GO:0071157

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Name negative regulation of cell cycle arrest
Categary Process
Go Slim No
Go Link GO:0071157
Unique Molecular Interactions 115
Total Molecular Interactions 181
Total Single Events 963
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cell cycle arrest. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cell cycle arrest. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
3 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
4 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
5 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
6 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
7 INT40636 Mif Negative_regulation of Pomc 1 0.25 0.07 0.9
8 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88
9 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87
10 INT75937 MLXIPL Regulation of Csf2 1 0.01 0.68 0.74
11 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
12 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
13 INT164990 Mif Positive_regulation of Gene_expression of Grina 1 0.24 0.53 0.6
14 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
15 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
16 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
17 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
18 INT195769 MIF Regulation of Gene_expression of TP53I11 1 0.19 1.24 0.47
19 INT253997 Binding of Cd200r1 and Mif 1 0.03 1.02 0.46
20 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
21 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44
22 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44
23 INT121364 ZNF398 Negative_regulation of Transcription of MIF 1 0.00 0.9 0.43
24 INT121378 Fancl Positive_regulation of MIF 1 0.01 0.92 0.42
25 INT121365 ZNF398 Negative_regulation of Gene_expression of MIF 1 0.00 0.73 0.38
26 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36
27 INT32212 POMC Regulation of Gene_expression of Mif 1 0.00 1.01 0.35
28 INT72953 Mif Positive_regulation of Localization of Prl 1 0.42 0 0.34
29 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
30 INT72951 Mif Regulation of Prl 1 0.41 0 0.32
31 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
32 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
33 INT337085 Binding of Cxcr4 and Mif 1 0.21 1.89 0.3
34 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
35 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
36 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
37 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28
38 INT72952 Mif Regulation of Localization of Prl 1 0.28 0 0.27
39 INT254000 Regulation of Binding of Cxcr4 and Mif 1 0.29 0.56 0.27
40 INT353330 F2r Positive_regulation of Positive_regulation of Mif 1 0.46 0 0.26
41 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
42 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25
43 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
44 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
45 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
46 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
47 INT195770 Binding of CPB1 and MIF 1 0.01 0.47 0.15
48 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13
49 INT222425 Mif Regulation of Tlr4 1 0.01 0.24 0.09
50 INT337090 Mif Positive_regulation of Gene_expression of Mapk1 1 0.10 1.11 0.08
51 INT337087 Negative_regulation of Binding of Mif and Cops5 1 0.13 1.64 0.08
52 INT222514 Mif Regulation of Localization of Il6 1 0.04 0.23 0.08
53 INT337088 Binding of Mif and Cops5 1 0.12 1.63 0.08
54 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
55 INT279417 Binding of PPARA and MLXIPL 3 0.00 0.33 0.07
56 INT279421 Binding of NR1H4 and MLXIPL 1 0.00 0.27 0.07
57 INT279413 Binding of RARB and MLXIPL 1 0.00 0.27 0.07
58 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
59 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
60 INT301653 Mlxipl Positive_regulation of Gene_expression of Scd1 1 0.08 0.5 0.05
61 INT273068 Binding of P2RY2 and TFAP4 1 0.01 0.27 0.05
62 INT353341 F2r Positive_regulation of Negative_regulation of Mif 1 0.49 0 0.05
63 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
