GO:0071479

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Name cellular response to ionizing radiation
Categary Process
Go Slim No
Go Link GO:0071479
Unique Molecular Interactions 719
Total Molecular Interactions 888
Total Single Events 6911
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to ionizing radiation. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to ionizing radiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
3 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
4 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
5 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
6 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
7 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5
8 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
9 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
10 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
11 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
12 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
13 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
14 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
15 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
16 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
17 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
18 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
19 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
20 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
21 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
22 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
23 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
24 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
25 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
26 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
27 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
28 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
29 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
30 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
31 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
32 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
33 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
34 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
35 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
36 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
37 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
38 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
39 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
40 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
41 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
42 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
43 INT210801 Bst2 Positive_regulation of Net1 1 0.35 0.54 0.89
44 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88
45 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
46 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
47 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
48 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
49 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
50 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
51 INT128590 Mapk14 Regulation of Nav1 1 0.21 0.25 0.82
52 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8
53 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
54 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79
55 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
56 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
57 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
58 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
59 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
60 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75
61 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
62 INT164783 Positive_regulation of Mapk14 Regulation of Gene_expression of Cx3cr1 1 0.19 0.81 0.68
63 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
64 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
65 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
66 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
67 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
68 INT166299 Binding of Mapk14 and Gpbar1 1 0.13 0.64 0.65
69 INT166302 Negative_regulation of Binding of Mapk14 and Gpbar1 1 0.12 0.64 0.65
70 INT288202 Negative_regulation of Cd14 Positive_regulation of Positive_regulation of Mapk14 1 0.09 1.08 0.64
71 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
72 INT223155 Binding of Mapk14 and Stat4 1 0.36 0.84 0.63
73 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
74 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
75 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
76 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
77 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
78 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
79 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61
80 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
81 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61
82 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
83 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61
84 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
85 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
86 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57
87 INT110032 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il12a 1 0.36 0 0.57
88 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
89 INT196585 Mapk14 Regulation of TNF 1 0.02 0.36 0.55
90 INT328744 TNF Regulation of Positive_regulation of Mapk14 1 0.02 0.81 0.55
91 INT248997 Gabrg1 Positive_regulation of Clock 1 0.37 0 0.54
92 INT248995 Gabrg1 Regulation of Transcription of Clock 1 0.36 0 0.54
93 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
94 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54
95 INT249016 Gabrg1 Positive_regulation of Transcription of Clock 1 0.37 0 0.54
96 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
97 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
98 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5
99 INT313376 Cnr1 Positive_regulation of Phosphorylation of Mapk14 1 0.20 0.38 0.5
100 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
101 INT313375 Cnr2 Positive_regulation of Phosphorylation of Mapk14 1 0.18 0.39 0.5
102 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
103 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
104 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
105 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
106 INT131504 Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.14 0.2 0.47
107 INT131507 Ngf Positive_regulation of Mapk14 1 0.13 0.2 0.47
108 INT265646 Binding of Mapk1 and Mapk14 1 0.01 1.53 0.46
109 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
110 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
111 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46
112 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46
113 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
114 INT313378 Trib3 Regulation of Phosphorylation of Mapk14 1 0.01 0.37 0.44
115 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43
116 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
117 INT249011 Gabrg1 Regulation of Clock 1 0.19 0 0.43
118 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
119 INT124088 Rab38 Negative_regulation of Mapk14 1 0.00 0.89 0.42
120 INT331799 IL8 Negative_regulation of Mapk14 1 0.01 1.6 0.42
121 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
122 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41
123 INT95402 Mapk14 Regulation of Positive_regulation of Trib3 1 0.06 0.19 0.41
124 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
125 INT152241 Mapk14 Positive_regulation of Localization of Nfkb1 1 0.25 0.13 0.39
126 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
127 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37
128 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37
129 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
130 INT249004 Helt Regulation of Clock 1 0.01 0.09 0.37
131 INT249015 Regulation of Helt Regulation of Clock 1 0.01 0.09 0.37
