GO:0071848

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Name positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
Categary Process
Go Slim No
Go Link GO:0071848
Unique Molecular Interactions 140
Total Molecular Interactions 282
Total Single Events 1195
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
2 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
3 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
4 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
5 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
6 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
7 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
8 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
9 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
10 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
11 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
12 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
13 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
14 INT187220 Il11 Positive_regulation of Gene_expression of Tnfsf11 1 0.13 0.86 0.69
15 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
16 INT254279 Il13 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
17 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
18 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
19 INT187227 Vip Negative_regulation of Gene_expression of Tnfsf11 1 0.35 1.23 0.51
20 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
21 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49
22 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
23 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
24 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41
25 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39
26 INT224423 Binding of TNFRSF11B and TNFRSF11A 3 0.19 2.36 0.37
27 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33
28 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
29 INT134888 Negative_regulation of TNFRSF11A Negative_regulation of Gene_expression of CCL2 1 0.24 0.38 0.33
30 INT165765 Tnfsf11 Positive_regulation of Nfkb1 1 0.01 1.07 0.33
31 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
32 INT187223 Il1 Positive_regulation of Gene_expression of Tnfsf11 1 0.09 0.64 0.32
33 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31
34 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
35 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3
36 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3
37 INT301276 Il6 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.06 0.37 0.26
38 INT254224 Binding of Ltbr and Tnfrsf11a 1 0.01 0.59 0.25
39 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21
40 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21
41 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21
42 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21
43 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21
44 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2
45 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
46 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
47 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
48 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19
49 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19
50 INT148531 Binding of TNFRSF11A and Tnfsf11 2 0.08 1.77 0.17
51 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
52 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14
53 INT289247 Ptger2 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.00 0.76 0.14
54 INT81992 IL1A Positive_regulation of Positive_regulation of Tnfsf11 1 0.05 0.27 0.13
55 INT153740 TNFRSF11A Positive_regulation of Vcp 1 0.04 1.15 0.13
56 INT153739 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.05 1.14 0.13
57 INT153742 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.00 1.15 0.13
58 INT153738 TNFRSF11A Positive_regulation of SQSTM1 1 0.05 1.22 0.13
59 INT301284 Tnfsf11 Positive_regulation of Localization of Nfatc1 1 0.16 0.32 0.11
60 INT93535 PTH Negative_regulation of Gene_expression of Tnfsf11 1 0.19 0.22 0.11
61 INT107909 Binding of Tnfsf11 and Tnfrsf22 1 0.01 2.12 0.11
62 INT254284 Binding of TNF and Tnfsf11 1 0.04 0.44 0.1
63 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09
64 INT210595 Binding of TNF and TNFSF11 1 0.10 5.13 0.09
65 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08
66 INT210600 IL1B Regulation of TNFSF11 1 0.04 1.45 0.08
67 INT338999 Binding of BTF3P11 and Tnfsf11 1 0.01 0.35 0.08
68 INT210601 IL8 Positive_regulation of TNFSF11 1 0.06 1.46 0.08
