GO:0071391

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Name cellular response to estrogen stimulus
Categary Process
Go Slim No
Go Link GO:0071391
Unique Molecular Interactions 276
Total Molecular Interactions 355
Total Single Events 3843
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to estrogen stimulus. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to estrogen stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
2 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
3 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
4 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
5 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
6 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
7 INT38057 Binding of Crp and Esr1 2 0.04 1.21 0.65
8 INT309158 Binding of Esr1 and Dlat 1 0.04 1.39 0.61
9 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
10 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
11 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
12 INT154014 Binding of Esr1 and Gabrg1 1 0.07 0.07 0.5
13 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
14 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46
15 INT323840 Binding of Esr1 and Il1 1 0.04 0.9 0.42
16 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
17 INT117361 Binding of Esr1 and sea 1 0.02 1.38 0.38
18 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
19 INT197591 Esr1 Regulation of Pgr 1 0.04 0 0.38
20 INT117359 Binding of Esr1 and Wbc1 1 0.00 1.38 0.37
21 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
22 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
23 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
24 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
25 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
26 INT309156 Esr1 Regulation of Gene_expression of Dlat 1 0.05 1.06 0.3
27 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
28 INT158734 Esr1 Regulation of Esrrb 1 0.00 0.28 0.29
29 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29
30 INT158733 Esr1 Regulation of Plxna3 1 0.03 0.27 0.29
31 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
32 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28
33 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27
34 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27
35 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
36 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26
37 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
38 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
39 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
40 INT182349 Binding of Ms4a1 and Esr1 1 0.04 1.26 0.25
41 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
42 INT309160 Binding of Esr1 and Edc4 1 0.03 0.34 0.24
43 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
44 INT63198 POMC Positive_regulation of ESR1 1 0.14 0.3 0.23
45 INT108842 RARA Positive_regulation of Gene_expression of GDF15 1 0.52 0.68 0.23
46 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22
47 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
48 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
49 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
50 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19
51 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
52 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
53 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18
54 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
55 INT19042 ESR1 Positive_regulation of GGT5 1 0.03 0.6 0.17
56 INT19045 ESR1 Positive_regulation of Salpa1 1 0.02 0.6 0.17
57 INT309154 Esr1 Positive_regulation of Gsdmc 1 0.01 0.44 0.15
58 INT309155 Negative_regulation of Esr1 Positive_regulation of Gsdmc 1 0.01 0.45 0.15
59 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14
60 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
61 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13
62 INT297312 Esr1 Positive_regulation of Scap 1 0.00 1.58 0.13
63 INT267973 Binding of CHKB and ESR1 1 0.02 1.67 0.13
64 INT86429 Binding of Hspb1 and Esr1 1 0.19 0.26 0.13
65 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13
