GO:0071224

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Name cellular response to peptidoglycan
Categary Process
Go Slim No
Go Link GO:0071224
Unique Molecular Interactions 78
Total Molecular Interactions 134
Total Single Events 650
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to peptidoglycan. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to peptidoglycan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
2 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
3 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
4 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
5 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
6 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
7 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
8 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39
9 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
10 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
11 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
12 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
13 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
14 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
15 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
16 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
17 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
18 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
19 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
20 INT276974 Tlr2 Positive_regulation of Gene_expression of Ccr8 1 0.27 0.16 0.24
21 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
22 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21
23 INT163096 Tlr2 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.16 0.21
24 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
25 INT348032 Fndc3b Positive_regulation of Tlr2 1 0.01 1.3 0.2
26 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
27 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
28 INT339503 Tlr2 Positive_regulation of Eif2ak2 1 0.12 0.09 0.19
29 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
30 INT324820 Hsp90b1 Positive_regulation of Tlr2 1 0.16 0.42 0.17
31 INT204791 Binding of Spg7 and Nod2 1 0.03 0.5 0.16
32 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
33 INT276958 Binding of Tlr2 and Clec7a 1 0.09 0.58 0.15
34 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15
35 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
36 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
37 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
38 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14
39 INT333270 Tlr2 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
40 INT348040 TNF Positive_regulation of Gene_expression of Tlr2 1 0.02 0.98 0.14
41 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
42 INT145830 Mdp1 Positive_regulation of Nod2 1 0.34 0.52 0.13
43 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
44 INT324695 Tlr6 Positive_regulation of Tlr2 1 0.14 0 0.12
45 INT276966 Tlr2 Negative_regulation of Gene_expression of Mcpt1 1 0.09 1.38 0.1
46 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08
47 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08
48 INT276987 Tlr2 Negative_regulation of Gene_expression of Il10 1 0.15 0.19 0.08
49 INT324871 Ros1 Positive_regulation of Gene_expression of Tlr2 1 0.03 1.12 0.07
50 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
51 INT276980 Binding of Tlr2 and Gopc 1 0.14 0.28 0.07
52 INT294638 Bcl2a1a Positive_regulation of Tlr2 1 0.58 0.43 0.07
53 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
54 INT324867 Positive_regulation of Binding of Tlr6 and Tlr2 1 0.10 0.79 0.05
55 INT324864 Positive_regulation of Binding of Tlr1 and Tlr2 1 0.10 0.79 0.05
56 INT276969 Tlr2 Positive_regulation of Il10 1 0.20 0.75 0.04
57 INT276955 Tlr2 Positive_regulation of Negative_regulation of Il13 1 0.14 0.76 0.04
58 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
59 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
60 INT276973 Tlr2 Positive_regulation of Il13 1 0.14 0.76 0.04
61 INT276981 Tlr2 Positive_regulation of Gene_expression of Il13 1 0.13 0.76 0.04
62 INT276990 Tlr2 Positive_regulation of Negative_regulation of Il10 1 0.20 0.75 0.04
63 INT324805 Tlr2 Positive_regulation of Cd14 1 0.14 0.09 0.03
64 INT276989 Stat3 Regulation of Positive_regulation of Tlr2 1 0.22 0.13 0.03
65 INT341043 Avp Regulation of Camp 1 0.10 0.47 0.03
66 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03
67 INT276972 Tlr2 Negative_regulation of Gene_expression of Hand1 1 0.14 0.65 0.03
68 INT313077 Cd180 Regulation of Tlr2 1 0.01 0.09 0
69 INT275842 HPD Positive_regulation of Tlr2 1 0.01 0.76 0
70 INT344224 Tlr2 Regulation of Gene_expression of Tlr4 1 0.03 0 0
71 INT313076 Tlr2 Positive_regulation of Gene_expression of Il10 1 0.02 0.14 0
72 INT228215 Tlr2 Positive_regulation of Gene_expression of Tlr4 1 0.19 1.47 0
73 INT344220 Itgam Regulation of Transcription of Tlr2 1 0.03 0.06 0
