GO:0070887

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Name cellular response to chemical stimulus
Categary Process
Go Slim No
Go Link GO:0070887
Unique Molecular Interactions 110
Total Molecular Interactions 164
Total Single Events 1824
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to chemical stimulus. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to chemical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
2 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
3 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
4 INT130355 spc Regulation of Serpine1 1 0.14 0.2 0.66
5 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66
6 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
7 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
8 INT143504 IFNG Positive_regulation of Gene_expression of Aif1 1 0.04 1.26 0.51
9 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
10 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
11 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
12 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
13 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 0.10 0.36 0.4
14 INT235887 CALM1 Regulation of Akap5 1 0.00 0 0.39
15 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
16 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
17 INT235861 Binding of Prkaca and Akap5 1 0.20 0 0.35
18 INT235862 Binding of Ppp3r2 and Akap5 1 0.01 0 0.35
19 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
20 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
21 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
22 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
23 INT56090 TNF Regulation of SERPINE1 1 0.43 0.41 0.33
24 INT337412 AKT3 Negative_regulation of Localization of AKT2 1 0.09 0.5 0.32
25 INT337418 AKT2 Negative_regulation of Localization of AKT3 1 0.09 0.5 0.32
26 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
27 INT15685 Binding of PLAT and Serpine1 3 0.36 1.01 0.31
28 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
29 INT56092 FGFR1 Positive_regulation of Transcription of SERPINE1 1 0.29 0.41 0.29
30 INT154194 Binding of KCNK2 and Akap5 1 0.08 0.19 0.29
31 INT56091 FGF2 Positive_regulation of Transcription of SERPINE1 1 0.43 0.41 0.28
32 INT230751 Agtr2 Positive_regulation of Gene_expression of Serpine1 1 0.03 1.3 0.23
33 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
34 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22
35 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22
36 INT48713 PTGER1 Negative_regulation of Gene_expression of SERPINE1 1 0.02 0.28 0.22
37 INT202184 SERPINE1 Regulation of Protein_catabolism of PLAUR 1 0.23 1.25 0.21
38 INT255257 Binding of Serpine1 and Tsp1 1 0.07 0.85 0.2
39 INT115006 Binding of Serpine1 and Cpb2 1 0.09 1.53 0.2
40 INT110745 Bphl Positive_regulation of Positive_regulation of Aif1 1 0.03 0.18 0.2
41 INT99727 Binding of SERPINE1 and PLG 1 0.02 0.24 0.19
42 INT99734 Binding of SERPINE1 and Serpinf2 1 0.00 0.25 0.19
43 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
44 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
45 INT306261 AKT2 Negative_regulation of Phosphorylation of FOXO1 1 0.25 0.41 0.17
46 INT97820 Serpine1 Negative_regulation of TIMP1 1 0.00 0.29 0.17
47 INT158613 Binding of Serpine1 and Vtn 1 0.02 0.95 0.16
48 INT294207 Serpine1 Regulation of Gene_expression of Plat 1 0.50 0.92 0.16
49 INT143505 Aif1 Positive_regulation of CETN1 1 0.01 0.35 0.16
50 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15
51 INT180671 Binding of Plat and Regulation of Serpine1 1 0.16 0.06 0.14
52 INT11641 Binding of SERPINE1 and Serpinc1 1 0.00 0.78 0.13
