GO:0071321

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Name cellular response to cGMP
Categary Process
Go Slim No
Go Link GO:0071321
Unique Molecular Interactions 86
Total Molecular Interactions 114
Total Single Events 1061
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to cGMP. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to cGMP. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169768 Binding of Slc6a4 and Mir16-1 1 0.33 0 1.25
2 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
3 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04
4 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03
5 INT333303 Zic2 Regulation of Gene_expression of Slc6a4 1 0.60 0.47 0.91
6 INT243024 Binding of Dcpp1 and Slc6a4 1 0.08 0.42 0.76
7 INT243025 Dcpp1 Regulation of Slc6a4 1 0.10 0.43 0.76
8 INT169769 Mir16-1 Regulation of Slc6a4 1 0.24 0 0.74
9 INT333296 Gtf3a Regulation of Gene_expression of Slc6a4 1 0.01 0 0.74
10 INT129919 IFNA2 Positive_regulation of Gene_expression of SLC6A4 1 0.02 0.38 0.69
11 INT74727 Binding of Slc6a4 and Hpic1 1 0.00 0.49 0.68
12 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
13 INT129921 IL4 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.38 0.68
14 INT333305 Zic2 Positive_regulation of Transcription of Slc6a4 1 0.68 0 0.66
15 INT144107 Binding of SLC6A2 and SLC6A4 1 0.00 0.18 0.62
16 INT333302 Zic2 Positive_regulation of Slc6a4 1 0.68 0.11 0.57
17 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54
18 INT128431 SLC6A4 Regulation of S100A4 1 0.48 0.65 0.53
19 INT47745 Binding of Slc6a4 and Htr2a 1 0.33 0.09 0.52
20 INT271191 Bdnf Regulation of Slc6a4 1 0.03 0.29 0.51
21 INT235870 Bdnf Regulation of Gene_expression of Slc6a4 1 0.09 0.77 0.5
22 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
23 INT113248 Olr1259 Negative_regulation of Slc6a4 1 0.00 0.23 0.44
24 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
25 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
26 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38
27 INT154782 Binding of SLC6A4 and Ndst2 1 0.01 0 0.37
28 INT140667 IFNG Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
29 INT140666 TNF Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
30 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31
31 INT235877 Prkaca Regulation of Transcription of Slc6a4 1 0.06 0.13 0.31
32 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3
33 INT235874 Camk2a Positive_regulation of Slc6a4 1 0.11 0.14 0.28
34 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
35 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
36 INT333298 Zic2 Regulation of Transcription of Slc6a4 1 0.44 0.09 0.2
37 INT30071 Gm8212 Regulation of Pde3a 1 0.00 0 0.2
38 INT235883 Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
39 INT263179 PDE3A Regulation of COPD 1 0.00 1 0.15
40 INT263177 Binding of PDE3A and COPD 1 0.01 1 0.15
41 INT235879 Regulation of Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
42 INT144027 Binding of Slc6a4 and Pdgfrb 1 0.23 0.25 0.14
43 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
44 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
45 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
46 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
47 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
48 INT249465 Positive_regulation of Slc6a4 Positive_regulation of Gene_expression of Bdnf 1 0.31 0.3 0.08
49 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
50 INT249466 Slc6a4 Positive_regulation of Phosphorylation of Creb1 1 0.09 0.36 0.07
51 INT333304 Zic2 Positive_regulation of Gene_expression of Slc6a4 1 0.68 0.1 0.06
52 INT333297 Gtf3a Positive_regulation of Gene_expression of Slc6a4 1 0.01 0.1 0.06
53 INT321652 Binding of Slc6a3 and Slc6a4 1 0.26 0.07 0.05
54 INT321654 Binding of Slc6a4 and Uts2r 1 0.05 0.07 0.05
55 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
56 INT333301 Binding of Slc6a4 and Zic2 1 0.47 0 0.03
57 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
58 INT333307 Gene_expression of Zic2 Positive_regulation of Gene_expression of Slc6a4 1 0.45 0.05 0.03
59 INT322236 Agt Regulation of Gene_expression of Slc6a4 1 0.42 0.63 0
60 INT322251 Slc6a4 Regulation of Gene_expression of Agtrap 1 0.43 0.63 0
61 INT127457 Ccl2 Positive_regulation of Gene_expression of Slc6a4 1 0.13 0 0