64 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
65 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
66 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
67 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
68 INT121545 Mif Negative_regulation of Regulation of Ptgs2 1 0.13 0.15 0
69 INT201534 RASSF1 Negative_regulation of ID2 1 0.33 1.41 0
70 INT127731 Binding of A2m and Mif 1 0.19 0 0
71 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
72 INT201532 RASSF1 Regulation of NPC1 1 0.44 1.41 0
73 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
74 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
75 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
76 INT301629 Ins1 Positive_regulation of Mlxipl 1 0.00 0.36 0
77 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
78 INT253993 Positive_regulation of Binding of Cxcr4 and Mif 1 0.50 0 0
79 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
80 INT201542 Positive_regulation of RASSF1 Negative_regulation of ID2 1 0.36 1.41 0
81 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
82 INT294523 Binding of MDM2 and PDB1 1 0.40 0.1 0
83 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
84 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
85 INT201536 RASSF1 Regulation of ID2 1 0.41 1.42 0
86 INT352614 Negative_regulation of Binding of Mdm2 and Trp53 1 0.19 1.16 0
87 INT294527 Binding of MDM2 and p53 1 0.40 0.1 0
88 INT307219 Mlxipl Regulation of Srebf1 1 0.07 0.12 0
89 INT201533 RASSF1 Positive_regulation of Gene_expression of ID2 1 0.38 1.41 0
90 INT127732 Binding of Mif and Ilf3 1 0.10 0 0
91 INT294524 Binding of MDM2 and TNF 1 0.03 0.1 0
92 INT301465 Mdm4 Negative_regulation of Trp53 1 0.13 0.35 0
93 INT294522 Binding of IL2 and MDM2 1 0.40 0.2 0
94 INT353337 F2r Positive_regulation of Gene_expression of Mif 1 0.46 0 0
95 INT214922 Binding of MDM2 and TP53 1 0.08 1.55 0
96 INT301639 Positive_regulation of Mlxipl Positive_regulation of Gene_expression of Pklr 1 0.03 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cell cycle arrest. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cell cycle arrest. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116737 Localization of Mif 63 0.81 52.97 28.11
2 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
3 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
4 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78
5 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
6 INT72949 Binding of Mif 31 0.46 23.12 11.65
7 INT117553 Regulation of MIF 10 0.56 12.76 8.67
8 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
9 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
10 INT517 Regulation of Mif 16 0.62 5.43 6.55
11 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08
12 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08
13 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12
14 INT174339 Positive_regulation of Localization of Mif 7 0.61 8.27 4.95
15 INT121372 Positive_regulation of Gene_expression of MIF 17 0.60 14.78 4.73
16 INT116738 Positive_regulation of Gene_expression of Mif 14 0.68 10.99 3.8
17 INT130226 Positive_regulation of Gene_expression of Mif 4 0.58 15.75 3.03
18 INT163290 Binding of MIF 9 0.31 7.57 2.8
19 INT203137 Binding of Mif 6 0.31 9.46 2.71
20 INT120011 Localization of MIF 6 0.58 5.72 2.6
21 INT40748 Negative_regulation of Mif 6 0.56 8.33 2.46
22 INT103304 Positive_regulation of Mif 6 0.48 8.66 2.05
23 INT75935 Regulation of MLXIPL 4 0.18 3.82 1.7
24 INT44149 Regulation of Gene_expression of Mif 6 0.54 2.45 1.63
25 INT353326 Negative_regulation of Localization of Mif 1 0.45 1.28 1.59
26 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
27 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
28 INT253987 Regulation of Localization of Mif 3 0.43 1.65 1.27
29 INT41418 Regulation of Mif 2 0.40 3.86 1.24
30 INT121368 Transcription of Mif 5 0.72 2.71 1.15
31 INT121375 Transcription of MIF 4 0.62 2.85 1.1
32 INT102827 Protein_catabolism of Mif 1 0.33 0 1.06
33 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
34 INT121369 Negative_regulation of Gene_expression of MIF 3 0.50 2.48 0.92
35 INT121376 Negative_regulation of Transcription of MIF 3 0.37 2.26 0.87