53 INT11632 Binding of SERPINE1 and TAT 1 0.11 0.78 0.13
54 INT300513 Binding of Serpine1 and Vtn 1 0.17 2.27 0.13
55 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12
56 INT99737 Serpinf2 Negative_regulation of Localization of SERPINE1 1 0.00 0.24 0.12
57 INT294208 Gene_expression of Serpine1 Negative_regulation of Plat 1 0.47 0.94 0.12
58 INT101310 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.04 0.19 0.12
59 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
60 INT22670 PLAT Positive_regulation of SERPINE1 1 0.03 0.1 0.1
61 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1
62 INT294450 KLK4 Negative_regulation of SERPINE1 1 0.01 0 0.1
63 INT352303 Binding of AIF1 and CD68 1 0.01 0.71 0.1
64 INT22672 Positive_regulation of Binding of SERPINE1 and PLAT 1 0.03 0.1 0.1
65 INT158615 Binding of Serpine1 and Plaur 1 0.04 0.38 0.1
66 INT158614 Negative_regulation of Binding of Serpine1 and Vtn 1 0.03 0.48 0.09
67 INT230746 Crp Positive_regulation of Localization of Serpine1 1 0.16 0.27 0.09
68 INT239237 TCN2 Positive_regulation of Gene_expression of Serpine1 1 0.00 0.68 0.08
69 INT294220 INCENP Positive_regulation of Gene_expression of Serpine1 1 0.00 0.41 0.08
70 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 0.01 0.45 0.07
71 INT58649 Binding of INS and Serpine1 1 0.01 1.64 0.07
72 INT57268 SERPINE1 Positive_regulation of SERPINC1 1 0.07 0.94 0.07
73 INT122480 Binding of SERPINE1 and PLAU 4 0.40 2.75 0.06
74 INT344703 Hdl1 Negative_regulation of Gene_expression of Serpine1 1 0.07 1.26 0.05
75 INT213037 Hdl1 Positive_regulation of Gene_expression of Serpine1 1 0.19 1.19 0.04
76 INT319120 CRP Positive_regulation of Gene_expression of SERPINE1 1 0.70 0.54 0.04
77 INT348694 Atp9a Negative_regulation of Serpine1 1 0.00 0.24 0.03
78 INT254867 Ctgf Negative_regulation of Serpine1 1 0.04 0.51 0.03
79 INT120661 Positive_regulation of Plg Positive_regulation of Serpine1 1 0.00 0 0
80 INT143067 Mthfd1 Positive_regulation of Serpine1 1 0.00 0 0
81 INT355637 OLR1 Positive_regulation of Gene_expression of SERPINE1 1 0.03 1.15 0
82 INT349315 Hspg2 Regulation of Gene_expression of Aif1 1 0.01 0 0
83 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
84 INT294205 Serpine1 Negative_regulation of Plat 1 0.47 0.51 0
85 INT22668 PNMA1 Regulation of SERPINE1 1 0.03 0 0
86 INT294204 Binding of Serpine1 and Plat 1 0.46 0.2 0
87 INT251893 Serpine1 Negative_regulation of Plau 1 0.39 0.6 0
88 INT200651 AKT2 Regulation of AKT1 1 0.31 0.21 0
89 INT78416 Binding of Serpine1 and Vwf 1 0.00 0.11 0
90 INT143065 Mthfd1 Positive_regulation of Gene_expression of Serpine1 1 0.00 0 0
91 INT251891 Serpine1 Negative_regulation of Plg 1 0.12 3.13 0
92 INT130414 TNFSF14 Positive_regulation of SERPINE1 1 0.29 0 0
93 INT130223 Binding of Serpinc1 and Serpine1 1 0.00 0.13 0
94 INT115465 Binding of Serpine1 and Plau 1 0.00 0.05 0
95 INT197040 SERPINE1 Regulation of PLAU 1 0.31 0.68 0
96 INT120660 Plg Positive_regulation of Serpine1 1 0.00 0 0
97 INT57791 Binding of Serpine1 and Plat 1 0.00 0.07 0
98 INT265934 SREBF1 Positive_regulation of Transcription of SERPINE1 1 0.01 0.62 0
99 INT22677 Binding of SERPINE1 and SGCG 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to chemical stimulus. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to chemical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68
2 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
3 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
4 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67
5 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
6 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61
7 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
