GO:0071260

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Name cellular response to mechanical stimulus
Categary Process
Go Slim No
Go Link GO:0071260
Unique Molecular Interactions 2022
Total Molecular Interactions 2789
Total Single Events 19917
Pain Genes Associated 82

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to mechanical stimulus. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to mechanical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
4 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
5 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
6 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
7 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
8 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
9 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
10 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
11 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
12 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
13 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
14 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
15 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
16 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
17 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
18 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
19 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
20 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
21 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
22 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13
23 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12
24 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
25 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
26 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
27 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
28 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
29 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
30 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
31 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
32 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
33 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
34 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
35 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
36 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
37 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
38 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
39 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
40 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
41 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
42 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
43 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
44 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
45 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
46 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
47 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
48 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
49 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
50 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
51 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
52 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
53 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 0.16 2.53 1.35
54 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
55 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
56 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
57 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
58 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
59 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
60 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
61 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
62 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
63 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
64 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
65 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
66 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
67 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
68 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
69 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
70 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
71 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
72 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
73 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
74 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
75 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
76 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
77 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
78 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
79 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
80 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
81 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
82 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
83 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
84 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
85 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14
86 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
87 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
88 INT156545 Il13 Positive_regulation of Gene_expression of Il12a 1 0.27 1.56 1.13
89 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
90 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
91 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11
92 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
93 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
94 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
95 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
96 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
97 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
98 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
99 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
100 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
101 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
102 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
103 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
104 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
105 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
106 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
107 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
108 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
109 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
110 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
111 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
112 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
113 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
114 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
115 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
116 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
117 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
118 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02
119 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
120 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
121 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
122 INT338892 TNFSF14 Regulation of Abat 1 0.00 0.61 1.01
123 INT338895 TNFSF14 Regulation of Regulation of Abat 1 0.00 0.62 1.01
124 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
125 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
126 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
127 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
128 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
129 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98
130 INT140934 Binding of Cd40 and Ean5 1 0.09 1.03 0.98
131 INT156508 Nfkb1 Regulation of Positive_regulation of Grin1 1 0.22 0.98 0.98
132 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
133 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
134 INT250016 Binding of IGHE and Il13 1 0.01 4.59 0.97
135 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
136 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
137 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
138 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
139 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
140 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
141 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
142 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
143 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
144 INT338893 TNFSF14 Positive_regulation of Gene_expression of Gria1 1 0.07 0.59 0.94
145 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
146 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
147 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
148 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
149 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
150 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
151 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
152 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
153 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
154 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
155 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
156 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
157 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
158 INT61862 Slc3a1 Positive_regulation of Egr1 1 0.05 0 0.92
159 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
160 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
161 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
162 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
163 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
164 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
165 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
166 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
167 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
168 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
169 INT318462 Nnat Positive_regulation of Nfkb1 1 0.46 0.9 0.88
170 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
171 INT152694 Negative_regulation of Nfkb1 Negative_regulation of Bdnf 1 0.24 0.15 0.88
172 INT152697 Nfkb1 Negative_regulation of Ltp 1 0.04 0.15 0.88
173 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
174 INT28193 Nppb Positive_regulation of Positive_regulation of RYBP 1 0.29 0.05 0.88
175 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
176 INT152695 Nfkb1 Negative_regulation of Bdnf 1 0.24 0.15 0.88
177 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
178 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
179 INT96811 Nfkb1 Regulation of Gene_expression of IK 1 0.00 1.06 0.87
180 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87
181 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
182 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
183 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
184 INT116555 Olr1627 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 1.51 0.86
185 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
186 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
187 INT116557 Olr1627 Negative_regulation of Localization of Nfkb1 1 0.02 1.51 0.85
188 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
189 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
190 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
191 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
192 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
193 INT116558 Ptpn5 Positive_regulation of Nfkb1 1 0.46 2.01 0.83
194 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
195 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
196 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
197 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
198 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
199 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
200 INT100677 IL13 Positive_regulation of STAT6 1 0.36 1.95 0.81

