GO:0070933

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Name histone H4 deacetylation
Categary Process
Go Slim No
Go Link GO:0070933
Unique Molecular Interactions 92
Total Molecular Interactions 144
Total Single Events 724
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone H4 deacetylation. They are ordered first by their pain relevance and then by number of times they were reported for histone H4 deacetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
2 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
3 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
4 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
5 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
6 INT200308 Binding of Rest and Rorb 1 0.00 0 0.87
7 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
8 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
9 INT200317 Rest Negative_regulation of Transcription of Oprm1 1 0.31 0 0.64
10 INT200321 Binding of Rest and Negative_regulation of Gene_expression of Oprm1 1 0.36 0.05 0.49
11 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49
12 INT200327 Oprm1 Negative_regulation of Gene_expression of Rest 1 0.31 0 0.41
13 INT200314 Oprm1 Regulation of Rest 1 0.20 0.1 0.39
14 INT200353 Rest Negative_regulation of Oprm1 1 0.31 0.1 0.39
15 INT200302 Rest Regulation of Rorb 1 0.00 0.07 0.38
16 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
17 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
18 INT200352 Binding of Rest and Rcor2 1 0.16 0.44 0.34
19 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34
20 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
21 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
22 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27
23 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
24 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
25 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
26 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
27 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
28 INT200309 Positive_regulation of Binding of Rest and Sp3 1 0.41 0.88 0.24
29 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
30 INT97691 Binding of REST and HDAC9 1 0.26 0.09 0.23
31 INT97694 Ngf Negative_regulation of Gene_expression of REST 1 0.01 0.09 0.21
32 INT191355 HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
33 INT191354 Negative_regulation of HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
34 INT104797 Smarce1 Positive_regulation of REST 1 0.01 0.24 0.15
35 INT347638 Negative_regulation of Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
36 INT347639 Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
37 INT138195 Binding of HDAC4 and Creb1 1 0.03 0.17 0.13
38 INT200338 Rest Positive_regulation of Gene_expression of Oprm1 1 0.36 0 0.13
39 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
40 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
41 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
42 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
43 INT153637 Gene_expression of REST Positive_regulation of Gene_expression of Oprm1 1 0.03 0.08 0.1
44 INT153636 Binding of REST and Oprm1 1 0.02 0.09 0.09
45 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08
46 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
47 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
48 INT339979 Binding of PRDX2 and HDAC9 1 0.02 0.16 0.05
49 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
50 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03
51 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
52 INT200311 Htt Positive_regulation of Rest 1 0.05 0.75 0.03
53 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0
54 INT280849 REST Negative_regulation of Gene_expression of Avp 1 0.09 0.09 0
55 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
56 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
57 INT200647 HDAC4 Positive_regulation of CASP9 1 0.10 0.93 0
58 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
59 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
60 INT121179 Binding of Htt and Rest 1 0.07 0.45 0
61 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0
62 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
63 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0
64 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
65 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0
66 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
67 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
68 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0
69 INT265383 Hsp90aa1 Negative_regulation of HDAC9 1 0.06 0.7 0
70 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
71 INT355201 Binding of HDAC9 and Gopc 1 0.01 0.06 0
72 INT200650 HDAC4 Regulation of Gene_expression of AKT1 1 0.16 0.66 0
73 INT326197 Negative_regulation of HDAC9 Negative_regulation of EPHB2 1 0.17 0.15 0
74 INT280848 Binding of REST and Rest 1 0.02 0.09 0
75 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
76 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
77 INT196215 Binding of L1RE1 and REST 1 0.33 0.47 0
78 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
79 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
80 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
81 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
82 INT196209 Binding of REST and SNAP25 1 0.25 0 0
83 INT121178 Binding of Bdnf and Rest 1 0.10 0.91 0
84 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0
85 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
86 INT200724 HDAC9 Positive_regulation of TP53 1 0.36 0.27 0
87 INT333684 Binding of Hr and Hdac1 1 0.19 0.56 0
88 INT280837 Binding of Rest and Negative_regulation of Gene_expression of Avp 1 0.00 0.09 0
89 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
