GO:0071351

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Name cellular response to interleukin-18
Categary Process
Go Slim No
Go Link GO:0071351
Unique Molecular Interactions 201
Total Molecular Interactions 251
Total Single Events 1938
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to interleukin-18. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to interleukin-18. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
2 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
3 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
4 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
5 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
6 INT92057 Ifng Positive_regulation of Gene_expression of Ik 1 0.03 0.45 1.49
7 INT83626 Ifng Positive_regulation of Gene_expression of Cd59 1 0.33 2.19 1.41
8 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
9 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
10 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
11 INT113235 Tacr1 Regulation of Gene_expression of Ifng 1 0.26 1 1.04
12 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
13 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
14 INT88879 Ifng Positive_regulation of Nfkb1 1 0.01 0.26 1.01
15 INT94493 Avp Positive_regulation of Gene_expression of Ifng 1 0.05 1.73 0.97
16 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95
17 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 0.03 1.63 0.92
18 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 0.20 0.89 0.92
19 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
20 INT120999 Binding of Oprm1 and Ifng 1 0.22 0.57 0.84
21 INT94331 IFNG Positive_regulation of CXCL10 4 0.11 1.31 0.82
22 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
23 INT146460 IFNG Positive_regulation of Gene_expression of TNFRSF10D 1 0.03 1.46 0.72
24 INT151679 Ifng Negative_regulation of Oas1b 1 0.12 1.24 0.71
25 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
26 INT151676 Ifng Negative_regulation of Art2a-ps 1 0.00 1.25 0.71
27 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
28 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
29 INT142076 IL4 Negative_regulation of Gene_expression of IFNG 1 0.01 1.58 0.64
30 INT56235 Ifng Positive_regulation of Gene_expression of RT1-EC2 1 0.23 0.33 0.62
31 INT154530 Positive_regulation of Ifng Negative_regulation of Il10 1 0.33 0.63 0.61
32 INT154533 Ifng Negative_regulation of Il4 1 0.11 0.62 0.6
33 INT154531 Ifng Negative_regulation of Il10 1 0.30 0.61 0.6
34 INT56451 Ifng Positive_regulation of Tnf 1 0.00 1.92 0.59
35 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
36 INT137162 IFNG Positive_regulation of Gene_expression of CXCL9 1 0.45 0.62 0.54
37 INT88024 Ifng Positive_regulation of Gene_expression of Faslg 2 0.50 1.19 0.53
38 INT138928 Ifng Positive_regulation of Transcription of Cxcl9 1 0.31 0.65 0.51
39 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51
40 INT143504 IFNG Positive_regulation of Gene_expression of Aif1 1 0.04 1.26 0.51
41 INT70925 Binding of Ifng and Il4 2 0.14 0.9 0.5
42 INT138927 Ifng Positive_regulation of Gene_expression of Stat1 1 0.29 0.7 0.49
43 INT142155 Ifng Positive_regulation of Il5 1 0.08 0 0.48
44 INT196634 IFNG Negative_regulation of DNAH8 1 0.03 1.49 0.47
