GO:0071469

From wiki-pain
Jump to: navigation, search
Name cellular response to alkalinity
Categary Process
Go Slim No
Go Link GO:0071469
Unique Molecular Interactions 207
Total Molecular Interactions 277
Total Single Events 1645
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to alkalinity. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to alkalinity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
3 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
4 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
5 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
6 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
7 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
8 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
9 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
10 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
11 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
12 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
13 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
14 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
15 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
16 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
17 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
18 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
19 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
20 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
21 INT159655 Binding of BDNF and INSRR 2 0.00 1.25 1.26
22 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
23 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
24 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
25 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
26 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
27 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
28 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
29 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
30 INT267886 Arl10 Positive_regulation of Insrr 1 0.00 0.07 0.98
31 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96
32 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92
33 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
34 INT151961 Rbm39 Positive_regulation of Insrr 1 0.17 0.26 0.89
35 INT60719 Insrr Positive_regulation of Fos 1 0.03 1.23 0.84
36 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
37 INT70058 Binding of Pnoc and Insrr 1 0.01 0.09 0.77
38 INT111904 Binding of Gabrg1 and Insrr 1 0.02 0 0.74
39 INT33479 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Insrr 1 0.17 0.15 0.73
40 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
41 INT70011 Binding of Hrh1 and Insrr 1 0.00 0.4 0.72
42 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
43 INT144459 Binding of GPM6A and INSRR 1 0.00 0 0.67
44 INT81407 Binding of Oprl1 and Insrr 1 0.02 0.13 0.66
45 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
46 INT267888 St13 Positive_regulation of Insrr 1 0.00 0.07 0.64
47 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
48 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
49 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
50 INT113163 Insrr Positive_regulation of Pscs 1 0.04 0 0.6
51 INT249029 Binding of Csn2 and Insrr 1 0.00 0 0.59
52 INT267887 St13 Positive_regulation of Localization of Insrr 1 0.00 0 0.58
53 INT81792 AGRP Negative_regulation of INSRR 3 0.01 0 0.55
54 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
55 INT267890 Arl10 Regulation of Insrr 1 0.00 0.43 0.54
56 INT85265 Binding of Il1rn and Insrr 1 0.01 0 0.54
57 INT267889 St13 Regulation of Insrr 1 0.00 0.43 0.54
58 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
59 INT151455 Binding of Insrr and Gtf3a 1 0.00 0.21 0.46
60 INT151456 Binding of KITLG and Insrr 1 0.00 0.21 0.46
61 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
62 INT126339 Pax3 Regulation of Insrr 1 0.00 0.56 0.44
