GO:0070888

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Name E-box binding
Categary Function
Go Slim No
Go Link GO:0070888
Unique Molecular Interactions 621
Total Molecular Interactions 715
Total Single Events 5639
Pain Genes Associated 36

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for E-box binding. They are ordered first by their pain relevance and then by number of times they were reported for E-box binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
2 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
3 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
4 INT249002 Gabrg1 Positive_regulation of Protein_catabolism of Per1 1 0.35 0.09 1.15
5 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
6 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
7 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
8 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
9 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
10 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
11 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
12 INT6975 Zeb1 Positive_regulation of St8sia1 1 0.03 0.17 0.91
13 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
14 INT56499 Neurod1 Positive_regulation of Maoa 1 0.47 0 0.8
15 INT111194 Binding of NEUROD1 and Pck1 1 0.39 0 0.75
16 INT190986 Per1 Positive_regulation of Scn2a1 1 0.17 0 0.74
17 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
18 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
19 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
20 INT249010 Gabrg1 Regulation of Positive_regulation of Per1 1 0.33 0 0.67
21 INT314560 RYBP Positive_regulation of Gene_expression of MYC 1 0.02 0.06 0.67
22 INT249008 Gabrg1 Regulation of Per1 1 0.33 0 0.67
23 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
24 INT154263 NEUROD1 Positive_regulation of Gene_expression of GAL 1 0.50 0.06 0.63
25 INT120348 Negative_regulation of Binding of DES and MYC 1 0.06 0.18 0.58
26 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
27 INT120350 Binding of DES and MYC 1 0.05 0.17 0.58
28 INT120347 Binding of KNG1 and MYC 1 0.21 0.17 0.58
29 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
30 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
31 INT249024 Gabrg1 Positive_regulation of Transcription of Per1 1 0.59 0 0.55
32 INT249020 Gabrg1 Positive_regulation of Per1 1 0.40 0 0.55
33 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
34 INT248997 Gabrg1 Positive_regulation of Clock 1 0.37 0 0.54
35 INT281129 Tcf21 Positive_regulation of Binding of Cd4 1 0.04 1.21 0.54
36 INT248995 Gabrg1 Regulation of Transcription of Clock 1 0.36 0 0.54
37 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
38 INT249016 Gabrg1 Positive_regulation of Transcription of Clock 1 0.37 0 0.54
39 INT281131 Tcf21 Positive_regulation of Rent1 1 0.00 1.19 0.53
40 INT119745 NEUROD1 Regulation of Gene_expression of BHLHE22 1 0.11 0.26 0.53
41 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 0.03 0 0.51
42 INT95042 Binding of NEUROD1 and Olr1246 1 0.02 0.23 0.51
43 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5
44 INT162499 Binding of AHR and NEUROD1 3 0.25 0.19 0.49
45 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
46 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
47 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
48 INT288265 Binding of FLG and NEUROG1 1 0.02 1.06 0.46
49 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
50 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
51 INT249011 Gabrg1 Regulation of Clock 1 0.19 0 0.43
52 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
53 INT171185 Binding of NEUROD1 and ACOT1 1 0.01 0.37 0.42
54 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
55 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39
56 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38
57 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38
58 INT70010 Binding of Neurod1 and Insrr 1 0.01 0.11 0.37
59 INT337890 Per1 Regulation of Nr2f2 1 0.08 0 0.37
60 INT249004 Helt Regulation of Clock 1 0.01 0.09 0.37
61 INT249015 Regulation of Helt Regulation of Clock 1 0.01 0.09 0.37
62 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
63 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
64 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
65 INT209312 Trpc5 Positive_regulation of Gene_expression of Scx 1 0.15 0.05 0.33
66 INT239540 Binding of CXCR2 and MYC 1 0.15 0.09 0.33
67 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33
68 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33
69 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
70 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
71 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
72 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
73 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
74 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32