74 INT313080 ST2 Regulation of Tlr2 1 0.02 0.09 0
75 INT313079 SIGIRR Regulation of Tlr2 1 0.18 0.09 0
76 INT275840 Cfp Positive_regulation of Tlr2 1 0.02 0.75 0
77 INT316536 Binding of Tlr2 and Il23a 1 0.11 0.78 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to peptidoglycan. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to peptidoglycan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
2 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
3 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
4 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
5 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
6 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
7 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
8 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
9 INT20459 Regulation of Ripk2 5 0.44 0 4.53
10 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
11 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
12 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
13 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
14 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
15 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
16 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
17 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
18 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
19 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3
20 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
21 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
22 INT190804 Positive_regulation of Tlr2 6 0.66 3.7 1.16
23 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
24 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
25 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
26 INT288493 Positive_regulation of Gene_expression of Tlr2 4 0.66 4.38 0.94
27 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
28 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
29 INT145760 Binding of Tlr2 5 0.46 3.59 0.89
30 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
31 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
32 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
33 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
34 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
35 INT41106 Gene_expression of Camp 2 0.75 0.24 0.64
36 INT41105 Regulation of Gene_expression of Camp 1 0.44 0 0.64
37 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
38 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
39 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5
40 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46
41 INT38738 Localization of RIPK2 2 0.68 0.07 0.45
42 INT288189 Negative_regulation of Negative_regulation of Tlr2 1 0.26 0.43 0.28
43 INT346895 Positive_regulation of Gene_expression of Nod2 1 0.33 0.74 0.28
44 INT288186 Regulation of Binding of Tlr2 2 0.32 1.72 0.26
45 INT224614 Regulation of Positive_regulation of Tlr2 1 0.13 0.56 0.26
46 INT346896 Binding of Nod2 1 0.21 0.72 0.26
47 INT145758 Regulation of Tlr2 3 0.43 0.94 0.23
48 INT145761 Negative_regulation of Tlr2 2 0.41 1.97 0.23
49 INT346899 Regulation of Positive_regulation of Nod2 1 0.18 0.75 0.22
50 INT201691 Binding of RIPK2 2 0.18 1.51 0.17
51 INT294633 Positive_regulation of Binding of Tlr2 1 0.44 0.42 0.16
52 INT240596 Negative_regulation of Gene_expression of RIPK2 1 0.06 0.91 0.15
53 INT136002 Positive_regulation of Gene_expression of RIPK2 1 0.67 0.52 0.15
54 INT145759 Regulation of Gene_expression of Tlr2 3 0.43 0.98 0.14
55 INT301958 Positive_regulation of Regulation of Tlr2 1 0.21 0.32 0.13
56 INT329058 Positive_regulation of Transcription of Tlr2 1 0.48 0.62 0.11
57 INT329049 Transcription of Tlr2 1 0.68 0.62 0.11
58 INT144094 Negative_regulation of Localization of Ripk2 1 0.42 0.49 0.09
59 INT204777 Negative_regulation of Localization of Nod2 1 0.28 0.61 0.09
60 INT255976 Regulation of Transcription of Tlr2 1 0.22 0.89 0.09
61 INT204779 Localization of Nod2 1 0.48 0.6 0.08
62 INT269821 Regulation of Localization of Tlr2 1 0.27 1.04 0.07
63 INT204770 Regulation of Nod2 1 0.29 0.66 0.07
64 INT246930 Negative_regulation of Transcription of Tlr2 1 0.36 0.92 0.04
65 INT346893 Negative_regulation of Gene_expression of Nod2 1 0.28 0.13 0.04
66 INT145757 Negative_regulation of Gene_expression of Tlr2 2 0.41 0.68 0.03
67 INT341036 Regulation of Camp 1 0.44 0.42 0.03
68 INT276939 Positive_regulation of Phosphorylation of Tlr2 1 0.46 0.6 0.03
69 INT276931 Phosphorylation of Tlr2 1 0.75 0.6 0.03
70 INT246929 Positive_regulation of Localization of Tlr2 2 0.42 0.26 0
71 INT246927 Negative_regulation of Binding of Tlr2 1 0.31 0 0
72 INT284053 Positive_regulation of Positive_regulation of Nod2 1 0.25 0.08 0
73 INT341040 Negative_regulation of Camp 1 0.42 0.36 0
74 INT341041 Localization of Camp 1 0.73 0.06 0
75 INT341038 Protein_catabolism of Camp 1 0.64 0 0
76 INT341037 Negative_regulation of Gene_expression of Camp 1 0.42 0 0
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