GO:0071294

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Name cellular response to zinc ion
Categary Process
Go Slim No
Go Link GO:0071294
Unique Molecular Interactions 86
Total Molecular Interactions 122
Total Single Events 1181
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to zinc ion. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to zinc ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
2 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
3 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
4 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
5 INT44504 Mt1a Positive_regulation of Prl 1 0.37 0 1.48
6 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
7 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
8 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
9 INT107579 Kitl Negative_regulation of Grin2a 1 0.10 1.02 1.18
10 INT59606 Binding of Tspo and Penk 1 0.04 0 1.12
11 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
12 INT269189 Binding of Grin2a and Grin3a 2 0.25 1.05 1.09
13 INT269193 Prkcg Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
14 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
15 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
16 INT251153 Dlg2 Positive_regulation of Gene_expression of Grin2a 1 0.40 0.6 0.92
17 INT108647 Binding of Grin2a and Camk1d 1 0.33 0.78 0.9
18 INT310348 Binding of Tspo and Gabrd 1 0.00 0.43 0.88
19 INT285656 Cnrip1 Negative_regulation of Kcnk3 1 0.00 0.23 0.85
20 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
21 INT44502 Regulation of Mt1a Positive_regulation of Prl 1 0.14 0 0.74
22 INT296292 Binding of Car1 and Grin2a 1 0.14 0.32 0.72
23 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
24 INT296288 Grin2a Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
25 INT69280 Negative_regulation of Binding of TSPO and Gabrg1 1 0.00 1.03 0.63
26 INT69278 Binding of TSPO and Gabrg1 1 0.00 1.01 0.62
27 INT112107 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2a 1 0.40 0.49 0.57
28 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
29 INT112106 Negative_regulation of Dlg2 Negative_regulation of Grin2a 1 0.40 0.48 0.56
30 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 0.02 0.54 0.55
31 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54
32 INT208121 Binding of Grin2a and Grin2b 3 0.35 0.06 0.51
33 INT208122 Grin2a Positive_regulation of Positive_regulation of Ltp 1 0.16 0.21 0.49
34 INT250081 Grin2a Positive_regulation of Ltp 1 0.20 0.14 0.48
35 INT208120 Binding of Grin2a and Hpcal1 1 0.10 0.07 0.48
36 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45
37 INT127396 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin2a 1 0.00 0.71 0.45
38 INT56577 Mt1a Positive_regulation of Localization of Gnrh1 1 0.04 0 0.43
39 INT105733 Grin2b Negative_regulation of Gene_expression of Grin2a 1 0.22 0.09 0.41
40 INT279620 Negative_regulation of Binding of Grin2a and Grin2b 1 0.18 0.99 0.4
41 INT296301 Binding of Grin2a and Kcnip3 1 0.27 0 0.4
42 INT52632 Binding of TSPO and CCK 1 0.15 0.53 0.37