75 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
76 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
77 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32
78 INT353208 NEUROG2 Positive_regulation of Gene_expression of HTR1A 1 0.05 0.35 0.31
79 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
80 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
81 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
82 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
83 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
84 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
85 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
86 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
87 INT281127 Tcf21 Positive_regulation of Gene_expression of Cxcr4 1 0.08 0.42 0.3
88 INT239537 CXCR2 Regulation of MYC 1 0.15 0.05 0.29
89 INT128046 Per1 Regulation of Fos 1 0.41 0 0.29
90 INT128048 Per1 Regulation of Gene_expression of Fos 1 0.41 0 0.29
91 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
92 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
93 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
94 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
95 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
96 INT190983 Vip Positive_regulation of Gene_expression of Per1 1 0.13 0.51 0.27
97 INT213816 Binding of Tcf12 and Tfeb 1 0.01 1.91 0.27
98 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
99 INT298277 Pou4f1 Negative_regulation of Gene_expression of Neurod1 1 0.58 0.48 0.27
100 INT167488 Binding of NEUROD1 and GGNBP2 1 0.08 0 0.27
101 INT190996 ADCYAP1 Positive_regulation of Per1 1 0.06 0.45 0.27
102 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
103 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
104 INT68298 Binding of Neurod1 and Abt1 1 0.24 0 0.26
105 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
106 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
107 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
108 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
109 INT327300 Binding of Hnrnpd and Myc 1 0.12 1.02 0.25
110 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
111 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
112 INT213813 Binding of Tcf4 and Tfeb 1 0.14 0.81 0.24
113 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
114 INT213805 Binding of Tcf12 and Tcf4 1 0.00 0.79 0.23
115 INT310497 Neurog2 Positive_regulation of Fate1 1 0.07 0.36 0.21
116 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
117 INT305203 Epo Positive_regulation of Gene_expression of Neurog1 1 0.06 0.4 0.21
118 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
119 INT203527 Pou4f1 Negative_regulation of Neurod1 1 0.32 0.54 0.2
120 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
121 INT18966 TNF Positive_regulation of NEUROD1 1 0.53 0.83 0.2
122 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
123 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
124 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
125 INT244054 Prkaca Regulation of Neurod1 1 0.02 0.06 0.19
126 INT310498 Gene_expression of Neurog2 Positive_regulation of Positive_regulation of Eomes 1 0.20 0.42 0.19
127 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
128 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
129 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
130 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
131 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
132 INT190635 Binding of Lmo2 and Nr1h2 1 0.09 0.59 0.16
133 INT190629 Binding of Lmo2 and Usf1 1 0.11 0.6 0.16
134 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
135 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
136 INT190634 Binding of Lmo2 and Maz 1 0.14 0.59 0.16
137 INT116268 Binding of Myc and Acsl1 1 0.08 0.19 0.16
138 INT190633 Binding of Lmo2 and Deaf1 1 0.18 0.59 0.16
139 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
140 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
141 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
142 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
143 INT251528 Binding of CRYGD and NEUROG1 1 0.00 0.38 0.15
144 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
145 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
146 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
147 INT223538 Binding of HAND1 and Tcf3 1 0.39 1.13 0.14
148 INT239557 Binding of MYC and Hopx 1 0.14 0 0.14
149 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
150 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
151 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
152 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
153 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
154 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
155 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
156 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