36 INT353328 Regulation of Positive_regulation of Mif 1 0.40 0.89 0.81
37 INT2108 Localization of Mif 5 0.77 2.7 0.73
38 INT32209 Regulation of Gene_expression of Mif 3 0.59 3.41 0.66
39 INT130229 Regulation of Negative_regulation of Mif 1 0.39 1.36 0.66
40 INT353322 Negative_regulation of Positive_regulation of Mif 1 0.38 0.35 0.66
41 INT44148 Negative_regulation of Gene_expression of Mif 6 0.41 0.95 0.64
42 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
43 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
44 INT337079 Negative_regulation of Gene_expression of Mif 1 0.41 4.17 0.51
45 INT61813 Localization of TFAP4 1 0.73 0 0.47
46 INT61812 Gene_expression of TFAP4 1 0.65 0 0.45
47 INT116735 Positive_regulation of Positive_regulation of Mif 1 0.70 0.61 0.38
48 INT253977 Positive_regulation of Binding of Mif 1 0.48 0.97 0.32
49 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
50 INT121374 Regulation of Gene_expression of MIF 2 0.39 1.01 0.29
51 INT121366 Regulation of Transcription of Mif 1 0.02 0.61 0.24
52 INT121367 Negative_regulation of Transcription of Mif 1 0.02 0.59 0.24
53 INT337077 Positive_regulation of Localization of Mif 1 0.58 0.96 0.21
54 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
55 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
56 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
57 INT271849 Gene_expression of Mlxipl 2 0.56 2.08 0.17
58 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
59 INT113346 Binding of MDM2 10 0.35 5.73 0.15
60 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
61 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
62 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
63 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
64 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
65 INT59955 Gene_expression of RASSF1 3 0.60 3.43 0.13
66 INT337076 Positive_regulation of Negative_regulation of Mif 1 0.48 1.44 0.12
67 INT59954 Localization of RASSF1 3 0.73 3.12 0.07
68 INT59953 Positive_regulation of Localization of RASSF1 1 0.00 0.75 0.07
69 INT219608 Regulation of RASSF1 1 0.01 0 0.07
70 INT273080 Binding of TFAP4 1 0.01 0.27 0.05
71 INT287282 Regulation of Binding of MDM2 1 0.04 0.63 0.04
72 INT174340 Protein_catabolism of Mif 1 0.89 0.09 0.04
73 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
74 INT176240 Phosphorylation of Mdm2 2 0.22 1.28 0.03
75 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
76 INT176252 Positive_regulation of Phosphorylation of Mdm2 1 0.14 0.42 0.03
77 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0
78 INT266011 Positive_regulation of Gene_expression of Mdm2 3 0.47 4.61 0
79 INT260276 Negative_regulation of MDM2 2 0.42 0.62 0
80 INT276357 Protein_catabolism of MDM2 2 0.32 1.18 0
81 INT172483 Positive_regulation of TFAP4 2 0.44 0.33 0
82 INT172481 Transcription of TFAP4 2 0.66 0.58 0
83 INT276370 Phosphorylation of MDM2 2 0.50 1.99 0
84 INT294536 Localization of MDM2 1 0.73 0.09 0
85 INT121497 Transcription of MDM2 1 0.54 0.12 0
86 INT301440 Gene_expression of Mdm4 1 0.43 0.34 0
87 INT235473 Negative_regulation of Gene_expression of MDM2 1 0.18 0.99 0
88 INT353329 Positive_regulation of Regulation of Mif 1 0.36 0 0
89 INT301458 Positive_regulation of Gene_expression of Mdm4 1 0.32 0.35 0
90 INT172478 Positive_regulation of Transcription of TFAP4 1 0.09 0.06 0
91 INT355160 Binding of RASSF1 1 0.36 1.06 0
92 INT337082 Phosphorylation of Mif 1 0.68 0.97 0
93 INT276343 Regulation of Phosphorylation of MDM2 1 0.14 0.85 0
94 INT276359 Positive_regulation of Protein_catabolism of MDM2 1 0.15 1.79 0
95 INT301589 Positive_regulation of Mlxipl 1 0.10 0.52 0
96 INT276366 Positive_regulation of Phosphorylation of MDM2 1 0.15 0.85 0
97 INT113347 Negative_regulation of Binding of MDM2 1 0.25 0.13 0
98 INT355161 Regulation of Localization of RASSF1 1 0.44 1.13 0
99 INT201572 Negative_regulation of Localization of RASSF1 1 0.35 1.35 0
100 INT222960 Gene_expression of MLXIPL 1 0.01 0 0
101 INT276365 Negative_regulation of Protein_catabolism of MDM2 1 0.14 0.86 0
102 INT266009 Negative_regulation of Gene_expression of Mdm2 1 0.43 1.03 0
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