GO:0071556

From wiki-pain
Jump to: navigation, search
Name integral to lumenal side of endoplasmic reticulum membrane
Categary Component
Go Slim No
Go Link GO:0071556
Unique Molecular Interactions 166
Total Molecular Interactions 274
Total Single Events 2038
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for integral to lumenal side of endoplasmic reticulum membrane. They are ordered first by their pain relevance and then by number of times they were reported for integral to lumenal side of endoplasmic reticulum membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
2 INT172047 Binding of HLA-A and LRRC23 1 0.22 3.32 1.64
3 INT174503 Binding of HLA-B and KIR3DL1 6 0.37 3.48 1.61
4 INT107965 Binding of HLA-B and Mefv 2 0.34 3.91 1.61
5 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
6 INT55837 Binding of HLA-B and PHB2 3 0.20 3.52 1.37
7 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
8 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14
9 INT107269 Binding of HLA-A and NCR3 1 0.35 1.42 1.1
10 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
11 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1
12 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
13 INT143323 Binding of HLA-B and HP 1 0.04 0.95 0.93
14 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
15 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
16 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
17 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
18 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71
19 INT240729 Binding of CRP and HLA-A 1 0.11 2.18 0.71
20 INT28711 Binding of HLA-B and MRAP 2 0.23 0.96 0.69
21 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
22 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63
23 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
24 INT122096 Binding of HLA-B and SFTPA1 2 0.04 1.81 0.6
25 INT174504 Binding of HLA-B and KIR3DL2 2 0.24 1.69 0.59
26 INT87683 Binding of HLA-B and Prnd 1 0.00 0.59 0.59
27 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
28 INT162742 Binding of HLA-A and KIR3DL1 1 0.40 0.68 0.58
29 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
30 INT341593 Binding of HLA-E and IL23R 1 0.15 1.15 0.5
31 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
32 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49
33 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
34 INT172096 Binding of HLA-E and Il27ra 2 0.01 1.32 0.48
35 INT328936 Binding of HLA-B and KIR3DS1 1 0.25 0.7 0.48
36 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47
37 INT48848 Binding of HLA-B and HLA-E 3 0.34 1.95 0.45
38 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
39 INT79151 Binding of HLA-B and OLAH 1 0.01 0.79 0.44
40 INT174507 Binding of HLA-B and LILRB4 1 0.02 1.16 0.43
41 INT79150 HLA-B Positive_regulation of OLAH 1 0.02 0.77 0.43
42 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
43 INT328935 Binding of HLA-G and KIR2DS4 1 0.39 0.75 0.41
44 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4
45 INT349290 Binding of HLA-B and SPATA19 1 0.00 1.25 0.4
46 INT183924 Binding of CHI3L1 and HLA-E 1 0.08 0.9 0.39
47 INT127587 Binding of HLA-B and CD300A 1 0.00 0.84 0.38
48 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
49 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