8 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03
9 INT75684 Regulation of Aif1 32 0.47 8.03 7.89
10 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
11 INT79770 Regulation of Gene_expression of Aif1 13 0.45 5.28 6.82
12 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
13 INT89959 Positive_regulation of Gene_expression of Aif1 14 0.58 7.44 5.05
14 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95
15 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
16 INT79767 Negative_regulation of Aif1 30 0.42 5.14 4.73
17 INT79768 Negative_regulation of Gene_expression of Aif1 8 0.58 5.15 4.52
18 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
19 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
20 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
21 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
22 INT16263 Regulation of Serpine1 13 0.45 5.24 3.6
23 INT57397 Binding of Aif1 15 0.28 4.06 3.49
24 INT200670 Gene_expression of AKT2 25 0.75 16.25 3
25 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
26 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
27 INT71115 Positive_regulation of Gene_expression of Serpine1 20 0.70 15.32 1.97
28 INT23188 Localization of Serpine1 22 0.79 16.06 1.96
29 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85
30 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67
31 INT335495 Regulation of Regulation of Aif1 5 0.21 1.22 1.51
32 INT77311 Localization of Aif1 10 0.75 4.21 1.5
33 INT24685 Localization of Serpine1 12 0.59 7.76 1.32
34 INT128061 Negative_regulation of Gene_expression of Serpine1 16 0.43 13.13 1.29
35 INT20100 Binding of Serpine1 16 0.29 6.78 1.18
36 INT160054 Localization of AKT2 4 0.73 1.93 1.18
37 INT15919 Positive_regulation of Gene_expression of Serpine1 6 0.41 4.5 1.15
38 INT272172 Regulation of Positive_regulation of Aif1 3 0.26 0 1.11
39 INT54137 Positive_regulation of Positive_regulation of Serpine1 4 0.70 0.79 1.06
40 INT20156 Positive_regulation of Negative_regulation of Serpine1 4 0.49 2.89 0.97
41 INT191478 Negative_regulation of Positive_regulation of Aif1 2 0.25 0.31 0.95
42 INT160056 Positive_regulation of AKT2 3 0.48 1.43 0.88
43 INT271605 Regulation of Gene_expression of AKT2 1 0.44 0.81 0.87
44 INT48717 Positive_regulation of Localization of SERPINE1 6 0.66 2.64 0.83
45 INT112336 Binding of Serpine1 8 0.41 4.62 0.78
46 INT142083 Positive_regulation of AIF1 4 0.12 4.86 0.77
47 INT139945 Transcription of Aif1 2 0.65 0.89 0.76
48 INT200669 Negative_regulation of AKT2 2 0.42 0.94 0.72
49 INT11362 Regulation of Localization of SERPINE1 3 0.39 1.55 0.69
50 INT309322 Gene_expression of AIF1 7 0.14 2.64 0.68
51 INT318499 Regulation of AIF1 2 0.03 4.89 0.6
52 INT70971 Negative_regulation of Positive_regulation of SERPINE1 3 0.40 2.65 0.58
53 INT142079 Negative_regulation of Positive_regulation of AIF1 1 0.00 1.01 0.57
54 INT20099 Regulation of Positive_regulation of Serpine1 2 0.40 1.75 0.52
55 INT58015 Regulation of Gene_expression of Serpine1 3 0.41 2.61 0.47
56 INT56094 Protein_catabolism of SERPINE1 2 0.61 1.66 0.47
57 INT271604 Positive_regulation of Gene_expression of AKT2 2 0.49 0.22 0.47
58 INT35435 Negative_regulation of Positive_regulation of Serpine1 5 0.42 2.26 0.46
59 INT20101 Regulation of Positive_regulation of Serpine1 1 0.10 0.94 0.44
60 INT126530 Negative_regulation of Positive_regulation of Serpine1 3 0.43 2.62 0.38
61 INT48721 Negative_regulation of Localization of SERPINE1 3 0.43 2.4 0.38
62 INT324921 Regulation of Localization of Aif1 1 0.23 0.46 0.38
63 INT187606 Negative_regulation of Gene_expression of Serpine1 3 0.05 1.78 0.36
64 INT354234 Regulation of Binding of Aif1 1 0.30 0.57 0.36
