GO:0071305

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Name cellular response to vitamin D
Categary Process
Go Slim No
Go Link GO:0071305
Unique Molecular Interactions 120
Total Molecular Interactions 160
Total Single Events 3125
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to vitamin D. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to vitamin D. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
2 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
3 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
4 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
5 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
6 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
7 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
8 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
9 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
10 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
11 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
12 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
13 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
14 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
15 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
16 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72
17 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
18 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
19 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
20 INT352462 Gse1 Positive_regulation of Gene_expression of Tnc 1 0.05 0.75 0.64
21 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
22 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
23 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
24 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
25 INT352459 Gse1 Regulation of Gene_expression of Tnc 1 0.05 0 0.6
26 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
27 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
28 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
29 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
30 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
31 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
32 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
33 INT235390 HTR1A Regulation of BGLAP 1 0.03 0.23 0.51
34 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
35 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
36 INT235389 Binding of BGLAP and HTR1A 1 0.03 0.15 0.45
37 INT148634 Abat Negative_regulation of Transcription of Nos2 1 0.19 0.52 0.44
38 INT97789 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Nos2 1 0.12 0.23 0.4
39 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4
40 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
41 INT61954 IFNA1 Positive_regulation of Nos2 1 0.05 0.46 0.38
42 INT296306 Binding of BGLAP and SPIN1 1 0.05 1.69 0.37
43 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
44 INT89500 Nos2 Positive_regulation of Il6 1 0.04 1.07 0.35
45 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
46 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35
47 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34
48 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
49 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34
50 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
51 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32
52 INT161435 OPA1 Positive_regulation of Gene_expression of Tnc 1 0.02 0.21 0.32
53 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31
54 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
55 INT352452 Calca Regulation of Gene_expression of Tnc 1 0.04 0 0.28
56 INT352448 Gse1 Regulation of Tnc 1 0.03 0 0.28
57 INT352458 Dusp1 Regulation of Gene_expression of Tnc 1 0.07 0 0.28
58 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
59 INT273055 Plat Positive_regulation of Gene_expression of Nos2 1 0.01 1.34 0.23
60 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
61 INT5645 Sult2a1 Positive_regulation of Positive_regulation of IGKV2-29 1 0.00 0.39 0.22
62 INT133163 Nos2 Regulation of Tnf 1 0.36 0.97 0.22
63 INT5646 Sult2a1 Positive_regulation of IGKV2-29 1 0.00 0.39 0.22
64 INT207456 LGALS3 Negative_regulation of Gene_expression of BGLAP 1 0.13 0.5 0.22
65 INT104846 TNF Positive_regulation of Nos2 1 0.10 0.83 0.22
66 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22
67 INT222568 Vip Negative_regulation of Transcription of Nos2 1 0.06 0.3 0.19
68 INT222473 Mzb1 Negative_regulation of Transcription of Nos2 1 0.04 0.29 0.19
69 INT81302 Tlr4 Negative_regulation of Gene_expression of Nos2 1 0.02 0.18 0.18
70 INT81298 Ifng Negative_regulation of Gene_expression of Nos2 1 0.40 0.18 0.18
71 INT226380 Gene_expression of IL15 Negative_regulation of Positive_regulation of CD8A 1 0.02 1.59 0.18