50 INT118285 Binding of EFNA1 and HLA-B 1 0.03 0.29 0.37
51 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
52 INT204091 Binding of HLA-G and KIR2DL1 1 0.15 0.86 0.32
53 INT227760 Binding of HLA-A and HLA-B 1 0.20 3.35 0.3
54 INT160923 Binding of ACLS and HLA-B 1 0.03 1.44 0.29
55 INT160924 Binding of ACLS and HLA-A 1 0.01 1.44 0.29
56 INT250951 Binding of HLA-E and SFTPA1 1 0.01 0.44 0.29
57 INT250958 Binding of HLA-A and SFTPA1 1 0.01 0.45 0.29
58 INT45048 Binding of HLA-B and TNFRSF10B 1 0.21 0.44 0.29
59 INT141882 Binding of CD8A and HLA-A 1 0.32 0.9 0.29
60 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
61 INT181843 PHB2 Regulation of HLA-B 1 0.03 1.4 0.28
62 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
63 INT71640 Binding of HLA-A and TYR 1 0.16 0.36 0.27
64 INT71642 Binding of HLA-A and PMEL 2 0.20 1.05 0.26
65 INT71643 Binding of HLA-A and TYRP1 1 0.24 0.36 0.26
66 INT174506 Binding of HLA-B and HLA-G 1 0.01 0.41 0.26
67 INT71641 Binding of MLANA and HLA-A 1 0.28 0.36 0.26
68 INT162743 Binding of HLA-A and TNFRSF10B 1 0.40 0.4 0.25
69 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
70 INT260870 Binding of HLA-E and IL7R 1 0.19 0.5 0.22
71 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
72 INT156251 Binding of HLA-A and Drb1 2 0.15 0.64 0.19
73 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
74 INT66279 Binding of FLNB and HLA-B 1 0.41 0.57 0.19
75 INT76078 Binding of HLA-A and TNFRSF10A 1 0.34 0.91 0.18
76 INT313799 Binding of HLA-B and TYRP1 1 0.01 0.54 0.18
77 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16
78 INT19645 Binding of HLA-B and KLRD1 1 0.00 0.73 0.15
79 INT115356 Binding of HLA-G and ATP8A1 1 0.00 0.52 0.15
80 INT258906 Binding of HLA-B and HLA-DRB1 1 0.31 1.36 0.15
81 INT194134 Binding of HLA-E and IGAD1 1 0.02 1.01 0.15
82 INT194136 Binding of HLA-E and INS 1 0.01 0.95 0.15
83 INT194135 Binding of CD79A and HLA-E 1 0.07 1.01 0.15
84 INT68736 Binding of HLA-B and Tyr 1 0.01 0.23 0.14
85 INT98565 HLA-B Positive_regulation of Cd8a 1 0.03 0.63 0.14
86 INT142845 Binding of HLA-B and SAT1 1 0.35 0.61 0.12
87 INT181844 Binding of CD8A and HLA-B 1 0.14 1.82 0.12
88 INT298059 Binding of HLA-A and Vip 1 0.00 0.97 0.12
89 INT289629 Binding of HLA-DMB and HLA-E 1 0.10 0.84 0.11
90 INT289627 Binding of HLA-E and RS1 1 0.01 0.83 0.11
91 INT2993 Binding of HLA-B and SUGT1 1 0.00 0.6 0.1
92 INT92671 Binding of CEL and HLA-B 1 0.38 0.19 0.1
93 INT88238 HLA-B Regulation of Gene_expression of Gbp1 1 0.03 0.27 0.1
94 INT167041 Binding of HLA-A and Aip 1 0.02 0.54 0.1
95 INT219155 Binding of HLA-G and LILRB2 1 0.15 0.23 0.1
96 INT152034 Binding of HLA-A and RDBP 1 0.05 0.34 0.1
97 INT132266 Binding of HLA-B and B2m 1 0.02 0.14 0.09
98 INT125089 Binding of HLA-B and TDGF1 1 0.24 0.18 0.09
99 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08
100 INT294116 CIITA Regulation of Gene_expression of HLA-E 1 0.05 0.05 0.08
101 INT331310 Binding of HLA-A and HLA-DOA 1 0.00 0.85 0.06
102 INT75234 Binding of HLA-B and BW6 1 0.39 0.06 0.06
103 INT356238 Binding of HLA-E and PI3 1 0.02 0 0.05
104 INT181168 Binding of CD79A and TAPBP 1 0.10 0.7 0.04
105 INT97430 Binding of B2M and HLA-B 1 0.00 0.66 0.04
106 INT225027 Binding of TAPBP and TRERF1 1 0.33 0 0.04
107 INT177948 IFNG Positive_regulation of Gene_expression of HLA-E 1 0.04 0.59 0.03
