GO:0070935

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Name 3'-UTR-mediated mRNA stabilization
Categary Process
Go Slim No
Go Link GO:0070935
Unique Molecular Interactions 133
Total Molecular Interactions 180
Total Single Events 944
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 3'-UTR-mediated mRNA stabilization. They are ordered first by their pain relevance and then by number of times they were reported for 3'-UTR-mediated mRNA stabilization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
2 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
3 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
4 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
5 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
6 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
7 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61
8 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61
9 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
10 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
11 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
12 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43
13 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
14 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37
15 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37
16 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
17 INT346228 MAP2K6 Positive_regulation of Positive_regulation of MAPK14 1 0.44 0.68 0.34
18 INT346229 PREP Positive_regulation of MAPK14 1 0.13 0.63 0.34
19 INT327308 Binding of Elavl1 and Ttpa 1 0.02 1.73 0.34
20 INT346236 Binding of MAPK14 and MAP2K6 1 0.32 0.65 0.33
21 INT346231 Binding of MAPK14 and MAP2K3 1 0.33 0.65 0.33
22 INT297972 MAPK14 Negative_regulation of ING5 1 0.21 1.67 0.33
23 INT255944 MAPK14 Positive_regulation of Tauph 1 0.00 0.1 0.32
24 INT194706 Binding of TNF and HNRNPA0 1 0.06 0.43 0.32
25 INT259639 MAPK14 Regulation of Gene_expression of IL8 1 0.02 1.2 0.32
26 INT255945 MAPK14 Positive_regulation of Rps6ka5 1 0.06 0.1 0.32
27 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
28 INT194666 Binding of CXCL2 and HNRNPA0 1 0.04 0.44 0.32
29 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
30 INT194733 Binding of CPOX and HNRNPA0 1 0.01 0.44 0.32
31 INT346235 IL1B Positive_regulation of Gene_expression of MAPK14 1 0.15 0.64 0.32
32 INT203087 Binding of Il1a and Myd88 1 0.05 0.65 0.31
33 INT327328 Binding of Hnrnpd and Elavl1 1 0.06 0.74 0.3
34 INT112799 Positive_regulation of CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.3
35 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
36 INT288205 Binding of Cd14 and Myd88 1 0.10 0.57 0.28
37 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
38 INT256063 Myd88 Positive_regulation of Gene_expression of Mcpt1 1 0.13 0.56 0.27
39 INT123663 F2R Positive_regulation of MAPK14 1 0.12 0.42 0.26
40 INT123662 Negative_regulation of F2R Positive_regulation of MAPK14 1 0.08 0.42 0.26
41 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
42 INT123661 COL7A1 Positive_regulation of MAPK14 1 0.08 0.42 0.26
43 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
44 INT327321 Binding of Elavl1 and Nos2 1 0.05 0.6 0.24
45 INT327320 Positive_regulation of Binding of Elavl1 and Nos2 1 0.06 0.6 0.24