45 INT99790 Ifng Positive_regulation of Cxcr2 1 0.12 0.28 0.46
46 INT126337 Pax3 Positive_regulation of Gene_expression of Ifng 1 0.05 0.56 0.44
47 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
48 INT126340 Pax3 Regulation of Gene_expression of Ifng 1 0.03 0.56 0.44
49 INT126338 Insrr Regulation of Gene_expression of Ifng 1 0.00 0.56 0.43
50 INT189154 MTNR1B Positive_regulation of Gene_expression of IFNG 1 0.01 0.06 0.43
51 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42
52 INT17305 Ifng Positive_regulation of RT1-CE1 1 0.06 0.46 0.41
53 INT17308 Ifng Positive_regulation of Atp8a1 1 0.64 0.45 0.41
54 INT141016 Il18 Positive_regulation of Gene_expression of Ifng 1 0.39 0.27 0.39
55 INT152361 Binding of Ifng and T2dm2 1 0.00 0.86 0.37
56 INT140569 Ifng Positive_regulation of Gene_expression of Il6 1 0.00 0.82 0.36
57 INT140571 Ifng Positive_regulation of Ifnb1 1 0.01 0.82 0.36
58 INT88192 IFNG Regulation of Gene_expression of ZAK 1 0.01 0.75 0.36
59 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
60 INT140572 Ifng Positive_regulation of Gene_expression of Ifnb1 1 0.01 0.82 0.36
61 INT140573 Positive_regulation of Ifng Positive_regulation of Ifnb1 1 0.01 0.83 0.36
62 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
63 INT144045 IFNG Negative_regulation of Gene_expression of PTGES 1 0.63 0.47 0.35
64 INT189492 Ifng Positive_regulation of Localization of Darc 1 0.00 0.53 0.34
65 INT140667 IFNG Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
66 INT112023 Binding of Ifng and Il10 1 0.03 0.31 0.33
67 INT112019 Binding of Ifng and Ighg1 1 0.10 0.3 0.33
68 INT137168 IFNG Positive_regulation of Gene_expression of CXCR3 1 0.32 0.34 0.32
69 INT167596 Il23a Positive_regulation of Gene_expression of Ifng 1 0.13 0.94 0.32
70 INT112022 Binding of Hand1 and Ifng 1 0.09 0.3 0.32
71 INT98013 Il18 Positive_regulation of Gene_expression of IFNG 1 0.66 0.44 0.32
72 INT9161 Tnf Negative_regulation of Localization of Ifng 1 0.20 0.85 0.3
73 INT93987 Positive_regulation of Rab8a Positive_regulation of Localization of Ifng 1 0.10 0.38 0.29
74 INT164432 Ifng Positive_regulation of Tnf 1 0.01 1.71 0.29
75 INT164431 Ifng Positive_regulation of Il6 1 0.01 1.71 0.29
76 INT136368 RYBP Regulation of Localization of Ifng 1 0.00 0.4 0.28
77 INT171720 IL4 Positive_regulation of Positive_regulation of IFNG 1 0.01 0.67 0.28
78 INT207442 IFNG Negative_regulation of Gene_expression of PLA2G7 1 0.08 0.9 0.28
79 INT171726 TNF Positive_regulation of IFNG 1 0.01 0.6 0.27
80 INT171725 IFNG Positive_regulation of CXCL9 1 0.02 0.6 0.27
81 INT93352 Ifng Positive_regulation of Positive_regulation of Fas 1 0.26 0.17 0.27
82 INT137167 Binding of IFNG and TLR3 1 0.24 0.32 0.27
83 INT24222 Ifng Positive_regulation of Gene_expression of Serping1 1 0.00 0 0.26
84 INT24223 Ifng Negative_regulation of Gene_expression of C3 1 0.01 0 0.26
85 INT129220 IFNG Positive_regulation of ICAM1 1 0.09 0.1 0.25
86 INT138925 Ifng Positive_regulation of Gene_expression of Cxcl9 1 0.25 0.32 0.25
87 INT129219 IFNG Positive_regulation of Gene_expression of ICAM1 1 0.13 0.1 0.25
88 INT196609 IFNG Positive_regulation of Positive_regulation of NA 1 0.03 0.87 0.24
89 INT196622 IFNG Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.87 0.24
90 INT196647 IFNG Negative_regulation of NA 1 0.04 0.79 0.24