66 INT236588 Binding of Esr1 and Ins1 1 0.05 0.73 0.12
67 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11
68 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11
69 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
70 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1
71 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1
72 INT237819 Binding of Esr1 and soc 1 0.04 0 0.1
73 INT279407 Binding of ESR1 and IGKV2-19 1 0.02 0.4 0.1
74 INT125000 Binding of Esr1 and Tas2r108 1 0.04 0.33 0.1
75 INT237812 Esr1 Positive_regulation of Positive_regulation of soc 1 0.05 0.6 0.1
76 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
77 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09
78 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
79 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
80 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09
81 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09
82 INT52836 ESR1 Positive_regulation of HSD17B7 1 0.43 0.41 0.09
83 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
84 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
85 INT192865 Binding of Esr1 and Pdia3 1 0.07 0.67 0.08
86 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08
87 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
88 INT199973 ESR1 Negative_regulation of EEF1B2P2 1 0.01 0.46 0.08
89 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
90 INT38188 PGR Positive_regulation of Gene_expression of ESR1 1 0.42 0.22 0.07
91 INT237811 Binding of Esr1 and Stim1 1 0.09 0 0.07
92 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07
93 INT224293 AR Positive_regulation of Protein_catabolism of ESR1 1 0.24 0.4 0.07
94 INT237809 Esr1 Positive_regulation of Localization of Car2 1 0.09 0.66 0.07
95 INT206855 Binding of ESR1 and PPARA 1 0.03 1.21 0.07
96 INT272388 Esr1 Regulation of Transcription of Trpv6 1 0.03 0.13 0.06
97 INT197594 Esr1 Regulation of Esr2 1 0.04 0 0.06
98 INT187845 Binding of ESR1 and Esr2 1 0.01 0.17 0.06
99 INT197592 Esr2 Regulation of Esr1 1 0.04 0 0.06
100 INT142744 Esr1 Regulation of Transcription of Trpv6 1 0.42 0 0.06
101 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05
102 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
103 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05
104 INT236591 Binding of Esr1 and Positive_regulation of Tmed4 1 0.04 0.52 0.05
105 INT240726 Binding of Esr1 and Ca2 1 0.02 0.57 0.05
106 INT316248 ESR1 Regulation of Gene_expression of TRPM8 1 0.34 0.17 0.05
107 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05
108 INT225493 Binding of Esr1 and Pprc1 2 0.01 0.17 0.04
109 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
110 INT206848 PLP1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
111 INT206853 ESR1 Positive_regulation of Gene_expression of PCP4 1 0.08 1.39 0.04
112 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
113 INT201445 ESR1 Regulation of Slc6a3 1 0.02 0.05 0.04
114 INT206851 NR4A1 Regulation of Gene_expression of ESR1 1 0.08 0.9 0.04
115 INT236595 Binding of Esr1 and PELP1 1 0.27 0.17 0.04
116 INT206896 ESR1 Positive_regulation of Gene_expression of Nr1i3 1 0.00 0.36 0.04
117 INT206847 ESR1 Negative_regulation of Gene_expression of PTGER3 1 0.08 1.52 0.04
118 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
119 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
120 INT206849 ESR1 Regulation of Gene_expression of ALDH1A1 1 0.11 2.26 0.04
121 INT206852 ESR1 Regulation of Gene_expression of CRABP2 1 0.08 1.52 0.04
122 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
123 INT183614 Binding of ESR1 and TMED4 2 0.02 0.13 0.03
124 INT278579 Esr1 Positive_regulation of Negative_regulation of Tac2 1 0.47 0.25 0.03
125 INT247080 Binding of CRH and CRHBP 1 0.11 0.2 0.03
126 INT278289 Binding of DBP and ESR1 1 0.03 0.82 0.03
127 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
128 INT331960 Positive_regulation of Binding of Esr1 and Tymp 1 0.00 0.15 0.03
129 INT331958 Binding of Esr1 and Tymp 1 0.00 0.15 0.03
130 INT245075 Binding of ESR1 and NR4A1 1 0.01 1.08 0.03
131 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
132 INT247085 Binding of CRHBP and GHRH 1 0.01 0.2 0.03