108 INT298058 Binding of HLA-A and Bpifa2 1 0.00 0.66 0.03
109 INT331324 Binding of HLA-G and Atp8a1 1 0.03 0.16 0.03
110 INT236235 HLA-A Positive_regulation of CD8A 1 0.01 1 0.03
111 INT331309 Binding of HLA-DOA and HLA-G 1 0.00 0.16 0.03
112 INT177947 IFN1@ Positive_regulation of Gene_expression of HLA-E 1 0.09 0.59 0.03
113 INT207031 Binding of HLA-C and HLA-E 1 0.35 0.1 0
114 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0
115 INT92381 Binding of HLA-B and Tap1 1 0.01 0 0
116 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
117 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0
118 INT252020 Binding of HLA-A and ELOVL1 1 0.01 1.41 0
119 INT300244 Binding of HLA-B and HSR 1 0.08 0.95 0
120 INT181167 TAPBP Negative_regulation of CD79A 1 0.11 0.48 0
121 INT336764 ERAP2 Regulation of Gene_expression of HLA-E 1 0.24 0 0
122 INT247114 Binding of HLA-A and MPZ 1 0.00 6.26 0
123 INT303088 Akt1 Negative_regulation of Gene_expression of CANX 1 0.10 0.28 0
124 INT275123 Binding of HLA-E and SUGT1 1 0.00 0.93 0
125 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
126 INT164332 Binding of HLA-E and KLRC2 1 0.00 0 0
127 INT351732 SSD Regulation of CALR 1 0.01 2.95 0
128 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
129 INT303089 Akt1 Negative_regulation of CANX 1 0.10 0.28 0
130 INT215470 Binding of HLA-B and CRAMP1L 1 0.05 0.94 0
131 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
132 INT110162 Binding of HLA-B and HLA-DQB1 1 0.09 0 0
133 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
134 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
135 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
136 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
137 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
138 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
139 INT261977 Binding of HLA-A and PDCD1 1 0.07 0.52 0
140 INT276138 Binding of COL19A1 and HLA-E 1 0.01 0.62 0
141 INT349077 Binding of HLA-E and KLRD1 1 0.00 0.16 0
142 INT250954 Binding of HLA-B and USO1 1 0.06 0.18 0
143 INT181165 TAPBP Regulation of Gene_expression of CD79A 1 0.07 0.35 0
144 INT90819 Binding of HLA-B and MICA 1 0.05 0 0
145 INT74066 Binding of DR1 and HLA-B 1 0.00 0.08 0
146 INT258911 Binding of CD4 and HLA-G 1 0.04 0.06 0
147 INT336762 Negative_regulation of ERAP2 Negative_regulation of HLA-E 1 0.23 0.31 0
148 INT250955 Binding of HLA-B and SETDB1 1 0.01 0.08 0
149 INT150180 KIT Negative_regulation of Gene_expression of HLA-B 1 0.39 0.09 0
150 INT333931 Binding of CALR and PDIA3 1 0.18 0.18 0
151 INT307309 Binding of CALR and EREG 1 0.00 0.83 0
152 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
153 INT258907 Binding of CD8A and HLA-G 1 0.05 0.07 0
154 INT301676 Binding of CD8A and HLA-E 1 0.02 2.24 0
155 INT313800 Binding of HLA-B and TYR 1 0.04 0.1 0
156 INT285399 Binding of DEFB1 and HLA-B 1 0.01 1.33 0
157 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0
158 INT307310 Binding of CALR and COMP 1 0.28 0.82 0
159 INT201079 Binding of HLA-B and HLA-C 1 0.40 1.36 0
160 INT336763 Binding of CD19 and HLA-A 1 0.01 0 0
161 INT174502 HLA-B Regulation of CD4 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for integral to lumenal side of endoplasmic reticulum membrane. They are ordered first by their pain relevance and then by number of times they were reported in integral to lumenal side of endoplasmic reticulum membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