157 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
158 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
159 INT223530 Binding of Tcf3 and Szf1 1 0.33 0.92 0.13
160 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
161 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12
162 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
163 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
164 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
165 INT10731 NEUROD1 Regulation of CD4 1 0.42 1.3 0.12
166 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
167 INT10732 NEUROD1 Regulation of CD9 1 0.49 1.29 0.12
168 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
169 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
170 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
171 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
172 INT281022 Clock Negative_regulation of Per1 1 0.26 0.09 0.11
173 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
174 INT281023 Clock Negative_regulation of Per2 1 0.31 0.09 0.11
175 INT69909 Binding of MYC and PURA 1 0.24 0 0.1
176 INT298267 Tcf3 Positive_regulation of Gene_expression of Runx1 1 0.21 0.6 0.1
177 INT139558 Chrna4 Regulation of Neurod1 1 0.17 0 0.1
178 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
179 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
180 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
181 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
182 INT171188 Positive_regulation of Binding of NEUROD1 and TNIP1 1 0.08 0 0.1
183 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 0.17 0 0.1
184 INT171184 Binding of NEUROD1 and TNIP1 1 0.06 0 0.1
185 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
186 INT147671 Tg(CAG-EGFP)D4Nagy Positive_regulation of Per1 1 0.05 0 0.09
187 INT147673 SRI Positive_regulation of Per1 1 0.03 0 0.09
188 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
189 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
190 INT221653 Binding of Myc and Gopc 2 0.12 0.51 0.08
191 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
192 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
193 INT147674 Binding of GRP and Per1 1 0.04 0 0.08
194 INT269569 MAPKAP1 Positive_regulation of PER1 1 0.01 0 0.08
195 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
196 INT269566 MAPKAP1 Positive_regulation of Localization of PER1 1 0.01 0 0.08
197 INT343792 Binding of TCF21 and CORO7 1 0.01 0.51 0.07
198 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
199 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
200 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for E-box binding. They are ordered first by their pain relevance and then by number of times they were reported in E-box binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
3 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31
4 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
5 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
6 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
7 INT173505 Localization of Hand2 63 0.57 45.32 13.66
8 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23
9 INT128054 Gene_expression of Per1 15 0.61 2.12 11.84
10 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
11 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04
12 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49
13 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
14 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
15 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89
16 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
17 INT130117 Regulation of Per1 26 0.53 3.25 7.63
18 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12
19 INT64370 Gene_expression of Neurod1 22 0.75 5.19 7.1
20 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
21 INT159518 Gene_expression of Clock 4 0.35 2.34 6.91
22 INT170385 Regulation of Clock 29 0.49 4.95 6.39
23 INT6097 Negative_regulation of NEUROD1 30 0.57 9.71 6.24
24 INT6098 Binding of NEUROD1 17 0.47 3.4 5.99
25 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
26 INT128045 Positive_regulation of Per1 29 0.69 5.32 5.5
27 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
28 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
29 INT128324 Regulation of Gene_expression of Per1 11 0.61 1.95 5.22
30 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17
31 INT72834 Negative_regulation of Tcf21 10 0.58 5.8 4.84
32 INT138216 Negative_regulation of PER1 13 0.37 9.66 4.55
33 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
34 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
35 INT127434 Negative_regulation of Gene_expression of Per1 12 0.58 2.58 4.2
36 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
37 INT156131 Binding of Hand2 14 0.25 10.35 3.99
38 INT22566 Positive_regulation of Tcf21 8 0.65 3.06 3.75
