GO:0071377

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Name cellular response to glucagon stimulus
Categary Process
Go Slim No
Go Link GO:0071377
Unique Molecular Interactions 107
Total Molecular Interactions 120
Total Single Events 1432
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to glucagon stimulus. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to glucagon stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
2 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
3 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
4 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
5 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04
6 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
7 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
8 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
9 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
10 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
11 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
12 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
13 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
14 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
15 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
16 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
17 INT30902 GCG Positive_regulation of Localization of SST 1 0.11 0.05 0.62
18 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
19 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
20 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
21 INT108467 GCG Positive_regulation of Cck 1 0.02 0.16 0.51
22 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
23 INT25524 Oprd1 Regulation of Localization of GCG 1 0.01 0.52 0.48
24 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
25 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
26 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
27 INT111275 BRI3P1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0 0.44
28 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
29 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
30 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
31 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
32 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41
33 INT105170 OPRD1 Positive_regulation of Phosphorylation of ADCY1 1 0.08 0 0.41
34 INT11425 OR2A12 Positive_regulation of Negative_regulation of ADCY1 1 0.01 0 0.4
35 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
36 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
37 INT43956 GCG Regulation of ALB 1 0.16 0.15 0.38
38 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32
39 INT207823 SSTR2 Negative_regulation of Localization of GCG 1 0.06 0 0.29
40 INT339001 GSX1 Positive_regulation of ADCY1 1 0.01 0 0.29
41 INT141438 Gnai2 Positive_regulation of Localization of ADCY1 1 0.01 0.43 0.29
42 INT26175 POMC Positive_regulation of GCG 2 0.47 0.57 0.28
43 INT210828 POMC Positive_regulation of ADCY1 1 0.03 0.34 0.28
44 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27
45 INT233784 Binding of GCG and SCT 1 0.06 0 0.27
46 INT93952 CGA Positive_regulation of ADCY1 1 0.03 0 0.27
47 INT93953 Negative_regulation of CGA Positive_regulation of ADCY1 1 0.03 0 0.27
48 INT36292 GCG Positive_regulation of MIA3 1 0.01 1.06 0.26
49 INT223042 AR Positive_regulation of ADCY1 1 0.01 0.41 0.25
50 INT223036 SLURP1 Regulation of Positive_regulation of ADCY1 1 0.00 0.42 0.25
51 INT34499 ADRB3 Positive_regulation of ADCY1 1 0.07 0.19 0.23
52 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22
53 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
54 INT7332 CALM3 Positive_regulation of ADCY1 1 0.46 0.13 0.21
55 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
56 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
57 INT326737 IL8 Positive_regulation of Gene_expression of ARG1 1 0.38 2.41 0.19
58 INT216841 TCIRG1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
59 INT75355 Negative_regulation of GCG Regulation of Gh 1 0.01 1.26 0.18
60 INT216842 ATP6V0A1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
61 INT75356 GCG Regulation of Gh 1 0.01 1.25 0.18
62 INT74600 Negative_regulation of YY1 Negative_regulation of ADCY1 1 0.36 0.25 0.17
63 INT71547 ADRA2C Positive_regulation of Localization of GCG 1 0.01 0.14 0.17
64 INT125770 GLP1R Negative_regulation of Localization of GCG 2 0.29 0.65 0.16
65 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
66 INT15524 GCG Negative_regulation of FFAR1 1 0.07 0.35 0.16
67 INT261521 Binding of ADCY1 and GLUL 1 0.01 0.09 0.15
68 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15
69 INT77122 WDTC1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0.39 0.15
70 INT326735 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG1 1 0.32 0.33 0.14
71 INT61998 GNPTAB Positive_regulation of ADCY1 1 0.03 0 0.13
72 INT52711 BSG Regulation of ADCY1 1 0.01 0.1 0.12
73 INT141426 ANTXRL Negative_regulation of ADCY1 1 0.00 0.41 0.11