43 INT250076 Grin2a Regulation of Positive_regulation of Ltp 1 0.10 0.06 0.35
44 INT251148 Negative_regulation of Binding of Grin2a and Dlg2 1 0.37 0.45 0.32
45 INT284689 Binding of Tspo and Map3k12 1 0.00 0.59 0.32
46 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
47 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3
48 INT122311 Sst Regulation of Kcnk3 1 0.14 0.28 0.29
49 INT158922 Positive_regulation of Binding of TSPO and Tspo 1 0.54 0.83 0.28
50 INT212289 Vsnl1 Negative_regulation of Grin2a 1 0.04 0.38 0.28
51 INT122312 Prkaca Regulation of Kcnk3 1 0.13 0.28 0.28
52 INT158923 Binding of TSPO and Tspo 1 0.40 0.82 0.28
53 INT263732 Binding of Grin2a and Neto1 1 0.41 0 0.27
54 INT317510 Binding of Grin2a and Gnptab 1 0.00 0 0.26
55 INT250075 Binding of Hpcal4 and Negative_regulation of Gene_expression of Grin2a 1 0.03 0 0.24
56 INT274005 KCNK3 Positive_regulation of SYNM 1 0.06 0 0.23
57 INT311527 Binding of Grin2a and Gria1 1 0.01 0 0.21
58 INT191336 Binding of TSPO and GOPC 1 0.01 0.65 0.16
59 INT191338 Binding of TSPO and IDO1 1 0.02 0.65 0.16
60 INT311526 Gria1 Regulation of Gene_expression of Grin2a 1 0.01 0.32 0.15
61 INT94523 Binding of MT2A and ALG1 1 0.16 0.72 0.09
62 INT263782 Grin2a Regulation of Localization of Grin1 1 0.29 0.17 0.07
63 INT263764 Dlg4 Regulation of Localization of Grin2a 1 0.16 0.17 0.07
64 INT263777 Grin2a Regulation of Localization of Vamp2 1 0.26 0.17 0.07
65 INT263759 Grin1 Regulation of Localization of Grin2a 1 0.29 0.17 0.07
66 INT263772 Grin2a Regulation of Localization of Gria2 1 0.19 0.17 0.07
67 INT263771 Grin2a Regulation of Localization of Dlg4 1 0.19 0.17 0.07
68 INT263762 Grin2a Regulation of Localization of Grin2b 1 0.26 0.17 0.07
69 INT263768 Grin2b Regulation of Localization of Grin2a 1 0.26 0.17 0.07
70 INT250073 Grin2a Regulation of Grin2b 1 0.39 0.9 0.05
71 INT263730 Binding of Grin2a and Rasgrf1 1 0.23 0 0.05
72 INT263780 Localization of Neto1 Regulation of Localization of Grin2a 1 0.38 0.18 0.05
73 INT269273 Regulation of Mt1 Regulation of Gene_expression of Mecr 1 0.12 0.34 0.04
74 INT229825 Fos Positive_regulation of Mt2A 1 0.41 0.71 0
75 INT315069 ITGB4 Regulation of MT1X 1 0.27 0.52 0
76 INT315049 IGF1R Regulation of MT1X 1 0.29 0.52 0
77 INT263766 Grin2a Positive_regulation of Negative_regulation of Neto1 1 0.42 0 0
78 INT229827 Fos Positive_regulation of Mt1a 1 0.40 0.36 0
79 INT321882 Binding of TSPO and Lm370 1 0.01 0.4 0
80 INT212864 MT1A Positive_regulation of PPRC1 1 0.20 0 0
81 INT180861 TGFB1 Positive_regulation of MT1E 1 0.17 1.22 0
82 INT343161 ACSL4 Regulation of Gene_expression of TSPO 1 0.25 0.75 0
83 INT193147 CRAMP1L Regulation of TSPO 1 0.01 0.27 0
84 INT343156 Binding of TSPO and DBI 1 0.04 0.63 0
85 INT219502 TSPO Positive_regulation of Positive_regulation of Ppib 1 0.01 0 0
86 INT219424 Binding of AHR and TSPO 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to zinc ion. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to zinc ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
2 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
3 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