133 INT278294 Binding of ESR1 and SHBG 1 0.01 0.82 0.03
134 INT221682 Binding of Esr1 and FRTS 1 0.01 0.15 0.03
135 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
136 INT215872 Atf4 Regulation of Esr1 1 0.30 0.42 0.03
137 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
138 INT182918 Binding of DR1 and RARA 2 0.08 0 0
139 INT192914 Binding of ESR1 and GOPC 2 0.02 0.61 0
140 INT260342 Binding of Esr1 and Rcc1 1 0.05 0.99 0
141 INT182949 Binding of RARA and VDR 1 0.20 0 0
142 INT198111 Binding of Esr1 and Esr2 1 0.05 0 0
143 INT335214 Binding of ESR1 and RARS 1 0.08 0.92 0
144 INT178638 Gh1 Regulation of Gene_expression of ESR1 1 0.01 0.47 0
145 INT206895 Binding of ESR1 and Aldh1a1 1 0.03 0 0
146 INT264663 Binding of ESR1 and PRL 1 0.22 0.18 0
147 INT98354 TXNRD1 Positive_regulation of Positive_regulation of ESR1 1 0.00 0.05 0
148 INT306500 Clu Regulation of Esr1 1 0.22 0.13 0
149 INT332958 Binding of Esr1 and Ppara 1 0.36 0.21 0
150 INT225559 Binding of Esr1 and Ncoa6 1 0.18 0 0
151 INT342281 Binding of INS and Esr1 1 0.08 0.57 0
152 INT206854 ESR1 Regulation of IGF1 1 0.01 0.33 0
153 INT173771 Gh1 Regulation of Transcription of Esr1 1 0.00 0.13 0
154 INT189115 Binding of Esr1 and Tap1 1 0.07 0.05 0
155 INT120549 Binding of ESR1 and Mpo 1 0.26 0.05 0
156 INT199975 ESR1 Positive_regulation of PGR 1 0.05 0.11 0
157 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
158 INT264662 ESR1 Regulation of Gene_expression of PRL 1 0.43 0.21 0
159 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
160 INT197615 Esr1 Regulation of Gene_expression of Pgr 1 0.01 0.21 0
161 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
162 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
163 INT206850 Binding of CRABP2 and ESR1 1 0.06 0 0
164 INT245077 Binding of ESR1 and CXCL12 1 0.06 1.42 0
165 INT191062 Esr1 Regulation of Gene_expression of Bcl2 1 0.12 0.73 0
166 INT313596 ESR1 Positive_regulation of Gene_expression of PGR 1 0.05 1 0
167 INT219421 Binding of ESR1 and MALAT1 1 0.34 0.63 0
168 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0
169 INT98353 THRB Negative_regulation of Positive_regulation of ESR1 1 0.00 0.09 0
170 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
171 INT208018 Col4a4 Regulation of Gene_expression of Esr1 1 0.06 0.69 0
172 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
173 INT244457 CS Positive_regulation of Gene_expression of ESR1 1 0.07 0.67 0
174 INT192913 Binding of ESR1 and HAMP 1 0.02 0.72 0
175 INT314687 ESR1 Regulation of PGR 1 0.27 0.88 0
176 INT197911 Dlst Positive_regulation of Gene_expression of Esr1 1 0.03 0.34 0
177 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0
178 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
179 INT225533 Binding of Emr1 and Esr1 1 0.01 0 0
180 INT333929 Binding of ESR1 and ERLEC1 1 0.01 0.09 0
181 INT223582 Negative_regulation of MTOR Positive_regulation of Phosphorylation of ESR1 1 0.31 0.67 0
182 INT178639 Binding of ESR1 and Igf1 1 0.02 0.39 0
183 INT197908 Dlst Positive_regulation of Esr1 1 0.03 0.34 0
184 INT244450 TMBIM6 Negative_regulation of Gene_expression of ESR1 1 0.04 0.68 0
185 INT225621 Positive_regulation of Binding of TARBP2 and Esr1 1 0.03 0 0
186 INT225531 R3hcc1 Positive_regulation of Positive_regulation of Esr1 1 0.00 0 0
187 INT197614 Esr1 Regulation of Pgr 1 0.01 0.07 0
188 INT260601 Binding of ESR1 and Ppargc1a 1 0.01 0.48 0
189 INT182919 TGFBI Regulation of RARA 1 0.29 0.08 0
190 INT206844 ESR1 Positive_regulation of Gene_expression of ANXA1 1 0.08 0.1 0
191 INT264661 ESR1 Positive_regulation of PRL 1 0.43 0.68 0
192 INT339102 Binding of ESR1 and PVT1 1 0.34 0.3 0
193 INT225626 Binding of TARBP2 and Esr1 1 0.02 0 0
194 INT225611 Binding of Esr1 and Asc2 1 0.05 0 0
195 INT98356 ADRA1D Positive_regulation of Positive_regulation of ESR1 1 0.02 0.05 0
196 INT192915 Binding of ESR1 and MIER3 1 0.00 0.72 0
197 INT219404 Binding of ESR1 and VEGFA 1 0.33 0.63 0
198 INT342366 Binding of Rara and OSBPL1A 1 0.16 0 0
199 INT225573 Rbm39 Positive_regulation of Positive_regulation of Esr1 1 0.08 0 0
