GO:0071013

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Name catalytic step 2 spliceosome
Categary Component
Go Slim No
Go Link GO:0071013
Unique Molecular Interactions 69
Total Molecular Interactions 90
Total Single Events 452
Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for catalytic step 2 spliceosome. They are ordered first by their pain relevance and then by number of times they were reported for catalytic step 2 spliceosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168303 Binding of SNRPB and UGT2B7 1 0.20 0 1.09
2 INT75823 Penk Positive_regulation of Gene_expression of Ddx5 1 0.03 0 0.92
3 INT75825 Ddx5 Positive_regulation of Gene_expression of Penk 1 0.03 0 0.92
4 INT73462 PTPLA Regulation of Gene_expression of SART1 1 0.00 0.79 0.82
5 INT76688 Binding of CALCA and SNRPB 1 0.30 0 0.63
6 INT158399 Binding of Preb and Frg1 1 0.01 0.3 0.62
7 INT293704 Binding of TNF and DDX41 1 0.00 1.01 0.61
8 INT346527 Binding of PTH2R and TFIP11 1 0.18 0.11 0.42
9 INT293703 Binding of DDX41 and C21orf91 1 0.00 0.99 0.42
10 INT308701 Binding of AQP4 and DDX41 1 0.15 3.53 0.32
11 INT185144 Prkca Positive_regulation of Snrpd1 1 0.00 0.16 0.29
12 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
13 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28
14 INT316713 Binding of Ddx41 and Pain1 1 0.00 0.94 0.28
15 INT308708 DDX41 Regulation of AQP4 1 0.10 2.79 0.26
16 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
17 INT185142 Rnpep Regulation of Snrpd1 1 0.01 0 0.22
18 INT333053 IL6 Positive_regulation of Gene_expression of HNRNPA1 1 0.02 2.39 0.2
19 INT287145 Binding of PNN and Shbg 1 0.07 0.14 0.18
20 INT220522 Ugt1a6b Positive_regulation of Sf3a3 1 0.00 0.92 0.18
21 INT346519 Binding of PTHLH and TFIP11 1 0.09 0.12 0.17
22 INT178266 Raly Regulation of a 1 0.14 0.97 0.16
23 INT138305 Binding of PNN and Agtr2 1 0.01 0.73 0.15
24 INT308709 Positive_regulation of Binding of AQP4 and DDX41 1 0.18 1.19 0.14
25 INT194360 SNRPD1 Negative_regulation of Dbh 1 0.00 0 0.14
26 INT249412 Frg1 Positive_regulation of Binding of Napa 1 0.02 0.13 0.13
27 INT222179 CDC5L Regulation of TFAM 1 0.01 0.26 0.13
28 INT346530 Binding of PTH1R and TFIP11 1 0.15 0 0.11
29 INT236467 MMP9 Negative_regulation of SNRPB 1 0.01 0.45 0.1
30 INT311009 Binding of LCN2 and SNRPB 1 0.01 0.35 0.1
31 INT308704 Binding of DDX41 and M1 1 0.02 2.09 0.1
32 INT311010 SNRPB Positive_regulation of SERPINA10 1 0.00 0.69 0.07
33 INT166734 BATF Negative_regulation of PPIL1 1 0.04 1.45 0.06
34 INT236466 SNRPB Positive_regulation of NFKB2 1 0.00 0.21 0.05
35 INT346518 TFIP11 Regulation of PTH2R 1 0.23 0 0.04
36 INT295854 Srpk2 Regulation of Localization of Srsf1 1 0.21 0 0.04
37 INT295867 Srsf1 Regulation of VEGFA 1 0.10 0 0.03
38 INT191899 Binding of EXOSC10 and PNN 1 0.00 0.96 0.03
39 INT255143 Regulation of Binding of Mbnl1 and Hnrnph1 1 0.07 0.07 0
40 INT255146 Negative_regulation of Binding of Dmpk and Hnrnph1 1 0.11 0 0
