9 0.46
21 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
22 INT303541 Gene_expression of Fgfr4 2 0.62 0.72 0.43
23 INT229307 Positive_regulation of Negative_regulation of CYP7A1 1 0.31 0.1 0.43
24 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
25 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
26 INT234463 Phosphorylation of NR1H4 23 0.34 14.56 0.39
27 INT176186 Negative_regulation of Cyp7a1 5 0.46 2.07 0.39
28 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
29 INT234456 Negative_regulation of Gene_expression of NR1H4 2 0.18 1.05 0.32
30 INT176170 Regulation of Cyp7a1 2 0.21 0.5 0.32
31 INT335088 Regulation of Regulation of Cyp7a1 1 0.19 0.1 0.32
32 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
33 INT176200 Positive_regulation of Cyp7a1 2 0.37 0.4 0.31
34 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
35 INT321344 Positive_regulation of Fgfr4 1 0.09 0.23 0.27
36 INT334990 Regulation of Positive_regulation of Fgfr4 1 0.36 0.25 0.25
37 INT334992 Positive_regulation of Fgfr4 1 0.40 0.24 0.25
38 INT329886 Transcription of CYP7A1 1 0.28 0.45 0.23
39 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
40 INT250849 Binding of Fgfr4 1 0.11 0.54 0.19
41 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
42 INT234469 Negative_regulation of Phosphorylation of NR1H4 2 0.14 1.25 0.16
43 INT173171 Gene_expression of CYP7A1 2 0.45 1.02 0.14
44 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
45 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
46 INT234464 Negative_regulation of NR1H4 6 0.19 3.54 0.12
47 INT173188 Regulation of Gene_expression of CYP7A1 1 0.22 0.48 0.12
48 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
49 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
50 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
51 INT234468 Protein_catabolism of NR1H4 2 0.32 0.87 0.09
52 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
53 INT177318 Negative_regulation of Binding of NR1H4 5 0.14 3.39 0.08
54 INT229319 Regulation of Positive_regulation of CYP7A1 1 0.30 0.42 0.08
55 INT234477 Localization of NR1H4 3 0.24 2.23 0.07
56 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
57 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
58 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
59 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
60 INT229325 Positive_regulation of Gene_expression of CYP7A1 1 0.34 0.6 0.05
61 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
62 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
63 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
64 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
65 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
66 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
67 INT345480 Binding of CYP7A1 1 0.29 0 0.03
68 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
69 INT204349 Regulation of SIRT1 8 0.61 1.99 0
70 INT256134 Localization of Sirt1 5 0.50 2.99 0
71 INT204353 Transcription of SIRT1 3 0.68 0.67 0
72 INT177301 Positive_regulation of Binding of NR1H4 3 0.29 0.45 0
73 INT176172 Transcription of Cyp7a1 1 0.57 1.04 0
74 INT176179 Negative_regulation of Positive_regulation of Cyp7a1 1 0.34 0.4 0
75 INT234451 Positive_regulation of Phosphorylation of NR1H4 1 0.22 5.15 0
76 INT187419 Regulation of CYP7A1 1 0.05 0.23 0
77 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
78 INT289569 Transcription of Sirt1 1 0.71 0.25 0
79 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
80 INT300287 Localization of Sirt1 1 0.66 1.46 0
81 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
82 INT234475 Transcription of NR1H4 1 0.17 1.62 0
83 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
84 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
85 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
86 INT176215 Regulation of Transcription of Cyp7a1 1 0.49 0.79 0
87 INT234470 Positive_regulation of Protein_catabolism of NR1H4 1 0.22 0.93 0
88 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
89 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
90 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
91 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
92 INT264439 Regulation of Binding of NR1H4 1 0.19 0 0
93 INT204331 Binding of SIRT1 1 0.47 0.39 0
94 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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