GO:0071397

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Name cellular response to cholesterol
Categary Process
Go Slim No
Go Link GO:0071397
Unique Molecular Interactions 75
Total Molecular Interactions 101
Total Single Events 382
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to cholesterol. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to cholesterol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86150 Inhba Positive_regulation of Gene_expression of Calca 1 0.09 0.61 0.81
2 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
3 INT20761 INHBA Regulation of Localization of GNRH1 1 0.02 0 0.46
4 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
5 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
6 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
7 INT335015 Fgf15 Negative_regulation of Gene_expression of Cyp7a1 1 0.57 0.2 0.24
8 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
9 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
10 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
11 INT153460 Inhba Positive_regulation of Gene_expression of Ctgf 1 0.77 1.14 0.19
12 INT229289 FGF19 Negative_regulation of CYP7A1 1 0.26 0.32 0.16
13 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
14 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12
15 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
16 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
17 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
18 INT222416 Tlr4 Positive_regulation of Gene_expression of Inhba 1 0.00 0.29 0.06
19 INT222463 Inhba Positive_regulation of Gene_expression of Fst 1 0.01 0 0.05
20 INT185037 INHBA Negative_regulation of Inhba 1 0.26 0.32 0.05
21 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
22 INT343540 Binding of PPP1R12A and MLC1 1 0.09 0.15 0.04
23 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
24 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
25 INT241460 Rock1 Positive_regulation of Phosphorylation of MLC1 1 0.38 0.63 0.03
26 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
27 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
28 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
29 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
30 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
31 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
32 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
33 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
34 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
35 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
36 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
37 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
38 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
39 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
40 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
41 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
42 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
43 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
44 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
45 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
46 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
47 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
48 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
49 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
50 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
51 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
52 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
53 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
54 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
55 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
56 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
57 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
58 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
59 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
60 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
61 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to cholesterol. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to cholesterol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT127111 Regulation of Inhba 5 0.60 2.85 3.28
2 INT127108 Gene_expression of Inhba 12 0.65 3.21 2.48
3 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45
4 INT86147 Positive_regulation of Inhba 8 0.63 1.94 2.39
5 INT262117 Negative_regulation of Gene_expression of Cyp7a1 3 0.25 0.91 1.6
6 INT127110 Transcription of Inhba 3 0.58 1.44 1.59
7 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
8 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
9 INT20764 Localization of INHBA 3 0.71 0.94 1.22
10 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
11 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
12 INT20762 Negative_regulation of Localization of INHBA 1 0.03 0 1.15
13 INT20763 Positive_regulation of Localization of INHBA 1 0.03 0 0.96
14 INT334977 Regulation of Gene_expression of Cyp7a1 2 0.40 0.43 0.94
15 INT127109 Negative_regulation of Regulation of Inhba 1 0.38 0.5 0.88
16 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
17 INT20765 Negative_regulation of INHBA 6 0.34 1.91 0.77
18 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
19 INT197010 Positive_regulation of CYP7A1 4 0.47 1.75 0.7
20 INT229326 Negative_regulation of CYP7A1 3 0.29 1.03 0.7
21 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
22 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
23 INT262093 Positive_regulation of Gene_expression of Cyp7a1 2 0.44 0.81 0.55
24 INT127114 Regulation of Phosphorylation of Inhba 1 0.41 0.52 0.53
25 INT127107 Phosphorylation of Inhba 1 0.73 0.52 0.53
26 INT20766 Positive_regulation of INHBA 4 0.66 5.66 0.48
27 INT329888 Positive_regulation of Transcription of CYP7A1 1 0.20 0.9 0.46
28 INT229307 Positive_regulation of Negative_regulation of CYP7A1 1 0.31 0.1 0.43
29 INT176186 Negative_regulation of Cyp7a1 5 0.46 2.07 0.39
30 INT107108 Gene_expression of MLC1 2 0.65 1.25 0.36
31 INT176170 Regulation of Cyp7a1 2 0.21 0.5 0.32
32 INT335088 Regulation of Regulation of Cyp7a1 1 0.19 0.1 0.32
33 INT176200 Positive_regulation of Cyp7a1 2 0.37 0.4 0.31
34 INT184949 Positive_regulation of Gene_expression of Inhba 2 0.49 0.77 0.31
35 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
36 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
37 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
38 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
39 INT349713 Positive_regulation of Transcription of Inhba 1 0.56 0.18 0.23
40 INT329886 Transcription of CYP7A1 1 0.28 0.45 0.23
41 INT25579 Regulation of Regulation of Mlc1 1 0.26 0.09 0.22
42 INT25580 Regulation of Mlc1 1 0.26 0.09 0.22
43 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
44 INT19710 Phosphorylation of MLC1 6 0.80 1.52 0.15
45 INT173171 Gene_expression of CYP7A1 2 0.45 1.02 0.14
46 INT173188 Regulation of Gene_expression of CYP7A1 1 0.22 0.48 0.12
47 INT305022 Positive_regulation of Transcription of INHBA 1 0.34 0.76 0.1
48 INT305023 Transcription of INHBA 1 0.47 0.75 0.1
49 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
50 INT14863 Positive_regulation of Mlc1 2 0.04 0.09 0.09
51 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
52 INT222597 Localization of Inhba 1 0.08 0.07 0.09
53 INT184950 Negative_regulation of Inhba 1 0.41 0.74 0.09
54 INT180424 Negative_regulation of Mlc1 1 0.03 0 0.09
55 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
56 INT144314 Gene_expression of INHBA 16 0.73 12.29 0.08
57 INT201554 Positive_regulation of Gene_expression of INHBA 3 0.47 2.9 0.08
58 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
59 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
60 INT229319 Regulation of Positive_regulation of CYP7A1 1 0.30 0.42 0.08
61 INT222590 Regulation of Positive_regulation of Inhba 1 0.04 0 0.07
62 INT593 Binding of MLC1 1 0.36 0.35 0.07
63 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
64 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
65 INT345344 Regulation of SMO 1 0.23 1.07 0.06
66 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
67 INT241438 Negative_regulation of Phosphorylation of MLC1 1 0.41 0.65 0.05
68 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
69 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
70 INT229325 Positive_regulation of Gene_expression of CYP7A1 1 0.34 0.6 0.05
71 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
72 INT262772 Binding of SMO 1 0.27 0.59 0.05
73 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
74 INT262777 Localization of SMO 1 0.59 0.6 0.04
75 INT212398 Gene_expression of Mlc1 3 0.05 0.15 0.03
76 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
77 INT345480 Binding of CYP7A1 1 0.29 0 0.03
78 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
79 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
80 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
81 INT176172 Transcription of Cyp7a1 1 0.57 1.04 0
82 INT176179 Negative_regulation of Positive_regulation of Cyp7a1 1 0.34 0.4 0
83 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
84 INT187419 Regulation of CYP7A1 1 0.05 0.23 0
85 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
86 INT222623 Negative_regulation of Gene_expression of Inhba 1 0.06 0.08 0
87 INT260089 Localization of PTCH1 1 0.70 0.37 0
88 INT176215 Regulation of Transcription of Cyp7a1 1 0.49 0.79 0
89 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
90 INT222637 Regulation of Gene_expression of Inhba 1 0.06 0.06 0
91 INT222578 Positive_regulation of Localization of Inhba 1 0.05 0.07 0
92 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
93 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
94 INT222642 Binding of Inhba 1 0.05 0 0
95 INT279773 Regulation of INHBA 1 0.26 0.65 0
96 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
97 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
98 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
99 INT335873 Transcription of Lrp6 1 0.64 0.25 0
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