GO:0071476

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Name cellular hypotonic response
Categary Process
Go Slim No
Go Link GO:0071476
Unique Molecular Interactions 99
Total Molecular Interactions 154
Total Single Events 1312
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular hypotonic response. They are ordered first by their pain relevance and then by number of times they were reported for cellular hypotonic response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
2 INT59606 Binding of Tspo and Penk 1 0.04 0 1.12
3 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
4 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
5 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
6 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
7 INT310348 Binding of Tspo and Gabrd 1 0.00 0.43 0.88
8 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
9 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
10 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
11 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
12 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
13 INT69280 Negative_regulation of Binding of TSPO and Gabrg1 1 0.00 1.03 0.63
14 INT69278 Binding of TSPO and Gabrg1 1 0.00 1.01 0.62
15 INT152766 TAT Positive_regulation of Positive_regulation of MYLK 1 0.44 0.67 0.61
16 INT152765 TAT Regulation of Positive_regulation of MYLK 1 0.40 0.66 0.6
17 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
18 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
19 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
20 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
21 INT52632 Binding of TSPO and CCK 1 0.15 0.53 0.37
22 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
23 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
24 INT284689 Binding of Tspo and Map3k12 1 0.00 0.59 0.32
25 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3
26 INT158922 Positive_regulation of Binding of TSPO and Tspo 1 0.54 0.83 0.28
27 INT221918 TRPV4 Positive_regulation of TRPM8 1 0.05 0 0.28
28 INT158923 Binding of TSPO and Tspo 1 0.40 0.82 0.28
29 INT322132 Binding of Mbp and Trpv4 1 0.11 0.39 0.27
30 INT309751 Binding of CA2 and TRPV4 1 0.08 0 0.23
31 INT118435 HGF Positive_regulation of TRPV4 1 0.54 0.13 0.2
32 INT291798 Binding of CALM1 and Positive_regulation of MYLK 1 0.09 0.33 0.19
33 INT291797 Binding of CA2 and Positive_regulation of MYLK 1 0.15 0.33 0.19
34 INT142227 Urb1 Regulation of Trpv4 1 0.02 0.1 0.17
35 INT142229 Trpa1 Regulation of Trpv4 1 0.15 0.1 0.17
36 INT191336 Binding of TSPO and GOPC 1 0.01 0.65 0.16
37 INT191338 Binding of TSPO and IDO1 1 0.02 0.65 0.16
38 INT137672 Baa1 Positive_regulation of Trpv4 1 0.17 0 0.11
39 INT164060 MYLK Positive_regulation of EFS 1 0.08 0.08 0.1
40 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1
41 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1
42 INT309724 Regulation of Binding of TYRP1 and TRPV4 1 0.01 0 0.09
43 INT309754 Binding of TYRP1 and TRPV4 1 0.02 0 0.09
44 INT309722 TRPV4 Positive_regulation of CA2 1 0.11 0 0.08
45 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07
46 INT196124 Trpm5 Negative_regulation of Trpv4 1 0.13 0.08 0.06
47 INT196134 Gopc Negative_regulation of Trpv4 1 0.07 0.08 0.06
48 INT196126 Gopc Negative_regulation of Gene_expression of Trpv4 1 0.15 0.08 0.06
49 INT309732 CALM3 Positive_regulation of Gene_expression of TRPV4 1 0.14 0 0.06
50 INT196131 Trpm7 Negative_regulation of Trpv4 1 0.14 0.08 0.06
51 INT196130 Trpm5 Negative_regulation of Gene_expression of Trpv4 1 0.30 0.08 0.06
52 INT196129 Trpm7 Negative_regulation of Gene_expression of Trpv4 1 0.32 0.08 0.06
53 INT322130 Trpv1 Positive_regulation of Positive_regulation of Trpv4 1 0.15 0.1 0.05
54 INT333034 Trpv4 Positive_regulation of Localization of Car2 1 0.06 0 0.05
55 INT348715 Positive_regulation of Binding of Ca2 and Mylk 1 0.02 0.47 0.05
56 INT348716 Binding of Ca2 and Mylk 1 0.02 0.47 0.05
57 INT169403 Binding of TRPV1 and Trpv4 1 0.23 0.94 0.05
58 INT333032 Binding of Trpv4 and Gopc 1 0.05 0 0.04
