GO:0071474

From wiki-pain
Jump to: navigation, search
Name cellular hyperosmotic response
Categary Process
Go Slim No
Go Link GO:0071474
Unique Molecular Interactions 128
Total Molecular Interactions 152
Total Single Events 1483
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular hyperosmotic response. They are ordered first by their pain relevance and then by number of times they were reported for cellular hyperosmotic response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
2 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
3 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
4 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
5 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
6 INT248172 Epo Regulation of Cysltr1 1 0.01 0.74 0.63
7 INT113338 Binding of EPO and KNCN 1 0.02 1.39 0.62
8 INT248170 Epo Regulation of Ltp 1 0.11 0.74 0.62
9 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52
10 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
11 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52
12 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48
13 INT341427 EPO Positive_regulation of BDNF 1 0.52 0.36 0.48
14 INT341426 EPO Regulation of NGF 1 0.51 0.5 0.47
15 INT341425 EPO Regulation of BDNF 1 0.51 0.5 0.47
16 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
17 INT133651 Epo Regulation of TNF 1 0.50 1.25 0.38
18 INT277985 Epo Positive_regulation of Epc1 1 0.03 1.36 0.36
19 INT305193 Binding of Epo and Cebpz 1 0.05 0.48 0.35
20 INT133653 Epo Regulation of Transcription of TNF 1 0.22 1.09 0.33
21 INT101219 TNF Negative_regulation of Gene_expression of EPO 1 0.47 2.8 0.3
22 INT139778 Binding of AQP1 and GBE1 1 0.00 0.22 0.3
23 INT101220 TNF Negative_regulation of EPO 1 0.48 2.8 0.3
24 INT305204 Pbrgcsf1 Positive_regulation of Gene_expression of Epo 1 0.27 0.6 0.27
25 INT336893 Epo Regulation of Epc2 1 0.00 0.69 0.23
26 INT58305 AQP1 Regulation of Localization of TNF 1 0.10 0.16 0.22
27 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 0.10 0.16 0.22
28 INT248171 Epo Regulation of Sult1a1 1 0.08 0.11 0.21
29 INT305203 Epo Positive_regulation of Gene_expression of Neurog1 1 0.06 0.4 0.21
30 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
31 INT12694 SMS Regulation of Localization of EPO 1 0.06 0 0.19
32 INT12692 C1QL1 Positive_regulation of Localization of EPO 1 0.15 0 0.17
33 INT12693 SST Negative_regulation of Localization of EPO 1 0.08 0 0.17
34 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
35 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
36 INT343484 Epo Regulation of Gene_expression of VEGFA 1 0.24 0.41 0.16
37 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
38 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
39 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14
40 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
41 INT352488 Binding of EPO and TNFRSF1A 1 0.14 0.18 0.12
42 INT305194 Bcl2 Positive_regulation of Epo 1 0.06 0.29 0.12
43 INT343472 Epo Positive_regulation of Gene_expression of Mmp2 1 0.15 0.62 0.12
44 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12
45 INT277986 Negative_regulation of Epo Positive_regulation of Localization of Cd34 1 0.08 0.77 0.12
46 INT327808 EPO Regulation of VEGFA 1 0.07 1.36 0.12
47 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11
48 INT148957 Binding of Epo and Epor 1 0.01 0.56 0.1
49 INT200811 Epo Positive_regulation of Akt1 2 0.30 1.77 0.09
50 INT343486 Epo Positive_regulation of Localization of VEGFA 1 0.25 0.41 0.09
51 INT343485 Epo Positive_regulation of Gene_expression of VEGFA 1 0.25 0.51 0.09
52 INT42586 EPO Regulation of POMC 1 0.02 0.19 0.09
53 INT315204 Binding of Epo and Nefh 1 0.26 1.01 0.09
54 INT349031 Epo Positive_regulation of Akt1 1 0.36 0.23 0.09
55 INT42587 EPO Regulation of GHRH 1 0.01 0.19 0.09
56 INT277835 EPO Positive_regulation of Localization of VEGFA 1 0.03 1.36 0.08
57 INT305205 Binding of Epo and Pbrgcsf1 1 0.14 0.23 0.07
58 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
59 INT343477 Epo Positive_regulation of Pdgfb 1 0.11 0.31 0.06
60 INT343479 Epo Positive_regulation of Fgf2 1 0.33 0.3 0.06
