GO:0071875

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Name adrenergic receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0071875
Unique Molecular Interactions 140
Total Molecular Interactions 190
Total Single Events 2358
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for adrenergic receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for adrenergic receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
2 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
3 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
4 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
5 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
6 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
7 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
8 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
9 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
10 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
11 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
12 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
13 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
14 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
15 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
16 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
17 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
18 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
19 INT284307 Mir155 Regulation of Adrb3 1 0.00 3.44 0.73
20 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
21 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
22 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
23 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
24 INT62250 Fdft1 Regulation of Adrb1 1 0.00 0 0.65
25 INT31418 Positive_regulation of Adra2c Positive_regulation of Gcg 1 0.22 0 0.65
26 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
27 INT108020 Binding of Adrb1 and Clec4d 1 0.00 1.19 0.61
28 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
29 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
30 INT78580 Binding of Adra2b and Oprd1 1 0.01 0.07 0.57
31 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
32 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
33 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
34 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
35 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
36 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
37 INT135799 Binding of Adra1d and Adra2b 1 0.02 0 0.48
38 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
39 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
40 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
41 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
42 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
43 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
44 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
45 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
46 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
47 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
48 INT145576 Binding of Adra2c and Hcn4 1 0.21 0.19 0.4
49 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
50 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
51 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
52 INT145574 Regulation of Binding of Adra2c and Hcn4 1 0.26 0.19 0.4
53 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
54 INT84602 Binding of Adrb1 and Avp 1 0.00 0 0.36
55 INT35981 Adrb1 Regulation of Localization of Prl 1 0.00 0 0.36
56 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
57 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
58 INT44654 Phc1 Negative_regulation of Adra1a 1 0.00 0.4 0.33
59 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
60 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
61 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
62 INT59326 Binding of Adra1a and Positive_regulation of Binding of Npy 1 0.44 0 0.31
63 INT26942 Adra2c Positive_regulation of Localization of Ins1 1 0.13 0 0.28
64 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
65 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
66 INT284297 Mir155 Positive_regulation of Adrb3 1 0.01 0.51 0.24
67 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
68 INT284299 Adrb3 Positive_regulation of Gene_expression of Mir155 1 0.01 0.51 0.24
69 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
70 INT143618 Msr1 Positive_regulation of Adrb3 1 0.16 0.85 0.2
71 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
72 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
73 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
74 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
75 INT284298 Adrb3 Regulation of Mir155 1 0.00 0.24 0.12
76 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
77 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
78 INT83831 Binding of PNMT and Adrb1 1 0.02 0 0.1
79 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
80 INT83832 Negative_regulation of Binding of PNMT and Adrb1 1 0.02 0 0.1
81 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
82 INT284310 Mir155 Negative_regulation of Adrb3 1 0.00 0.55 0.08
83 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