59 INT241253 Gene_expression of Trpv4 Positive_regulation of Gene_expression of Pkd2 1 0.52 0.29 0.03
60 INT333037 Binding of Agt and Trpv4 1 0.09 0 0.03
61 INT309744 Binding of GOPC and TRPV4 1 0.09 0 0
62 INT322126 Binding of Trpv4 and Fig4 1 0.02 0 0
63 INT333035 Positive_regulation of Binding of Agt and Trpv4 1 0.11 0 0
64 INT309745 Negative_regulation of Binding of CALM3 and TRPV4 1 0.12 0 0
65 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
66 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
67 INT333036 Trpv4 Positive_regulation of Gene_expression of Agt 1 0.12 0 0
68 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0
69 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0
70 INT321882 Binding of TSPO and Lm370 1 0.01 0.4 0
71 INT169448 Binding of Prkce and Trpv4 1 0.04 0.08 0
72 INT162407 TNF Positive_regulation of Gene_expression of TRPV4 1 0.47 0.22 0
73 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0
74 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0
75 INT343161 ACSL4 Regulation of Gene_expression of TSPO 1 0.25 0.75 0
76 INT309736 PACSIN3 Regulation of TRPV4 1 0.55 0 0
77 INT333044 Positive_regulation of Binding of AGTR1 and Trpv4 1 0.48 0 0
78 INT309728 TRPV4 Positive_regulation of CFP 1 0.10 0 0
79 INT193147 CRAMP1L Regulation of TSPO 1 0.01 0.27 0
80 INT164929 Binding of Calca and Trpv4 1 0.32 0 0
81 INT343156 Binding of TSPO and DBI 1 0.04 0.63 0
82 INT219502 TSPO Positive_regulation of Positive_regulation of Ppib 1 0.01 0 0
83 INT333038 Agt Positive_regulation of Positive_regulation of Trpv4 1 0.12 0 0
84 INT333043 Binding of AGTR1 and Trpv4 1 0.50 0 0
85 INT219424 Binding of AHR and TSPO 1 0.01 0 0
86 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular hypotonic response. They are ordered first by their pain relevance and then by number of times they were reported in cellular hypotonic response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
2 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
3 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
4 INT18088 Binding of Tspo 26 0.48 9.12 10.2
5 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02
6 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
7 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05
8 INT6335 Binding of TSPO 39 0.44 10.88 7.66
9 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
10 INT14258 Regulation of TSPO 32 0.60 10.16 6.24
11 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
12 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
13 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
14 INT7841 Gene_expression of Tspo 10 0.75 7.63 4.45
15 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
16 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58
17 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
18 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
19 INT25745 Regulation of Tspo 6 0.45 0.25 3.1
20 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
21 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
22 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
23 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
24 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
25 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
26 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
27 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
28 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
29 INT74131 Positive_regulation of Tspo 7 0.50 0.92 2.11
30 INT14257 Localization of TSPO 9 0.73 1.48 1.87
31 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
32 INT19576 Negative_regulation of Tspo 3 0.42 1.02 1.75
33 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
34 INT91739 Positive_regulation of MYLK 9 0.54 2.89 1.58
35 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
36 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23
37 INT181497 Regulation of Regulation of TRPV4 1 0.23 0.69 1.08
38 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07
39 INT284686 Positive_regulation of Gene_expression of Tspo 1 0.66 2.55 0.9
40 INT6806 Localization of Tspo 3 0.70 0 0.82