62 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
63 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
64 INT127464 Binding of PAH and Slc6a4 1 0.08 0 0
65 INT121478 Binding of Pde3a and Positive_regulation of Localization of Ins1 1 0.24 0 0
66 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
67 INT322248 Slc6a4 Regulation of Gene_expression of Agt 1 0.42 0.63 0
68 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
69 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
70 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
71 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
72 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
73 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
74 INT322238 Slc6a4 Regulation of Gene_expression of Ace 1 0.37 0.63 0
75 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
76 INT322256 Ace Regulation of Gene_expression of Slc6a4 1 0.37 0.63 0
77 INT333306 Ephb1 Regulation of Gene_expression of Slc6a4 1 0.19 0.21 0
78 INT333295 Gtf3a Positive_regulation of Slc6a4 1 0.01 0 0
79 INT322247 Slc6a4 Regulation of Gene_expression of Htr2a 1 0.13 0.63 0
80 INT333300 Positive_regulation of Zic2 Positive_regulation of Slc6a4 1 0.45 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to cGMP. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to cGMP. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64
2 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23
3 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84
4 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6
5 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9
6 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09
7 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42
8 INT100096 Regulation of Slc6a4 24 0.62 7.25 12.28
9 INT47743 Negative_regulation of Slc6a4 22 0.59 6.23 12.23
10 INT66303 Regulation of Slc6a4 10 0.45 4.82 10.55
11 INT47744 Binding of Slc6a4 21 0.48 5.52 9.45
12 INT119651 Binding of Slc6a4 12 0.32 4.65 7.07
13 INT15092 Positive_regulation of SLC6A4 17 0.67 7.32 6.7
14 INT109714 Transcription of SLC6A4 7 0.72 3.8 6.19
15 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
16 INT137593 Regulation of Gene_expression of SLC6A4 7 0.60 2.59 5.23
17 INT119711 Positive_regulation of Slc6a4 16 0.69 4.44 5.21
18 INT121471 Negative_regulation of Pde3a 24 0.34 13.79 4.73
19 INT122675 Negative_regulation of Gene_expression of Slc6a4 14 0.59 6.4 4.69
20 INT79343 Positive_regulation of Slc6a4 10 0.50 1.77 4.05
21 INT140670 Negative_regulation of Gene_expression of SLC6A4 4 0.51 2.7 3.88
22 INT103021 Transcription of Slc6a4 16 0.70 3.93 3.77
23 INT99291 Transcription of Slc6a4 7 0.46 1.16 3.28
24 INT127455 Positive_regulation of Gene_expression of Slc6a4 9 0.59 5.62 3.2
25 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
26 INT100190 Regulation of Gene_expression of Slc6a4 5 0.39 1.8 3.14
27 INT124438 Regulation of Gene_expression of Slc6a4 9 0.62 3.5 2.97
28 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
29 INT80320 Negative_regulation of Gene_expression of Slc6a4 4 0.42 0.85 2.6
30 INT120726 Positive_regulation of Gene_expression of Slc6a4 4 0.68 0.51 2.34
31 INT152554 Regulation of Transcription of SLC6A4 3 0.62 1.52 2.18
32 INT195430 Regulation of Positive_regulation of SLC6A4 1 0.42 1.01 1.98
33 INT125974 Localization of Slc6a4 5 0.66 2.27 1.97
34 INT243017 Negative_regulation of Binding of Slc6a4 1 0.25 0.22 1.89
35 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
36 INT141937 Negative_regulation of Regulation of SLC6A4 1 0.41 0.27 1.8
37 INT119905 Negative_regulation of PDE3A 5 0.18 5 1.77
38 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
39 INT64529 Localization of Pde2a 1 0.59 0 1.63
40 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
41 INT147808 Positive_regulation of Gene_expression of SLC6A4 4 0.50 1.03 1.57
42 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
43 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
44 INT47839 Localization of Slc6a4 4 0.79 0.96 1.14
45 INT147286 Negative_regulation of Regulation of Slc6a4 1 0.21 0 1.13
46 INT128444 Phosphorylation of SLC6A4 2 0.61 0.49 1.02
47 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
48 INT129674 Regulation of Negative_regulation of Slc6a4 1 0.38 0.46 0.98
49 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
