GO:0071731

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Name response to nitric oxide
Categary Process
Go Slim No
Go Link GO:0071731
Unique Molecular Interactions 58
Total Molecular Interactions 77
Total Single Events 1048
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to nitric oxide. They are ordered first by their pain relevance and then by number of times they were reported for response to nitric oxide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
2 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
3 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
4 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
5 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
6 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
7 INT181437 Binding of Ccr7 and Ccl21b 1 0.01 2.23 0.87
8 INT181452 Binding of Ccl19 and Ccl21b 1 0.02 2.22 0.86
9 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
10 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
11 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
12 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
13 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
14 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
15 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
16 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
17 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
18 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68
19 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
20 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
21 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
22 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
23 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
24 INT85487 IL1RN Negative_regulation of IL1R1 1 0.02 0 0.57
25 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
26 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5
27 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
28 INT307675 Binding of IL1R1 and SNRNP70 1 0.02 1.05 0.45
29 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
30 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
31 INT181439 Csf2 Positive_regulation of Ccl19 1 0.06 1.68 0.38
32 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
33 INT229087 IL1R1 Negative_regulation of ACCS 1 0.03 0.86 0.33
34 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
35 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3
36 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
37 INT242763 Olr1746 Negative_regulation of Nos1 1 0.02 0.97 0.26
38 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
39 INT222661 IFNA1 Positive_regulation of Gene_expression of Nos1 1 0.01 0.25 0.18
40 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
41 INT304496 Mknk1 Positive_regulation of Gene_expression of Nos1 1 0.19 0.18 0.15
42 INT78662 Dlst Positive_regulation of Gene_expression of Nos1 1 0.20 0.17 0.14
43 INT181842 PHB2 Regulation of CCR7 1 0.00 0.7 0.14
44 INT229088 IL1R1 Positive_regulation of Gene_expression of IL6 1 0.04 0.45 0.14
45 INT352073 Positive_regulation of Binding of ADAM11 and CCL19 1 0.22 1.27 0.13
46 INT352080 Binding of ADAM11 and CCL19 1 0.16 1.27 0.13
47 INT229089 IL1R1 Positive_regulation of IL6 1 0.03 0.45 0.12
48 INT304502 Mknk1 Positive_regulation of Phosphorylation of Nos1 1 0.19 0.16 0.11
49 INT337174 Binding of TLR3 and Positive_regulation of CCR7 1 0.15 0.31 0.03
50 INT352074 ADAM11 Positive_regulation of Gene_expression of CCL19 1 0.17 0.74 0.03
51 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
52 INT189555 EGLN1 Regulation of Gene_expression of VEGFA 1 0.07 0.57 0
53 INT117647 Agt Regulation of Nos1 1 0.19 0.13 0
54 INT249937 Nos1 Regulation of Nos3 1 0.23 0.19 0
55 INT352082 Binding of CCR7 and ADAM11 1 0.15 0.76 0
56 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
57 INT249934 Nos1 Regulation of Nos2 1 0.20 0.19 0
58 INT168246 Pomgnt1 Positive_regulation of Transcription of Nos1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to nitric oxide. They are ordered first by their pain relevance and then by number of times they were reported in response to nitric oxide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
2 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
3 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
4 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
5 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
6 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
7 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
8 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
9 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48
10 INT69499 Binding of Nos1 15 0.36 2.56 6.23
11 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
12 INT84673 Localization of Nos1 19 0.80 5.01 5.62