4 INT14647 Positive_regulation of Grin2a 26 0.67 4.69 14.8
5 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67
6 INT100799 Negative_regulation of Grin2a 27 0.57 7.33 12.2
7 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6
8 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5
9 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32
10 INT64193 Regulation of Grin2a 19 0.54 2.98 10.31
11 INT18088 Binding of Tspo 26 0.48 9.12 10.2
12 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02
13 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28
14 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05
15 INT6335 Binding of TSPO 39 0.44 10.88 7.66
16 INT27916 Gene_expression of Mt1a 6 0.47 4.4 7.04
17 INT100926 Positive_regulation of Gene_expression of Grin2a 11 0.63 3.24 6.41
18 INT14258 Regulation of TSPO 32 0.60 10.16 6.24
19 INT35780 Positive_regulation of Mt1a 9 0.55 4.9 6.08
20 INT67693 Binding of Grin2a 9 0.38 1.74 5.68
21 INT208108 Localization of Grin2a 19 0.70 1.5 5.22
22 INT19549 Binding of Grin2a 12 0.45 1.24 5.09
23 INT135474 Negative_regulation of Gene_expression of Grin2a 7 0.39 6.94 4.89
24 INT104760 Localization of MT1A 13 0.44 1.5 4.85
25 INT111947 Positive_regulation of Gene_expression of Grin2a 7 0.68 1.75 4.84
26 INT7841 Gene_expression of Tspo 10 0.75 7.63 4.45
27 INT73114 Gene_expression of Kcnk3 32 0.77 1.57 4.03
28 INT103999 Positive_regulation of Phosphorylation of Grin2a 5 0.38 3.12 3.94
29 INT121986 Phosphorylation of Grin2a 5 0.76 0.83 3.71
30 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58
31 INT209221 Regulation of Gene_expression of Grin2a 5 0.24 2.81 3.45
32 INT28390 Negative_regulation of Mt1a 4 0.36 1.13 3.39
33 INT111369 Transcription of Mt1a 4 0.68 1.01 3.35
34 INT25745 Regulation of Tspo 6 0.45 0.25 3.1
35 INT109496 Gene_expression of KCNK3 9 0.78 0.59 3.02
36 INT90611 Positive_regulation of Positive_regulation of Grin2a 4 0.63 1.89 3
37 INT111368 Transcription of Mt2A 1 0.69 0.94 2.66
38 INT105730 Localization of Grin2a 7 0.67 0.64 2.56
39 INT63238 Gene_expression of Mt1 27 0.65 10.86 2.53
40 INT141075 Transcription of Grin2a 5 0.49 1.89 2.46
41 INT60156 Regulation of Kcnk3 7 0.42 2.47 2.4
42 INT74131 Positive_regulation of Tspo 7 0.50 0.92 2.11
43 INT145539 Negative_regulation of KCNK3 3 0.59 0 2.07
44 INT74595 Regulation of Transcription of Grin2a 2 0.42 0.66 1.92
45 INT103624 Negative_regulation of Gene_expression of Grin2a 5 0.56 1.58 1.9
46 INT14257 Localization of TSPO 9 0.73 1.48 1.87
47 INT104759 Positive_regulation of MT1A 3 0.26 0.28 1.84
48 INT104761 Positive_regulation of Localization of MT1A 1 0.38 0.23 1.84
49 INT151174 Negative_regulation of Transcription of Grin2a 3 0.40 0 1.8
50 INT326006 Regulation of Gene_expression of Mt1a 1 0.07 0.55 1.79
51 INT94534 Gene_expression of MT2A 8 0.75 11.28 1.76
52 INT94524 Gene_expression of MT1A 6 0.39 1.66 1.75
53 INT19576 Negative_regulation of Tspo 3 0.42 1.02 1.75
54 INT326007 Negative_regulation of Gene_expression of Mt1a 1 0.07 1.32 1.68
55 INT73112 Negative_regulation of Kcnk3 7 0.58 1.2 1.55