46 INT339516 Binding of Eif2ak2 and TIRAP 1 0.25 0.19 0.23
47 INT179230 Binding of MAPK14 and GSR 1 0.03 0.5 0.23
48 INT112794 CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.23
49 INT112793 IL4I1 Positive_regulation of Positive_regulation of MAPK14 1 0.04 0 0.22
50 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
51 INT297965 MAPK14 Negative_regulation of GADD45A 1 0.05 1 0.21
52 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
53 INT348789 Positive_regulation of Binding of MYD88 and Tlr4 1 0.46 0.93 0.2
54 INT221955 Binding of ELAVL1 and CDK5R1 1 0.01 0.93 0.19
55 INT327317 Ttpa Negative_regulation of Elavl1 1 0.02 0.45 0.19
56 INT327312 Positive_regulation of Ttpa Negative_regulation of Elavl1 1 0.03 0.45 0.19
57 INT343854 TIRAP Positive_regulation of IRF3 1 0.06 0.19 0.19
58 INT179504 Tlr4 Regulation of Myd88 1 0.07 0.29 0.17
59 INT194696 TTPA Positive_regulation of Phosphorylation of MAPKAPK2 1 0.01 0.08 0.17
60 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
61 INT194737 Binding of TTPA and MAPKAPK2 1 0.01 0.08 0.17
62 INT327310 Binding of Ccnd1 and Elavl1 1 0.04 0.38 0.16
63 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
64 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15
65 INT278394 Myd88 Regulation of Phosphorylation of Hps5 1 0.11 0.35 0.15
66 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15
67 INT327326 Binding of Mapkapk2 and Ttpa 1 0.02 0.34 0.14
68 INT327316 Binding of Elavl1 and Khsrp 1 0.12 0.36 0.14
69 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13
70 INT346501 MYD88 Positive_regulation of Nfkb1 1 0.01 0.5 0.13
71 INT327322 Mapkapk2 Regulation of Il6 1 0.02 0.26 0.13
72 INT327318 Mapk14 Regulation of Localization of Elavl1 1 0.09 0.42 0.13
73 INT295480 MAPK14 Positive_regulation of Localization of TNF 1 0.08 1.08 0.12
74 INT297967 MAPK14 Negative_regulation of SCUBE3 1 0.01 0.67 0.12
75 INT254201 Myd88 Positive_regulation of Ik 1 0.00 0.14 0.12
76 INT291260 Map3k8 Regulation of Gene_expression of MAPK14 1 0.07 0.52 0.11
77 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1
78 INT194671 MAPKAPK2 Positive_regulation of CREB1 1 0.06 0.05 0.1
79 INT194689 MAPKAPK2 Positive_regulation of TFAM 1 0.00 0.05 0.1
80 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
81 INT343858 Binding of AKT1 and MYD88 1 0.02 0.26 0.1
82 INT334266 Binding of Irak1 and Myd88 2 0.35 0.16 0.09
83 INT343845 TICAM1 Positive_regulation of TIRAP 1 0.05 0.25 0.09
84 INT350073 Binding of co and Myd88 1 0.00 0.17 0.08
85 INT343865 IRF6 Positive_regulation of TIRAP 1 0.03 0.28 0.08
86 INT254223 Tlr3 Positive_regulation of Myd88 1 0.16 0.23 0.08
87 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
88 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
89 INT140289 ROS1 Positive_regulation of MAPK14 1 0.44 1.27 0.06
90 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
91 INT350481 Tlr4 Positive_regulation of Gene_expression of Myd88 1 0.26 0.06 0.06
92 INT334260 Negative_regulation of Binding of Myd88 and Il1 1 0.01 0.4 0.06
93 INT334258 Binding of Myd88 and Irak4 2 0.26 0.24 0.05
94 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
95 INT164128 TNFSF10 Positive_regulation of MAPK14 1 0.28 2.09 0.05
96 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
97 INT350802 Binding of MYD88 and TLR3 1 0.01 0 0.04