200 INT96975 Binding of Atp7b and Esr1 1 0.07 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to estrogen stimulus. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to estrogen stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
2 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
3 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
4 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
5 INT37296 Binding of Esr1 117 0.43 62.51 27.33
6 INT20462 Binding of ESR1 210 0.44 102.7 26.34
7 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
8 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
9 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
10 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
11 INT92354 Localization of ESR1 77 0.75 33.04 15.51
12 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
13 INT2038 Localization of Esr1 104 0.79 40.12 13.27
14 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
15 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
16 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
17 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
18 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
19 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
20 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29
21 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69
22 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51
23 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84
24 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
25 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
26 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
27 INT117205 Transcription of Esr1 23 0.65 9.4 4.14
28 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
29 INT20461 Binding of Esr1 34 0.48 9.58 3.66
30 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
31 INT73918 Transcription of Esr1 21 0.66 8.74 3.12
32 INT31541 Regulation of Esr1 15 0.54 4.12 2.82
33 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
34 INT73913 Regulation of Gene_expression of Esr1 2 0.41 2.24 1.92
35 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
36 INT192092 Positive_regulation of Gene_expression of Rara 8 0.32 4.41 1.68
37 INT116022 Positive_regulation of Positive_regulation of RARA 3 0.11 0.94 1.68
38 INT96971 Positive_regulation of Gene_expression of Esr1 6 0.46 2.27 1.67
39 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58
40 INT67457 Binding of Rara 12 0.24 8.28 1.45
41 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
42 INT81400 Binding of RARA 25 0.36 12.93 1.27
43 INT8511 Localization of Esr1 6 0.80 3.27 1.26
44 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23
45 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
46 INT182985 Transcription of RARA 9 0.60 3.52 1.12
47 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06
48 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
49 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98
50 INT69758 Negative_regulation of Positive_regulation of Rara 2 0.32 0.24 0.97
51 INT154468 Negative_regulation of Transcription of ESR1 3 0.29 1.14 0.96
52 INT173747 Regulation of Positive_regulation of Esr1 4 0.37 4.85 0.95
53 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
54 INT236576 Positive_regulation of Binding of Esr1 3 0.41 2.39 0.92
55 INT154465 Negative_regulation of Transcription of Esr1 1 0.05 0 0.92
56 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9
57 INT192090 Localization of Rara 6 0.46 4.15 0.89
58 INT48251 Regulation of Positive_regulation of Rara 2 0.33 0 0.88
59 INT120366 Negative_regulation of Rara 2 0.35 0.15 0.86
60 INT73914 Negative_regulation of Transcription of Esr1 3 0.39 0.75 0.84
61 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83
62 INT48250 Regulation of Rara 3 0.29 2.47 0.83
63 INT48249 Positive_regulation of Positive_regulation of Rara 2 0.26 0 0.83
64 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82
65 INT33818 Positive_regulation of Negative_regulation of Esr1 3 0.40 0.98 0.82
66 INT212109 Localization of RARA 5 0.65 3.17 0.79
67 INT161778 Regulation of Gene_expression of Esr1 13 0.51 9.46 0.73
68 INT92082 Regulation of Binding of ESR1 5 0.45 2.41 0.73
69 INT239494 Regulation of Localization of Esr1 4 0.19 1.15 0.72