2 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
3 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72
4 INT19330 Binding of HLA-A 99 0.48 76.26 22.85
5 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08
6 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1
7 INT11699 Binding of HLA-E 85 0.47 52.51 13.41
8 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46
9 INT3353 Localization of HLA-B 25 0.75 16.05 8.62
10 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39
11 INT5284 Regulation of HLA-B 25 0.59 12.91 7.74
12 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97
13 INT64767 Negative_regulation of Gene_expression of HLA-E 18 0.57 12.64 5.23
14 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07
15 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88
16 INT19331 Positive_regulation of HLA-A 12 0.49 7.72 3.28
17 INT16959 Positive_regulation of Binding of HLA-B 8 0.50 6.77 2.96
18 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94
19 INT65472 Binding of HLA-G 9 0.36 6.06 2.6
20 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
21 INT50006 Regulation of HLA-E 12 0.44 8.78 2.37
22 INT34644 Binding of HLA-C 19 0.47 9.41 2.2
23 INT117545 Regulation of Gene_expression of HLA-A 2 0.33 2.3 1.99
24 INT70526 Binding of CALR 11 0.35 7.09 1.97
25 INT21941 Regulation of CALR 7 0.53 3.88 1.96
26 INT101013 Regulation of HLA-A 7 0.33 6.7 1.8
27 INT122951 Regulation of Binding of HLA-B 4 0.39 3.08 1.65
28 INT62430 Negative_regulation of HLA-A 5 0.32 4.3 1.63
29 INT69398 Regulation of Gene_expression of HLA-E 14 0.60 3.54 1.27
30 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
31 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09
32 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08
33 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
34 INT64903 Positive_regulation of HLA-C 3 0.49 2.54 0.93
35 INT748 Transcription of HLA-B 6 0.67 1.56 0.91
36 INT240736 Localization of HLA-A 7 0.21 6.88 0.86
37 INT328959 Localization of HLA-G 3 0.73 2.22 0.83
38 INT11698 Positive_regulation of Gene_expression of HLA-A 5 0.67 4.64 0.76
39 INT10710 Positive_regulation of Positive_regulation of HLA-B 2 0.38 0.83 0.73
40 INT132528 Gene_expression of TAPBP 17 0.65 5.93 0.69
41 INT5285 Regulation of Gene_expression of HLA-B 4 0.41 3.39 0.68
42 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
43 INT162801 Localization of CALR 7 0.73 8.69 0.6
44 INT11700 Negative_regulation of Gene_expression of HLA-B 3 0.50 2.61 0.6
45 INT177951 Transcription of HLA-E 7 0.67 2.36 0.52
46 INT139674 Regulation of TAPBP 2 0.44 1.34 0.46
47 INT328952 Negative_regulation of Localization of HLA-G 1 0.41 1.07 0.43
48 INT328956 Positive_regulation of Localization of HLA-G 1 0.49 1.03 0.4
49 INT177954 Negative_regulation of Positive_regulation of HLA-E 2 0.07 0.61 0.33
50 INT188706 Localization of HLA-E 8 0.33 2.43 0.32
51 INT201084 Localization of HLA-C 2 0.73 1.04 0.3
52 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
53 INT44012 Phosphorylation of HLA-B 3 0.81 0.96 0.27
54 INT147335 Positive_regulation of Gene_expression of HLA-G 2 0.49 2.38 0.27
55 INT160925 Transcription of HLA-A 1 0.31 1.41 0.24