72 INT81297 Positive_regulation of Pparg Regulation of Gene_expression of Nos2 1 0.23 0.17 0.17
73 INT94864 Regulation of Litaf Positive_regulation of Nos2 1 0.05 0.05 0.15
74 INT94865 Litaf Positive_regulation of Nos2 1 0.08 0.05 0.15
75 INT139343 Il1b Positive_regulation of Nos2 1 0.09 1.26 0.14
76 INT194975 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Nos2 1 0.13 0.69 0.13
77 INT352450 Tnc Regulation of Trib3 1 0.00 0.22 0.13
78 INT194976 Alox5 Regulation of Gene_expression of Nos2 1 0.07 0.56 0.12
79 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
80 INT151423 Tfrc Positive_regulation of Gene_expression of Nos2 1 0.24 0.49 0.1
81 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
82 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
83 INT244291 Nos2 Positive_regulation of Positive_regulation of Hmox1 1 0.34 0.07 0.07
84 INT207463 Negative_regulation of LGALS3 Negative_regulation of BGLAP 1 0.13 0.18 0.06
85 INT207458 LGALS3 Negative_regulation of Negative_regulation of BGLAP 1 0.12 0.18 0.06
86 INT207468 LGALS3 Regulation of Gene_expression of BGLAP 1 0.11 0.13 0.06
87 INT207467 LGALS3 Negative_regulation of BGLAP 1 0.13 0.18 0.06
88 INT249955 Cpa1 Positive_regulation of Nos2 1 0.02 0.33 0.06
89 INT317416 Binding of FN1 and ITGB1 1 0.47 0.69 0.05
90 INT351012 IL2RB Positive_regulation of Gene_expression of IL15 1 0.10 0.42 0.05
91 INT181568 Positive_regulation of Mapk1 Positive_regulation of Gene_expression of Nos2 1 0.16 1.35 0.05
92 INT197646 DPH1 Negative_regulation of Localization of BGLAP 1 0.01 0.26 0.04
93 INT340273 Fig4 Regulation of BGLAP 1 0.00 0.55 0.04
94 INT300179 Binding of BGLAP and INCENP 1 0.02 0.08 0.03
95 INT207457 LGALS3 Positive_regulation of Gene_expression of BGLAP 1 0.12 0.1 0.03
96 INT230066 IL15 Positive_regulation of Gene_expression of KLRD1 1 0.01 0.37 0.03
97 INT340214 BGLAP Regulation of Gene_expression of NFATC1 1 0.02 0.76 0
98 INT96044 Rasgrp1 Positive_regulation of Gene_expression of Nos2 1 0.14 0.05 0
99 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
100 INT249935 Nos3 Regulation of Nos2 1 0.25 0.19 0
101 INT347124 Binding of FZD1 and Lrp1 1 0.11 0.24 0
102 INT290909 Negative_regulation of Binding of Nos2 and Ntn1 1 0.12 0 0
103 INT111719 Cd68 Positive_regulation of Nos2 1 0.03 0.17 0
104 INT290903 Binding of Nos2 and Ntn1 1 0.10 0 0
105 INT143286 Negative_regulation of Nfkb1 Negative_regulation of Gene_expression of Nos2 1 0.01 0 0
106 INT293625 Binding of BGLAP and SHBG 1 0.03 0.1 0
107 INT254043 Binding of BGLAP and EBF1 1 0.07 0.11 0
108 INT166848 Tnf Positive_regulation of Nos2 1 0.23 0 0
109 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
110 INT295292 Jun Positive_regulation of Transcription of Nos2 1 0.01 0 0
111 INT295291 Mapk14 Positive_regulation of Gene_expression of Nos2 1 0.04 0.05 0
112 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
113 INT249952 Cpa1 Regulation of Nos2 1 0.02 0.08 0
114 INT249934 Nos1 Regulation of Nos2 1 0.20 0.19 0
115 INT254044 Binding of BGLAP and NEU4 1 0.04 0.29 0
116 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
117 INT290899 Prkcg Regulation of Positive_regulation of Nos2 1 0.14 0 0
118 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0
119 INT207462 CRX Negative_regulation of Gene_expression of BGLAP 1 0.02 0 0
120 INT223734 Binding of VEGFA and Nos2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to vitamin D. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to vitamin D. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
3 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
4 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
5 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
6 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
7 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
8 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
9 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41
10 INT32054 Gene_expression of Tnc 14 0.59 9.36 12.22
11 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
12 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81
13 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9
14 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
15 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26
16 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
17 INT4938 Localization of Tnc 5 0.65 1.73 5.64
18 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07
19 INT73608 Localization of Nos2 21 0.75 9.58 5.05
20 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
21 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
22 INT79194 Positive_regulation of Tnc 5 0.41 2.25 4.69
23 INT68260 Localization of BGLAP 34 0.78 16.04 4.63
