GO:0071526

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Name semaphorin-plexin signaling pathway
Categary Process
Go Slim No
Go Link GO:0071526
Unique Molecular Interactions 61
Total Molecular Interactions 118
Total Single Events 357
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for semaphorin-plexin signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for semaphorin-plexin signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
2 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
3 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
4 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
5 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7
6 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56
7 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
8 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
9 INT97950 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of ST3GAL3 1 0.02 0.72 0.5
10 INT36340 Binding of NRP2 and Penk 1 0.04 0.07 0.39
11 INT304339 Negative_regulation of CD79A Positive_regulation of NRP2 1 0.06 0.86 0.33
12 INT304338 CD79A Positive_regulation of NRP2 1 0.08 0.84 0.32
13 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29
14 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
15 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28
16 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24
17 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
18 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22
19 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
20 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22
21 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
22 INT172237 TAS2R14 Positive_regulation of Gene_expression of NRP1 1 0.01 0.07 0.17
23 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
24 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14
25 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13
26 INT146997 Binding of PLXNA3 and RLS 1 0.36 0.47 0.1
27 INT224026 P2RY6 Positive_regulation of NRP2 1 0.10 0.98 0.1
28 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04
29 INT173053 Binding of VEGFA and NRP2 3 0.12 1.36 0.04
30 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04
31 INT265771 NRP1 Positive_regulation of VEGFA 1 0.46 0 0.04
32 INT311925 Binding of NRP2 and SEMA3A 1 0.26 0.06 0.04
33 INT265764 NRP1 Positive_regulation of FLT1 1 0.45 0 0.04
34 INT315915 VEGFA Regulation of NRP1 1 0.22 0.32 0.04
35 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
36 INT311926 Binding of NRP1 and SEMA3A 1 0.26 0.48 0.04
37 INT265749 Binding of FLT1 and NRP1 1 0.43 0 0.04
38 INT315912 VEGFA Regulation of NRP2 1 0.04 0.32 0.04
39 INT311927 AASDH Positive_regulation of NRP2 1 0.02 0.1 0.03
40 INT265744 VEGFA Regulation of Localization of NRP1 1 0.25 0 0
41 INT276285 Binding of SEPHS1 and PLXNA3 1 0.00 0.41 0
42 INT265767 Positive_regulation of Binding of VEGFA and NRP1 1 0.46 0 0
43 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0
44 INT311948 Binding of NRP1 and Plxna3 1 0.05 0.26 0
45 INT311947 Binding of SEMA3A and Plxna3 1 0.07 0.26 0
46 INT265752 NRP1 Negative_regulation of Gene_expression of FLT1 1 0.33 0 0
47 INT265765 Binding of NRP1 and GOPC 1 0.13 0 0
48 INT351678 Nrp1 Regulation of Binding of Ecm1 1 0.00 1.55 0
49 INT265737 Binding of AR and NRP1 1 0.10 0 0
50 INT265751 NRP1 Negative_regulation of Localization of FLT1 1 0.33 0 0
51 INT265756 Positive_regulation of Binding of AR and NRP1 1 0.10 0 0
52 INT196185 Binding of SEMA3A and Nrp1 1 0.01 0.05 0
53 INT265757 Regulation of Binding of VEGFA and NRP1 1 0.41 0 0
54 INT221638 Binding of Nrp1 and Sema3a 1 0.05 0.38 0
55 INT265738 NRP1 Positive_regulation of KLKB1 1 0.03 0 0