132 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37
133 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
134 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
135 INT223874 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Ltp 1 0.13 0 0.34
136 INT346228 MAP2K6 Positive_regulation of Positive_regulation of MAPK14 1 0.44 0.68 0.34
137 INT346229 PREP Positive_regulation of MAPK14 1 0.13 0.63 0.34
138 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
139 INT346236 Binding of MAPK14 and MAP2K6 1 0.32 0.65 0.33
140 INT302830 Mapk14 Regulation of Mapkapk5 1 0.12 0.53 0.33
141 INT346231 Binding of MAPK14 and MAP2K3 1 0.33 0.65 0.33
142 INT297972 MAPK14 Negative_regulation of ING5 1 0.21 1.67 0.33
143 INT255944 MAPK14 Positive_regulation of Tauph 1 0.00 0.1 0.32
144 INT259639 MAPK14 Regulation of Gene_expression of IL8 1 0.02 1.2 0.32
145 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
146 INT255945 MAPK14 Positive_regulation of Rps6ka5 1 0.06 0.1 0.32
147 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
148 INT346235 IL1B Positive_regulation of Gene_expression of MAPK14 1 0.15 0.64 0.32
149 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
150 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
151 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
152 INT288198 Binding of Tlr4 and Mapk14 1 0.01 0.63 0.31
153 INT288203 Binding of Cd14 and Mapk14 1 0.08 0.63 0.31
154 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
155 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
156 INT112799 Positive_regulation of CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.3
157 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
158 INT167982 Mapk14 Negative_regulation of gr 1 0.02 0.45 0.29
159 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
160 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
161 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
162 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
163 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
164 INT196584 Binding of Mapk14 and NeuN 1 0.02 0.39 0.27
165 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
166 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
167 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
168 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
169 INT123663 F2R Positive_regulation of MAPK14 1 0.12 0.42 0.26
170 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
171 INT123662 Negative_regulation of F2R Positive_regulation of MAPK14 1 0.08 0.42 0.26
172 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
173 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
174 INT123661 COL7A1 Positive_regulation of MAPK14 1 0.08 0.42 0.26
175 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
176 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
177 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
178 INT270216 Mapk14 Positive_regulation of Mknk1 1 0.10 0.5 0.26
179 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
180 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
181 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
182 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25
183 INT312546 Ros1 Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.87 0.25
184 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
185 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
186 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24
187 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
188 INT179230 Binding of MAPK14 and GSR 1 0.03 0.5 0.23
189 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
190 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
191 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
192 INT112794 CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.23
193 INT327313 Positive_regulation of Mapk14 Positive_regulation of Phosphorylation of Khsrp 1 0.09 0.24 0.22
194 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
195 INT112793 IL4I1 Positive_regulation of Positive_regulation of MAPK14 1 0.04 0 0.22
196 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
197 INT297965 MAPK14 Negative_regulation of GADD45A 1 0.05 1 0.21
198 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
199 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
200 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to ionizing radiation. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to ionizing radiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
2 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
3 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
4 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
5 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
6 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
7 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
8 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
9 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
10 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
11 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
12 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
13 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
14 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
15 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
16 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
17 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
18 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
19 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
20 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
21 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
22 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
23 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
24 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
25 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
26 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
27 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
28 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
29 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
30 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04
31 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
32 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
33 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
34 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
35 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
36 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
37 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
38 INT159518 Gene_expression of Clock 4 0.35 2.34 6.91
39 INT170385 Regulation of Clock 29 0.49 4.95 6.39
40 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
41 INT128587 Localization of Mapk14 15 0.81 8.41 6.1
42 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
43 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
44 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
45 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
46 INT60585 Regulation of TP53 59 0.59 54.55 5.21
47 INT176524 Binding of Mapk14 19 0.43 12.54 5.21
48 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03
49 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
50 INT171472 Binding of Mapk14 10 0.36 6.79 4.83
51 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
52 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
53 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
54 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
55 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
56 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
57 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21
58 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
59 INT131782 Regulation of Positive_regulation of Mapk14 7 0.43 2.68 4.02
60 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86
61 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
62 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
63 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
64 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
65 INT8103 Binding of TP53 46 0.44 40.2 2.96
66 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