84 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
85 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
86 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03
87 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
88 INT233526 Tlr4 Regulation of Adrb2 1 0.03 0.07 0
89 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for adrenergic receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in adrenergic receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
4 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
5 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
6 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
7 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
8 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
9 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
10 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
11 INT170 Negative_regulation of Adrb1 52 0.55 13.46 14.78
12 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41
13 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
14 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
15 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
16 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
17 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
18 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
19 INT59 Regulation of Adrb1 25 0.42 8.32 9.78
20 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
21 INT30247 Regulation of Adrb1 18 0.44 4.45 8.93
22 INT96 Binding of Adrb1 18 0.48 2.8 8.52
23 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
24 INT26115 Gene_expression of Adrb1 14 0.64 5.13 7.78
25 INT23992 Positive_regulation of Adrb1 25 0.56 4.01 7.62
26 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
27 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
28 INT335 Binding of Adra1a 16 0.36 6.16 6
29 INT26940 Positive_regulation of Adra2c 9 0.49 2.21 5.27
30 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
31 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
32 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
33 INT5675 Gene_expression of Adra2c 7 0.75 1.25 4.58
34 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
35 INT465 Binding of Adrb1 14 0.35 3.04 4.07
36 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
37 INT8711 Binding of Adra2b 6 0.42 0.08 3.78
38 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
39 INT30181 Gene_expression of Adra2b 10 0.62 1.89 3.48
40 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
41 INT18459 Regulation of Adra2c 6 0.45 0.42 3.4
42 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
43 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
44 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
45 INT30870 Negative_regulation of Adra2b 8 0.44 4.5 2.8
46 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
47 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
48 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
49 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
50 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
51 INT4495 Gene_expression of Adrb1 7 0.66 2.43 2.29
52 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
53 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
54 INT94 Positive_regulation of Negative_regulation of Adrb1 4 0.46 0.97 2.16
55 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
56 INT15211 Localization of Adra1a 3 0.16 0 2.08
57 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
58 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
59 INT23884 Negative_regulation of Negative_regulation of Adrb1 7 0.38 2.3 1.83
60 INT32176 Negative_regulation of Negative_regulation of Adrb1 2 0.40 0.4 1.77
61 INT110026 Localization of Adrb1 4 0.72 1.56 1.71
62 INT1731 Localization of Adrb1 5 0.43 0.31 1.67
63 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
64 INT31052 Gene_expression of Adra1d 5 0.65 1.46 1.53
65 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
66 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
67 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
68 INT78363 Negative_regulation of Adrb3 2 0.19 3.32 1.38
69 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
70 INT14803 Positive_regulation of Positive_regulation of Adra1a 4 0.35 0.49 1.36
71 INT38312 Positive_regulation of Gene_expression of Adrb1 2 0.07 0.22 1.33
72 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
73 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
74 INT82729 Transcription of Adra2b 1 0.02 1.05 1.23
75 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
76 INT140159 Regulation of Gene_expression of Adrb1 1 0.00 0.17 1.07
77 INT284269 Positive_regulation of Negative_regulation of Adrb3 1 0.01 2.42 1.06
78 INT41043 Regulation of Adra2b 3 0.39 0.47 1.03
79 INT78362 Gene_expression of Adrb3 2 0.67 3.28 1.02
80 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
81 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
82 INT42420 Negative_regulation of Binding of Adrb1 2 0.58 0.8 0.97
83 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
84 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
85 INT31828 Transcription of Adrb1 2 0.27 0.18 0.94
86 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
