GO:0071732

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Name cellular response to nitric oxide
Categary Process
Go Slim No
Go Link GO:0071732
Unique Molecular Interactions 43
Total Molecular Interactions 71
Total Single Events 542
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to nitric oxide. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to nitric oxide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
3 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
4 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
5 INT231225 Binding of C1S and SFTPC 1 0.39 1.51 0.43
6 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
7 INT139778 Binding of AQP1 and GBE1 1 0.00 0.22 0.3
8 INT141109 Sftpa1 Positive_regulation of Mapk1 1 0.77 0.65 0.27
9 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
10 INT58305 AQP1 Regulation of Localization of TNF 1 0.10 0.16 0.22
11 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 0.10 0.16 0.22
12 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
13 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19
14 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
15 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15
16 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14
17 INT141110 Negative_regulation of Sftpa1 Positive_regulation of Mapk1 1 0.47 0.31 0.14
18 INT141111 Sftpa1 Positive_regulation of Ptgs2 1 0.64 0.3 0.14
19 INT141112 Negative_regulation of Sftpa1 Positive_regulation of Ptgs2 1 0.39 0.31 0.14
20 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
21 INT220244 IL1B Regulation of Gene_expression of DPEP1 1 0.17 0 0.08
22 INT220241 IL1RN Regulation of Gene_expression of DPEP1 1 0.24 0 0.08
23 INT220238 IL1RN Regulation of Protein_catabolism of DPEP1 1 0.14 0 0.08
24 INT220247 IL1B Regulation of Protein_catabolism of DPEP1 1 0.10 0 0.08
25 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
26 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
27 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
28 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
29 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
30 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
31 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
32 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0
33 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
34 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 0.03 0 0
35 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
36 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
37 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
38 INT186449 Binding of SFTPB and SFTPC 1 0.38 0.09 0
39 INT98626 Aqp1 Positive_regulation of Aqp4 1 0.52 0 0
40 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
41 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
42 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to nitric oxide. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to nitric oxide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
2 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
3 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
4 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
5 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
6 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
7 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
8 INT186456 Gene_expression of SFTPC 2 0.75 11.46 2.38
9 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15
10 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
11 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
12 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
13 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41
14 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
15 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
16 INT186458 Negative_regulation of SFTPC 11 0.57 8.6 1.29
17 INT186461 Gene_expression of SFTPB 10 0.73 8.69 1.09
18 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
19 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99
20 INT220249 Gene_expression of DPEP1 1 0.40 0.99 0.95
21 INT183362 Regulation of AQP1 3 0.23 1.49 0.92
22 INT186463 Negative_regulation of Gene_expression of SFTPC 2 0.42 4.52 0.75
23 INT231228 Regulation of Gene_expression of SFTPC 1 0.60 3.8 0.73
24 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
25 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
26 INT139780 Binding of AQP1 7 0.32 4.62 0.54
27 INT186455 Localization of SFTPB 2 0.74 3.24 0.53
28 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
29 INT141097 Binding of Sftpa1 1 0.48 1.28 0.47
30 INT19592 Localization of AQP1 4 0.81 1.09 0.44
31 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44
32 INT220254 Positive_regulation of Gene_expression of DPEP1 1 0.22 0.56 0.44
33 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
34 INT231232 Negative_regulation of Negative_regulation of SFTPC 1 0.42 2.01 0.37
35 INT186459 Positive_regulation of SFTPC 4 0.45 4.64 0.36
36 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31
37 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
38 INT186454 Binding of SFTPB 3 0.35 1.48 0.24
39 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
40 INT69801 Positive_regulation of DPEP1 3 0.49 0.89 0.23
41 INT231231 Regulation of SFTPB 1 0.27 1.47 0.22
42 INT104568 Negative_regulation of Localization of Aqp1 1 0.36 2.47 0.2
43 INT233856 Regulation of SFTPC 4 0.60 2.25 0.19
44 INT239883 Transcription of SFTPC 3 0.69 1.11 0.18
45 INT239885 Positive_regulation of Transcription of SFTPC 1 0.67 0.44 0.18
46 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17
47 INT98625 Regulation of Aqp1 1 0.27 0.1 0.17
48 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
49 INT231230 Localization of SFTPC 2 0.68 2.06 0.16
50 INT220251 Regulation of DPEP1 1 0.12 0.33 0.15
51 INT141095 Negative_regulation of Binding of Sftpa1 1 0.42 0.31 0.14
52 INT141096 Positive_regulation of Binding of Sftpa1 1 0.50 0.34 0.13
53 INT201462 Binding of CDK2 12 0.39 5.2 0.12
54 INT220259 Protein_catabolism of DPEP1 1 0.34 0 0.11
55 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1
56 INT159343 Positive_regulation of Localization of AQP1 1 0.11 0 0.1
57 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
58 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
59 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
60 INT302272 Localization of CDK2 2 0.30 1.09 0.09
61 INT69802 Binding of DPEP1 1 0.02 0 0.09
62 INT220263 Negative_regulation of DPEP1 1 0.22 0.28 0.09
63 INT327827 Negative_regulation of Gene_expression of Aqp1 1 0.45 0.8 0.08
64 INT262510 Regulation of Gene_expression of Aqp1 1 0.33 1.18 0.07
65 INT270815 Localization of DPEP1 1 0.06 0.08 0.07
66 INT270819 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
67 INT212049 Protein_catabolism of SFTPB 1 0.44 0.15 0.04
68 INT186452 Positive_regulation of SFTPB 7 0.47 6.43 0.03
69 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
70 INT220258 Negative_regulation of Gene_expression of DPEP1 1 0.22 0 0.03
71 INT169427 Transcription of CDK2 2 0.09 0.42 0
72 INT262504 Positive_regulation of Aqp1 1 0.25 0.43 0
73 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
74 INT286264 Positive_regulation of Negative_regulation of AQP1 1 0.01 0.79 0
75 INT262513 Negative_regulation of Binding of Aqp1 1 0.23 0.64 0
76 INT212050 Negative_regulation of Gene_expression of SFTPB 1 0.32 0.95 0
77 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
78 INT141101 Gene_expression of Sftpa1 1 0.77 0.38 0
79 INT262514 Binding of Aqp1 1 0.20 0.64 0
80 INT186451 Positive_regulation of Negative_regulation of SFTPB 1 0.47 0.52 0
81 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
82 INT331624 Transcription of SFTPB 1 0.03 0.48 0
83 INT299193 Transcription of Aqp1 1 0.56 0.62 0
84 INT205997 Regulation of Gene_expression of SFTPB 1 0.44 0.71 0
85 INT262511 Positive_regulation of Gene_expression of Aqp1 1 0.37 1.78 0
86 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
87 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
88 INT327782 Regulation of Gene_expression of AQP1 1 0.36 1.63 0
89 INT186462 Binding of SFTPC 1 0.35 0.09 0
90 INT262512 Localization of Aqp1 1 0.40 0.7 0
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