63 INT126338 Insrr Regulation of Gene_expression of Ifng 1 0.00 0.56 0.43
64 INT60718 Negative_regulation of Insrr Positive_regulation of Fos 1 0.01 0.6 0.42
65 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
66 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
67 INT283842 Binding of hb and Insrr 1 0.01 1.35 0.38
68 INT70010 Binding of Neurod1 and Insrr 1 0.01 0.11 0.37
69 INT70009 Binding of Gabpb1 and Insrr 1 0.00 0.11 0.37
70 INT67288 Binding of Insrr and Positive_regulation of Localization of Abat 1 0.00 0.18 0.37
71 INT189687 INSRR Negative_regulation of Transcription of TERT 1 0.00 0.24 0.35
72 INT71518 Binding of INSRR and Nisch 1 0.00 0.22 0.35
73 INT136008 Binding of BDKRB2 and INSRR 1 0.01 0.17 0.34
74 INT136007 Binding of INSRR and KNG1 1 0.00 0.17 0.34
75 INT99676 Cck Positive_regulation of Insrr 1 0.11 0.07 0.33
76 INT283841 Dlg4 Negative_regulation of Insrr 1 0.01 0.95 0.33
77 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3
78 INT70184 INSRR Positive_regulation of FOS 1 0.03 0.09 0.29
79 INT334668 Gria2 Regulation of Gene_expression of Insrr 1 0.01 0.27 0.29
80 INT213802 Il4 Regulation of Gene_expression of Insrr 1 0.00 0.76 0.29
81 INT70186 PRCP Positive_regulation of INSRR 1 0.01 0.09 0.29
82 INT120236 Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28
83 INT274946 Binding of Pick1 and Insrr 1 0.00 0 0.28
84 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
85 INT120237 Positive_regulation of Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28
86 INT213808 Il12a Regulation of Gene_expression of Insrr 1 0.00 0.76 0.28
87 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
88 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
89 INT189692 INSRR Positive_regulation of PRKCA 1 0.00 0 0.24
90 INT50619 Positive_regulation of Insrr Positive_regulation of Fos 1 0.07 0 0.23
91 INT192331 UBR7 Negative_regulation of INSRR 1 0.00 0.54 0.23
92 INT267885 Binding of Insrr and St13 1 0.00 0.09 0.23
93 INT58579 Binding of INSRR and RPA1 1 0.00 0 0.18
94 INT263774 Neto1 Regulation of Insrr 1 0.00 0.28 0.18
95 INT127734 Binding of Insrr and Ogfr 1 0.01 0.35 0.17
96 INT94017 Binding of EDN3 and INSRR 1 0.03 0 0.16
97 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
98 INT224308 INSRR Regulation of VEGFA 1 0.00 1.42 0.16
99 INT94013 Positive_regulation of Binding of EDN2 and INSRR 1 0.04 0 0.16
100 INT94019 Positive_regulation of Binding of EDN3 and INSRR 1 0.04 0 0.16
101 INT58403 INSRR Negative_regulation of RTCA 1 0.00 0.06 0.15
102 INT189694 Negative_regulation of INSRR Negative_regulation of CHKB 1 0.00 0.07 0.15
103 INT189695 INSRR Negative_regulation of CHKB 1 0.00 0.07 0.15
104 INT316817 Ifnar1 Positive_regulation of Phosphorylation of Insrr 1 0.00 0.43 0.13
105 INT153028 Binding of INSRR and KCNMA1 1 0.06 0.29 0.1
106 INT153026 Binding of HTR3A and INSRR 1 0.13 0.29 0.1
107 INT143399 Binding of INSRR and NMU 1 0.01 0.12 0.09
108 INT119859 Gabbr1 Positive_regulation of INSRR 1 0.00 0 0.09
109 INT109465 Dmp1 Positive_regulation of Insrr 1 0.00 0 0.08
110 INT345370 Binding of Vegfa and Insrr 1 0.01 2.29 0.08
111 INT251775 AGK Negative_regulation of INSRR 1 0.00 1.1 0.07
112 INT223085 Binding of Pdgfb and Insrr 1 0.01 0.91 0.07
113 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
114 INT189679 INSRR Regulation of Transcription of TERT 1 0.00 1 0.05
115 INT71160 Positive_regulation of INSRR Positive_regulation of Binding of ANGPTL5 1 0.00 0.25 0
116 INT189678 Positive_regulation of CHKB Regulation of INSRR 1 0.00 0.06 0
117 INT189686 CHKB Regulation of Negative_regulation of INSRR 1 0.00 0.46 0
118 INT189705 INSRR Negative_regulation of Gene_expression of TERT 1 0.00 0.46 0
119 INT71159 Binding of INSRR and ANGPTL5 1 0.00 0.25 0
120 INT189697 INSRR Regulation of Gene_expression of TERT 1 0.00 0.46 0
121 INT202431 Binding of IGF2 and INSRR 1 0.01 0.85 0