56 INT111367 Regulation of Transcription of Mt2A 1 0.44 0.65 1.5
57 INT111366 Regulation of Transcription of Mt1a 1 0.43 0.65 1.5
58 INT9269 Regulation of Mt1a 3 0.36 0 1.43
59 INT39503 Positive_regulation of KCNK3 3 0.47 0.09 1.29
60 INT105729 Negative_regulation of Localization of Grin2a 3 0.38 0.08 1.29
61 INT90397 Positive_regulation of Kcnk3 3 0.68 1.31 1.29
62 INT94776 Binding of MT1E 1 0.35 0.15 1.29
63 INT155946 Positive_regulation of Mt1 7 0.45 4.31 1.23
64 INT142530 Negative_regulation of Positive_regulation of Mt2A 1 0.43 0.36 1.23
65 INT145919 Regulation of KCNK3 5 0.62 0.09 1.22
66 INT142531 Positive_regulation of Mt2A 1 0.70 0.36 1.22
67 INT139647 Positive_regulation of Positive_regulation of Grin2a 2 0.44 0.38 1.11
68 INT67589 Gene_expression of MT1E 8 0.51 7.52 1.09
69 INT94532 Regulation of MT2A 5 0.36 4.25 0.98
70 INT326005 Positive_regulation of Positive_regulation of Mt1a 1 0.08 0.48 0.97
71 INT326008 Positive_regulation of Negative_regulation of Mt1a 1 0.08 0.48 0.97
72 INT288625 Localization of MT2A 1 0.46 0.46 0.95
73 INT19550 Positive_regulation of Binding of Grin2a 1 0.04 0 0.94
74 INT141076 Negative_regulation of Transcription of Grin2a 2 0.40 0.82 0.92
75 INT44499 Localization of Mt1a 2 0.59 0.12 0.9
76 INT284686 Positive_regulation of Gene_expression of Tspo 1 0.66 2.55 0.9
77 INT263688 Negative_regulation of Localization of Grin2a 2 0.31 0.16 0.84
78 INT203377 Regulation of MT1E 1 0.17 3.25 0.84
79 INT6806 Localization of Tspo 3 0.70 0 0.82
80 INT44501 Regulation of Localization of Mt1a 1 0.30 0 0.75
81 INT69003 Negative_regulation of Binding of TSPO 4 0.03 2.78 0.69
82 INT152672 Positive_regulation of Gene_expression of MT1A 2 0.29 0.35 0.68
83 INT326004 Binding of Mt1a 1 0.06 0.24 0.68
84 INT139649 Positive_regulation of Negative_regulation of Grin2a 2 0.44 0.63 0.65
85 INT191341 Negative_regulation of Gene_expression of TSPO 3 0.34 1.66 0.64
86 INT73850 Transcription of TSPO 6 0.59 0.83 0.61
87 INT275637 Positive_regulation of Gene_expression of MT2A 2 0.28 2.49 0.6
88 INT204138 Regulation of Gene_expression of TSPO 2 0.36 0.99 0.6
89 INT120054 Regulation of Gene_expression of Tspo 2 0.44 0.97 0.59
90 INT296254 Regulation of Phosphorylation of Grin2a 1 0.32 0.14 0.58
91 INT178718 Phosphorylation of TSPO 1 0.79 0.91 0.56
92 INT178717 Negative_regulation of Localization of TSPO 1 0.41 0.92 0.56
93 INT73849 Negative_regulation of TSPO 8 0.59 2.4 0.53
94 INT156379 Regulation of Binding of Grin2a 1 0.36 0.17 0.52
95 INT203382 Regulation of MT1X 1 0.17 2.26 0.52
96 INT205265 Regulation of Transcription of TSPO 1 0.21 0.13 0.49
97 INT74871 Negative_regulation of Gene_expression of Mt1 3 0.26 1.8 0.48
98 INT274343 Localization of Mt1 1 0.11 0.84 0.48
99 INT271628 Negative_regulation of Regulation of Grin2a 2 0.28 1.05 0.47
100 INT147368 Negative_regulation of Regulation of Kcnk3 1 0.25 0.6 0.47
101 INT250060 Positive_regulation of Localization of Grin2a 1 0.42 0 0.47
102 INT250446 Positive_regulation of Localization of Grin2a 2 0.37 0 0.44
103 INT350910 Regulation of Positive_regulation of Mt1 1 0.12 0.51 0.44