90 INT196214 Binding of FRAXD and REST 1 0.00 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone H4 deacetylation. They are ordered first by their pain relevance and then by number of times they were reported in histone H4 deacetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9
2 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
3 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36
4 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
5 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
6 INT97693 Gene_expression of REST 29 0.75 5.51 5.26
7 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11
8 INT200248 Gene_expression of Rest 1 0.66 1.25 3.7
9 INT199255 Binding of Rest 14 0.41 1.43 2.94
10 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18
11 INT191154 Binding of HDAC9 20 0.36 14.12 1.83
12 INT277591 Gene_expression of Hdac4 22 0.77 7.77 1.79
13 INT153635 Positive_regulation of Gene_expression of REST 10 0.54 1.38 1.6
14 INT28367 Positive_regulation of REST 10 0.54 2.07 1.52
15 INT332792 Positive_regulation of Gene_expression of HDAC9 5 0.45 4.61 1.44
16 INT165005 Binding of REST 26 0.43 2.81 1.39
17 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
18 INT277581 Positive_regulation of Hdac4 4 0.50 1.47 1.25
19 INT258053 Positive_regulation of Negative_regulation of HDAC9 8 0.27 7.37 1.23
20 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
21 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
22 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99
23 INT190591 Positive_regulation of Rest 3 0.37 2.52 0.92
24 INT200255 Localization of Rest 1 0.68 0.14 0.86
25 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
26 INT200273 Negative_regulation of Rest 1 0.43 0.69 0.55
27 INT153634 Regulation of REST 4 0.48 1.42 0.54
28 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
29 INT333910 Positive_regulation of Gene_expression of HDAC4 2 0.07 1.5 0.49
30 INT179685 Positive_regulation of HDAC4 3 0.24 4.09 0.48
31 INT333915 Negative_regulation of Binding of HDAC9 1 0.21 0.83 0.41
32 INT165006 Positive_regulation of Binding of REST 1 0.23 0.94 0.4
33 INT277579 Binding of Hdac4 1 0.37 3.84 0.38
34 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
35 INT277604 Negative_regulation of Hdac4 4 0.51 2.89 0.36
36 INT277598 Regulation of Gene_expression of Hdac4 1 0.45 0.91 0.36
37 INT200269 Negative_regulation of Transcription of Rest 1 0.31 0.08 0.35
38 INT200245 Transcription of Rest 1 0.51 0.08 0.35
39 INT200270 Regulation of Rest 1 0.20 0.07 0.32
40 INT200256 Negative_regulation of Regulation of Rest 1 0.32 0.07 0.32
41 INT333912 Regulation of Positive_regulation of HDAC9 1 0.19 0.63 0.31
42 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
43 INT124568 Regulation of HDAC4 5 0.24 3.03 0.27
44 INT234466 Regulation of Negative_regulation of HDAC9 2 0.25 1.82 0.26
45 INT234461 Negative_regulation of Gene_expression of HDAC9 5 0.24 2.74 0.24
46 INT104789 Negative_regulation of REST 3 0.33 0.44 0.23
47 INT277584 Negative_regulation of Gene_expression of Hdac4 1 0.43 0.85 0.21
48 INT277594 Positive_regulation of Localization of Hdac4 1 0.50 1.71 0.21
49 INT277593 Localization of Hdac4 1 0.75 2.07 0.2
50 INT277600 Positive_regulation of Gene_expression of Hdac4 1 0.60 0.48 0.2
51 INT191155 Binding of HDAC4 5 0.08 2.79 0.17
52 INT133646 Positive_regulation of Regulation of HDAC9 1 0.49 0.83 0.17
53 INT200275 Positive_regulation of Gene_expression of Rest 1 0.59 0.92 0.17
54 INT277601 Positive_regulation of Positive_regulation of Hdac4 1 0.50 0.18 0.16
55 INT277582 Regulation of Hdac4 1 0.45 0.36 0.14
56 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
57 INT234460 Negative_regulation of Gene_expression of HDAC4 2 0.04 1.55 0.11
58 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
59 INT200281 Negative_regulation of Negative_regulation of Rest 1 0.31 0.44 0.11
60 INT234465 Regulation of Negative_regulation of HDAC4 1 0.04 0.74 0.11
61 INT196248 Localization of REST 1 0.66 0.15 0.08
62 INT346968 Positive_regulation of Transcription of HDAC9 1 0.22 0.21 0.07
63 INT346969 Transcription of HDAC9 1 0.23 0.21 0.07
64 INT191153 Negative_regulation of Negative_regulation of HDAC9 1 0.09 0.57 0.05
65 INT277599 Phosphorylation of Hdac4 1 0.82 3.24 0.05
66 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
67 INT326227 Phosphorylation of HDAC9 1 0.22 2.32 0.03
68 INT259662 Positive_regulation of Regulation of HDAC4 1 0.03 0.77 0.03
69 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
70 INT332926 Localization of HDAC4 1 0.10 0.11 0.03
71 INT277595 Localization of Hdac1 4 0.73 0.81 0
72 INT277612 Localization of HDAC9 3 0.45 0.55 0
73 INT265379 Positive_regulation of Binding of HDAC9 2 0.19 1.06 0
74 INT261751 Regulation of Hdac1 2 0.41 0 0
75 INT200682 Phosphorylation of HDAC4 2 0.44 1.24 0
76 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
77 INT319154 Transcription of Hdac1 1 0.66 0 0
78 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
79 INT277580 Regulation of Localization of Hdac4 1 0.39 0 0
80 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
81 INT326229 Regulation of Phosphorylation of HDAC9 1 0.07 0.48 0
82 INT200668 Regulation of Phosphorylation of HDAC4 1 0.24 0.71 0
83 INT326233 Negative_regulation of Phosphorylation of HDAC9 1 0.11 0 0
84 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
85 INT277577 Transcription of Hdac4 1 0.69 0 0
86 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
87 INT239368 Negative_regulation of Binding of HDAC4 1 0.06 1.44 0
88 INT355200 Regulation of Gene_expression of HDAC9 1 0.14 1.77 0
89 INT338233 Regulation of Gene_expression of HDAC4 1 0.03 0.18 0
90 INT196244 Negative_regulation of Gene_expression of REST 1 0.38 0.09 0
91 INT319162 Regulation of Gene_expression of Hdac1 1 0.56 0 0
92 INT319152 Positive_regulation of Gene_expression of Hdac1 1 0.46 0 0
93 INT277603 Negative_regulation of Phosphorylation of Hdac4 1 0.43 0.39 0
94 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0
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