67 INT155453 Protein_catabolism of Mapk14 6 0.36 4.24 2.85
68 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
69 INT96901 Regulation of Negative_regulation of Mapk14 3 0.45 4.07 2.79
70 INT351263 Binding of CLOCK 1 0.18 0.46 2.71
71 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
72 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
73 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
74 INT55952 Transcription of TP53 16 0.61 12.14 2.36
75 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
76 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
77 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
78 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
79 INT65855 Localization of TP53 18 0.76 17.08 1.89
80 INT240058 Gene_expression of RHOB 2 0.55 4.29 1.84
81 INT170387 Transcription of Clock 11 0.63 1.78 1.83
82 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
83 INT118907 Negative_regulation of Negative_regulation of Mapk14 2 0.57 2.09 1.77
84 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74
85 INT168686 Transcription of Mapk14 6 0.52 2.96 1.67
86 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
87 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
88 INT240059 Binding of RHOB 7 0.48 3.96 1.59
89 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
90 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
91 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
92 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
93 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
94 INT149815 Positive_regulation of Gene_expression of Clock 7 0.46 0.87 1.45
95 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
96 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
97 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
98 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
99 INT172953 Binding of Trp53 33 0.37 20.76 1.41
100 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
101 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
102 INT248976 Positive_regulation of Clock 8 0.48 0.15 1.38
103 INT145221 Binding of Tp53 10 0.37 8.59 1.37
104 INT202365 Regulation of Gene_expression of Mapk14 6 0.45 4.89 1.26
105 INT112823 Negative_regulation of Positive_regulation of MAPK14 5 0.36 1.49 1.22
106 INT174156 Localization of Trp53 16 0.72 13.52 1.18
107 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
108 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
109 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
110 INT126525 Regulation of Negative_regulation of Mapk14 2 0.41 0.81 1.11
111 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
112 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
113 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
114 INT124090 Gene_expression of Gadd45a 9 0.63 3.25 0.99
115 INT178391 Localization of Mapk14 9 0.68 5.27 0.97
116 INT145028 Positive_regulation of Localization of Mapk14 2 0.20 0.85 0.96
117 INT352919 Positive_regulation of Gene_expression of RHOB 1 0.35 2.21 0.96
118 INT231494 Regulation of Phosphorylation of Mapk14 2 0.24 2.59 0.93
119 INT351266 Regulation of Binding of CLOCK 1 0.21 0 0.92
120 INT194875 Regulation of Negative_regulation of MAPK14 1 0.04 2.39 0.91
121 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
122 INT175747 Regulation of CLOCK 4 0.21 0.06 0.84
123 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
124 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
125 INT219268 Negative_regulation of Negative_regulation of Mapk14 2 0.38 0.99 0.8
126 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
127 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
128 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
129 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
130 INT248971 Binding of Clock 8 0.34 1.12 0.73
131 INT124093 Negative_regulation of Gene_expression of Gadd45a 2 0.35 1.52 0.71
132 INT314190 Negative_regulation of Localization of Mapk14 1 0.36 0.91 0.69
133 INT139840 Positive_regulation of Negative_regulation of MAPK14 2 0.21 1.55 0.67
134 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
135 INT248978 Localization of Clock 1 0.70 0.3 0.61
136 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
137 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
138 INT209936 Negative_regulation of Gene_expression of MAPK14 7 0.20 4.95 0.53
139 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
140 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
141 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
142 INT121027 Regulation of Phosphorylation of MAPK14 2 0.38 1.1 0.46
143 INT204005 Negative_regulation of Gene_expression of Clock 3 0.39 0.58 0.45
144 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
145 INT173625 Positive_regulation of Localization of MAPK14 3 0.17 1.05 0.44
146 INT179170 Protein_catabolism of MAPK14 3 0.43 0.88 0.43
147 INT231499 Positive_regulation of Negative_regulation of Mapk14 3 0.24 1.58 0.43
148 INT304572 Regulation of Binding of Clock 1 0.30 0.29 0.43
149 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
150 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
151 INT255902 Positive_regulation of Binding of MAPK14 1 0.17 0.93 0.42
152 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
153 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
154 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
155 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
156 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
157 INT196973 Regulation of Gene_expression of Clock 12 0.38 3.58 0.38
158 INT114740 Binding of GRB2 8 0.36 2.24 0.37
159 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
160 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
161 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
162 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
163 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
164 INT191211 Gene_expression of GRB2 5 0.62 0.96 0.32
165 INT207377 Positive_regulation of Regulation of Mapk14 1 0.20 0.67 0.32
166 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
167 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
168 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
169 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
170 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
171 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
172 INT301057 Regulation of Transcription of Mapk14 1 0.25 0.5 0.29
173 INT188074 Gene_expression of GADD45A 12 0.65 5.11 0.28
174 INT255923 Positive_regulation of Regulation of MAPK14 1 0.17 0.41 0.28
175 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
176 INT240034 Phosphorylation of GRB2 3 0.79 1.79 0.25
177 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
178 INT345923 Positive_regulation of Transcription of Mapk14 1 0.07 0.41 0.25
179 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
180 INT228124 Positive_regulation of Bbc3 3 0.49 2.29 0.24
181 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
182 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
183 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
184 INT282970 Gene_expression of Bbc3 2 0.02 2.83 0.2
185 INT304145 Phosphorylation of Grb2 1 0.03 0.72 0.2
186 INT222020 Positive_regulation of Gadd45a 1 0.47 0.38 0.19
187 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
188 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
189 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
190 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
191 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
192 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
193 INT267610 Negative_regulation of Negative_regulation of MAPK14 1 0.03 1.08 0.15
194 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
195 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
196 INT222021 Positive_regulation of Gene_expression of Gadd45a 3 0.47 1.29 0.14
197 INT250776 Protein_catabolism of Mapk14 3 0.52 1.04 0.14
198 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
199 INT290777 Phosphorylation of Clock 1 0.42 0.41 0.14
200 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
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