GO:0070885

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Name negative regulation of calcineurin-NFAT signaling cascade
Categary Process
Go Slim No
Go Link GO:0070885
Unique Molecular Interactions 53
Total Molecular Interactions 70
Total Single Events 1522
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of calcineurin-NFAT signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of calcineurin-NFAT signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
2 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
3 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
4 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
5 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19
6 INT134698 Regulation of Prnp Positive_regulation of Nup214 1 0.26 1.18 0.14
7 INT134697 Prnp Positive_regulation of Nup214 1 0.44 1.18 0.13
8 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08
9 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
10 INT229539 Cpz Negative_regulation of Localization of Prnp 1 0.05 0.58 0.07
11 INT229538 Cpz Negative_regulation of Positive_regulation of Prnp 1 0.05 0.58 0.07
12 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
13 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05
14 INT231299 Prnp Regulation of Grin2d 1 0.28 0 0.05
15 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05
16 INT231302 Binding of Grin2d and Prnp 1 0.38 0.11 0.05
17 INT231311 Prnp Negative_regulation of Helt 1 0.04 0.05 0.03
18 INT231308 Prnp Negative_regulation of Gene_expression of Grin1 1 0.41 0.05 0.03
19 INT231312 Prnp Negative_regulation of Grin1 1 0.42 0.05 0.03
20 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0
21 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0
22 INT335952 Prnp Positive_regulation of can 1 0.17 0.58 0
23 INT268183 Gene_expression of Rab22a Negative_regulation of Gene_expression of Prnp 1 0.28 0.1 0
24 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
25 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0
26 INT260523 Binding of Cnp and Prnp 1 0.33 0.34 0
27 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
28 INT268192 Gene_expression of Rab22a Positive_regulation of Protein_catabolism of Prnp 1 0.30 0.08 0
29 INT260561 Binding of AFM and PRNP 1 0.22 0 0
30 INT260519 Binding of Prnp and Scarb1 1 0.41 0.21 0
31 INT268191 Rab4a Regulation of Gene_expression of Prnp 1 0.23 0.22 0
32 INT260522 Binding of Myc and Prnp 1 0.30 0.35 0
33 INT335950 Negative_regulation of Prnp Positive_regulation of can 1 0.16 0.59 0
34 INT268197 Gene_expression of Rab22a Regulation of Prnp 1 0.29 0.08 0
35 INT268184 Prnp Regulation of Gene_expression of Rab22a 1 0.34 0.17 0
36 INT231313 Prnp Positive_regulation of Grin2d 1 0.47 0.16 0
37 INT268201 Tg(CAG-EGFP)D4Nagy Regulation of Prnp 1 0.01 0.22 0
38 INT268198 Prnp Positive_regulation of Erc1 1 0.04 0.26 0
39 INT268194 Erc1 Positive_regulation of Gene_expression of Prnp 1 0.05 0.2 0
40 INT344000 PROC Positive_regulation of PRNP 1 0.00 0.07 0
41 INT268190 Gene_expression of Rab22a Negative_regulation of Prnp 1 0.32 0.08 0
42 INT268177 Rab4a Regulation of Prnp 1 0.14 0.22 0
43 INT268182 Positive_regulation of Binding of Prnp and Erc1 1 0.06 0.1 0
44 INT268188 Binding of Prnp and Erc1 1 0.04 0.27 0
45 INT268185 Rab22a Negative_regulation of Gene_expression of Prnp 1 0.32 0.08 0
46 INT268195 Rab22a Negative_regulation of Prnp 1 0.44 0.09 0
47 INT193307 Binding of PDGFA and PRNP 1 0.01 0 0
48 INT268176 Positive_regulation of Erc1 Positive_regulation of Gene_expression of Prnp 1 0.06 0.2 0
49 INT287034 Pgp Regulation of Positive_regulation of Prnp 1 0.13 0.09 0
50 INT268646 Prnp Positive_regulation of PRNP 1 0.08 0.42 0
51 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of calcineurin-NFAT signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of calcineurin-NFAT signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
2 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
3 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
4 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
5 INT69572 Localization of Prnp 96 0.81 38.11 5.45
6 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
7 INT69570 Binding of Prnp 75 0.48 44.26 4.37
8 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
9 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
10 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
11 INT167203 Binding of PRNP 25 0.48 20.09 1.84
12 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
13 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
14 INT85621 Regulation of PRNP 16 0.60 8.7 1.15
15 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03
16 INT136634 Transcription of Prnp 9 0.72 3.34 0.83
17 INT100601 Localization of PRNP 17 0.66 13.61 0.71
18 INT190662 Regulation of Positive_regulation of Prnp 4 0.24 1.15 0.7
19 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67
20 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44
21 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3
22 INT335949 Positive_regulation of Positive_regulation of PRNP 2 0.25 0.82 0.29
23 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27
24 INT331055 Positive_regulation of Phosphorylation of Prnp 1 0.07 0.24 0.27
25 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26
26 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26
27 INT268171 Negative_regulation of Binding of Prnp 3 0.42 0.82 0.25
28 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16
29 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1
30 INT207304 Positive_regulation of Protein_catabolism of Prnp 9 0.69 2.08 0.09
31 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09
32 INT303459 Transcription of PRNP 4 0.69 1.44 0.08
33 INT354480 Regulation of Gene_expression of PRNP 1 0.39 1.96 0.08
34 INT354479 Positive_regulation of Transcription of PRNP 1 0.50 0.4 0.08
35 INT207302 Positive_regulation of Transcription of Prnp 1 0.47 0.71 0.06
36 INT229516 Negative_regulation of Positive_regulation of Prnp 5 0.42 0.95 0.04
37 INT229519 Regulation of Localization of Prnp 4 0.61 0.7 0.03
38 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03
39 INT287031 Positive_regulation of Negative_regulation of Prnp 1 0.46 0.16 0.03
40 INT268144 Negative_regulation of Localization of Prnp 3 0.37 0.71 0
41 INT190666 Positive_regulation of Binding of Prnp 2 0.50 1.87 0
42 INT268161 Regulation of Negative_regulation of Prnp 2 0.39 0.33 0
43 INT229517 Regulation of Phosphorylation of Prnp 1 0.39 0.26 0
44 INT188131 Negative_regulation of Regulation of PRNP 1 0.41 0.06 0
45 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0
46 INT344005 Regulation of Positive_regulation of PRNP 1 0.20 0.08 0
47 INT240690 Positive_regulation of Binding of PRNP 1 0.07 0.53 0
48 INT315417 Negative_regulation of Transcription of Prnp 1 0.43 0.14 0
49 INT268173 Negative_regulation of Negative_regulation of Prnp 1 0.37 0 0
50 INT222723 Negative_regulation of Localization of PRNP 1 0.05 2.06 0
51 INT268148 Regulation of Protein_catabolism of Prnp 1 0.45 0 0
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