GO:0071353

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Name cellular response to interleukin-4
Categary Process
Go Slim No
Go Link GO:0071353
Unique Molecular Interactions 36
Total Molecular Interactions 42
Total Single Events 284
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to interleukin-4. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to interleukin-4. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
2 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
3 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
4 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
5 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
6 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
7 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
8 INT246435 Xcl1 Positive_regulation of Gene_expression of Cd79a 1 0.07 0.83 0.27
9 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
10 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
11 INT318174 Binding of Crp and Xcl1 1 0.03 1.9 0.22
12 INT246440 Ccl5 Positive_regulation of Positive_regulation of Xcl1 1 0.27 1.28 0.16
13 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
14 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
15 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
16 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
17 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
18 INT235640 Binding of GATA3 and Mrgpre 1 0.01 0.8 0.04
19 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
20 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
21 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
22 INT183648 Binding of Lef1 and Ctnnd2 1 0.07 1.05 0
23 INT337415 Negative_regulation of MIR203 Positive_regulation of Positive_regulation of LEF1 1 0.03 0.25 0
24 INT337405 MIR203 Regulation of LEF1 1 0.02 0.31 0
25 INT337411 Negative_regulation of MIR203 Positive_regulation of Gene_expression of LEF1 1 0.04 0.25 0
26 INT249960 Arg1 Negative_regulation of NOS1 1 0.01 0.1 0
27 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 0.00 0.44 0
28 INT289098 KCNA1 Regulation of LEF1 1 0.00 0.67 0
29 INT337491 Binding of E2F1 and Tcf7 1 0.19 0 0
30 INT337417 MIR203 Negative_regulation of LEF1 1 0.04 0.57 0
31 INT220822 Binding of Myc and LEF1 1 0.26 0.08 0
32 INT197675 Regulation of Binding of ESR1 and Arg1 1 0.05 0 0
33 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
34 INT220766 Binding of MAX and LEF1 1 0.40 0.08 0
35 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 0.00 0.68 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to interleukin-4. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to interleukin-4. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
2 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
3 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
4 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
5 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47
6 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
7 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
8 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
9 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
10 INT116008 Binding of Gata3 2 0.34 1.37 1.41
11 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
12 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
13 INT133079 Positive_regulation of Gene_expression of GATA3 3 0.50 1.03 1.11
14 INT156727 Gene_expression of Arg1 4 0.44 2.1 0.97
15 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
16 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
17 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
18 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
19 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
20 INT17840 Negative_regulation of GATA3 3 0.41 1.96 0.63
21 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61
22 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
23 INT226481 Negative_regulation of Gene_expression of GATA3 1 0.06 1.41 0.57
24 INT144053 Transcription of GATA3 1 0.67 0.89 0.54
25 INT242004 Binding of Tcf7 4 0.36 2.66 0.49
26 INT110165 Negative_regulation of Arg1 8 0.38 3.21 0.48
27 INT299799 Negative_regulation of Negative_regulation of GATA3 1 0.09 1.32 0.47
28 INT312270 Positive_regulation of Xcl1 4 0.31 3.32 0.44
29 INT197674 Positive_regulation of Gene_expression of Arg1 2 0.33 0.63 0.44
30 INT296112 Positive_regulation of Positive_regulation of Arg1 1 0.05 0.55 0.4
31 INT136851 Regulation of Arg1 7 0.38 3.05 0.37
32 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
33 INT27399 Protein_catabolism of Arg1 1 0.64 0 0.31
34 INT325072 Gene_expression of Xcl1 1 0.33 0.88 0.24
35 INT314003 Negative_regulation of Positive_regulation of Arg1 1 0.13 0.63 0.23
36 INT336864 Negative_regulation of Tcf7 1 0.41 0.44 0.22
37 INT150203 Positive_regulation of Xcl1 2 0.40 2.47 0.21
38 INT318169 Regulation of Xcl1 1 0.15 1.14 0.19
39 INT68735 Binding of Arg2 2 0.05 0.22 0.17
40 INT15734 Negative_regulation of Xcl1 2 0.18 0 0.16
41 INT15735 Positive_regulation of Negative_regulation of Xcl1 1 0.02 0 0.16
42 INT280717 Positive_regulation of Regulation of Arg1 1 0.12 0 0.16
43 INT336865 Regulation of Binding of Tcf7 1 0.44 0.33 0.15
44 INT313999 Regulation of Positive_regulation of Arg1 1 0.08 0.22 0.13
45 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
46 INT280705 Localization of Arg1 2 0.22 0.26 0.08
47 INT123164 Positive_regulation of Arg2 2 0.04 0.34 0.05
48 INT123165 Positive_regulation of Positive_regulation of Arg2 1 0.01 0.34 0.05
49 INT220802 Binding of LEF1 7 0.36 3.86 0.04
50 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04
51 INT289110 Localization of LEF1 2 0.32 1.19 0.04
52 INT197017 Binding of GATA3 2 0.36 0.94 0.04
53 INT296111 Negative_regulation of Binding of Arg1 1 0.04 0.12 0.04
54 INT296110 Binding of Arg1 1 0.03 0.07 0.04
55 INT325069 Regulation of Gene_expression of Xcl1 1 0.19 0 0.04
56 INT325073 Positive_regulation of Gene_expression of Xcl1 1 0.19 0 0.03
57 INT289127 Positive_regulation of LEF1 2 0.22 0.76 0
58 INT336866 Gene_expression of Tcf7 2 0.65 1.02 0
59 INT337425 Phosphorylation of Tcf7 1 0.79 0 0
60 INT325070 Negative_regulation of Positive_regulation of Xcl1 1 0.18 0 0
61 INT337456 Positive_regulation of Binding of LEF1 1 0.22 0 0
62 INT234916 Gene_expression of Lef1 1 0.04 0.25 0
63 INT337422 Positive_regulation of Tcf7 1 0.49 0 0
64 INT337423 Positive_regulation of Binding of Tcf7 1 0.49 0 0
65 INT289129 Positive_regulation of Gene_expression of LEF1 1 0.13 0.76 0
66 INT337428 Negative_regulation of Binding of Tcf7 1 0.41 0.06 0
67 INT325068 Negative_regulation of Gene_expression of Xcl1 1 0.16 0.09 0
68 INT235637 Localization of GATA3 1 0.73 0.55 0
69 INT323259 Gene_expression of Arg2 1 0.03 0.59 0
70 INT197673 Regulation of Gene_expression of Arg1 1 0.29 0 0
71 INT337461 Positive_regulation of Transcription of LEF1 1 0.22 0.26 0
72 INT289108 Negative_regulation of Transcription of LEF1 1 0.11 0.32 0
73 INT337426 Localization of Tcf7 1 0.73 0.16 0
74 INT242002 Transcription of Tcf7 1 0.29 0.47 0
75 INT337427 Positive_regulation of Localization of Tcf7 1 0.49 0.17 0
76 INT220775 Binding of Lef1 1 0.20 0.06 0
77 INT325071 Binding of Xcl1 1 0.13 0 0
78 INT289124 Negative_regulation of Positive_regulation of LEF1 1 0.11 0.34 0
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