122 INT189683 CHKB Negative_regulation of Negative_regulation of INSRR 1 0.00 0.46 0
123 INT189669 INSRR Regulation of TERT 1 0.00 0 0
124 INT102798 OPRM1 Regulation of INSRR 1 0.01 0 0
125 INT189672 Positive_regulation of INSRR Regulation of Transcription of TERT 1 0.00 0.23 0
126 INT189667 INSRR Regulation of CHKB 1 0.00 0.06 0
127 INT189706 CHKB Regulation of INSRR 1 0.00 0.06 0
128 INT114711 SRC Positive_regulation of Gene_expression of INSRR 1 0.01 0.51 0
129 INT189691 CHKB Negative_regulation of Positive_regulation of INSRR 1 0.00 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to alkalinity. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to alkalinity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
2 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
3 INT4153 Binding of Insrr 109 0.40 17.99 72.15
4 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
5 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
6 INT9781 Binding of INSRR 64 0.31 19.1 25.2
7 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52
8 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38
9 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05
10 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85
11 INT20999 Negative_regulation of Binding of Insrr 17 0.47 3.53 8.93
12 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88
13 INT12859 Localization of Insrr 16 0.32 2.68 8.07
14 INT62260 Negative_regulation of Gene_expression of Insrr 10 0.06 1.36 6.92
15 INT12632 Negative_regulation of Binding of INSRR 13 0.38 6.54 6.39
16 INT12631 Positive_regulation of Binding of INSRR 11 0.45 6.13 6.04
17 INT83056 Transcription of Insrr 11 0.11 2.43 5.11
18 INT12474 Regulation of INSRR 18 0.29 6.29 4.81
19 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24
20 INT25841 Regulation of Binding of Insrr 6 0.50 0.4 4.03
21 INT33332 Positive_regulation of Binding of Insrr 6 0.38 0.77 3.94
22 INT51178 Transcription of INSRR 9 0.17 2.09 3.09
23 INT33241 Localization of INSRR 10 0.10 1.24 3.08
24 INT95037 Negative_regulation of Regulation of Insrr 1 0.02 0 2.77
25 INT83058 Regulation of Positive_regulation of Insrr 2 0.11 0.66 2.31
26 INT51149 Positive_regulation of Gene_expression of INSRR 5 0.17 2.94 1.86
27 INT88518 Negative_regulation of Positive_regulation of INSRR 4 0.27 2.26 1.86
28 INT89652 Phosphorylation of INSRR 4 0.01 1.36 1.6
29 INT345367 Negative_regulation of Phosphorylation of Insrr 2 0.01 2.9 1.53
30 INT99694 Negative_regulation of Positive_regulation of Insrr 1 0.08 0.54 1.5
31 INT125855 Regulation of Negative_regulation of Insrr 1 0.01 0.26 1.45
32 INT16172 Protein_catabolism of Insrr 5 0.18 1.39 1.11
33 INT72590 Regulation of Binding of INSRR 1 0.15 1.79 1.02
34 INT79889 Positive_regulation of Gene_expression of Insrr 4 0.24 1.01 1.01
35 INT12858 Negative_regulation of Localization of Insrr 2 0.18 0.26 0.92
36 INT100097 Negative_regulation of Transcription of Insrr 3 0.03 0.24 0.8
37 INT83057 Regulation of Transcription of Insrr 1 0.04 0.09 0.71
38 INT163543 Positive_regulation of Localization of INSRR 1 0.03 0 0.68
39 INT89654 Positive_regulation of Negative_regulation of INSRR 2 0.01 0.37 0.49
40 INT267882 Positive_regulation of Phosphorylation of Insrr 2 0.01 0.71 0.32
41 INT99674 Regulation of Localization of Insrr 1 0.09 0.1 0.32
42 INT132488 Positive_regulation of Localization of Insrr 1 0.07 0.35 0.3
43 INT192345 Positive_regulation of Phosphorylation of INSRR 1 0.01 0.68 0.27
44 INT250992 Regulation of Gene_expression of INSRR 2 0.00 1.22 0.24
45 INT183683 Negative_regulation of Negative_regulation of Insrr 1 0.01 0.69 0.22
46 INT95659 Negative_regulation of Gene_expression of INSRR 1 0.02 0.51 0.13
47 INT189730 Negative_regulation of Negative_regulation of INSRR 3 0.01 0.09 0.03
48 INT261550 Regulation of Positive_regulation of INSRR 1 0.00 0 0.03
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox