GO:0071599

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Name otic vesicle development
Categary Process
Go Slim No
Go Link GO:0071599
Unique Molecular Interactions 39
Total Molecular Interactions 46
Total Single Events 621
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for otic vesicle development. They are ordered first by their pain relevance and then by number of times they were reported for otic vesicle development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
2 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
3 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
4 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
5 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
6 INT220190 PTGER2 Regulation of COL2A1 1 0.32 0.92 0.18
7 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18
8 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
9 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
10 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
11 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
12 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14
13 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
14 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
15 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
16 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09
17 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06
18 INT350010 Binding of IL6 and AHI1 1 0.01 0.29 0.06
19 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
20 INT323807 NFAT5 Regulation of Gene_expression of COL2A1 1 0.29 0.19 0.04
21 INT220196 Binding of PTGER2 and Negative_regulation of Gene_expression of COL2A1 1 0.26 0.77 0.04
22 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
23 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03
24 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
25 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0
26 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
27 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
28 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
29 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
30 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0
31 INT252888 Binding of SLC5A5 and PAX8 1 0.02 0.22 0
32 INT88567 COL2A1 Positive_regulation of A1cf 1 0.09 0.36 0
33 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
34 INT312227 INPP5K Regulation of Negative_regulation of COL2A1 1 0.06 0 0
35 INT312345 Binding of COL2A1 and COL5A2 1 0.00 1.21 0
36 INT323804 NFAT5 Regulation of Transcription of COL2A1 1 0.43 0.07 0
37 INT213556 Binding of Eya1 and Six1 1 0.41 0.48 0
38 INT312213 INPP5K Regulation of COL2A1 1 0.06 0 0
39 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for otic vesicle development. They are ordered first by their pain relevance and then by number of times they were reported in otic vesicle development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
2 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
3 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
4 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
5 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
6 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
7 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
8 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
9 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
10 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
11 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
12 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
13 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
14 INT116008 Binding of Gata3 2 0.34 1.37 1.41
15 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
16 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
17 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
18 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11
19 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
20 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
21 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
22 INT174517 Localization of AHI1 2 0.24 1.62 0.68
23 INT95337 Negative_regulation of AHI1 2 0.02 0.75 0.68
24 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
25 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
26 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
27 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
28 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
29 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
30 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
31 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44
32 INT180577 Positive_regulation of Protein_catabolism of COL2A1 2 0.12 0.91 0.31
33 INT220209 Negative_regulation of Localization of COL2A1 1 0.41 0.48 0.29
34 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
35 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
36 INT220208 Regulation of Protein_catabolism of COL2A1 1 0.26 0.28 0.17
37 INT296875 Positive_regulation of AHI1 2 0.15 3.53 0.16
38 INT76794 Gene_expression of AHI1 3 0.04 1.69 0.14
39 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
40 INT221000 Phosphorylation of COL2A1 1 0.19 0.18 0.12
41 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
42 INT245059 Localization of PAX8 1 0.51 1.43 0.08
43 INT76793 Regulation of Gene_expression of AHI1 1 0.00 0.13 0.07
44 INT145889 Positive_regulation of Gene_expression of AHI1 1 0.01 0.47 0.07
45 INT250505 Positive_regulation of Negative_regulation of COL2A1 1 0.41 0.57 0.05
46 INT272249 Negative_regulation of Negative_regulation of COL2A1 1 0.06 0 0.05
47 INT184729 Transcription of COL2A1 4 0.67 1.1 0
48 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
49 INT245757 Localization of SOX9 4 0.62 0.8 0
50 INT165862 Positive_regulation of Binding of COL2A1 2 0.43 0 0
51 INT312246 Regulation of Negative_regulation of COL2A1 1 0.07 0 0
52 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
53 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
54 INT322897 Negative_regulation of Transcription of COL2A1 1 0.17 0 0
55 INT245765 Binding of SOX9 1 0.31 0.87 0
56 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
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