98 INT334262 Myd88 Positive_regulation of Tlr7 1 0.05 0.3 0.04
99 INT327336 Binding of VEGFA and Elavl1 1 0.06 0.94 0.04
100 INT238008 Myd88 Regulation of Hand1 1 0.03 0.82 0.04
101 INT290313 Binding of MYD88 and TLR7 1 0.03 0.1 0.03
102 INT237682 LDHA Positive_regulation of MAPK14 1 0.02 0.16 0.03
103 INT209927 MAPK14 Positive_regulation of IL1B 1 0.13 0.05 0.03
104 INT298002 Gene_expression of Gadd45b Positive_regulation of MAPK14 1 0.29 0.67 0.03
105 INT221963 ELAVL1 Regulation of Gene_expression of CDK5R1 1 0.01 0.58 0.03
106 INT260948 Khsrp Negative_regulation of Binding of Elavl1 1 0.24 0.11 0.03
107 INT221961 Binding of ELAVL1 and UTS2R 1 0.00 0.26 0.03
108 INT260946 Zfp36 Negative_regulation of Binding of Elavl1 1 0.21 0.11 0.03
109 INT297962 MAP3K4 Positive_regulation of MAPK14 1 0.21 0.66 0.03
110 INT299006 Binding of Il18 and Myd88 1 0.21 0.19 0.03
111 INT350077 Negative_regulation of Binding of Myd88 and Tlr4 1 0.12 0.16 0
112 INT348039 Binding of Myd88 and Irak2 1 0.22 0 0
113 INT221960 Binding of C4B and ELAVL1 1 0.00 0.15 0
114 INT350429 Negative_regulation of MAPK14 Regulation of Gene_expression of ATF3 1 0.12 0.78 0
115 INT324696 Binding of Myd88 and Mapk10 1 0.05 0.68 0
116 INT209925 Binding of MAPK14 and IL1B 1 0.09 0 0
117 INT303336 MAPKAPK2 Positive_regulation of Hspb2 1 0.04 0.24 0
118 INT202398 Mapk14 Regulation of Phosphorylation of Mapkapk2 1 0.44 0.1 0
119 INT194675 MAPK14 Positive_regulation of CREB1 1 0.07 0.33 0
120 INT194684 MAPK14 Positive_regulation of Transcription of CREB1 1 0.07 0.33 0
121 INT327341 VEGFA Regulation of Elavl1 1 0.08 1.27 0
122 INT162436 Binding of Igfals and Tardbp 1 0.16 2.68 0
123 INT285641 Zfp36 Negative_regulation of Egr1 1 0.06 0.28 0
124 INT327335 VEGFA Regulation of Binding of Elavl1 1 0.08 1.27 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 3'-UTR-mediated mRNA stabilization. They are ordered first by their pain relevance and then by number of times they were reported in 3'-UTR-mediated mRNA stabilization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
2 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
3 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
4 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
5 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29
6 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4
7 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
8 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
9 INT142754 Binding of Myd88 20 0.36 9.61 3.8
10 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
11 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
12 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
13 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65
14 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
15 INT149642 Binding of Elavl1 5 0.23 5.49 1.59
16 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
17 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
18 INT149646 Gene_expression of Elavl1 2 0.44 18.47 1.34
19 INT246928 Negative_regulation of Myd88 12 0.38 6.16 1.3
20 INT233970 Regulation of Myd88 7 0.45 5.2 1.28
21 INT149644 Positive_regulation of Gene_expression of Elavl1 2 0.32 13.13 1.27
22 INT112823 Negative_regulation of Positive_regulation of MAPK14 5 0.36 1.49 1.22
23 INT260901 Localization of Elavl1 2 0.47 8.78 1.18