61 INT343480 Epo Positive_regulation of Mmp2 1 0.15 0.31 0.06
62 INT343471 Epo Positive_regulation of Gene_expression of Pdgfb 1 0.11 0.31 0.06
63 INT226043 Epo Positive_regulation of Ecm1 1 0.04 1.35 0.05
64 INT254161 Epo Positive_regulation of Nos2 1 0.37 0.54 0.05
65 INT254162 Epo Positive_regulation of NOS1 1 0.01 0.53 0.05
66 INT315206 Binding of Epo and Positive_regulation of Binding of Cnp 1 0.44 0.39 0.04
67 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04
68 INT200809 Binding of Akt1 and Epo 1 0.23 0.98 0.03
69 INT326046 Binding of Epo and Csf2 1 0.38 0.22 0.03
70 INT343487 Epo Positive_regulation of Gene_expression of EPOR 1 0.76 0.32 0.03
71 INT346331 Binding of Epo and Egf 1 0.19 0.1 0.03
72 INT326045 Epo Positive_regulation of Mki67 1 0.16 0.18 0.03
73 INT200814 Epo Positive_regulation of Lyn 1 0.36 1.42 0.03
74 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
75 INT343476 Epo Positive_regulation of Kdr 1 0.11 0.31 0.03
76 INT200820 Epo Positive_regulation of Src 1 0.25 1.41 0.03
77 INT343474 Epo Positive_regulation of Gene_expression of Kdr 1 0.11 0.32 0.03
78 INT336894 Binding of Epo and Epc2 1 0.00 0.55 0.03
79 INT343488 Epo Positive_regulation of EPOR 1 0.24 0.31 0.03
80 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
81 INT254089 EPO Regulation of Gene_expression of Bcl2 1 0.03 0.63 0
82 INT326047 Csf2 Regulation of Epo 1 0.29 0.22 0
83 INT241852 Binding of EPO and EPCAM 1 0.06 0.84 0
84 INT8771 EPO Positive_regulation of HBG1 1 0.52 0.73 0
85 INT326049 Csf2 Negative_regulation of Epo 1 0.46 0.25 0
86 INT343473 Epo Positive_regulation of Gene_expression of Akt1 1 0.45 0.05 0
87 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
88 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0
89 INT247575 Binding of Epo and Hif1a 1 0.09 1.24 0
90 INT220286 Epo Regulation of hb 1 0.23 0.21 0
91 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 0.03 0 0
92 INT273480 Binding of EPO and RNASEL 1 0.08 0.77 0
93 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
94 INT254090 EPO Negative_regulation of Gene_expression of Bax 1 0.10 0.63 0
95 INT98626 Aqp1 Positive_regulation of Aqp4 1 0.52 0 0
96 INT305201 Pbrgcsf1 Positive_regulation of Epo 1 0.18 0.07 0
97 INT254091 EPO Positive_regulation of Gene_expression of Bcl2l1 1 0.11 0.66 0
98 INT278760 EPO Positive_regulation of RAP1A 1 0.13 0.16 0
99 INT331117 EPO Positive_regulation of FXN 1 0.29 1.09 0
100 INT183750 Binding of EPO and TF 1 0.42 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular hyperosmotic response. They are ordered first by their pain relevance and then by number of times they were reported in cellular hyperosmotic response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
2 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66
3 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75
4 INT3098 Positive_regulation of Epo 46 0.70 28.27 7
5 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67
6 INT3738 Regulation of Epo 25 0.61 13.73 6.18
7 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
8 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
9 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
10 INT54895 Binding of Epo 24 0.48 11.38 4.48
11 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
12 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
13 INT53065 Negative_regulation of Gene_expression of EPO 15 0.49 16.39 3.12
14 INT45503 Binding of EPO 42 0.48 24.85 2.88
15 INT8112 Regulation of EPO 38 0.58 22.04 2.76
16 INT8111 Localization of EPO 32 0.81 19.53 2.54
17 INT45597 Negative_regulation of Epo 22 0.59 12.47 2.35
18 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15
19 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
20 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
21 INT11905 Protein_catabolism of EPO 6 1.00 2.36 2
22 INT178030 Localization of Epo 11 0.78 6.03 1.86
23 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84
24 INT55479 Localization of Epo 13 0.81 6.1 1.53
25 INT178029 Gene_expression of Epo 25 0.76 14.98 1.46
26 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45