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to mechanical stimulus. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to mechanical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73
3 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
4 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
5 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
6 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
7 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
8 INT6849 Localization of IL1B 229 0.81 112.56 69.63
9 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
10 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
11 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
12 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
13 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
14 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
15 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
16 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
17 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
18 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
19 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
20 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
21 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
22 INT6484 Binding of IL1B 122 0.47 75.84 35.07
23 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94
24 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
25 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
26 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
27 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33
28 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58
29 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26
30 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
31 INT9347 Localization of Il1b 58 0.81 26.13 31.53
32 INT1158 Regulation of Agt 106 0.61 29.4 30.29
33 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
34 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
35 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
36 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
37 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
38 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35
39 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
40 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95
41 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
42 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
43 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
44 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
45 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
46 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
47 INT134651 Binding of TLR4 89 0.48 66.96 23.19
48 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
49 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
50 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
51 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
52 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
53 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
54 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
55 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
56 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
57 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42
58 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
59 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
60 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
61 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
62 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
63 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
64 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
65 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
66 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
67 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61
68 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
69 INT2066 Localization of Agt 56 0.80 9.95 16.25
70 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
71 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
72 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4
73 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
74 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
75 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
76 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
77 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
78 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
79 INT78480 Localization of Nfkb1 39 0.80 23.14 13.64
80 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
81 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
82 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
83 INT3962 Regulation of AGT 50 0.62 20.96 13.01
84 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
85 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
86 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
87 INT4199 Binding of Agt 76 0.48 21.06 12.66
88 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19
89 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85
90 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
91 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62
92 INT398 Localization of AGT 45 0.78 16.97 11.54
93 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44
94 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
95 INT81531 Positive_regulation of Gene_expression of Nfkb1 27 0.69 13.9 11.04
96 INT8065 Binding of AGT 54 0.48 20.54 10.85
97 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
98 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
99 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
100 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02
101 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
102 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97
103 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
104 INT87863 Positive_regulation of IL18 40 0.69 34.08 9.53
105 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
106 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37
107 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08
108 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
109 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
110 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
111 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
112 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
113 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
114 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
115 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
116 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
117 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
118 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
119 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
120 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
121 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
122 INT121977 Phosphorylation of Nfkb1 15 0.51 9.83 7.77
123 INT116552 Positive_regulation of Localization of Nfkb1 16 0.61 12.7 7.74
124 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
125 INT6055 Transcription of Egr1 47 0.69 3.61 7.68
126 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
127 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
128 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
129 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
130 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
131 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52
132 INT81537 Regulation of Gene_expression of Nfkb1 10 0.57 7.09 7.48
133 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47
134 INT94127 Positive_regulation of Il18 14 0.69 14 7.47
135 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
136 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17
137 INT93003 Binding of CD40 28 0.47 20.25 7.13
138 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
139 INT47707 Negative_regulation of Egr1 9 0.41 0.17 7.03
140 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
141 INT167049 Binding of Ednra 3 0.07 3.47 6.84
142 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
143 INT132822 Localization of IL13 26 0.67 22.85 6.66
144 INT91721 Binding of IL18 21 0.48 21.17 6.56
145 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53
146 INT65538 Regulation of Positive_regulation of Nfkb1 17 0.51 8.31 6.5
147 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
148 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
149 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
150 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38
151 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36
152 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
153 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
154 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
155 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
156 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12
157 INT78955 Regulation of Gene_expression of Ptgs2 12 0.62 7.22 6.02
158 INT97797 Localization of TLR4 18 0.77 13.78 6
159 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
160 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93
161 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
162 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84
163 INT32155 Gene_expression of TNFRSF10B 36 0.67 30.32 5.74
164 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69
165 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
166 INT80033 Binding of FAS 37 0.48 41.19 5.67
167 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
168 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
169 INT113420 Positive_regulation of Gene_expression of IL18 22 0.69 19.96 5.53
170 INT10705 Binding of Il1b 9 0.36 2.8 5.53
171 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
172 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
173 INT96234 Localization of Il13 11 0.62 10.94 5.48
174 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
175 INT92398 Negative_regulation of Localization of Nfkb1 17 0.42 11.24 5.4
176 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
177 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
178 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
179 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
180 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
181 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32
182 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
183 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
184 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
185 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
186 INT47704 Regulation of Egr1 17 0.60 2.43 5.18
187 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1
188 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
189 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
190 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
191 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
192 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
193 INT51944 Positive_regulation of Transcription of Egr1 12 0.49 1.96 4.72
194 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
195 INT246315 Localization of Ednra 22 0.15 2.73 4.64
196 INT113517 Binding of Fas 16 0.37 15.86 4.62
197 INT21953 Binding of Ednra 12 0.33 4.72 4.56
198 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
199 INT45159 Regulation of Nppb 16 0.54 13.57 4.46
200 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
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