104 INT61831 Regulation of Regulation of TSPO 1 0.03 0.16 0.43
105 INT253337 Localization of MT1E 4 0.59 8.89 0.41
106 INT271627 Regulation of Positive_regulation of Grin2a 1 0.30 0.23 0.4
107 INT135139 Regulation of Positive_regulation of Tspo 1 0.05 0.17 0.37
108 INT94543 Binding of MT2A 5 0.29 0.96 0.36
109 INT249529 Regulation of Phosphorylation of Grin2a 1 0.21 0.16 0.34
110 INT263687 Regulation of Localization of Grin2a 2 0.29 0 0.33
111 INT146646 Protein_catabolism of TSPO 3 0.86 0.58 0.32
112 INT94540 Gene_expression of MT1X 6 0.49 5.51 0.28
113 INT213473 Regulation of Positive_regulation of Grin2a 1 0.16 0.05 0.28
114 INT311509 Regulation of Transcription of Grin2a 1 0.13 0.42 0.27
115 INT212295 Regulation of Negative_regulation of Grin2a 1 0.39 0.28 0.24
116 INT90398 Regulation of Gene_expression of Kcnk3 1 0.27 0 0.24
117 INT108279 Positive_regulation of Binding of Grin2a 1 0.41 0 0.23
118 INT288627 Positive_regulation of MT2A 1 0.33 0.3 0.23
119 INT145920 Regulation of Gene_expression of KCNK3 1 0.27 0 0.22
120 INT274011 Positive_regulation of Positive_regulation of KCNK3 1 0.08 0 0.21
121 INT139651 Negative_regulation of Negative_regulation of Grin2a 1 0.38 0.05 0.21
122 INT274012 Negative_regulation of Gene_expression of KCNK3 1 0.07 0.09 0.21
123 INT269264 Regulation of Mt1 6 0.21 2.71 0.2
124 INT208113 Regulation of Negative_regulation of Grin2a 1 0.42 0 0.19
125 INT94533 Positive_regulation of MT1X 1 0.44 1.78 0.14
126 INT237931 Negative_regulation of Mt1 1 0.57 0.58 0.13
127 INT237930 Regulation of Negative_regulation of Mt1 1 0.44 0.58 0.13
128 INT310294 Transcription of Mt1 1 0.25 0.26 0.12
129 INT103508 Binding of Mt2A 1 0.47 1.24 0.12
130 INT180883 Positive_regulation of MT1E 7 0.27 4.63 0.11
131 INT73848 Positive_regulation of Transcription of TSPO 3 0.42 0.58 0.1
132 INT94531 Transcription of MT2A 2 0.56 1.52 0.07
133 INT94535 Negative_regulation of Gene_expression of MT2A 1 0.34 1.7 0.07
134 INT94525 Transcription of MT1X 1 0.43 1.08 0.07
135 INT94541 Positive_regulation of Gene_expression of MT1X 1 0.44 1.84 0.06
136 INT236280 Positive_regulation of Gene_expression of Mt1 2 0.24 1 0.04
137 INT269266 Regulation of Regulation of Mt1 1 0.13 0.17 0.04
138 INT269262 Positive_regulation of Regulation of Mt1 1 0.23 0.62 0.04
139 INT296123 Negative_regulation of Transcription of MT2A 1 0.13 0.44 0
140 INT212867 Regulation of MT1A 1 0.23 0 0
141 INT188646 Binding of MT1A 1 0.05 0.62 0
142 INT118104 Transcription of Kcnk3 1 0.52 0.07 0
143 INT296125 Regulation of Gene_expression of MT2A 1 0.14 0.49 0
144 INT263684 Regulation of Regulation of Grin2a 1 0.29 0 0
145 INT315117 Localization of MT1X 1 0.57 0.26 0
146 INT180906 Negative_regulation of Positive_regulation of TSPO 1 0.50 0 0
147 INT155518 Negative_regulation of Phosphorylation of Grin2a 1 0.31 0.05 0
148 INT296127 Negative_regulation of MT2A 1 0.06 0.43 0
149 INT280587 Negative_regulation of MT1E 1 0.01 2.56 0
150 INT274728 Regulation of Binding of TSPO 1 0.02 0 0
151 INT293972 Positive_regulation of Binding of TSPO 1 0.04 1.01 0
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