91 INT80278 IFNG Positive_regulation of CCL13 1 0.12 0.39 0.24
92 INT138930 Ifng Positive_regulation of Cxcl9 1 0.43 0.29 0.24
93 INT80289 IFNG Positive_regulation of Gene_expression of CCL13 1 0.40 0.39 0.24
94 INT138924 Negative_regulation of Ifng Positive_regulation of Cxcl9 1 0.37 0.29 0.24
95 INT196646 IFNG Positive_regulation of Negative_regulation of DNAH8 1 0.03 0.87 0.24
96 INT80277 IFNG Positive_regulation of CCL7 1 0.13 0.39 0.24
97 INT168709 Ifng Regulation of Il10 1 0.02 0.3 0.23
98 INT163760 Ifng Positive_regulation of Phosphorylation of Stat1 1 0.12 0.08 0.23
99 INT67084 Penk Positive_regulation of Gene_expression of Ifng 1 0.06 0.08 0.23
100 INT80279 IFNG Positive_regulation of Gene_expression of CCL11 1 0.06 0.37 0.23
101 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
102 INT138929 Ifng Positive_regulation of Stat1 1 0.29 0.28 0.23
103 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
104 INT138926 Regulation of Ifng Positive_regulation of Stat1 1 0.17 0.28 0.23
105 INT138931 Ifng Positive_regulation of Positive_regulation of Stat1 1 0.31 0.28 0.23
106 INT88025 Ifng Negative_regulation of Gene_expression of Fas 1 0.32 0.74 0.22
107 INT94338 IFNG Positive_regulation of Phosphorylation of Stat1 1 0.01 0.26 0.21
108 INT137074 IFNG Positive_regulation of Protein_catabolism of DOHH 1 0.04 1.06 0.21
109 INT137072 IFNG Positive_regulation of DOHH 1 0.05 1.05 0.21
110 INT94339 IFNG Positive_regulation of Localization of Stat1 1 0.01 0.26 0.21
111 INT35013 IFNG Positive_regulation of ADI1 1 0.22 0.16 0.21
112 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19
113 INT95363 IFNG Positive_regulation of Gene_expression of NOS2 1 0.43 0 0.19
114 INT58588 IFNG Positive_regulation of ARHGAP4 1 0.31 1.22 0.19
115 INT284677 IFNG Negative_regulation of IL4 1 0.01 0.98 0.18
116 INT81298 Ifng Negative_regulation of Gene_expression of Nos2 1 0.40 0.18 0.18
117 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
118 INT140093 Ifng Regulation of Gene_expression of Gtf3a 1 0.05 0.44 0.18
119 INT140095 Stat1 Positive_regulation of Positive_regulation of Ifng 1 0.52 0.42 0.18
120 INT81301 Ifng Positive_regulation of Gene_expression of Tlr4 1 0.02 0.17 0.17
121 INT312858 Negative_regulation of Binding of GYPA and IFNG 1 0.20 0.41 0.17
122 INT312857 Binding of GYPA and IFNG 1 0.17 0.41 0.17
123 INT73506 Binding of IFNG and IRF6 1 0.02 0.42 0.17
124 INT249599 Ifng Positive_regulation of Gene_expression of Il6 1 0.15 0.38 0.16
125 INT196606 IFNG Positive_regulation of CFTR 1 0.16 0.45 0.16
126 INT143503 IFNG Positive_regulation of CETN1 1 0.00 0.35 0.16
127 INT43492 Pomc Regulation of Gene_expression of Ifng 1 0.34 0 0.16
128 INT111486 Binding of IFNG and IL8 1 0.13 0.28 0.15
129 INT43494 Akt1s1 Regulation of Gene_expression of Ifng 1 0.05 0 0.15
130 INT99241 IFNG Regulation of IL1B 2 0.21 1.26 0.14
131 INT43497 KRT18P39 Regulation of Gene_expression of Ifng 1 0.00 0 0.14
132 INT43496 SERPINB1 Negative_regulation of Ifng 1 0.00 0 0.14
133 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
134 INT7204 Binding of IFNA1 and IFNG 1 0.01 1.34 0.11
135 INT99242 IFNG Regulation of IL8 1 0.23 0.57 0.1
136 INT261761 Ifng Positive_regulation of Stat6 1 0.13 0 0.1
137 INT99243 IFNG Regulation of HLA-DRA 1 0.25 0.57 0.1