41 INT128751 Binding of Ddx41 and Igis1 1 0.00 0 0
42 INT219256 Binding of Ddx41 and G2e3 1 0.01 1.63 0
43 INT346520 Binding of TPM3 and TFIP11 1 0.06 0 0
44 INT311012 SNRPB Positive_regulation of Gene_expression of ROS1 1 0.00 0.27 0
45 INT295857 Igf1 Regulation of Localization of Srsf1 1 0.50 0 0
46 INT301464 Binding of Smyd3 and Dhx8 1 0.05 0.08 0
47 INT255144 Binding of Dmpk and Hnrnph1 1 0.09 0 0
48 INT295869 Binding of VEGFA and Srsf1 1 0.17 0 0
49 INT315700 Binding of PPFIBP1 and CWC22 1 0.01 0.27 0
50 INT301473 Binding of Dhx8 and Smyd2 1 0.06 0.14 0
51 INT311392 Binding of Cnbp and Pabpc1 1 0.04 0.14 0
52 INT253630 Binding of HNRNPA1 and Npm1 1 0.00 0.19 0
53 INT346521 Binding of PTH and TFIP11 1 0.10 0 0
54 INT304191 Binding of SNRPD1 and ADHD1 1 0.01 0.99 0
55 INT295856 Binding of Prkca and Srsf1 1 0.10 0 0
56 INT255145 Binding of Mbnl1 and Hnrnph1 1 0.09 0.15 0
57 INT177566 Binding of Gtayu6 and Syf2 1 0.00 0.13 0
58 INT290214 Binding of FRG1 and FSHMD1A 1 0.22 0.98 0
59 INT236468 TP53 Positive_regulation of Protein_catabolism of SNRPB 1 0.00 0.52 0
60 INT295859 Srsf1 Positive_regulation of Binding of U2af2 1 0.01 0 0
61 INT255810 SLU7 Positive_regulation of Binding of SNRPA 1 0.01 0.23 0
62 INT138304 PNN Negative_regulation of Nr3c2 1 0.00 0.23 0
63 INT311377 Binding of Eef2 and Pabpc1 1 0.01 0.15 0
64 INT221241 Sf3a2 Negative_regulation of Gene_expression of Ros1 1 0.00 0.91 0
65 INT213869 Binding of RBM8A and Mar1 1 0.00 0 0
66 INT204483 Binding of Ncl and Hnrnpa2b1 1 0.02 0 0
67 INT311011 SNRPB Positive_regulation of Gene_expression of LCN2 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for catalytic step 2 spliceosome. They are ordered first by their pain relevance and then by number of times they were reported in catalytic step 2 spliceosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48661 Gene_expression of Ddx5 7 0.07 0.15 4.04
2 INT78023 Gene_expression of DDX41 13 0.65 23.55 3.84
3 INT39414 Gene_expression of SNRPB 37 0.59 14.07 2.52
4 INT48662 Negative_regulation of Gene_expression of Ddx5 5 0.04 0.07 2.41
5 INT39413 Negative_regulation of SNRPB 7 0.31 2.57 2.36
6 INT66391 Negative_regulation of Ddx5 2 0.04 0 2.17
7 INT148940 Positive_regulation of Sf3a3 3 0.05 4.83 1.93
8 INT8538 Positive_regulation of Ddx5 2 0.19 0 1.73
9 INT168304 Positive_regulation of SNRPB 17 0.25 9.62 1.64
10 INT70404 Positive_regulation of Gene_expression of Ddx5 2 0.02 0 1.62
11 INT129231 Gene_expression of Ddx41 29 0.63 9.73 1.52
12 INT333071 Gene_expression of HNRNPA1 1 0.04 22.7 1.47
13 INT70860 Binding of SNRPB 17 0.35 7 1.46
14 INT188883 Binding of DDX41 9 0.39 11.55 1.29
15 INT92455 Transcription of SNRPB 3 0.52 1.21 1.27
16 INT136271 Gene_expression of PNN 9 0.63 5.44 1
17 INT219247 Positive_regulation of Ddx41 9 0.36 6.7 0.84
18 INT333086 Positive_regulation of Gene_expression of HNRNPA1 1 0.03 12.29 0.82
19 INT73464 Gene_expression of SART1 1 0.02 0.79 0.81