41 INT156175 Positive_regulation of Positive_regulation of Trpv4 5 0.50 0.86 0.8
42 INT158547 Negative_regulation of Positive_regulation of Trpv4 2 0.57 0.47 0.77
43 INT263225 Positive_regulation of Positive_regulation of Trpv4 3 0.46 0.75 0.7
44 INT69003 Negative_regulation of Binding of TSPO 4 0.03 2.78 0.69
45 INT156302 Positive_regulation of Phosphorylation of Trpv4 2 0.46 0.92 0.68
46 INT191341 Negative_regulation of Gene_expression of TSPO 3 0.34 1.66 0.64
47 INT156303 Regulation of Regulation of Trpv4 2 0.27 0.26 0.63
48 INT73850 Transcription of TSPO 6 0.59 0.83 0.61
49 INT204138 Regulation of Gene_expression of TSPO 2 0.36 0.99 0.6
50 INT120054 Regulation of Gene_expression of Tspo 2 0.44 0.97 0.59
51 INT158548 Regulation of Gene_expression of Trpv4 3 0.61 1.03 0.57
52 INT125188 Negative_regulation of Transcription of Trpv4 3 0.42 0.44 0.56
53 INT178718 Phosphorylation of TSPO 1 0.79 0.91 0.56
54 INT178717 Negative_regulation of Localization of TSPO 1 0.41 0.92 0.56
55 INT73849 Negative_regulation of TSPO 8 0.59 2.4 0.53
56 INT263224 Phosphorylation of Trpv4 2 0.76 0.73 0.49
57 INT205265 Regulation of Transcription of TSPO 1 0.21 0.13 0.49
58 INT137671 Negative_regulation of Positive_regulation of Trpv4 3 0.58 0.25 0.48
59 INT61831 Regulation of Regulation of TSPO 1 0.03 0.16 0.43
60 INT212307 Regulation of Gene_expression of Trpv4 8 0.44 2.85 0.39
61 INT135139 Regulation of Positive_regulation of Tspo 1 0.05 0.17 0.37
62 INT33569 Gene_expression of MYLK 6 0.25 2.56 0.34
63 INT111674 Phosphorylation of MYLK 3 0.81 0.35 0.33
64 INT146646 Protein_catabolism of TSPO 3 0.86 0.58 0.32
65 INT8449 Positive_regulation of Phosphorylation of Mylk 1 0.05 0.16 0.3
66 INT8448 Phosphorylation of Mylk 1 0.07 0.16 0.3
67 INT24992 Regulation of Mylk 2 0.20 0.4 0.26
68 INT118446 Positive_regulation of Transcription of TRPV4 1 0.49 0.26 0.21
69 INT118447 Transcription of TRPV4 1 0.67 0.26 0.21
70 INT156172 Transcription of Trpv4 3 0.72 1.19 0.19
71 INT209259 Regulation of Gene_expression of TRPV4 1 0.22 0.93 0.19
72 INT322153 Positive_regulation of Binding of Trpv4 1 0.49 0 0.18
73 INT162409 Positive_regulation of Gene_expression of TRPV4 2 0.45 0 0.16
74 INT164831 Negative_regulation of Mylk 1 0.49 0.07 0.15
75 INT333015 Regulation of Binding of Trpv4 1 0.42 0.43 0.13
76 INT73848 Positive_regulation of Transcription of TSPO 3 0.42 0.58 0.1
77 INT156173 Positive_regulation of Transcription of Trpv4 1 0.61 0.43 0.1
78 INT173322 Negative_regulation of Gene_expression of MYLK 1 0.14 0.14 0.09
79 INT309764 Regulation of Binding of TRPV4 1 0.36 0 0.08
80 INT173327 Positive_regulation of Gene_expression of MYLK 1 0.22 0.24 0.07
81 INT348719 Positive_regulation of Mylk 1 0.20 0.4 0.05
82 INT348722 Positive_regulation of Positive_regulation of Mylk 1 0.13 0.42 0.05
83 INT269650 Positive_regulation of Phosphorylation of MYLK 1 0.24 0.08 0.04
84 INT333013 Positive_regulation of Protein_catabolism of Trpv4 1 0.43 0 0
85 INT333010 Positive_regulation of Binding of Trpv4 1 0.47 0 0
86 INT158549 Negative_regulation of Transcription of Trpv4 1 0.42 0 0
87 INT156298 Negative_regulation of Phosphorylation of Trpv4 1 0.43 0.14 0
88 INT322151 Positive_regulation of Localization of Trpv4 1 0.49 0.31 0
89 INT333022 Positive_regulation of Phosphorylation of Trpv4 1 0.47 0 0
90 INT333018 Positive_regulation of Negative_regulation of Trpv4 1 0.43 0 0
91 INT333016 Protein_catabolism of Trpv4 1 0.93 0 0
92 INT333026 Regulation of Localization of Trpv4 1 0.42 0 0
93 INT311856 Positive_regulation of Positive_regulation of MYLK 1 0.01 0.18 0
94 INT309763 Localization of TRPV4 1 0.60 0 0
95 INT180906 Negative_regulation of Positive_regulation of TSPO 1 0.50 0 0
96 INT333027 Negative_regulation of Binding of Trpv4 1 0.40 0 0
97 INT158546 Regulation of Transcription of Trpv4 1 0.45 0.17 0
98 INT333017 Negative_regulation of Localization of Trpv4 1 0.40 0 0
99 INT309758 Negative_regulation of Gene_expression of TRPV4 1 0.34 0 0
100 INT274728 Regulation of Binding of TSPO 1 0.02 0 0
101 INT293972 Positive_regulation of Binding of TSPO 1 0.04 1.01 0
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