69 INT321867 TNFRSF11B Negative_regulation of TNFSF11 1 0.00 0.85 0.08
70 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08
71 INT334061 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.01 0.52 0.08
72 INT321868 Binding of TNFRSF11B and Negative_regulation of TNFSF11 1 0.00 0.91 0.08
73 INT210599 IL8 Regulation of TNFSF11 1 0.05 1.44 0.08
74 INT254277 Binding of Hand1 and Tnfsf11 1 0.02 0.08 0.08
75 INT301403 Enpp2 Positive_regulation of Tnfrsf11a 1 0.05 0.59 0.07
76 INT127722 CSF1 Positive_regulation of TNFSF11 1 0.08 0.26 0.06
77 INT340274 Cd14 Regulation of Gene_expression of TNFRSF11A 1 0.05 0.8 0.05
78 INT314369 Tnfsf11 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.08 2.2 0.05
79 INT224421 TNFRSF11B Regulation of TNFSF11 1 0.27 0 0.05
80 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05
81 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04
82 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04
83 INT289252 Il6 Negative_regulation of Tnfrsf11a 1 0.11 0.82 0.04
84 INT210594 TNFRSF11B Negative_regulation of Binding of TNFRSF11A 1 0.15 0.77 0.04
85 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
86 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04
87 INT217474 Tnfrsf11a Regulation of Gene_expression of Tnfsf11 1 0.41 1.2 0.04
88 INT232207 Binding of Tgfb1 and Tnfrsf11a 1 0.02 0.51 0.04
89 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
90 INT340276 Tnfsf11 Positive_regulation of Localization of RELA 1 0.02 0.58 0.03
91 INT165988 PTGER1 Positive_regulation of TNFSF11 1 0.05 0.13 0
92 INT340270 Negative_regulation of Tnfsf11 Positive_regulation of TRAP 1 0.03 0.37 0
93 INT205159 SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 0.8 0
94 INT327969 Binding of PNLIP and TNFRSF11A 1 0.09 0.89 0
95 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0
96 INT298585 TNFSF11 Positive_regulation of ACP5 1 0.16 0.09 0
97 INT165986 PTGER1 Regulation of Positive_regulation of TNFSF11 1 0.04 0.12 0
98 INT210581 Binding of AMELX and Tnfsf11 1 0.01 0.15 0
99 INT327980 PNLIP Regulation of TNFRSF11A 1 0.15 0.89 0
100 INT307225 CYLD Regulation of TNFRSF11A 1 0.14 0.81 0
101 INT327977 TNFRSF11A Regulation of BCL2 1 0.05 0.67 0
102 INT217487 Binding of PDB1 and Tnfrsf11a 1 0.03 0.76 0
103 INT298586 PTGER2 Regulation of Gene_expression of TNFSF11 1 0.06 0 0
104 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0
105 INT298587 TNFSF11 Regulation of IL1B 1 0.18 0 0
106 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0
107 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0
108 INT210580 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.07 0.19 0
109 INT135179 DCSTAMP Positive_regulation of Gene_expression of TNFSF11 1 0.06 0 0
110 INT129852 OLR1 Positive_regulation of Positive_regulation of TNFRSF11A 1 0.56 0.24 0
111 INT340277 Tnfsf11 Positive_regulation of TRAP 1 0.03 0.76 0
112 INT340272 Tnfsf11 Positive_regulation of Gene_expression of NFATC1 1 0.09 0.56 0
113 INT165987 PTGER1 Regulation of Gene_expression of TNFSF11 1 0.06 0.16 0
114 INT298582 IL1B Regulation of Gene_expression of TNFSF11 1 0.46 0 0
115 INT340238 Tnfsf11 Positive_regulation of Gene_expression of Fig4 1 0.02 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
2 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
3 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
4 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
5 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
6 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
7 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
8 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
9 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
10 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
11 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
12 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
13 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
14 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
15 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
16 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
17 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
18 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39
19 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39
20 INT97019 Negative_regulation of Binding of TNFRSF11A 4 0.17 1.8 1.89
21 INT134890 Localization of TNFRSF11A 1 0.79 3.75 1.86
22 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82
23 INT134889 Negative_regulation of TNFRSF11A 9 0.42 12.65 1.76
24 INT171964 Positive_regulation of Gene_expression of Tnfrsf11a 5 0.37 4.11 1.73
