GO:0071363

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Name cellular response to growth factor stimulus
Categary Process
Go Slim No
Go Link GO:0071363
Unique Molecular Interactions 2438
Total Molecular Interactions 3362
Total Single Events 33347
Pain Genes Associated 82

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to growth factor stimulus. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to growth factor stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
2 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
3 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
4 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
5 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
6 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
7 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
8 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
9 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
10 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
11 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
12 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
13 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
14 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
15 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
16 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
17 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
18 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
19 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
20 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
21 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
22 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
23 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
24 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
25 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
26 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
27 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
28 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
29 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
30 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
31 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
32 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
33 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
34 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
35 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
36 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
37 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
38 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
39 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
40 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
41 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
42 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
43 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
44 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
45 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
46 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
47 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
48 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
49 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
50 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
51 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
52 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
53 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
54 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
55 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
56 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
57 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
58 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
59 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
60 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
61 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
62 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
63 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
64 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
65 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
66 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
67 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
68 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
69 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
70 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
71 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
72 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
73 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
74 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
75 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
76 INT161079 Mcs18 Negative_regulation of Trpv1 1 0.40 0.82 1.9
77 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
78 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
79 INT166945 Ngf Positive_regulation of Trpv1 1 0.01 0.47 1.88
80 INT338691 Binding of Trpv1 and Aff3 1 0.24 1.21 1.88
81 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
82 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
83 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
84 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
85 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
86 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
87 INT23392 Gal Regulation of Trpv1 1 0.05 0.33 1.77
88 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
89 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
90 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
91 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
92 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
93 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
94 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
95 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
96 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
97 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
98 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
99 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
100 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
101 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
102 INT147654 DYT10 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.93 1.62
103 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
104 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
105 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
106 INT276670 Binding of Trpv1 and Nkx1-1 1 0.07 0.68 1.6
107 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
108 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
109 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
110 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
111 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
112 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
113 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
114 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
115 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
116 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
117 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
118 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
119 INT40887 Penk Regulation of Th 1 0.04 0 1.53
120 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
121 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
122 INT42000 Trpv1 Positive_regulation of Cck 1 0.04 0 1.49
123 INT41999 Trpv1 Positive_regulation of Vip 1 0.04 0 1.49
124 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
125 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
126 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
127 INT180789 Ngf Regulation of Localization of Trpv1 1 0.28 1.22 1.44
128 INT180768 Bdnf Regulation of Localization of Trpv1 1 0.13 1.21 1.43
129 INT180790 Gdnf Regulation of Localization of Trpv1 1 0.15 1.21 1.43
130 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
131 INT139768 Binding of TRPV1 and ICK 1 0.41 1.59 1.42
132 INT139767 ICK Regulation of TRPV1 1 0.30 1.59 1.42
133 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
134 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
135 INT144123 Binding of P2rx6 and Trpv1 1 0.11 0 1.4
136 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
137 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39
138 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
139 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 0.26 0.49 1.38
140 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
141 INT276673 Nkx1-1 Regulation of Trpv1 1 0.05 0.16 1.37
142 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
143 INT261483 Binding of Ephb1 and Trpv1 1 0.39 1.37 1.37
144 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
145 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
146 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
147 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
148 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
149 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
150 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
151 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
152 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
153 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
154 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
155 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
156 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
157 INT121457 KNG1 Positive_regulation of Trpv1 1 0.16 0.91 1.33
158 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
159 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
160 INT13755 Binding of Oprd1 and Ap2m1 1 0.20 0 1.32
161 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
162 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
163 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
164 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
165 INT208990 Binding of CALM1 and Trpv1 1 0.10 0.07 1.29
166 INT147653 TACR1 Positive_regulation of TRPV1 1 0.02 0.72 1.29
167 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
168 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
169 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
170 INT64077 Trpv1 Positive_regulation of Kcnma1 1 0.00 0.37 1.27
171 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
172 INT342990 TRPV1 Positive_regulation of Gene_expression of SFTPA1 1 0.06 1.44 1.26
173 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
174 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
175 INT116892 Binding of TRPV1 and Phax 4 0.00 0.1 1.24
176 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
177 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
178 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
179 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
180 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24
181 INT63864 Oprd1 Regulation of Localization of Prl 2 0.16 0 1.23
182 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23
183 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23
184 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23
185 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
186 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
187 INT342988 HCL1 Positive_regulation of TRPV1 1 0.04 1.15 1.21
188 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
189 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
190 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
191 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
192 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
193 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
194 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
195 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
196 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
197 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