70 INT73917 Regulation of Transcription of Esr1 4 0.25 1.5 0.7
71 INT91398 Regulation of RARA 7 0.59 5.84 0.67
72 INT191177 Regulation of Localization of ESR1 7 0.42 2.04 0.64
73 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
74 INT9836 Negative_regulation of Negative_regulation of Esr1 3 0.29 0.95 0.63
75 INT234472 Positive_regulation of Transcription of RARA 2 0.44 0.13 0.58
76 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55
77 INT173744 Positive_regulation of Positive_regulation of Esr1 10 0.43 7.05 0.52
78 INT201392 Negative_regulation of RARA 8 0.30 2.99 0.5
79 INT190899 Negative_regulation of Phosphorylation of ESR1 3 0.33 1.01 0.49
80 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
81 INT240710 Positive_regulation of Regulation of Esr1 1 0.09 1.34 0.47
82 INT305077 Localization of CRHBP 1 0.76 0.28 0.44
83 INT182966 Regulation of Gene_expression of RARA 2 0.39 0.12 0.42
84 INT211982 Negative_regulation of Binding of Rara 1 0.28 0.24 0.42
85 INT174725 Positive_regulation of Localization of ESR1 8 0.47 2.45 0.41
86 INT268930 Regulation of Regulation of Esr1 2 0.41 0.48 0.38
87 INT178630 Positive_regulation of Negative_regulation of ESR1 2 0.04 0.64 0.35
88 INT236580 Regulation of Binding of Esr1 4 0.39 1.1 0.34
89 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33
90 INT183916 Negative_regulation of Binding of Esr1 1 0.06 0.91 0.32
91 INT192845 Negative_regulation of Positive_regulation of Esr1 2 0.35 1.15 0.31
92 INT73915 Negative_regulation of Negative_regulation of Esr1 1 0.40 0.06 0.31
93 INT247097 Binding of CRHBP 3 0.34 0.4 0.28
94 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27
95 INT10375 Negative_regulation of Gene_expression of RARA 1 0.57 0.97 0.22
96 INT96972 Positive_regulation of Binding of Esr1 4 0.22 1.35 0.21
97 INT186021 Positive_regulation of Positive_regulation of Esr1 1 0.08 0 0.19
98 INT176571 Negative_regulation of Positive_regulation of ESR1 5 0.47 3.15 0.17
99 INT291955 Positive_regulation of Protein_catabolism of Esr1 1 0.06 0.14 0.17
100 INT269777 Regulation of Regulation of Esr1 2 0.02 1.17 0.16
101 INT176461 Protein_catabolism of Esr1 1 0.12 0.37 0.16
102 INT183400 Positive_regulation of Transcription of Esr1 4 0.30 1.06 0.14
103 INT192091 Regulation of Localization of Rara 1 0.04 0.67 0.13
104 INT162109 Negative_regulation of Gene_expression of Esr1 4 0.16 2.41 0.12
105 INT232556 Positive_regulation of Phosphorylation of Esr1 1 0.20 0.41 0.12
106 INT224299 Positive_regulation of Protein_catabolism of ESR1 3 0.64 1.43 0.07
107 INT214071 Negative_regulation of Transcription of RARA 3 0.37 1.77 0.07
108 INT182975 Phosphorylation of RARA 2 0.58 0.23 0.07
109 INT178868 Regulation of Positive_regulation of ESR1 1 0.42 0.52 0.07
110 INT253882 Positive_regulation of Localization of Esr1 1 0.30 1.21 0.06
111 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
112 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
113 INT272379 Positive_regulation of Transcription of Esr1 1 0.04 0.13 0.04
114 INT221677 Negative_regulation of Protein_catabolism of Esr1 1 0.08 0.15 0.03
115 INT174726 Regulation of Regulation of ESR1 1 0.41 0.73 0.03
116 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
117 INT182990 Positive_regulation of Gene_expression of RARA 5 0.40 3.45 0
118 INT174724 Regulation of Transcription of ESR1 2 0.18 0.49 0
119 INT178629 Positive_regulation of Phosphorylation of ESR1 2 0.36 0.93 0
120 INT335681 Regulation of Negative_regulation of Esr1 1 0.03 0 0
121 INT182965 Positive_regulation of Phosphorylation of RARA 1 0.29 0 0
122 INT335229 Regulation of Transcription of RARA 1 0.15 0.95 0
123 INT173746 Regulation of Transcription of Esr1 1 0.04 0 0
124 INT183002 Positive_regulation of Binding of RARA 1 0.29 1.08 0
125 INT335226 Negative_regulation of Negative_regulation of RARA 1 0.24 0.71 0
126 INT315189 Binding of SFRP1 1 0.15 2.96 0
127 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
128 INT223607 Regulation of Phosphorylation of ESR1 1 0.35 0.65 0
129 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
130 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
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