39 INT130119 Transcription of Per1 28 0.67 1.92 3.56
40 INT20011 Regulation of NEUROD1 10 0.44 3.83 3.53
41 INT132385 Gene_expression of Neurog2 12 0.73 7.03 3.44
42 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
43 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29
44 INT72618 Regulation of Tcf3 5 0.44 1.48 3.16
45 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95
46 INT161812 Positive_regulation of PER1 17 0.56 5.64 2.93
47 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
48 INT281367 Regulation of Gene_expression of Tcf21 1 0.09 1.39 2.89
49 INT39856 Binding of Neurod1 8 0.47 1.44 2.88
50 INT36886 Transcription of Myc 6 0.69 3.16 2.86
51 INT116540 Binding of Twist1 35 0.48 16.32 2.85
52 INT351263 Binding of CLOCK 1 0.18 0.46 2.71
53 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
54 INT185407 Binding of PER1 13 0.42 9.32 2.6
55 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
56 INT196971 Positive_regulation of Gene_expression of Per1 8 0.69 1.23 2.44
57 INT281369 Negative_regulation of Gene_expression of Tcf21 1 0.08 1.4 2.44
58 INT82798 Regulation of MYC 19 0.60 12.06 2.31
59 INT107685 Phosphorylation of MYC 3 0.80 2.52 2.28
60 INT41775 Gene_expression of NEUROG1 10 0.71 5.46 2.14
61 INT73476 Transcription of MYC 18 0.69 12.14 2.13
62 INT82048 Positive_regulation of Neurod1 7 0.49 2.39 2.13
63 INT72616 Negative_regulation of Tcf3 2 0.41 0.97 2.04
64 INT90004 Gene_expression of TCF21 4 0.65 2.48 2.02
65 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
66 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
67 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9
68 INT128058 Regulation of PER1 6 0.43 1.82 1.89
69 INT13999 Positive_regulation of Positive_regulation of NEUROD1 5 0.67 4.07 1.86
70 INT201993 Binding of NEUROG1 4 0.09 4.62 1.85
71 INT170387 Transcription of Clock 11 0.63 1.78 1.83
72 INT128053 Positive_regulation of Per1 5 0.35 0.54 1.83
73 INT155110 Negative_regulation of Phosphorylation of MYC 1 0.57 1.61 1.83
74 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
75 INT128060 Regulation of Gene_expression of PER1 4 0.52 2.41 1.72
76 INT316162 Localization of TCF21 1 0.18 0.28 1.71
77 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66
78 INT139254 Negative_regulation of Per1 12 0.56 3.17 1.62
79 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
80 INT65602 Negative_regulation of Neurod1 7 0.42 2.52 1.55
81 INT244735 Gene_expression of Ascl1 12 0.58 2.48 1.54
82 INT58195 Positive_regulation of Neurog1 2 0.39 1.21 1.51
83 INT188683 Binding of Per1 10 0.37 0.9 1.47
84 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
85 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
86 INT149815 Positive_regulation of Gene_expression of Clock 7 0.46 0.87 1.45
87 INT64371 Positive_regulation of Gene_expression of Neurod1 4 0.64 1.56 1.45
88 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
89 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
90 INT116008 Binding of Gata3 2 0.34 1.37 1.41
91 INT27356 Localization of NEUROD1 8 0.78 3.44 1.39
92 INT128057 Positive_regulation of Gene_expression of PER1 7 0.59 1.21 1.39
93 INT222228 Positive_regulation of Gene_expression of Tcf21 4 0.38 0.84 1.39
94 INT248976 Positive_regulation of Clock 8 0.48 0.15 1.38
95 INT10873 Localization of Twist1 21 0.74 10.43 1.37
96 INT110485 Binding of Tcf21 2 0.36 0.76 1.37
97 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36
98 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
99 INT116265 Binding of Myc 9 0.36 4.28 1.36
100 INT20418 Regulation of Gene_expression of MYC 6 0.60 4.4 1.29
101 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
102 INT294804 Positive_regulation of Gene_expression of Neurog2 3 0.57 2.69 1.26
103 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
104 INT18971 Positive_regulation of Gene_expression of NEUROD1 8 0.67 1.91 1.23
105 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23
106 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
107 INT72614 Negative_regulation of Regulation of Tcf3 1 0.41 0.17 1.2
108 INT128052 Positive_regulation of Gene_expression of Per1 1 0.05 0 1.14
109 INT97369 Regulation of Gene_expression of NEUROD1 1 0.26 0.25 1.12
110 INT133079 Positive_regulation of Gene_expression of GATA3 3 0.50 1.03 1.11
111 INT71848 Positive_regulation of Transcription of Myc 1 0.67 0.16 1.11
112 INT160319 Negative_regulation of Gene_expression of Per1 1 0.41 0 1.09
113 INT332771 Phosphorylation of Tcf21 1 0.09 0.21 1.07
114 INT332772 Positive_regulation of Phosphorylation of Tcf21 1 0.06 0.21 1.07
115 INT94210 Regulation of Neurod1 2 0.33 0.07 1.04
116 INT217879 Protein_catabolism of Per1 2 0.54 0.09 1.03
117 INT206672 Positive_regulation of Transcription of Per1 8 0.55 0.61 1
118 INT147665 Positive_regulation of Positive_regulation of Per1 2 0.49 0.57 0.99
119 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
120 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