50 INT131649 Positive_regulation of Negative_regulation of Slc6a4 2 0.44 0.32 0.91
51 INT286694 Positive_regulation of Localization of Slc6a4 1 0.26 0 0.9
52 INT152101 Regulation of Transcription of Slc6a4 1 0.14 0 0.89
53 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
54 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
55 INT177533 Negative_regulation of Binding of Pde3a 1 0.21 2.46 0.76
56 INT243015 Regulation of Binding of Slc6a4 1 0.16 0.43 0.75
57 INT147809 Localization of SLC6A4 5 0.71 1.69 0.74
58 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
59 INT162911 Gene_expression of PDE3A 2 0.24 2.47 0.65
60 INT286687 Phosphorylation of Slc6a4 1 0.46 0 0.58
61 INT286690 Positive_regulation of Phosphorylation of Slc6a4 1 0.28 0 0.58
62 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
63 INT106568 Regulation of Regulation of Slc6a4 1 0.22 0.07 0.52
64 INT271164 Negative_regulation of Transcription of Slc6a4 1 0.04 0.47 0.52
65 INT129524 Regulation of Regulation of SLC6A4 1 0.26 0.16 0.5
66 INT352021 Negative_regulation of Negative_regulation of SLC6A4 1 0.08 0.2 0.5
67 INT150168 Negative_regulation of Transcription of SLC6A4 1 0.42 0.16 0.47
68 INT150167 Positive_regulation of Transcription of SLC6A4 1 0.45 0.16 0.46
69 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
70 INT121469 Binding of Pde3a 2 0.23 1.42 0.44
71 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
72 INT333278 Negative_regulation of Transcription of Slc6a4 2 0.37 0.56 0.36
73 INT140668 Positive_regulation of Negative_regulation of SLC6A4 1 0.56 0.23 0.36
74 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
75 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
76 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
77 INT148455 Positive_regulation of Negative_regulation of Slc6a4 1 0.50 0.18 0.34
78 INT124930 Positive_regulation of Binding of SLC6A4 1 0.40 0.06 0.33
79 INT219588 Negative_regulation of Gene_expression of Pde3a 1 0.25 0 0.32
80 INT219563 Gene_expression of Pde3a 1 0.39 0 0.32
81 INT341784 Positive_regulation of Phosphorylation of SLC6A4 1 0.29 0.07 0.26
82 INT79350 Positive_regulation of Binding of Slc6a4 1 0.34 0 0.24
83 INT340198 Regulation of Transcription of Slc6a4 1 0.36 0.66 0.22
84 INT103022 Positive_regulation of Transcription of Slc6a4 2 0.44 0.52 0.21
85 INT30069 Regulation of Pde3a 1 0.06 0 0.2
86 INT263126 Negative_regulation of Binding of PDE3A 1 0.13 0.62 0.18
87 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
88 INT219576 Positive_regulation of Gene_expression of Pde3a 1 0.29 0 0.17
89 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
90 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
91 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
92 INT263134 Binding of PDE3A 1 0.15 0.47 0.09
93 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
94 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
95 INT332749 Positive_regulation of Binding of Slc6a4 1 0.23 0.19 0.07
96 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
97 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
98 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
99 INT263142 Positive_regulation of Negative_regulation of PDE3A 1 0.15 0.15 0.03
100 INT263131 Localization of PDE3A 1 0.23 0.35 0.03
101 INT162918 Transcription of PDE2A 1 0.65 0 0
102 INT162919 Regulation of Transcription of PDE3A 1 0.06 0 0
103 INT162923 Regulation of PDE3A 1 0.06 0 0
104 INT333286 Negative_regulation of Positive_regulation of Slc6a4 1 0.50 0 0
105 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
106 INT333280 Regulation of Localization of Slc6a4 1 0.38 0.18 0
107 INT263132 Phosphorylation of PDE3A 1 0.25 0.19 0
108 INT263119 Positive_regulation of Phosphorylation of PDE3A 1 0.21 0.19 0
109 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
110 INT101927 Negative_regulation of Binding of Slc6a4 1 0.59 0 0
111 INT263123 Positive_regulation of PDE3A 1 0.21 0.19 0
112 INT263136 Positive_regulation of Positive_regulation of PDE3A 1 0.21 0.19 0
113 INT127454 Negative_regulation of Positive_regulation of Slc6a4 1 0.32 0 0
114 INT183430 Binding of Pde2a 1 0.07 0 0
115 INT162904 Transcription of PDE3A 1 0.07 0 0
116 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
117 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
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