138 INT43493 Cd164 Regulation of Gene_expression of Ifng 1 0.01 0 0.09
139 INT297309 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Ifng 1 0.07 0.79 0.08
140 INT58586 IFNG Positive_regulation of Gene_expression of PLG 1 0.41 0.38 0.06
141 INT342887 Binding of IFNG and IFNGR1 1 0.02 0.65 0.05
142 INT351983 Mtpn Positive_regulation of Gene_expression of Ifng 1 0.01 0.41 0.05
143 INT196628 IFNG Negative_regulation of Gene_expression of DNAH8 1 0.02 0.31 0.05
144 INT185376 IFNG Regulation of IL10 1 0.01 0.69 0.04
145 INT185380 IFNG Regulation of CSF2 1 0.03 0.69 0.04
146 INT185382 IFNG Regulation of TLR2 1 0.09 0.69 0.04
147 INT338766 Tlr4 Positive_regulation of Gene_expression of Ifng 1 0.13 0.77 0.04
148 INT35172 IL2 Positive_regulation of Gene_expression of IFNG 1 0.01 0.27 0.04
149 INT338770 IFN1@ Positive_regulation of Gene_expression of Ifng 1 0.51 0.74 0.04
150 INT228925 Binding of IFN1@ and IFNG 1 0.24 2.06 0.03
151 INT177948 IFNG Positive_regulation of Gene_expression of HLA-E 1 0.04 0.59 0.03
152 INT196607 IFNG Regulation of Gene_expression of SCNN1G 1 0.03 0.08 0.03
153 INT164899 IL33 Positive_regulation of IFNG 1 0.25 0.05 0
154 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
155 INT164907 IFNG Positive_regulation of Gene_expression of IL1RL1 1 0.31 0.11 0
156 INT95364 IFNG Positive_regulation of IRF6 1 0.24 0 0
157 INT134563 Cpe Positive_regulation of Gene_expression of Ifng 1 0.39 0 0
158 INT130900 Jag2 Regulation of Localization of Ifng 1 0.01 0.05 0
159 INT134562 Cpe Regulation of Gene_expression of Ifng 1 0.30 0 0
160 INT95366 IFNG Negative_regulation of Gene_expression of NOS2 1 0.40 0 0
161 INT95365 Positive_regulation of IFNG Positive_regulation of IRF6 1 0.24 0 0
162 INT95362 IFNG Positive_regulation of NOS2 1 0.43 0 0
163 INT20010 Binding of Ifnb1 and Ifng 1 0.01 0 0
164 INT246912 Binding of Ifng and Igf2bp2 1 0.01 0.6 0
165 INT271288 Ifng Positive_regulation of Transcription of IFNA1 1 0.07 0.93 0
166 INT164889 IL33 Positive_regulation of Gene_expression of IFNG 1 0.25 0.05 0
167 INT130899 Jag2 Negative_regulation of Ifng 1 0.03 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to interleukin-18. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to interleukin-18. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57
2 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14
3 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6
4 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08
5 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77
6 INT8518 Localization of Ifng 53 0.81 36.68 24.13
7 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05
8 INT25222 Positive_regulation of Gene_expression of Ifng 32 0.50 24.18 19.58
9 INT19509 Localization of Ifng 55 0.78 28.25 18.67
10 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35
11 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15
12 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89
13 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19
14 INT4931 Localization of IFNG 53 0.78 33.25 13.65
15 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14
16 INT5057 Negative_regulation of Gene_expression of IFNG 23 0.58 8.33 12.3
17 INT9160 Negative_regulation of Ifng 31 0.58 16.37 11.84
18 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91