121 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
122 INT102070 Regulation of Gene_expression of Myc 4 0.60 2.68 0.96
123 INT17894 Regulation of Myc 10 0.60 5.65 0.93
124 INT351266 Regulation of Binding of CLOCK 1 0.21 0 0.92
125 INT51906 Negative_regulation of Gene_expression of NEUROD1 4 0.57 1.56 0.91
126 INT351261 Regulation of Binding of PER1 1 0.40 0 0.91
127 INT82795 Binding of MYC 16 0.47 6.1 0.9
128 INT102677 Negative_regulation of TCF21 2 0.41 0.22 0.89
129 INT203502 Gene_expression of Neurog1 4 0.64 1.58 0.87
130 INT196974 Regulation of Regulation of Per1 2 0.34 0.52 0.87
131 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
132 INT285477 Positive_regulation of Zeb1 2 0.17 0.86 0.86
133 INT41774 Positive_regulation of NEUROG1 2 0.40 1.81 0.85
134 INT183517 Negative_regulation of Neurog1 2 0.35 1.28 0.85
135 INT175747 Regulation of CLOCK 4 0.21 0.06 0.84
136 INT206670 Localization of Per1 4 0.75 0.96 0.83
137 INT149817 Gene_expression of Bhlhe41 2 0.43 2.47 0.81
138 INT30050 Gene_expression of Tcf3 13 0.48 2.57 0.77
139 INT52187 Regulation of Binding of NEUROD1 1 0.44 0 0.77
140 INT157238 Transcription of PER1 3 0.50 0.21 0.74
141 INT190968 Regulation of Per1 1 0.14 0 0.74
142 INT248971 Binding of Clock 8 0.34 1.12 0.73
143 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
144 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
145 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
146 INT149819 Regulation of Gene_expression of Bhlhe41 1 0.29 0 0.7
147 INT268557 Regulation of Regulation of MYC 1 0.44 0.86 0.69
148 INT149804 Regulation of Bhlhe41 1 0.29 0 0.69
149 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
150 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
151 INT17840 Negative_regulation of GATA3 3 0.41 1.96 0.63
152 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61
153 INT248978 Localization of Clock 1 0.70 0.3 0.61
154 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
155 INT107686 Positive_regulation of Negative_regulation of MYC 2 0.49 1.59 0.6
156 INT248974 Negative_regulation of Transcription of Per1 2 0.48 0.33 0.6
157 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
158 INT105266 Localization of Tcf3 3 0.32 1.08 0.59
159 INT281366 Regulation of Tcf21 1 0.09 0.23 0.59
160 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
161 INT226481 Negative_regulation of Gene_expression of GATA3 1 0.06 1.41 0.57
162 INT316161 Negative_regulation of Gene_expression of TCF21 1 0.10 0.11 0.56
163 INT146784 Gene_expression of MYOD1 13 0.74 4.41 0.54
164 INT144053 Transcription of GATA3 1 0.67 0.89 0.54
165 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
166 INT299799 Negative_regulation of Negative_regulation of GATA3 1 0.09 1.32 0.47
167 INT61813 Localization of TFAP4 1 0.73 0 0.47
168 INT204005 Negative_regulation of Gene_expression of Clock 3 0.39 0.58 0.45
169 INT6808 Localization of Zeb1 2 0.18 0 0.45
170 INT222229 Localization of Tcf21 1 0.57 0.45 0.45
171 INT61812 Gene_expression of TFAP4 1 0.65 0 0.45
172 INT76845 Regulation of Gene_expression of Neurod1 2 0.44 0.28 0.44
173 INT128059 Regulation of Regulation of PER1 1 0.20 0 0.44
174 INT154042 Localization of Neurod1 1 0.02 0.08 0.44
175 INT304572 Regulation of Binding of Clock 1 0.30 0.29 0.43
176 INT88005 Binding of MYOD1 6 0.30 2.08 0.42
177 INT133315 Gene_expression of ZEB1 4 0.59 2.93 0.42
178 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
179 INT60952 Negative_regulation of Regulation of NEUROD1 1 0.42 0.3 0.41
180 INT60953 Negative_regulation of Negative_regulation of NEUROD1 1 0.41 0.3 0.41
181 INT90354 Negative_regulation of Myc 6 0.57 4.24 0.4
182 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
183 INT196973 Regulation of Gene_expression of Clock 12 0.38 3.58 0.38
184 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
185 INT234421 Binding of TCF4 13 0.18 2.3 0.37
186 INT30052 Positive_regulation of Tcf3 3 0.41 0.27 0.37
187 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
188 INT156490 Protein_catabolism of Neurod1 1 0.34 0.16 0.37
189 INT51266 Transcription of Neurod1 2 0.69 0.19 0.35
190 INT47995 Positive_regulation of Regulation of NEUROD1 1 0.45 0.68 0.34
191 INT24861 Regulation of Positive_regulation of NEUROD1 2 0.44 0.39 0.33
192 INT285492 Transcription of Zeb1 1 0.17 0.61 0.33
193 INT285469 Positive_regulation of Transcription of Zeb1 1 0.12 0.61 0.33
194 INT209302 Gene_expression of Scx 1 0.20 0.05 0.33
195 INT148980 Negative_regulation of Gene_expression of PER1 1 0.49 0.08 0.3
196 INT104311 Positive_regulation of Transcription of NEUROD1 1 0.49 0.28 0.29
197 INT104309 Transcription of NEUROD1 1 0.69 0.28 0.29
198 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
199 INT98598 Negative_regulation of Positive_regulation of TCF4 1 0.22 0.57 0.28
200 INT98596 Positive_regulation of TCF4 3 0.26 1.13 0.27
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