65 INT200606 Regulation of Gene_expression of Serpine1 4 0.38 2.07 0.35
66 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33
67 INT172783 Regulation of Localization of Serpine1 3 0.30 3.83 0.32
68 INT323118 Positive_regulation of Localization of AKT2 2 0.49 0.48 0.31
69 INT99739 Protein_catabolism of Serpine1 4 0.87 1.71 0.29
70 INT48719 Negative_regulation of Transcription of SERPINE1 1 0.42 0.17 0.26
71 INT180280 Positive_regulation of Phosphorylation of SERPINE1 2 0.48 0 0.24
72 INT180281 Phosphorylation of SERPINE1 2 0.78 0 0.24
73 INT202186 Negative_regulation of Phosphorylation of SERPINE1 1 0.41 0 0.24
74 INT125772 Positive_regulation of Negative_regulation of Serpine1 1 0.42 0.4 0.22
75 INT100870 Positive_regulation of Binding of SERPINE1 2 0.49 1.24 0.21
76 INT48723 Regulation of Transcription of SERPINE1 1 0.27 0.26 0.2
77 INT333083 Positive_regulation of Regulation of AIF1 1 0.06 3.65 0.2
78 INT125773 Transcription of Serpine1 4 0.53 2.35 0.19
79 INT200676 Phosphorylation of AKT2 1 0.53 1.01 0.19
80 INT25009 Regulation of Localization of Serpine1 2 0.36 0.15 0.17
81 INT191479 Negative_regulation of Negative_regulation of Aif1 1 0.08 0.09 0.17
82 INT270426 Regulation of Binding of SERPINE1 1 0.06 0.42 0.17
83 INT167360 Negative_regulation of Regulation of Aif1 2 0.38 0.59 0.16
84 INT82636 Negative_regulation of Localization of Serpine1 1 0.29 1.01 0.16
85 INT212989 Negative_regulation of Localization of Serpine1 1 0.26 2.2 0.16
86 INT179260 Binding of AKT2 2 0.27 1.8 0.15
87 INT212957 Positive_regulation of Localization of Serpine1 2 0.50 1.89 0.15
88 INT67181 Positive_regulation of Positive_regulation of SERPINE1 3 0.49 3.02 0.14
89 INT305016 Positive_regulation of Negative_regulation of SERPINE1 1 0.10 1.13 0.11
90 INT277070 Negative_regulation of Negative_regulation of SERPINE1 1 0.12 0.55 0.1
91 INT51990 Transcription of Serpine1 3 0.45 2.01 0.09
92 INT245881 Negative_regulation of Negative_regulation of Serpine1 1 0.04 1.66 0.09
93 INT309320 Binding of AIF1 3 0.07 1.08 0.07
94 INT81879 Regulation of Regulation of SERPINE1 1 0.27 0.73 0.06
95 INT272173 Positive_regulation of Positive_regulation of Aif1 1 0.03 0 0.04
96 INT200687 Positive_regulation of Phosphorylation of AKT2 1 0.33 0.43 0.04
97 INT254810 Negative_regulation of Protein_catabolism of Serpine1 1 0.08 0.51 0.03
98 INT254787 Positive_regulation of Protein_catabolism of Serpine1 1 0.10 0.52 0.03
99 INT246763 Gene_expression of Akt2 2 0.53 1.22 0
100 INT200678 Transcription of AKT2 1 0.47 0.57 0
101 INT254802 Phosphorylation of Serpine1 1 0.05 0 0
102 INT66115 Regulation of Binding of Serpine1 1 0.09 0.12 0
103 INT200685 Negative_regulation of Gene_expression of AKT2 1 0.38 6.09 0
104 INT200607 Positive_regulation of Regulation of Serpine1 1 0.42 0.97 0
105 INT353031 Negative_regulation of Transcription of Serpine1 1 0.02 0.69 0
106 INT246746 Positive_regulation of Gene_expression of Akt2 1 0.23 0.32 0
107 INT167359 Positive_regulation of Regulation of Aif1 1 0.41 0.06 0
108 INT310172 Positive_regulation of Transcription of Serpine1 1 0.18 1.99 0
109 INT348217 Regulation of Akt2 1 0.13 0.25 0
110 INT310178 Negative_regulation of Transcription of Serpine1 1 0.15 0.98 0
111 INT200686 Negative_regulation of Transcription of AKT2 1 0.28 0.58 0
112 INT309319 Positive_regulation of Binding of AIF1 1 0.09 0.06 0
113 INT348213 Positive_regulation of Akt2 1 0.32 0.58 0
114 INT323119 Protein_catabolism of AKT2 1 0.96 0 0
115 INT272171 Regulation of Negative_regulation of Aif1 1 0.02 0 0
116 INT143064 Positive_regulation of Localization of Serpine1 1 0.13 0 0
117 INT278429 Positive_regulation of Localization of Aif1 1 0.13 0.47 0
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