74 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
75 INT242203 GLP1R Regulation of GCG 1 0.04 0.64 0.1
76 INT207822 ABAT Positive_regulation of Localization of GCG 1 0.02 0 0.1
77 INT57220 Positive_regulation of ATF3 Positive_regulation of PRKACA 1 0.17 0.1 0.09
78 INT57214 ATF3 Positive_regulation of PRKACA 1 0.17 0.1 0.09
79 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
80 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
81 INT32621 POMC Positive_regulation of Positive_regulation of GCG 1 0.35 0.05 0.06
82 INT32622 POMC Negative_regulation of Negative_regulation of GCG 1 0.30 0.05 0.05
83 INT297121 Binding of GNB3 and Eps8l3 1 0.00 0.81 0.05
84 INT326742 AR Regulation of Gene_expression of ARG1 1 0.24 0.43 0.03
85 INT331875 Binding of GCG and Mst1r 1 0.08 0 0
86 INT311223 GLP1R Regulation of Localization of GCG 1 0.16 0.74 0
87 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
88 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
89 INT326744 ARG1 Regulation of ARG2 1 0.50 1.04 0
90 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
91 INT331874 Positive_regulation of Binding of GCG and Mst1r 1 0.11 0 0
92 INT238870 INS Positive_regulation of Gene_expression of GCG 1 0.39 1.06 0
93 INT331880 Binding of GCG and Mest 1 0.08 0 0
94 INT344893 Binding of ADCY1 and Ptger4 1 0.00 0 0
95 INT249960 Arg1 Negative_regulation of NOS1 1 0.01 0.1 0
96 INT314624 Ex Regulation of GCG 1 0.01 0.67 0
97 INT230763 GCG Positive_regulation of Localization of INS 1 0.17 0.26 0
98 INT313572 GLP1R Negative_regulation of GCG 1 0.29 0.54 0
99 INT256400 GLP1R Positive_regulation of Localization of GCG 1 0.02 0.15 0
100 INT253213 Negative_regulation of Dpp4 Positive_regulation of Localization of GCG 1 0.05 0.4 0
101 INT331879 Positive_regulation of Binding of GCG and Mest 1 0.11 0 0
102 INT197675 Regulation of Binding of ESR1 and Arg1 1 0.05 0 0
103 INT326743 Gene_expression of AR Negative_regulation of Gene_expression of ARG1 1 0.32 0.8 0
104 INT326738 Gene_expression of IL8 Positive_regulation of Gene_expression of ARG1 1 0.26 0.41 0
105 INT253214 Negative_regulation of Dpp4 Negative_regulation of Gene_expression of GCG 1 0.04 0.43 0
106 INT326748 IL8 Positive_regulation of ARG1 1 0.26 0.26 0
107 INT344892 Binding of ADCY1 and Ptger2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to glucagon stimulus. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to glucagon stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
2 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
3 INT17625 Localization of GCG 210 0.80 55.69 24.97
4 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
5 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
6 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
7 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
8 INT4494 Regulation of GCG 41 0.45 18.38 9.68
9 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48
10 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35
11 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
12 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14
13 INT31227 Regulation of Localization of GCG 28 0.48 4.86 5.72
14 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
15 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98
16 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
17 INT17626 Positive_regulation of Localization of GCG 36 0.69 13.94 4.06
18 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
19 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
20 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
21 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
22 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
23 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
24 INT109833 Binding of GNB3 7 0.48 8.83 2.84
25 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
26 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
27 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
28 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47
29 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
30 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
31 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9
32 INT28954 Binding of GCG 7 0.36 3.14 1.68
33 INT26180 Regulation of Regulation of GCG 3 0.39 1.43 1.65
34 INT87289 Positive_regulation of Localization of ADCY1 3 0.43 0.36 1.65
35 INT80890 Negative_regulation of Phosphorylation of ADCY1 2 0.36 0.24 1.57
36 INT72310 Regulation of Regulation of ADCY1 6 0.24 1.24 1.55
37 INT121347 Binding of GNAS 8 0.13 3.99 1.47
38 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
39 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
40 INT80887 Negative_regulation of Regulation of ADCY1 3 0.35 0.1 1.26
41 INT75891 Regulation of ADCY2 3 0.06 0.06 1.17
42 INT114326 Phosphorylation of ADCY6 2 0.70 0.05 1.11
43 INT124810 Gene_expression of ADCY6 6 0.65 0 1.06
44 INT72868 Transcription of ADCY1 4 0.57 0.69 1.04
45 INT156727 Gene_expression of Arg1 4 0.44 2.1 0.97