24 INT303287 Gene_expression of Tardbp 4 0.77 44.78 1.09
25 INT292763 Localization of Tardbp 6 0.80 12.51 0.91
26 INT194875 Regulation of Negative_regulation of MAPK14 1 0.04 2.39 0.91
27 INT237858 Positive_regulation of MYD88 5 0.49 2.93 0.9
28 INT327232 Positive_regulation of Transcription of Elavl1 1 0.23 2.79 0.89
29 INT250171 Localization of Myd88 4 0.72 1.95 0.88
30 INT166126 Gene_expression of MYD88 5 0.54 2.67 0.84
31 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82
32 INT264973 Binding of MYD88 4 0.35 1.2 0.74
33 INT131433 Phosphorylation of MAPKAPK2 3 0.30 0.99 0.73
34 INT139840 Positive_regulation of Negative_regulation of MAPK14 2 0.21 1.55 0.67
35 INT334226 Positive_regulation of Localization of Myd88 1 0.36 0.54 0.67
36 INT327280 Positive_regulation of Elavl1 1 0.23 3.3 0.66
37 INT202385 Gene_expression of Mapkapk2 4 0.57 2.86 0.64
38 INT327287 Transcription of Elavl1 1 0.31 2.11 0.64
39 INT233973 Negative_regulation of Gene_expression of Myd88 4 0.38 1.32 0.61
40 INT209936 Negative_regulation of Gene_expression of MAPK14 7 0.20 4.95 0.53
41 INT264963 Positive_regulation of Binding of MYD88 1 0.17 0.18 0.52
42 INT284454 Binding of Tirap 4 0.26 2.07 0.49
43 INT149643 Binding of Zfp36 2 0.29 0.45 0.49
44 INT121027 Regulation of Phosphorylation of MAPK14 2 0.38 1.1 0.46
45 INT173625 Positive_regulation of Localization of MAPK14 3 0.17 1.05 0.44
46 INT179170 Protein_catabolism of MAPK14 3 0.43 0.88 0.43
47 INT204827 Positive_regulation of Zfp36 1 0.26 0.33 0.43
48 INT255902 Positive_regulation of Binding of MAPK14 1 0.17 0.93 0.42
49 INT335733 Positive_regulation of Tardbp 8 0.69 28.41 0.41
50 INT260917 Positive_regulation of Localization of Elavl1 2 0.32 4.1 0.41
51 INT327228 Phosphorylation of Elavl1 1 0.38 2.07 0.4
52 INT246422 Transcription of MYD88 2 0.52 0.77 0.38
53 INT260916 Regulation of Elavl1 2 0.21 2.47 0.38
54 INT327234 Negative_regulation of Elavl1 1 0.20 3.04 0.37
55 INT256056 Positive_regulation of Binding of Myd88 2 0.48 0.36 0.36
56 INT272875 Localization of Mapkapk2 1 0.23 0.9 0.34
57 INT194770 Positive_regulation of Phosphorylation of HNRNPA0 1 0.25 0.45 0.33
58 INT203076 Positive_regulation of Positive_regulation of Myd88 1 0.19 0.65 0.32
59 INT203072 Positive_regulation of Myd88 1 0.19 0.65 0.32
60 INT85944 Binding of ELAVL1 5 0.07 1.11 0.31
61 INT158048 Gene_expression of MAPKAPK2 2 0.28 0.79 0.29
62 INT292766 Negative_regulation of Localization of Tardbp 1 0.07 0.75 0.29
63 INT126522 Positive_regulation of Phosphorylation of Mapkapk2 7 0.59 3.8 0.28
64 INT255923 Positive_regulation of Regulation of MAPK14 1 0.17 0.41 0.28
65 INT197492 Regulation of Gene_expression of Myd88 2 0.39 1.95 0.27
66 INT194781 Phosphorylation of HNRNPA0 1 0.41 0.42 0.27
67 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
68 INT335724 Positive_regulation of Localization of Tardbp 3 0.47 4.9 0.25
69 INT131426 Negative_regulation of Phosphorylation of Mapkapk2 1 0.04 0.41 0.23
70 INT3239 Negative_regulation of ELAVL1 1 0.41 0.25 0.22
71 INT158050 Regulation of MAPKAPK2 1 0.00 0.8 0.22
72 INT327268 Regulation of Phosphorylation of Elavl1 1 0.28 1.02 0.21
73 INT131432 Negative_regulation of Phosphorylation of MAPKAPK2 1 0.11 0.4 0.21
74 INT131434 Binding of MAPKAPK2 2 0.17 0.42 0.2