13 INT181596 Binding of IL1R1 9 0.36 7.99 4.32
14 INT166966 Gene_expression of Ccr7 14 0.48 7.36 4.2
15 INT181414 Gene_expression of Ccl19 12 0.74 9.8 4.11
16 INT108481 Positive_regulation of CCL19 4 0.44 15.22 3.77
17 INT108484 Gene_expression of CCL19 4 0.50 12.56 3.63
18 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
19 INT64437 Gene_expression of IL1R1 9 0.65 6.22 2.99
20 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84
21 INT126514 Positive_regulation of CCR7 16 0.43 16.21 2.79
22 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
23 INT67895 Negative_regulation of IL1R1 7 0.57 5.76 1.9
24 INT124559 Gene_expression of Il1r1 4 0.54 2.14 1.89
25 INT85492 Localization of IL1R1 6 0.72 2.44 1.85
26 INT108486 Positive_regulation of Gene_expression of CCL19 2 0.45 6.2 1.79
27 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
28 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
29 INT52873 Localization of Il1r1 4 0.56 1.28 1.48
30 INT33299 Binding of CCR7 3 0.31 2.88 1.45
31 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
32 INT152010 Positive_regulation of Ccr7 3 0.47 1.46 1.15
33 INT124560 Negative_regulation of Il1r1 2 0.07 0.77 1.14
34 INT181400 Negative_regulation of Ccl19 3 0.43 1.97 1.13
35 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
36 INT181354 Binding of Ccr7 2 0.23 1.94 1.01
37 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
38 INT182239 Negative_regulation of Gene_expression of CCR7 1 0.36 1.16 0.91
39 INT184687 Transcription of Ccl19 1 0.68 1.04 0.9
40 INT151626 Negative_regulation of Gene_expression of Il1r1 1 0.20 1.33 0.8
41 INT112947 Regulation of Il1r1 2 0.24 0.36 0.78
42 INT181370 Positive_regulation of Ccl19 2 0.37 2.28 0.77
43 INT112945 Transcription of Il1r1 1 0.39 0.32 0.76
44 INT97192 Regulation of Transcription of Nos1 1 0.55 1.94 0.68
45 INT116716 Positive_regulation of Gene_expression of CCR7 5 0.68 6.92 0.67
46 INT64438 Regulation of IL1R1 2 0.26 1.62 0.64
47 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54
48 INT252284 Binding of Ccl19 1 0.17 0.54 0.48
49 INT182236 Transcription of CCR7 2 0.58 1.07 0.47
50 INT354384 Regulation of CCL19 1 0.23 1.89 0.47
51 INT67894 Transcription of IL1R1 4 0.67 2.17 0.45
52 INT181358 Transcription of Ccr7 1 0.43 1.33 0.43
53 INT177505 Regulation of CCR7 3 0.38 2.19 0.42
54 INT104414 Negative_regulation of Transcription of Nos1 1 0.42 0.96 0.38
55 INT201841 Negative_regulation of Negative_regulation of IL1R1 1 0.01 0.78 0.34
56 INT229092 Positive_regulation of Localization of IL1R1 1 0.14 0.41 0.34
57 INT120320 Positive_regulation of Transcription of Nos1 3 0.46 0.58 0.29
58 INT124558 Regulation of Gene_expression of Il1r1 1 0.07 0.29 0.28
59 INT107757 Regulation of Negative_regulation of Nos1 2 0.39 0 0.27
60 INT201860 Negative_regulation of Transcription of IL1R1 1 0.01 0.85 0.26
61 INT112278 Positive_regulation of Regulation of Nos1 4 0.38 0.99 0.25
62 INT181914 Positive_regulation of EGLN1 1 0.36 2.03 0.25
63 INT305840 Positive_regulation of Gene_expression of Ccr7 1 0.27 0.25 0.24
64 INT184699 Localization of Ccl19 1 0.72 0.47 0.24
65 INT105900 Regulation of Binding of Nos1 1 0.35 0.52 0.22
66 INT227245 Localization of CCR7 4 0.47 0.74 0.18
67 INT220167 Localization of Ccr7 1 0.31 0.39 0.18
68 INT229093 Negative_regulation of Localization of IL1R1 1 0.12 0.39 0.15
69 INT184666 Negative_regulation of Localization of Ccl19 1 0.41 0.25 0.15
70 INT189614 Gene_expression of EGLN1 6 0.49 4.3 0.12
71 INT285485 Negative_regulation of Gene_expression of Ccl19 1 0.07 1.15 0.1
72 INT285481 Positive_regulation of Gene_expression of Ccl19 1 0.08 1.15 0.1
73 INT158616 Localization of EGLN1 1 0.73 0.54 0.06
74 INT352112 Transcription of CCL19 1 0.38 1.37 0.06
75 INT352100 Positive_regulation of Transcription of CCL19 1 0.37 1.38 0.06
76 INT216078 Negative_regulation of CCR7 2 0.27 0.36 0.03
77 INT352095 Regulation of Gene_expression of CCL19 1 0.21 0.68 0.03
78 INT112277 Negative_regulation of Regulation of Nos1 1 0.35 0.33 0.03
79 INT337244 Positive_regulation of Binding of CCR7 1 0.31 0.6 0.03
80 INT109984 Positive_regulation of Localization of Nos1 2 0.39 0.86 0
81 INT352097 Positive_regulation of Positive_regulation of CCR7 1 0.25 1.06 0
82 INT189577 Negative_regulation of EGLN1 1 0.31 1.73 0
83 INT189603 Negative_regulation of Transcription of EGLN1 1 0.31 0.94 0
84 INT352113 Positive_regulation of Positive_regulation of CCL19 1 0.27 1.06 0
85 INT139479 Protein_catabolism of Nos1 1 0.58 0.05 0
86 INT189605 Regulation of EGLN1 1 0.33 1.65 0
87 INT189617 Transcription of EGLN1 1 0.50 0.94 0
88 INT166967 Negative_regulation of Ccr7 1 0.09 0 0
89 INT189572 Positive_regulation of Gene_expression of EGLN1 1 0.34 0.92 0
90 INT352098 Negative_regulation of Gene_expression of CCL19 1 0.23 1.48 0
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