46 INT80871 Negative_regulation of Binding of ADCY1 1 0.03 0.1 0.91
47 INT124814 Localization of ADCY6 1 0.65 0 0.78
48 INT43857 Regulation of Gene_expression of GCG 2 0.25 0.64 0.76
49 INT124813 Negative_regulation of ADCY6 1 0.37 0 0.73
50 INT124811 Positive_regulation of Negative_regulation of ADCY6 1 0.40 0 0.73
51 INT84910 Gene_expression of GNB3 4 0.67 2.74 0.71
52 INT353152 Localization of PRKACA 1 0.01 1.15 0.66
53 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
54 INT127930 Gene_expression of ADCY2 6 0.11 0.1 0.59
55 INT165848 Protein_catabolism of ADCY1 1 0.25 0.28 0.57
56 INT165845 Positive_regulation of Transcription of ADCY1 1 0.26 0.36 0.55
57 INT15526 Positive_regulation of Gene_expression of GCG 3 0.38 1.64 0.53
58 INT110165 Negative_regulation of Arg1 8 0.38 3.21 0.48
59 INT110905 Regulation of Negative_regulation of ADCY1 1 0.59 0 0.48
60 INT83548 Negative_regulation of Positive_regulation of GCG 1 0.42 1.06 0.46
61 INT197674 Positive_regulation of Gene_expression of Arg1 2 0.33 0.63 0.44
62 INT326766 Positive_regulation of Gene_expression of ARG1 12 0.67 8.32 0.42
63 INT296112 Positive_regulation of Positive_regulation of Arg1 1 0.05 0.55 0.4
64 INT124808 Positive_regulation of Localization of ADCY6 1 0.43 0 0.38
65 INT136851 Regulation of Arg1 7 0.38 3.05 0.37
66 INT45708 Positive_regulation of Positive_regulation of GCG 1 0.48 0.76 0.35
67 INT47340 Regulation of Positive_regulation of GCG 1 0.45 0 0.34
68 INT138362 Regulation of Negative_regulation of ADCY2 1 0.01 0 0.34
69 INT124812 Positive_regulation of ADCY6 1 0.43 0 0.33
70 INT84908 Positive_regulation of GNB3 1 0.49 0.9 0.32
71 INT208776 Positive_regulation of Gene_expression of GNB3 1 0.49 1.02 0.31
72 INT27399 Protein_catabolism of Arg1 1 0.64 0 0.31
73 INT138363 Positive_regulation of Gene_expression of ADCY2 1 0.01 0 0.3
74 INT310936 Phosphorylation of GCG 1 0.10 1 0.24
75 INT108902 Localization of GNAS 5 0.13 1.31 0.23
76 INT48785 Gene_expression of PRKACA 1 0.35 0 0.23
77 INT314003 Negative_regulation of Positive_regulation of Arg1 1 0.13 0.63 0.23
78 INT303671 Negative_regulation of Regulation of GCG 1 0.13 1.44 0.22
79 INT264796 Regulation of Binding of GCG 1 0.04 0.16 0.21
80 INT258055 Positive_regulation of ARG1 7 0.49 3.45 0.19
81 INT26178 Negative_regulation of Gene_expression of GCG 4 0.35 1.43 0.19
82 INT127931 Positive_regulation of Gene_expression of ADCY6 2 0.49 0 0.17
83 INT326763 Negative_regulation of ARG1 1 0.57 1.49 0.16
84 INT280717 Positive_regulation of Regulation of Arg1 1 0.12 0 0.16
85 INT26179 Regulation of Negative_regulation of GCG 2 0.38 1.04 0.14
86 INT127934 Regulation of ADCY6 1 0.09 0 0.13
87 INT313999 Regulation of Positive_regulation of Arg1 1 0.08 0.22 0.13
88 INT127929 Regulation of Gene_expression of ADCY6 1 0.21 0 0.13
89 INT326764 Negative_regulation of Gene_expression of ARG1 1 0.57 3.52 0.13
90 INT127928 Regulation of Gene_expression of ADCY2 1 0.08 0 0.13
91 INT252444 Positive_regulation of Binding of ADCY1 1 0.03 0 0.09
92 INT280705 Localization of Arg1 2 0.22 0.26 0.08
93 INT127926 Negative_regulation of Gene_expression of ADCY2 1 0.06 0 0.08
94 INT127924 Transcription of ADCY6 1 0.18 0 0.07
95 INT127932 Regulation of Transcription of ADCY6 1 0.09 0 0.07
96 INT26182 Negative_regulation of Negative_regulation of GCG 1 0.27 0.07 0.06
97 INT179307 Regulation of GNAS 7 0.01 1.93 0.05
98 INT244700 Regulation of Gene_expression of ARG1 2 0.60 3.09 0.04
99 INT296111 Negative_regulation of Binding of Arg1 1 0.04 0.12 0.04
100 INT296110 Binding of Arg1 1 0.03 0.07 0.04
101 INT326776 Localization of ARG1 1 0.73 0 0.03
102 INT177312 Negative_regulation of Gene_expression of GNAS 2 0.05 0.46 0
103 INT230374 Regulation of ARG1 2 0.60 1.94 0
104 INT326779 Binding of ARG1 1 0.36 0.56 0
105 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0
106 INT326765 Positive_regulation of Transcription of ARG1 1 0.67 0.6 0
107 INT329344 Positive_regulation of Positive_regulation of ARG1 1 0.01 0.73 0
108 INT207840 Positive_regulation of Negative_regulation of GCG 1 0.36 0.1 0
109 INT326774 Regulation of Transcription of ARG1 1 0.44 0.11 0
110 INT84292 Negative_regulation of Positive_regulation of ADCY2 1 0.03 0 0
111 INT238873 Positive_regulation of Regulation of GCG 1 0.38 0.95 0
112 INT179318 Regulation of Transcription of GNAS 1 0.01 0 0
113 INT179310 Positive_regulation of Gene_expression of GNAS 1 0.01 0 0
114 INT351494 Positive_regulation of Protein_catabolism of GNAS 1 0.00 0.94 0
115 INT197673 Regulation of Gene_expression of Arg1 1 0.29 0 0
116 INT326780 Transcription of ARG1 1 0.69 0.71 0
117 INT110597 Positive_regulation of Protein_catabolism of GCG 1 0.15 0 0
118 INT351518 Protein_catabolism of GNAS 1 0.01 1.29 0
119 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0
120 INT110596 Protein_catabolism of GCG 1 0.30 0 0
121 INT249548 Negative_regulation of Positive_regulation of GNAS 1 0.06 0 0
122 INT326782 Regulation of Regulation of ARG1 1 0.26 0.81 0
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