56 INT265741 Negative_regulation of Binding of FLT1 and NRP1 1 0.38 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for semaphorin-plexin signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in semaphorin-plexin signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32256 Gene_expression of PLXNA3 11 0.75 7.8 4.92
2 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3
3 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73
4 INT82347 Regulation of PLXNA3 5 0.60 4.59 2.45
5 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4
6 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24
7 INT196176 Gene_expression of SEMA3A 3 0.75 4.75 2.17
8 INT64609 Negative_regulation of PLXNA3 5 0.57 3.64 1.94
9 INT196158 Binding of NRP2 16 0.06 7.03 1.73
10 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
11 INT16622 Positive_regulation of PLXNA3 6 0.67 5.2 1.69
12 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
13 INT196182 Localization of NRP2 9 0.46 3.61 0.8
14 INT62760 Localization of PLXNA3 3 0.78 2.06 0.8
15 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
16 INT168189 Positive_regulation of PLXNA2 1 0.20 0.49 0.75
17 INT139205 Binding of NRP1 27 0.45 4.34 0.71
18 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7
19 INT265800 Localization of NRP1 14 0.75 3.66 0.69
20 INT196155 Binding of Nrp1 5 0.16 2.38 0.69
21 INT342318 Localization of PLXNA2 1 0.25 0.75 0.67
22 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65
23 INT311943 Negative_regulation of Gene_expression of SEMA3A 1 0.56 0.66 0.55
24 INT97962 Negative_regulation of NRP2 2 0.08 0.91 0.5
25 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46
26 INT79935 Negative_regulation of Nrp1 3 0.17 1.36 0.46
27 INT112379 Positive_regulation of Gene_expression of NRP2 3 0.50 0.18 0.46
28 INT149293 Negative_regulation of Protein_catabolism of NRP1 1 0.05 0.93 0.44
29 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3
30 INT264305 Negative_regulation of Gene_expression of NRP1 3 0.40 1.4 0.25
31 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25
32 INT248347 Negative_regulation of PLXNA2 1 0.38 0.24 0.22
33 INT311446 Negative_regulation of Gene_expression of PLXNA2 1 0.12 1.1 0.18
34 INT265792 Regulation of Localization of NRP1 1 0.22 0.21 0.13
35 INT265797 Regulation of Protein_catabolism of NRP1 1 0.51 0.21 0.13
36 INT203612 Positive_regulation of NRP2 2 0.33 0.49 0.12
37 INT143446 Positive_regulation of Gene_expression of NRP1 1 0.45 1.02 0.12
38 INT196181 Binding of SEMA3A 2 0.36 0.64 0.07
39 INT354592 Positive_regulation of Gene_expression of PLXNA2 1 0.04 0.37 0.07
40 INT196164 Localization of SEMA3A 5 0.77 1.39 0.06
41 INT311940 Negative_regulation of SEMA3A 1 0.56 0.71 0.06
42 INT354593 Regulation of Gene_expression of PLXNA2 1 0.04 0.34 0.05
43 INT196179 Regulation of Gene_expression of SEMA3A 3 0.43 0.45 0
44 INT235629 Phosphorylation of NRP1 2 0.76 0.81 0
45 INT196157 Regulation of NRP2 1 0.00 0.16 0
46 INT113675 Regulation of Gene_expression of NRP1 1 0.00 1.62 0
47 INT196170 Regulation of Gene_expression of NRP2 1 0.00 0.16 0
48 INT315923 Negative_regulation of Positive_regulation of NRP1 1 0.40 0.19 0
49 INT311941 Transcription of SEMA3A 1 0.66 0.34 0
50 INT302041 Negative_regulation of Gene_expression of Nrp1 1 0.07 0.14 0
51 INT311933 Regulation of SEMA3A 1 0.43 0.33 0
52 INT196167 Positive_regulation of Gene_expression of SEMA3A 1 0.22 0.06 0
53 INT265785 Positive_regulation of Localization of NRP1 1 0.41 0 0
54 INT311944 Negative_regulation of Gene_expression of NRP2 1 0.39 0.17 0
55 INT311938 Regulation of Transcription of SEMA3A 1 0.43 0.34 0
56 INT265793 Regulation of NRP1 1 0.22 0 0
57 INT265798 Positive_regulation of Binding of NRP1 1 0.41 0 0
58 INT188898 Negative_regulation of Localization of PLXNA3 1 0.09 0.47 0
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