20 INT65187 Positive_regulation of PNN 2 0.02 1.12 0.77
21 INT168305 Regulation of SNRPB 2 0.25 0.9 0.76
22 INT185120 Regulation of Snrpd1 1 0.01 0.07 0.73
23 INT314566 Positive_regulation of Dhx8 1 0.17 0.07 0.67
24 INT158398 Binding of Frg1 1 0.01 0.3 0.62
25 INT340209 Negative_regulation of Frg1 1 0.01 0.52 0.6
26 INT128750 Binding of Ddx41 13 0.34 4.35 0.57
27 INT118585 Binding of PNN 6 0.25 2.47 0.56
28 INT185126 Negative_regulation of Snrpd1 1 0.02 0.05 0.5
29 INT315712 Positive_regulation of Gene_expression of Ddx41 3 0.31 2.24 0.46
30 INT78022 Positive_regulation of Gene_expression of DDX41 1 0.45 1.26 0.44
31 INT222197 Binding of CDC5L 1 0.16 1.4 0.39
32 INT222200 Regulation of CDC5L 1 0.27 0.76 0.38
33 INT208895 Gene_expression of PPIL1 1 0.09 0.37 0.38
34 INT154675 Binding of SNRPE 1 0.36 0.54 0.38
35 INT346541 Positive_regulation of Gene_expression of TFIP11 1 0.32 0.91 0.36
36 INT202863 Binding of Hnrnpa2b1 3 0.08 0.23 0.34
37 INT341687 Negative_regulation of PNN 1 0.35 1.98 0.33
38 INT222199 Negative_regulation of CDC5L 1 0.25 1.14 0.31
39 INT346547 Gene_expression of TFIP11 1 0.43 0.84 0.3
40 INT340202 Gene_expression of Frg1 1 0.01 0.13 0.29
41 INT202812 Phosphorylation of PPIL1 1 0.02 0.61 0.28
42 INT202811 Binding of PPIL1 1 0.02 0.61 0.28
43 INT39412 Negative_regulation of Gene_expression of SNRPB 2 0.14 0.95 0.27
44 INT333075 Positive_regulation of HNRNPA1 1 0.03 1.07 0.26
45 INT346535 Positive_regulation of TFIP11 1 0.39 0.75 0.25
46 INT78941 Positive_regulation of DDX41 4 0.45 2.46 0.23
47 INT77691 Binding of SNRPD1 2 0.29 2.19 0.22
48 INT36879 Positive_regulation of SYNCRIP 1 0.17 0 0.22
49 INT333072 Regulation of Gene_expression of HNRNPA1 1 0.03 2.52 0.19
50 INT185123 Positive_regulation of Negative_regulation of Snrpd1 1 0.02 0 0.19
51 INT308714 Regulation of Gene_expression of DDX41 1 0.08 1.9 0.19
52 INT333079 Negative_regulation of HNRNPA1 1 0.03 2.22 0.15
53 INT130004 Positive_regulation of Protein_catabolism of FRG1 1 0.01 1.16 0.15
54 INT130003 Protein_catabolism of FRG1 1 0.03 1.16 0.15
55 INT346540 Binding of TFIP11 1 0.31 0 0.15
56 INT304192 Negative_regulation of SNRPD1 2 0.15 1.44 0.14
57 INT315714 Phosphorylation of Ddx41 1 0.12 0.97 0.14
58 INT295836 Localization of Srsf1 1 0.70 0.16 0.13
59 INT236475 Localization of SNRPB 1 0.04 2.85 0.13
60 INT341690 Regulation of Transcription of PNN 1 0.37 0.09 0.12
61 INT185124 Protein_catabolism of Snrpd1 1 0.02 0 0.12
62 INT308715 Regulation of DDX41 1 0.08 2.12 0.12
63 INT287144 Negative_regulation of Gene_expression of PNN 1 0.17 0.82 0.12
64 INT341688 Transcription of PNN 1 0.56 0.09 0.12
65 INT253626 Binding of HNRNPA1 3 0.02 1.87 0.11
66 INT236480 Positive_regulation of Gene_expression of SNRPB 2 0.13 0.79 0.1
67 INT315713 Negative_regulation of Binding of Ddx41 1 0.06 1 0.1
68 INT249374 Binding of Frg1 1 0.02 0.16 0.1
69 INT188884 Localization of DDX41 3 0.60 2.56 0.09
70 INT304201 Gene_expression of SNRPD1 2 0.22 1.12 0.09