27 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41
28 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
29 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
30 INT60685 Positive_regulation of Gene_expression of Epo 21 0.53 15.86 1.25
31 INT178023 Regulation of Epo 11 0.45 3.87 1.22
32 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99
33 INT178026 Positive_regulation of Epo 12 0.70 8.14 0.95
34 INT53066 Positive_regulation of Positive_regulation of EPO 4 0.49 2.38 0.95
35 INT94565 Regulation of Regulation of Epo 1 0.07 0.14 0.95
36 INT183362 Regulation of AQP1 3 0.23 1.49 0.92
37 INT54896 Positive_regulation of Binding of Epo 1 0.49 0.24 0.75
38 INT52345 Regulation of Gene_expression of Epo 4 0.45 2.07 0.61
39 INT106020 Transcription of EPO 8 0.71 9.34 0.6
40 INT248166 Protein_catabolism of Epo 1 0.89 0.71 0.59
41 INT139780 Binding of AQP1 7 0.32 4.62 0.54
42 INT118607 Positive_regulation of Positive_regulation of Epo 4 0.50 3.67 0.5
43 INT67068 Positive_regulation of Protein_catabolism of EPO 1 0.47 0 0.49
44 INT19592 Localization of AQP1 4 0.81 1.09 0.44
45 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44
46 INT47415 Transcription of Epo 3 0.67 1.42 0.41
47 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
48 INT241717 Regulation of Localization of Epo 1 0.10 0.55 0.37
49 INT12697 Negative_regulation of Localization of EPO 2 0.58 1.35 0.35
50 INT226037 Binding of Epo 5 0.36 2.99 0.32
51 INT106482 Negative_regulation of Gene_expression of Epo 3 0.07 10.96 0.31
52 INT55478 Regulation of Localization of Epo 3 0.62 0.48 0.31
53 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
54 INT288613 Regulation of Transcription of EPO 1 0.41 1.01 0.21
55 INT56199 Negative_regulation of Positive_regulation of EPO 3 0.37 2.44 0.2
56 INT273491 Negative_regulation of Transcription of EPO 1 0.58 4.29 0.2
57 INT104568 Negative_regulation of Localization of Aqp1 1 0.36 2.47 0.2
58 INT248169 Positive_regulation of Transcription of Epo 1 0.50 0 0.19
59 INT248165 Transcription of Epo 1 0.69 0 0.19
60 INT349030 Regulation of Binding of Epo 1 0.39 0.12 0.19
61 INT200796 Negative_regulation of Epo 7 0.43 3.22 0.18
62 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17
63 INT98625 Regulation of Aqp1 1 0.27 0.1 0.17
64 INT136021 Positive_regulation of Localization of EPO 2 0.23 1.63 0.14
65 INT59286 Regulation of Gene_expression of EPO 7 0.62 6.13 0.13
66 INT228608 Positive_regulation of Gene_expression of Epo 5 0.68 2.85 0.13
67 INT127987 Regulation of Binding of EPO 3 0.45 0.6 0.1
68 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1
69 INT159343 Positive_regulation of Localization of AQP1 1 0.11 0 0.1
70 INT46823 Regulation of Regulation of EPO 1 0.23 0.44 0.09
71 INT343457 Regulation of Binding of Epo 1 0.44 0 0.09
72 INT327827 Negative_regulation of Gene_expression of Aqp1 1 0.45 0.8 0.08
73 INT262510 Regulation of Gene_expression of Aqp1 1 0.33 1.18 0.07
74 INT130942 Positive_regulation of Regulation of EPO 1 0.47 0.54 0.07
75 INT226039 Positive_regulation of Positive_regulation of Epo 1 0.45 1.38 0.04
76 INT220284 Phosphorylation of Epo 2 0.63 1.2 0.03
77 INT241860 Positive_regulation of Transcription of EPO 3 0.55 4 0
78 INT116425 Phosphorylation of EPO 2 0.78 0.63 0
79 INT262504 Positive_regulation of Aqp1 1 0.25 0.43 0
80 INT241316 Positive_regulation of Binding of EPO 1 0.44 0 0
81 INT286264 Positive_regulation of Negative_regulation of AQP1 1 0.01 0.79 0
82 INT262513 Negative_regulation of Binding of Aqp1 1 0.23 0.64 0
83 INT325779 Positive_regulation of Phosphorylation of EPO 1 0.48 0.2 0
84 INT262514 Binding of Aqp1 1 0.20 0.64 0
85 INT299193 Transcription of Aqp1 1 0.56 0.62 0
86 INT318168 Positive_regulation of Localization of Epo 1 0.01 1.54 0
87 INT262511 Positive_regulation of Gene_expression of Aqp1 1 0.37 1.78 0
88 INT327782 Regulation of Gene_expression of AQP1 1 0.36 1.63 0
89 INT228609 Negative_regulation of Localization of Epo 1 0.42 0.62 0
90 INT262512 Localization of Aqp1 1 0.40 0.7 0
91 INT273490 Regulation of Localization of EPO 1 0.45 0.76 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox