GO:0071881

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Name inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0071881
Unique Molecular Interactions 44
Total Molecular Interactions 60
Total Single Events 660
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
2 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
3 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
4 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
5 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
6 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
7 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
8 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
9 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
10 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
11 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
12 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
13 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
14 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
15 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
16 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
17 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
18 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
19 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
20 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
21 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
22 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
23 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
24 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
25 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
26 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
27 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
28 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
29 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
30 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
31 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
32 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
33 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
34 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
35 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
36 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
37 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
38 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
39 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
40 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
41 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
42 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
43 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
44 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
4 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
5 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
6 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
7 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
8 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
9 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
10 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
11 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
12 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
13 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
14 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
15 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
16 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
17 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
18 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
19 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
20 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
21 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
22 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
23 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
24 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
25 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
26 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
27 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
28 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
29 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
30 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
31 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
32 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
33 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
34 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
35 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
36 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
37 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
38 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
39 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
40 INT82128 Negative_regulation of Transcription of Adra2a 1 0.18 1.32 0.55
41 INT59394 Regulation of Regulation of Adra2a 1 0.17 0 0.55
42 INT31363 Positive_regulation of Regulation of Adra2a 1 0.04 0 0.55
43 INT30428 Positive_regulation of Binding of ADRA2A 1 0.34 0.59 0.53
44 INT77904 Negative_regulation of Gene_expression of Adra2a 2 0.43 0.87 0.5
45 INT41146 Negative_regulation of Localization of Adra2a 1 0.37 0.1 0.49
46 INT29102 Transcription of ADRA2A 2 0.27 0.83 0.46
47 INT33171 Positive_regulation of Negative_regulation of Adra2a 1 0.39 0 0.4
48 INT29100 Negative_regulation of Binding of ADRA2A 1 0.19 0.84 0.37
49 INT29101 Positive_regulation of Transcription of ADRA2A 1 0.19 0.76 0.32
50 INT13453 Regulation of Negative_regulation of Adra2a 2 0.27 0.49 0.28
51 INT134176 Gene_expression of ADRA2A 4 0.58 1.45 0.25
52 INT25928 Positive_regulation of Negative_regulation of ADRA2A 1 0.05 0 0.23
53 INT134177 Positive_regulation of Gene_expression of ADRA2A 1 0.10 0.26 0.12
54 INT134178 Positive_regulation of Regulation of ADRA2A 1 0.10 0.24 0.12
55 INT210662 Transcription of Adra2a 1 0.01 0.09 0
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