198 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18
199 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
200 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to growth factor stimulus. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to growth factor stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59
2 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42
3 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81
4 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
5 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
6 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
7 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05
8 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
9 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
10 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
11 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
12 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
13 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4
14 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
15 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
16 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
17 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
18 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
19 INT7327 Regulation of Th 164 0.62 29.67 110.14
20 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
21 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
22 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03
23 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
24 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
25 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
26 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
27 INT38731 Localization of Trpv1 138 0.81 52.73 90.49
28 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
29 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
30 INT4830 Binding of Trpv1 158 0.48 45.11 84.2
31 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
32 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
33 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46
34 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
35 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
36 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26
37 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
38 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
39 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
40 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
41 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
42 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77
43 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
44 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
45 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39
46 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35
47 INT49436 Binding of TRPV1 145 0.48 38.35 55.08
48 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
49 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
50 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
51 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
52 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
53 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
54 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
55 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
56 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
57 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
58 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
59 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
60 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
61 INT9383 Localization of TRPV1 98 0.81 33.23 46.24
62 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
63 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
64 INT350 Localization of Th 79 0.80 10.26 41.17
65 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
66 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
67 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88
68 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
69 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
70 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
71 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
72 INT7326 Transcription of Th 83 0.72 13.5 35.33
73 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77
74 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
75 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28
76 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
77 INT16714 Regulation of Creb1 64 0.62 22.23 33.56
78 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
79 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
80 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
81 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
82 INT8691 Localization of Insr 85 0.80 9.27 30.32
83 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25
84 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
85 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
86 INT5300 Regulation of Insr 54 0.60 11.33 29.26
87 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
88 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04
89 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96
90 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
91 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
92 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
93 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
94 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28
95 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
96 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
97 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
98 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
99 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
100 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
101 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
102 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47
103 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
104 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
105 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
106 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
107 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
108 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28
109 INT100026 Gene_expression of Tnfrsf1b 73 0.72 43.26 23.23
110 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17
111 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
112 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
113 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
114 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
115 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
116 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7
117 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46
118 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
119 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
120 INT89056 Phosphorylation of Trpv1 46 0.82 13.52 22.16
121 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
122 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
123 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
124 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
125 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
126 INT6230 Localization of Ddc 40 0.79 13.11 20.88
127 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84
128 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75
129 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
130 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52
131 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
132 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
133 INT96511 Negative_regulation of Positive_regulation of Trpv1 35 0.59 10.95 19.79
134 INT77902 Negative_regulation of Positive_regulation of TRPV1 30 0.59 9.36 19.2
135 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
136 INT9230 Gene_expression of Htr3a 43 0.78 10.54 18.81
137 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
138 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1
139 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06
140 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
141 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
142 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
143 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65
144 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
145 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
146 INT101501 Phosphorylation of TRPV1 31 0.82 9.26 17.27
147 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92
148 INT102023 Regulation of Creb1 51 0.62 16.29 16.71
149 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63
150 INT9069 Regulation of Htr3a 29 0.60 6.18 16.55
151 INT13716 Positive_regulation of TH 33 0.68 19.11 16
152 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97
153 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
154 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
155 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
156 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
157 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
158 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
159 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
160 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
161 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34
162 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
163 INT103828 Negative_regulation of Gene_expression of TRPV1 23 0.59 13.63 13.81
164 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
165 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
166 INT107248 Negative_regulation of Gene_expression of Creb1 26 0.58 9.24 13.41
167 INT97848 Positive_regulation of Localization of Trpv1 18 0.50 7.66 13.36
168 INT49538 Binding of Gria1 22 0.47 2.66 13.35
169 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
170 INT16713 Binding of Creb1 53 0.48 20.24 13.06
171 INT9231 Binding of Htr3a 27 0.47 7.29 13.04
172 INT101494 Regulation of Positive_regulation of Trpv1 18 0.62 6.57 12.9
173 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85
174 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
175 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
176 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67
177 INT12369 Negative_regulation of Htr3a 28 0.59 8.78 12.62
178 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55
179 INT18539 Gene_expression of Pnmt 33 0.78 3.08 12.47
180 INT97237 Transcription of TRPV1 33 0.72 10.56 12.4
181 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
182 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
183 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
184 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
185 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
186 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6
187 INT80251 Binding of Nos1 21 0.30 8.24 11.31
188 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
189 INT141 Binding of Th 21 0.48 3.53 11.04
190 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
191 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
192 INT62576 Transcription of Creb1 34 0.69 16.97 10.6
193 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
194 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5
195 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
196 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37
197 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32
198 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
199 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19
200 INT8072 Localization of Gria1 17 0.75 2.62 10.04
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