25 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61
26 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46
27 INT105551 Transcription of Tnfsf11 6 0.69 4.21 1.38
28 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34
29 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27
30 INT135186 Negative_regulation of Gene_expression of TNFSF11 10 0.58 2.69 1.25
31 INT105552 Positive_regulation of Transcription of Tnfsf11 3 0.31 2.94 1.17
32 INT224429 Regulation of TNFSF11 8 0.61 4.35 1.13
33 INT209895 Transcription of TNFRSF11A 4 0.52 2.56 1.09
34 INT153769 Negative_regulation of Tnfrsf11a 4 0.39 2.13 1.05
35 INT210586 Negative_regulation of Positive_regulation of Tnfsf11 3 0.41 1.4 1.02
36 INT132847 Negative_regulation of Localization of Tnfsf11 1 0.32 0.16 1.01
37 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94
38 INT171963 Positive_regulation of Positive_regulation of Tnfsf11 3 0.42 2.44 0.93
39 INT187218 Negative_regulation of Gene_expression of Tnfrsf11a 1 0.31 1.65 0.8
40 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79
41 INT298598 Positive_regulation of Positive_regulation of TNFSF11 2 0.38 1.26 0.72
42 INT165760 Positive_regulation of Binding of Tnfsf11 2 0.36 1.83 0.71
43 INT187210 Negative_regulation of Binding of Tnfrsf11a 1 0.23 1.77 0.7
44 INT185729 Negative_regulation of Gene_expression of Tnfsf11 3 0.52 2.07 0.69
45 INT205171 Localization of TNFSF11 4 0.74 3.94 0.66
46 INT264991 Positive_regulation of Localization of Tnfsf11 5 0.24 3.22 0.59
47 INT207379 Regulation of Negative_regulation of Tnfsf11 2 0.28 1.7 0.5
48 INT187215 Transcription of Tnfrsf11a 1 0.28 1.15 0.49
49 INT134891 Negative_regulation of Positive_regulation of TNFRSF11A 1 0.22 0.34 0.45
50 INT340265 Localization of Tnfsf11 2 0.30 1.65 0.44
51 INT341289 Positive_regulation of Localization of Tnfsf11 1 0.13 1.26 0.44
52 INT137846 Regulation of Tnfsf11 5 0.48 1.62 0.42
53 INT209899 Positive_regulation of Protein_catabolism of TNFRSF11A 1 0.49 0.77 0.42
54 INT209894 Protein_catabolism of TNFRSF11A 1 0.87 0.76 0.42
55 INT165761 Phosphorylation of Tnfsf11 3 0.75 2.76 0.4
56 INT187214 Negative_regulation of Binding of Tnfsf11 1 0.25 1.01 0.38
57 INT135188 Transcription of TNFSF11 4 0.59 0.72 0.36
58 INT254264 Positive_regulation of Protein_catabolism of Tnfrsf11a 1 0.21 0.74 0.35
59 INT295000 Binding of Tnfsf11 5 0.32 2.27 0.32
60 INT137847 Negative_regulation of Tnfsf11 4 0.42 1.31 0.24
61 INT210588 Protein_catabolism of Tnfsf11 1 0.72 1.43 0.23
62 INT64184 Negative_regulation of Gene_expression of TNFRSF11A 7 0.57 2.81 0.22
63 INT254265 Protein_catabolism of Tnfrsf11a 1 0.29 0.32 0.15
64 INT217448 Regulation of Tnfrsf11a 1 0.42 2.31 0.14
65 INT294997 Regulation of Gene_expression of Tnfsf11 1 0.35 0.81 0.13
66 INT210605 Negative_regulation of Negative_regulation of TNFSF11 2 0.42 1.65 0.1
67 INT167180 Phosphorylation of TNFRSF11A 1 0.79 1.03 0.09
68 INT224430 Positive_regulation of Transcription of TNFSF11 1 0.43 0.06 0.07
69 INT144491 Negative_regulation of Transcription of Tnfsf11 1 0.42 0.82 0.07
70 INT217453 Regulation of Positive_regulation of Tnfrsf11a 1 0.42 0.38 0.05
71 INT210608 Negative_regulation of Binding of TNFSF11 2 0.25 2.31 0.04
72 INT129853 Positive_regulation of Positive_regulation of TNFRSF11A 2 0.64 0.81 0.04
73 INT232197 Positive_regulation of Phosphorylation of Tnfsf11 1 0.46 0.6 0.04
74 INT232198 Phosphorylation of Tnfrsf11a 1 0.56 0.6 0.04
75 INT232201 Negative_regulation of Positive_regulation of Tnfrsf11a 1 0.40 1.16 0.04
76 INT232196 Negative_regulation of Negative_regulation of Tnfsf11 1 0.39 1.5 0.04
77 INT232199 Positive_regulation of Phosphorylation of Tnfrsf11a 1 0.34 0.6 0.04
78 INT210609 Positive_regulation of Localization of TNFSF11 1 0.41 1.12 0.04
79 INT209892 Regulation of Gene_expression of TNFRSF11A 2 0.27 0.61 0.03
80 INT210604 Negative_regulation of Negative_regulation of TNFRSF11A 1 0.32 1.59 0.03
81 INT210591 Positive_regulation of Negative_regulation of Tnfsf11 1 0.47 1.46 0.03
82 INT221486 Positive_regulation of Binding of TNFSF11 1 0.15 0.98 0
83 INT274022 Regulation of Positive_regulation of TNFSF11 1 0.05 0.29 0
84 INT205176 Protein_catabolism of TNFSF11 1 0.29 0.25 0
85 INT185731 Negative_regulation of Regulation of Tnfsf11 1 0.34 0.89 0
86 INT339785 Positive_regulation of Transcription of TNFRSF11A 1 0.10 0.5 0
87 INT329484 Regulation of Regulation of TNFSF11 1 0.23 0.71 0
88 INT185728 Positive_regulation of Positive_regulation of Tnfsf11 1 0.36 0.25 0
89 INT340267 Negative_regulation of Localization of Tnfsf11 1 0.19 0.45 0
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