87 INT33665 Positive_regulation of Gene_expression of Adra2c 1 0.50 0.43 0.89
88 INT65230 Negative_regulation of Adra2c 3 0.42 0.44 0.88
89 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
90 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
91 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
92 INT1732 Positive_regulation of Localization of Adrb1 2 0.22 0.06 0.8
93 INT125157 Negative_regulation of Gene_expression of Adra1a 1 0.18 0.54 0.8
94 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
95 INT33481 Positive_regulation of Gene_expression of Adrb2 2 0.48 0.38 0.78
96 INT32751 Regulation of Positive_regulation of Adrb1 2 0.36 0.07 0.77
97 INT110117 Negative_regulation of Positive_regulation of Adra2c 1 0.12 0.33 0.77
98 INT28057 Binding of Adra2c 4 0.36 0.25 0.75
99 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72
100 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
101 INT139092 Negative_regulation of Gene_expression of Adra1d 1 0.07 0 0.69
102 INT139088 Positive_regulation of Gene_expression of Adra1d 1 0.05 0 0.69
103 INT95816 Regulation of Positive_regulation of Adra2c 2 0.28 0.66 0.68
104 INT6734 Localization of Adra1a 3 0.31 0.25 0.67
105 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
106 INT24095 Protein_catabolism of Adrb1 2 0.10 0.59 0.61
107 INT83826 Negative_regulation of Binding of Adrb1 3 0.25 0.67 0.6
108 INT29111 Negative_regulation of Positive_regulation of Adrb1 1 0.37 0.14 0.58
109 INT18657 Negative_regulation of Binding of Adra1a 2 0.43 0.17 0.56
110 INT56708 Positive_regulation of Positive_regulation of Adra1a 1 0.25 0 0.55
111 INT82128 Negative_regulation of Transcription of Adra2a 1 0.18 1.32 0.55
112 INT59394 Regulation of Regulation of Adra2a 1 0.17 0 0.55
113 INT31363 Positive_regulation of Regulation of Adra2a 1 0.04 0 0.55
114 INT13738 Negative_regulation of Positive_regulation of Adra1a 3 0.29 0.08 0.52
115 INT21090 Regulation of Negative_regulation of Adra1a 1 0.18 0.35 0.52
116 INT77904 Negative_regulation of Gene_expression of Adra2a 2 0.43 0.87 0.5
117 INT42184 Positive_regulation of Binding of Adrb1 1 0.31 0.19 0.5
118 INT56662 Regulation of Protein_catabolism of Adrb1 1 0.05 0.27 0.5
119 INT56661 Positive_regulation of Protein_catabolism of Adrb1 1 0.06 0.27 0.49
120 INT41146 Negative_regulation of Localization of Adra2a 1 0.37 0.1 0.49
121 INT26917 Regulation of Adra1d 2 0.21 1.56 0.47
122 INT124786 Localization of Adrb2 1 0.04 0.07 0.44
123 INT13884 Positive_regulation of Positive_regulation of Adrb2 1 0.34 0 0.42
124 INT143617 Positive_regulation of Adrb3 3 0.20 2.07 0.41
125 INT33171 Positive_regulation of Negative_regulation of Adra2a 1 0.39 0 0.4
126 INT66593 Regulation of Gene_expression of Adra1a 2 0.05 0 0.39
127 INT513 Transcription of Adrb2 2 0.06 0.55 0.37
128 INT102164 Positive_regulation of Binding of Adra1a 1 0.35 0.19 0.37
129 INT34162 Regulation of Regulation of Adra1a 1 0.02 0 0.36
130 INT97767 Positive_regulation of Adra2b 3 0.45 1.75 0.34
131 INT63924 Regulation of Binding of Adrb1 1 0.16 0.27 0.34
132 INT52207 Positive_regulation of Positive_regulation of Adrb1 1 0.09 0 0.33
133 INT69187 Regulation of Positive_regulation of Adrb1 1 0.25 0 0.33
134 INT26941 Localization of Adra2c 2 0.23 0 0.3
135 INT113578 Negative_regulation of Adra1d 2 0.42 0.24 0.3
136 INT26939 Positive_regulation of Positive_regulation of Adra2c 1 0.16 0 0.3
137 INT44623 Positive_regulation of Regulation of Adra1a 1 0.04 0.64 0.29
138 INT78364 Positive_regulation of Gene_expression of Adrb3 2 0.50 0.3 0.28
139 INT13453 Regulation of Negative_regulation of Adra2a 2 0.27 0.49 0.28
140 INT10857 Regulation of Negative_regulation of Adrb1 2 0.45 0.65 0.28
141 INT284287 Regulation of Adrb3 1 0.00 0.82 0.28
142 INT42351 Regulation of Positive_regulation of Adra1a 1 0.01 0 0.26
143 INT118118 Positive_regulation of Binding of Adra1a 1 0.18 0.3 0.26
144 INT1440 Binding of Adra1d 1 0.16 0 0.24
145 INT122590 Transcription of Adra1a 1 0.03 0.73 0.24
146 INT113577 Transcription of Adra1d 1 0.52 0.27 0.23
147 INT115874 Negative_regulation of Positive_regulation of Adrb2 1 0.20 0 0.21
148 INT230389 Binding of Adrb3 1 0.35 1.26 0.2
149 INT39288 Regulation of Binding of Adra1a 1 0.20 0.35 0.2
150 INT133507 Regulation of Negative_regulation of Adrb2 1 0.18 0 0.17
151 INT31927 Positive_regulation of Localization of Adra1a 1 0.10 0.17 0.16
152 INT81943 Regulation of Regulation of Adrb2 1 0.29 0 0.12
153 INT81944 Regulation of Positive_regulation of Adrb2 1 0.18 0 0.12
154 INT263872 Localization of Adra1d 1 0.01 2.5 0.11
155 INT40871 Regulation of Negative_regulation of Adrb1 1 0.24 0.32 0.1
156 INT44040 Negative_regulation of Gene_expression of Adrb1 1 0.35 0.34 0.09
157 INT38754 Regulation of Negative_regulation of Adra2b 1 0.34 0.44 0.08
158 INT45551 Regulation of Regulation of Adrb1 1 0.22 0.29 0.08
159 INT125793 Protein_catabolism of Adra1a 1 0.39 0.24 0.05
160 INT284278 Transcription of Adrb3 1 0.01 0.26 0.05
161 INT263879 Positive_regulation of Adra1d 1 0.00 0.47 0.04
162 INT210662 Transcription of Adra2a 1 0.01 0.09 0
163 INT157839 Positive_regulation of Gene_expression of Adra2b 1 0.03 0 0
164 INT230388 Localization of Adrb2 1 0.51 0.71 0
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