56 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
57 INT117251 Positive_regulation of Localization of TAPBP 1 0.40 0.8 0.22
58 INT117250 Localization of TAPBP 1 0.61 0.8 0.22
59 INT294137 Positive_regulation of Positive_regulation of HLA-E 1 0.09 0.33 0.2
60 INT177956 Positive_regulation of Transcription of HLA-E 3 0.49 1.02 0.19
61 INT132529 Binding of TAPBP 8 0.47 1.43 0.18
62 INT250970 Positive_regulation of Localization of HLA-B 1 0.48 0.57 0.17
63 INT156328 Protein_catabolism of HLA-B 1 0.09 0.17 0.17
64 INT328942 Negative_regulation of Binding of HLA-G 1 0.41 0.39 0.13
65 INT197053 Negative_regulation of Binding of HLA-E 1 0.20 1.07 0.12
66 INT172369 Negative_regulation of Gene_expression of TAPBP 1 0.09 0.25 0.07
67 INT354146 Regulation of Gene_expression of CALR 1 0.04 0.73 0.07
68 INT286583 Localization of PKD2 1 0.35 0.17 0.06
69 INT261879 Binding of PKD2 3 0.13 2.59 0.05
70 INT321875 Regulation of HLA-G 1 0.00 0.99 0.05
71 INT181175 Negative_regulation of TAPBP 1 0.35 0.81 0.05
72 INT254338 Positive_regulation of Localization of HLA-E 1 0.03 0.26 0.03
73 INT351824 Regulation of Binding of HLA-E 1 0.03 0.89 0.03
74 INT356246 Negative_regulation of Transcription of HLA-E 1 0.41 0.05 0.03
75 INT353546 Positive_regulation of Localization of CALR 1 0.05 0.49 0.03
76 INT307326 Negative_regulation of Gene_expression of CALR 3 0.25 1.78 0
77 INT201086 Regulation of Phosphorylation of HLA-B 2 0.45 0.41 0
78 INT241245 Negative_regulation of PKD2 2 0.42 2.35 0
79 INT215472 Protein_catabolism of HLA-A 2 0.53 0.34 0
80 INT54611 Positive_regulation of Regulation of HLA-B 1 0.37 0 0
81 INT308196 Negative_regulation of Negative_regulation of HLA-E 1 0.28 0 0
82 INT276139 Regulation of Negative_regulation of HLA-E 1 0.39 0.07 0
83 INT201088 Negative_regulation of Binding of HLA-C 1 0.42 0.61 0
84 INT250968 Positive_regulation of Phosphorylation of HLA-B 1 0.48 0.08 0
85 INT275143 Positive_regulation of Binding of HLA-E 1 0.16 0.32 0
86 INT132530 Positive_regulation of Binding of TAPBP 1 0.67 0.08 0
87 INT156329 Binding of CANX 1 0.47 0.08 0
88 INT303067 Gene_expression of CANX 1 0.29 0.28 0
89 INT264190 Negative_regulation of Gene_expression of HLA-A 1 0.04 0.57 0
90 INT245872 Positive_regulation of HLA-G 1 0.02 0.78 0
91 INT214061 Negative_regulation of HLA-G 1 0.41 0.34 0
92 INT232493 Negative_regulation of Positive_regulation of PKD2 1 0.23 0.61 0
93 INT261878 Negative_regulation of Binding of PKD2 1 0.14 0.6 0
94 INT201087 Regulation of Phosphorylation of HLA-C 1 0.44 0.32 0
95 INT307324 Positive_regulation of Positive_regulation of CALR 1 0.25 0.36 0
96 INT232491 Positive_regulation of PKD2 1 0.27 0.56 0
97 INT221119 Negative_regulation of Negative_regulation of HLA-A 1 0.01 0.61 0
98 INT201083 Gene_expression of HLA-C 1 0.66 0.17 0
99 INT136090 Positive_regulation of Transcription of HLA-B 1 0.34 0.15 0
100 INT307331 Negative_regulation of Positive_regulation of CALR 1 0.29 0.36 0
101 INT145383 Negative_regulation of HLA-C 1 0.12 0 0
102 INT150063 Positive_regulation of Positive_regulation of HLA-A 1 0.05 0.08 0
103 INT201089 Phosphorylation of HLA-C 1 0.80 0.32 0
104 INT132527 Positive_regulation of Gene_expression of TAPBP 1 0.49 0.84 0
105 INT307332 Negative_regulation of Localization of CALR 1 0.29 0.72 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox