GO:0071504

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Name cellular response to heparin
Categary Process
Go Slim No
Go Link GO:0071504
Unique Molecular Interactions 98
Total Molecular Interactions 128
Total Single Events 1351
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to heparin. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to heparin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11
2 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
3 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
4 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
5 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
6 INT61862 Slc3a1 Positive_regulation of Egr1 1 0.05 0 0.92
7 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
8 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
9 INT92026 Egr1 Positive_regulation of Fos 1 0.50 0.61 0.67
10 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
11 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
12 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
13 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
14 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
15 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
16 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
17 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
18 INT90722 Nr4a1 Positive_regulation of Egr1 1 0.20 0.48 0.35
19 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
20 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
21 INT90724 Egr3 Positive_regulation of Egr1 1 0.33 0.48 0.35
22 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
23 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
24 INT74334 Penk Regulation of Transcription of Egr1 1 0.40 0.25 0.29
25 INT74336 Crh Regulation of Transcription of Egr1 1 0.49 0.24 0.28
26 INT147356 Egr1 Positive_regulation of Gene_expression of Btg1 1 0.14 1.56 0.28
27 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
28 INT147358 Egr1 Positive_regulation of Gene_expression of Gdf15 1 0.14 1.56 0.28
29 INT58182 Fos Regulation of Egr1 1 0.49 0.09 0.27
30 INT147359 Positive_regulation of Pik3cd Positive_regulation of Egr1 1 0.09 1.51 0.27
31 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
32 INT130931 Sis Negative_regulation of Egr1 1 0.01 0.52 0.27
33 INT58176 Junb Regulation of Egr1 1 0.46 0.09 0.27
34 INT147360 Pik3cd Positive_regulation of Egr1 1 0.12 1.51 0.27
35 INT125521 EGR1 Regulation of GDF15 1 0.13 0.47 0.26
36 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24
37 INT130060 PPARG Positive_regulation of Positive_regulation of Egr1 1 0.22 0.46 0.24
38 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24
39 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
40 INT184162 Egr1 Positive_regulation of Transcription of Ptges2 1 0.08 0.42 0.22
41 INT184160 Binding of Egr1 and Ptges2 1 0.07 0.4 0.22
42 INT271853 Ngf Positive_regulation of Gene_expression of Egr1 1 0.53 1.36 0.21
43 INT259817 Ltp Positive_regulation of Egr1 1 0.03 0.28 0.2
44 INT259812 Gtf3a Regulation of Egr1 1 0.01 0.58 0.19
45 INT184159 Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
46 INT58178 Gtf3a Positive_regulation of Egr1 1 0.07 0.09 0.19
47 INT184161 Negative_regulation of Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
48 INT259814 Binding of Arc and Egr1 1 0.34 0.55 0.19
49 INT259813 Binding of Egr1 and Arc 1 0.32 0.55 0.19
50 INT149096 PITX2 Positive_regulation of Gene_expression of Egr1 1 0.01 1.23 0.19
51 INT58181 Gtf3a Positive_regulation of Gene_expression of Egr1 1 0.07 0.1 0.19
52 INT189563 Binding of SLIT2 and ROBO4 1 0.03 0.71 0.18
53 INT312090 EGR1 Regulation of Positive_regulation of PTGES 1 0.42 0.21 0.18
54 INT317895 Fos Regulation of Transcription of Egr1 1 0.41 1.03 0.17
55 INT317897 Egr1 Regulation of Transcription of Fosb 1 0.34 1.08 0.17
56 INT317892 Egr1 Regulation of Transcription of Fos 1 0.41 1.03 0.17
57 INT312109 ELANE Positive_regulation of EGR1 1 0.15 0.23 0.16
58 INT312100 ELANE Positive_regulation of Binding of EGR1 1 0.16 0.23 0.16
59 INT146025 EGR1 Negative_regulation of Gene_expression of GDF15 1 0.28 0.81 0.15
60 INT312092 ELANE Positive_regulation of Gene_expression of EGR1 1 0.19 0.21 0.15
61 INT168806 Tlr4 Positive_regulation of Gene_expression of Egr1 1 0.18 0.3 0.15
62 INT115140 PPARG Positive_regulation of EGR1 1 0.36 0.45 0.13
63 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
64 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13
65 INT115141 TGM7 Positive_regulation of EGR1 1 0.26 0.44 0.13
66 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13
67 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12
68 INT154803 Gene_expression of EGR1 Positive_regulation of Positive_regulation of GDF15 1 0.33 0.84 0.12
69 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
70 INT267016 Bdnf Positive_regulation of Egr1 1 0.12 0.09 0.07
71 INT129184 Gene_expression of EGR1 Positive_regulation of ATF3 1 0.72 0.22 0.07
72 INT129183 EGR1 Negative_regulation of Positive_regulation of ATF3 1 0.44 0.19 0.06
73 INT60221 Agt Regulation of Gene_expression of Egr1 1 0.42 0 0.04
74 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
75 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
76 INT243766 Binding of Egr1 and Proc 1 0.01 0.2 0.03
77 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
78 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
79 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
80 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
81 INT184955 EGR1 Regulation of Regulation of TGFB1 1 0.39 0.3 0
82 INT332409 Egr1 Regulation of Hgf 1 0.26 0.14 0
83 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
84 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
85 INT177793 EGR1 Positive_regulation of Negative_regulation of TP53 1 0.18 0.44 0
86 INT240122 Nab2 Regulation of Egr1 1 0.09 0.59 0
87 INT332408 Binding of Egr1 and Hgf 1 0.35 0.14 0
88 INT243770 Egr1 Regulation of Nab2 1 0.28 0.09 0
89 INT312114 EGR1 Positive_regulation of Positive_regulation of PTGES 1 0.32 0 0
90 INT259811 Narp Positive_regulation of Gene_expression of Egr1 1 0.26 0.86 0
91 INT191276 Binding of ABP1 and LSS 1 0.17 0.68 0
92 INT269014 Binding of EGR1 and COPD 1 0.12 0.96 0
93 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
94 INT286770 Skil Negative_regulation of Egr1 1 0.08 0.75 0
95 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
96 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0
97 INT285641 Zfp36 Negative_regulation of Egr1 1 0.06 0.28 0
98 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to heparin. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to heparin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
2 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
3 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
4 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95
5 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45
6 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89
7 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41
8 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18
9 INT6055 Transcription of Egr1 47 0.69 3.61 7.68
10 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17
11 INT47707 Negative_regulation of Egr1 9 0.41 0.17 7.03
12 INT73022 Positive_regulation of Gene_expression of EGR1 21 0.69 10.61 6.5
13 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38
14 INT47704 Regulation of Egr1 17 0.60 2.43 5.18
15 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1
16 INT57376 Transcription of EGR1 20 0.69 12.94 4.84
17 INT51944 Positive_regulation of Transcription of Egr1 12 0.49 1.96 4.72
18 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45
19 INT123502 Binding of Egr1 11 0.35 6.7 3.77
20 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48
21 INT98634 Positive_regulation of Positive_regulation of EGR1 9 0.68 3.43 2.47
22 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41
23 INT15243 Regulation of Egr1 19 0.61 7.6 2.13
24 INT80599 Regulation of Positive_regulation of Egr1 3 0.28 0.46 2.09
25 INT73023 Binding of EGR1 7 0.48 4.23 1.86
26 INT57375 Regulation of EGR1 5 0.40 1.94 1.78
27 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75
28 INT57877 Negative_regulation of Positive_regulation of Egr1 4 0.42 1.63 1.57
29 INT53003 Positive_regulation of Positive_regulation of Egr1 6 0.64 2.36 1.44
30 INT98635 Negative_regulation of Gene_expression of EGR1 5 0.58 2.2 1.42
31 INT72249 Negative_regulation of ABP1 6 0.36 1.08 1.41
32 INT72248 Binding of ABP1 7 0.29 4.33 1.36
33 INT141344 Transcription of Egr1 11 0.70 5.59 1.34
34 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
35 INT98633 Negative_regulation of Transcription of EGR1 3 0.43 0.79 1.11
36 INT123503 Positive_regulation of Binding of Egr1 3 0.13 2.34 1.04
37 INT123501 Negative_regulation of Binding of Egr1 2 0.12 2.04 0.99
38 INT51947 Regulation of Transcription of Egr1 2 0.59 0.15 0.96
39 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
40 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
41 INT98638 Positive_regulation of Transcription of EGR1 3 0.49 2.83 0.91
42 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
43 INT98636 Negative_regulation of Positive_regulation of EGR1 3 0.58 2.21 0.73
44 INT6050 Localization of Egr1 4 0.68 0.53 0.7
45 INT141341 Binding of Egr1 5 0.48 2.65 0.67
46 INT102686 Phosphorylation of Egr1 3 0.59 2.57 0.64
47 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
48 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
49 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
50 INT73020 Positive_regulation of Binding of EGR1 1 0.49 0.46 0.56
51 INT98632 Negative_regulation of EGR1 6 0.42 3.38 0.54
52 INT81061 Regulation of Negative_regulation of Egr1 1 0.22 0 0.53
53 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
54 INT191287 Positive_regulation of ABP1 6 0.39 3.72 0.51
55 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
56 INT168801 Localization of Egr1 4 0.78 0.7 0.48
57 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
58 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
59 INT141342 Negative_regulation of Transcription of Egr1 4 0.43 2.39 0.45
60 INT191288 Gene_expression of ABP1 7 0.52 6.61 0.4
61 INT243756 Regulation of Positive_regulation of Egr1 7 0.45 1.18 0.4
62 INT144968 Positive_regulation of Localization of EGR1 1 0.69 0.82 0.35
63 INT144970 Localization of EGR1 1 0.80 0.82 0.34
64 INT188498 Negative_regulation of Transcription of Egr1 3 0.41 0.14 0.32
65 INT34827 Regulation of ABP1 1 0.62 0.24 0.29
66 INT177838 Regulation of Gene_expression of EGR1 2 0.17 2.38 0.25
67 INT141343 Positive_regulation of Transcription of Egr1 1 0.47 1.43 0.24
68 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
69 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
70 INT346813 Positive_regulation of Regulation of Egr1 1 0.49 0.27 0.21
71 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
72 INT102793 Regulation of Phosphorylation of Egr1 1 0.33 0 0.17
73 INT115159 Regulation of Positive_regulation of EGR1 1 0.20 0.18 0.16
74 INT350601 Regulation of Negative_regulation of ABP1 1 0.04 0.23 0.14
75 INT350602 Positive_regulation of Positive_regulation of ABP1 1 0.05 0.24 0.13
76 INT189625 Binding of SLIT2 3 0.33 0.49 0.12
77 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
78 INT346814 Phosphorylation of Egr1 1 0.62 0 0.12
79 INT33738 Protein_catabolism of ABP1 1 0.62 0 0.11
80 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
81 INT346807 Regulation of Transcription of Egr1 1 0.44 0.27 0.09
82 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
83 INT320268 Positive_regulation of Negative_regulation of EGR1 1 0.26 0.69 0.07
84 INT255040 Positive_regulation of Gene_expression of ABP1 1 0.02 1.01 0.07
85 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
86 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
87 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
88 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
89 INT225365 Binding of Sox9 2 0.28 0.48 0.03
90 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
91 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
92 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
93 INT245757 Localization of SOX9 4 0.62 0.8 0
94 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
95 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
96 INT213595 Localization of SLIT2 1 0.67 0.06 0
97 INT213593 Gene_expression of SLIT2 1 0.60 0 0
98 INT211943 Transcription of Sox9 1 0.50 0.3 0
99 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
100 INT315189 Binding of SFRP1 1 0.15 2.96 0
101 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
102 INT191283 Transcription of ABP1 1 0.53 0.44 0
103 INT322886 Transcription of Sox9 1 0.50 0.25 0
104 INT285638 Regulation of Negative_regulation of Egr1 1 0.37 0.14 0
105 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
106 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
107 INT191282 Regulation of Gene_expression of ABP1 1 0.35 0.46 0
108 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
109 INT245765 Binding of SOX9 1 0.31 0.87 0
110 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
111 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
112 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
113 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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