75 INT292764 Negative_regulation of Tardbp 2 0.58 2.59 0.19
76 INT242901 Regulation of Gene_expression of MYD88 2 0.18 0.19 0.19
77 INT242897 Positive_regulation of Gene_expression of MYD88 2 0.20 0.27 0.19
78 INT327283 Negative_regulation of Zfp36 1 0.39 0.5 0.18
79 INT126521 Positive_regulation of Mapkapk2 13 0.49 5.9 0.17
80 INT233971 Transcription of Myd88 2 0.60 1.01 0.17
81 INT327279 Regulation of Gene_expression of Elavl1 1 0.21 0.85 0.16
82 INT275513 Regulation of Mapkapk2 1 0.01 0.86 0.16
83 INT194790 Positive_regulation of Phosphorylation of MAPKAPK2 1 0.19 0.09 0.16
84 INT344990 Binding of Tardbp 1 0.37 3.5 0.15
85 INT327236 Positive_regulation of Gene_expression of Mapkapk2 1 0.36 1.01 0.15
86 INT267610 Negative_regulation of Negative_regulation of MAPK14 1 0.03 1.08 0.15
87 INT334237 Negative_regulation of Binding of Myd88 1 0.30 1.16 0.12
88 INT306310 Positive_regulation of Positive_regulation of Myd88 1 0.38 0.41 0.12
89 INT242898 Regulation of MYD88 2 0.33 0.88 0.11
90 INT329055 Gene_expression of Myd88 1 0.72 1.18 0.11
91 INT343883 Gene_expression of TIRAP 2 0.65 0.28 0.09
92 INT343902 Positive_regulation of Gene_expression of TIRAP 1 0.22 0.28 0.09
93 INT346252 Regulation of Gene_expression of MAPK14 1 0.38 0 0.09
94 INT260907 Phosphorylation of Zfp36 1 0.54 0.47 0.08
95 INT334227 Positive_regulation of Regulation of Myd88 1 0.36 0.63 0.08
96 INT329054 Negative_regulation of Gene_expression of Myd88 1 0.54 0.13 0.06
97 INT343889 Positive_regulation of TIRAP 1 0.20 0.11 0.06
98 INT329067 Positive_regulation of Gene_expression of Myd88 1 0.64 0.12 0.05
99 INT344991 Negative_regulation of Positive_regulation of Tardbp 1 0.43 0.81 0.05
100 INT182288 Negative_regulation of Binding of MAPK14 1 0.21 0.08 0.04
101 INT260911 Regulation of Phosphorylation of Zfp36 1 0.30 0.23 0.04
102 INT182280 Negative_regulation of Localization of MAPK14 1 0.21 0.39 0.04
103 INT327252 Negative_regulation of Gene_expression of Elavl1 1 0.19 0.81 0.03
104 INT186409 Negative_regulation of MAPKAPK2 1 0.20 0.06 0.03
105 INT339489 Binding of TIRAP 1 0.36 0.05 0.03
106 INT303295 Regulation of Tardbp 2 0.45 4.74 0
107 INT260926 Regulation of Zfp36 2 0.21 0.47 0
108 INT303284 Regulation of Gene_expression of Tardbp 2 0.45 6.82 0
109 INT345270 Negative_regulation of Tirap 1 0.02 0.15 0
110 INT344986 Regulation of Positive_regulation of Tardbp 1 0.39 0.98 0
111 INT221979 Regulation of ELAVL1 1 0.01 0 0
112 INT186410 Positive_regulation of MAPKAPK2 1 0.22 0 0
113 INT291177 Binding of Mapkapk2 1 0.08 0.3 0
114 INT344999 Protein_catabolism of Tardbp 1 0.66 1.18 0
115 INT291178 Positive_regulation of Binding of Mapkapk2 1 0.10 0.3 0
116 INT344996 Negative_regulation of Gene_expression of Tardbp 1 0.43 0.73 0
117 INT254185 Positive_regulation of Tirap 1 0.32 0 0
118 INT254183 Regulation of Positive_regulation of Tirap 1 0.29 0 0
119 INT149645 Positive_regulation of Gene_expression of Zfp36 1 0.14 0 0
120 INT254176 Positive_regulation of Positive_regulation of Tirap 1 0.32 0 0
121 INT177865 Negative_regulation of HNRNPA0 1 0.22 0 0
122 INT149639 Gene_expression of Zfp36 1 0.22 0 0
123 INT344988 Positive_regulation of Gene_expression of Tardbp 1 0.47 3.29 0
124 INT291179 Positive_regulation of Positive_regulation of Mapkapk2 1 0.10 0.36 0
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