71 INT341689 Localization of PNN 1 0.61 0.5 0.09
72 INT189970 Positive_regulation of Positive_regulation of SNRPB 1 0.22 1.69 0.08
73 INT78942 Negative_regulation of DDX41 1 0.57 1.79 0.08
74 INT295820 Phosphorylation of Srsf1 1 0.71 1.35 0.07
75 INT82955 Localization of Ddx41 4 0.53 1.08 0.06
76 INT253625 Localization of HNRNPA1 2 0.04 1.13 0.06
77 INT295845 Positive_regulation of Gene_expression of Srsf1 1 0.60 0.97 0.05
78 INT295844 Positive_regulation of Binding of Srsf1 1 0.40 0.34 0.05
79 INT295852 Positive_regulation of Localization of Srsf1 1 0.40 0.08 0.05
80 INT304200 Positive_regulation of SNRPD1 2 0.18 0.67 0.04
81 INT295843 Binding of Srsf1 1 0.42 0.44 0.04
82 INT333065 Negative_regulation of Gene_expression of HNRNPA1 1 0.03 1.76 0.04
83 INT295822 Regulation of Localization of Srsf1 1 0.53 0 0.04
84 INT295847 Negative_regulation of Phosphorylation of Srsf1 1 0.37 0 0.04
85 INT255109 Binding of Hnrnph1 3 0.10 0.22 0.03
86 INT240711 Gene_expression of Srsf1 3 0.67 1.99 0.03
87 INT193612 Transcription of SART1 2 0.58 1.56 0.03
88 INT202860 Negative_regulation of Binding of Hnrnpa2b1 1 0.05 0.14 0.03
89 INT255103 Negative_regulation of Hnrnph1 1 0.11 0 0
90 INT301435 Binding of Dhx8 1 0.06 0.06 0
91 INT237994 Negative_regulation of Localization of Ddx41 1 0.04 0.08 0
92 INT172468 Transcription of Pabpc1 1 0.67 0.06 0
93 INT236479 Positive_regulation of Localization of SNRPB 1 0.03 1.39 0
94 INT304196 Regulation of SNRPD1 1 0.04 0.53 0
95 INT326426 Negative_regulation of Ddx41 1 0.04 0.32 0
96 INT172469 Positive_regulation of Pabpc1 1 0.49 0.06 0
97 INT295832 Positive_regulation of Srsf1 1 0.60 0.24 0
98 INT255124 Positive_regulation of Negative_regulation of Hnrnph1 1 0.11 0 0
99 INT172470 Positive_regulation of Transcription of Pabpc1 1 0.49 0.06 0
100 INT166736 Negative_regulation of PPIL1 1 0.37 1.2 0
101 INT290242 Localization of FRG1 1 0.68 0.56 0
102 INT275456 Binding of Pabpc1 1 0.24 1.62 0
103 INT178258 Gene_expression of Raly 1 0.27 0.82 0
104 INT295849 Positive_regulation of Phosphorylation of Srsf1 1 0.60 0.64 0
105 INT290237 Negative_regulation of Localization of FRG1 1 0.39 0.58 0
106 INT204448 Localization of Hnrnpa2b1 1 0.12 0.68 0
107 INT236477 Regulation of Binding of SNRPB 1 0.02 0.1 0
108 INT351033 Regulation of SNRPE 1 0.12 0.81 0
109 INT236476 Protein_catabolism of SNRPB 1 0.04 0.64 0
110 INT290267 Gene_expression of FRG1 1 0.71 2.63 0
111 INT290258 Binding of FRG1 1 0.36 0.3 0
112 INT208897 Regulation of PPIL1 1 0.03 0 0
113 INT287142 Regulation of PNN 1 0.18 0.58 0
114 INT290248 Positive_regulation of Gene_expression of FRG1 1 0.46 1.14 0
115 INT222189 Gene_expression of CDC5L 1 0.29 0 0
116 INT315702 Negative_regulation of CWC22 1 0.05 0.13 0
117 INT193611 Negative_regulation of SART1 1 0.41 0.68 0
118 INT177553 Gene_expression of Syf2 1 0.01 0.06 0
119 INT236482 Regulation of Localization of SNRPB 1 0.01 0.17 0
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