24 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
25 INT32053 Positive_regulation of Gene_expression of Tnc 5 0.45 3.4 4.13
26 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96
27 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
28 INT126223 Binding of Nos2 17 0.37 6 3.22
29 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02
30 INT91342 Negative_regulation of Negative_regulation of BGLAP 2 0.55 1.39 2.88
31 INT19685 Localization of Sult2a1 12 0.70 0.83 2.7
32 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
33 INT4939 Negative_regulation of Tnc 2 0.32 0.79 2.46
34 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
35 INT226453 Positive_regulation of Gene_expression of IL15 9 0.24 12.66 2.38
36 INT91340 Regulation of Localization of BGLAP 5 0.58 2.82 2.14
37 INT186893 Binding of BGLAP 10 0.37 6.19 2.02
38 INT161432 Negative_regulation of Gene_expression of Tnc 2 0.38 1.44 1.93
39 INT181720 Regulation of IL15 9 0.20 3.65 1.79
40 INT181574 Phosphorylation of Nos2 9 0.70 2.92 1.55
41 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
42 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39
43 INT103699 Negative_regulation of IL15 5 0.24 2.42 1.12
44 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
45 INT188398 Positive_regulation of IL15 8 0.19 4.64 1.06
46 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
47 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
48 INT312011 Negative_regulation of Binding of BGLAP 1 0.11 1.04 0.76
49 INT124873 Positive_regulation of Positive_regulation of Tnc 1 0.35 0.14 0.75
50 INT159556 Binding of Sult2a1 1 0.32 0.82 0.73
51 INT258630 Binding of IL15 3 0.24 2.2 0.65
52 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
53 INT235398 Regulation of Gene_expression of BGLAP 3 0.27 1.03 0.61
54 INT96037 Positive_regulation of Localization of Nos2 2 0.49 0.78 0.52
55 INT90353 Regulation of Gene_expression of Tnc 1 0.26 0.22 0.52
56 INT124872 Regulation of Localization of Tnc 1 0.31 0.1 0.52
57 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
58 INT349037 Regulation of Phosphorylation of Nos2 1 0.39 1.02 0.51
59 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
60 INT224428 Positive_regulation of Localization of BGLAP 5 0.30 2.34 0.44
61 INT19686 Negative_regulation of Localization of Sult2a1 2 0.43 0 0.43
62 INT208368 Negative_regulation of Regulation of Nos2 1 0.42 0.35 0.42
63 INT285554 Regulation of Transcription of IL15 1 0.15 0.61 0.4
64 INT285546 Regulation of Gene_expression of IL15 1 0.15 0.61 0.4
65 INT285556 Transcription of IL15 1 0.23 0.6 0.4
66 INT235498 Localization of IL15 6 0.21 2.17 0.39
67 INT57118 Transcription of BGLAP 4 0.56 1.65 0.37
68 INT22786 Regulation of Tnc 1 0.23 0.18 0.37
69 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
70 INT106275 Regulation of Localization of Nos2 1 0.25 0.38 0.32
71 INT132377 Negative_regulation of Binding of Nos2 5 0.29 0.75 0.28
72 INT117878 Positive_regulation of Regulation of Nos2 3 0.41 1.35 0.25
73 INT124200 Negative_regulation of Localization of Nos2 1 0.22 0.7 0.25
74 INT19684 Regulation of Localization of Sult2a1 1 0.24 0 0.24
75 INT293351 Negative_regulation of Regulation of IL15 1 0.04 0.34 0.22
76 INT340249 Positive_regulation of Positive_regulation of BGLAP 1 0.04 0.95 0.21
77 INT30211 Gene_expression of Sult2a1 1 0.58 0.1 0.17
78 INT222042 Localization of ITGB1 3 0.29 0.72 0.12
79 INT274488 Positive_regulation of Localization of IL15 1 0.07 0.9 0.1
80 INT57117 Negative_regulation of Transcription of BGLAP 1 0.35 0.83 0.09
81 INT248596 Regulation of Binding of BGLAP 1 0.27 0.39 0.09
82 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
83 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
84 INT104032 Negative_regulation of Localization of BGLAP 4 0.33 2.22 0.04
85 INT347119 Localization of FZD1 1 0.68 0.16 0.03
86 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
87 INT203702 Protein_catabolism of BGLAP 4 0.52 0.35 0
88 INT349470 Regulation of Binding of Nos2 1 0.35 0 0
89 INT109125 Positive_regulation of Protein_catabolism of Nos2 1 0.39 0 0
90 INT315189 Binding of SFRP1 1 0.15 2.96 0
91 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
92 INT293348 Negative_regulation of Positive_regulation of IL15 1 0.04 0.12 0
93 INT291604 Binding of ITGB1 1 0.05 0.16 0
94 INT109126 Protein_catabolism of Nos2 1 0.55 0 0
95 INT104037 Regulation of Regulation of BGLAP 1 0.25 0 0
96 INT201624 Regulation of FZD1 1 0.01 0 0
97 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
98 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
99 INT340248 Negative_regulation of Regulation of BGLAP 1 0.03 1.01 0
100 INT175647 Regulation of Gene_expression of ITGB1 1 0.01 0.4 0
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