19 INT5326 Regulation of Ifng 12 0.55 4.56 7.19
20 INT74154 Transcription of Ifng 14 0.67 10.33 6.21
21 INT15803 Regulation of IFNG 21 0.44 12.57 5.98
22 INT5186 Regulation of Ifng 11 0.45 8.78 5.9
23 INT62132 Regulation of Gene_expression of Ifng 12 0.62 1.28 4.77
24 INT34054 Regulation of Gene_expression of IFNG 8 0.42 3.69 3.76
25 INT87027 Positive_regulation of Localization of IFNG 12 0.67 5.78 3.35
26 INT67078 Binding of Ifng 7 0.48 4.84 2.73
27 INT15197 Regulation of Gene_expression of Ifng 8 0.34 2.66 2.69
28 INT111145 Negative_regulation of Positive_regulation of Ifng 7 0.41 2.21 2.61
29 INT91669 Negative_regulation of Localization of IFNG 5 0.57 4.1 2.58
30 INT16964 Binding of IFNG 27 0.48 14.31 2.45
31 INT73980 Transcription of Ifng 12 0.72 5.42 2.4
32 INT70918 Positive_regulation of Localization of Ifng 5 0.45 2.79 2.33
33 INT67437 Negative_regulation of Localization of Ifng 7 0.47 2.23 2.28
34 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18
35 INT140818 Positive_regulation of Positive_regulation of Ifng 2 0.47 4.2 2.06
36 INT111530 Positive_regulation of Regulation of Ifng 1 0.41 0.32 2.01
37 INT11136 Positive_regulation of Localization of Ifng 4 0.49 3.13 1.89
38 INT61627 Transcription of IFNG 6 0.69 4.28 1.83
39 INT113716 Positive_regulation of Transcription of Ifng 1 0.53 2.56 1.61
40 INT56228 Positive_regulation of Positive_regulation of Ifng 2 0.43 2.83 1.4
41 INT11137 Negative_regulation of Localization of Ifng 3 0.38 2.45 1.26
42 INT19923 Regulation of Localization of Ifng 3 0.22 1.1 1.25
43 INT109243 Regulation of Positive_regulation of IFNG 1 0.45 1.27 1.23
44 INT111536 Positive_regulation of Negative_regulation of Ifng 1 0.41 0.35 1.18
45 INT122884 Positive_regulation of Transcription of Ifng 1 0.39 1.08 1.03
46 INT103303 Negative_regulation of Transcription of Ifng 6 0.43 2.7 0.83
47 INT43488 Regulation of Positive_regulation of Ifng 1 0.42 0.71 0.83
48 INT64635 Binding of Ifng 2 0.36 0.57 0.81
49 INT11138 Regulation of Localization of Ifng 2 0.56 0.8 0.77
50 INT73240 Negative_regulation of Transcription of IFNG 1 0.41 0.92 0.76
51 INT116009 Regulation of Negative_regulation of Ifng 1 0.44 0.09 0.67
52 INT61622 Positive_regulation of Transcription of IFNG 1 0.26 0.29 0.63
53 INT56231 Regulation of Positive_regulation of Ifng 1 0.39 0.33 0.62
54 INT116045 Negative_regulation of Positive_regulation of Ifng 2 0.03 2.5 0.57
55 INT61109 Negative_regulation of Positive_regulation of IFNG 1 0.53 0.57 0.5
56 INT123721 Negative_regulation of Negative_regulation of Ifng 1 0.34 0.26 0.45
57 INT9156 Negative_regulation of Regulation of Ifng 1 0.19 0.94 0.3
58 INT312860 Positive_regulation of Binding of IFNG 1 0.42 0.09 0.21
59 INT94336 Phosphorylation of IFNG 1 0.19 0.25 0.21
60 INT100769 Negative_regulation of Transcription of Ifng 3 0.42 0.7 0.2
61 INT58590 Protein_catabolism of IFNG 2 0.84 0.75 0.1
62 INT181476 Negative_regulation of Binding of IFNG 1 0.01 1.18 0.08
63 INT58592 Negative_regulation of Protein_catabolism of IFNG 1 0.40 0.51 0.07
64 INT165925 Negative_regulation of Negative_regulation of Ifng 1 0.36 0.14 0
65 INT112746 Phosphorylation of Ifng 1 0.58 0 0
66 INT112745 Positive_regulation of Phosphorylation of Ifng 1 0.43 0 0
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