GO:0071889

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Name 14-3-3 protein binding
Categary Function
Go Slim No
Go Link GO:0071889
Unique Molecular Interactions 102
Total Molecular Interactions 150
Total Single Events 639
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 14-3-3 protein binding. They are ordered first by their pain relevance and then by number of times they were reported for 14-3-3 protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
2 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
3 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
4 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
5 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
6 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
7 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
8 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
9 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
10 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
11 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
12 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
13 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
14 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
15 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
16 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
17 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
18 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
19 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
20 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
21 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67
22 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
23 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
24 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
25 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
26 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
27 INT179566 Binding of C1qa and Ywhaq 1 0.00 0.56 0.26
28 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12
29 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
30 INT238207 Binding of Bmx and Sik1 1 0.01 0.43 0.07
31 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
32 INT238208 Sik1 Positive_regulation of Positive_regulation of Bmx 1 0.01 0 0.05
33 INT299302 Negative_regulation of RPTOR Regulation of AKT1 1 0.30 0.1 0.05
34 INT299304 RPTOR Regulation of AKT1 1 0.19 0.1 0.05
35 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
36 INT238211 Binding of STAT3 and Sik1 1 0.04 0.25 0.04
37 INT343540 Binding of PPP1R12A and MLC1 1 0.09 0.15 0.04
38 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
39 INT295854 Srpk2 Regulation of Localization of Srsf1 1 0.21 0 0.04
40 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
41 INT260946 Zfp36 Negative_regulation of Binding of Elavl1 1 0.21 0.11 0.03
42 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
43 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
44 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
45 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
46 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
47 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
48 INT299292 RPTOR Negative_regulation of PI3 1 0.25 0 0
49 INT299296 SRC Regulation of RPTOR 1 0.32 0 0
50 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
51 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
52 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
53 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
54 INT246801 Negative_regulation of Akt1 Negative_regulation of Phosphorylation of Tsc2 1 0.17 0 0
55 INT246792 Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.78 0
56 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0
57 INT339977 Positive_regulation of Binding of HDAC3 and HDAC7 1 0.23 0.52 0
58 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0
59 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
60 INT246798 Akt1 Regulation of Tsc2 1 0.16 0.34 0
61 INT299280 VEGFA Positive_regulation of RPTOR 1 0.29 0 0
62 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0
63 INT299283 Binding of VEGFA and RPTOR 1 0.19 0 0
64 INT246797 Tgfb1i1 Positive_regulation of Phosphorylation of Tsc2 1 0.01 0.66 0
65 INT339978 Binding of HDAC3 and HDAC7 1 0.17 1.04 0
66 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0
67 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0
68 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0
69 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0
70 INT246806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.32 0
71 INT295871 Binding of RNPS1 and Srpk2 1 0.01 0.76 0
72 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0
73 INT246803 Binding of Akt1 and Tsc2 1 0.14 0.85 0
74 INT299293 Binding of QPCT and RPTOR 1 0.02 0 0
75 INT339980 Binding of MEF2D and HDAC7 1 0.19 0.78 0
76 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0
77 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0
78 INT246790 Gene_expression of Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.02 0 0
79 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0
80 INT285641 Zfp36 Negative_regulation of Egr1 1 0.06 0.28 0
81 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0
82 INT246800 Binding of Tsc2 and Ogg1 1 0.16 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 14-3-3 protein binding. They are ordered first by their pain relevance and then by number of times they were reported in 14-3-3 protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
2 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
3 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
4 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
5 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
6 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
7 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
8 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
9 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
10 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
11 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
12 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
13 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
14 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
15 INT299340 Negative_regulation of RPTOR 1 0.53 1.68 2.6
16 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
17 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
18 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
19 INT299331 Positive_regulation of RPTOR 1 0.63 0.9 1.62
20 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
21 INT179550 Phosphorylation of Ywhaq 8 0.03 6.24 1.48
22 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
23 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
24 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
25 INT299333 Gene_expression of RPTOR 1 0.61 0.25 1.18
26 INT299342 Regulation of RPTOR 1 0.41 1.06 1.1
27 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
28 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
29 INT299350 Phosphorylation of RPTOR 1 0.75 0.26 0.82
30 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
31 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
32 INT149643 Binding of Zfp36 2 0.29 0.45 0.49
33 INT204827 Positive_regulation of Zfp36 1 0.26 0.33 0.43
34 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
35 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
36 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
37 INT339992 Positive_regulation of Transcription of HDAC7 1 0.45 1.56 0.28
38 INT340001 Transcription of HDAC7 1 0.61 1.5 0.27
39 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
40 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
41 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
42 INT270417 Binding of Ywhaq 1 0.00 0.52 0.2
43 INT277393 Gene_expression of HDAC7 2 0.65 4.71 0.18
44 INT327283 Negative_regulation of Zfp36 1 0.39 0.5 0.18
45 INT339984 Positive_regulation of HDAC7 1 0.45 1.07 0.16
46 INT299349 Localization of RPTOR 1 0.68 0 0.16
47 INT299315 Regulation of Gene_expression of RPTOR 1 0.41 0 0.14
48 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13
49 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13
50 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12
51 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12
52 INT271941 Binding of Tsc2 12 0.24 2.96 0.11
53 INT246772 Regulation of Phosphorylation of Tsc2 1 0.26 1.37 0.09
54 INT260907 Phosphorylation of Zfp36 1 0.54 0.47 0.08
55 INT299343 Negative_regulation of Gene_expression of RPTOR 1 0.39 0 0.08
56 INT238167 Localization of Sik1 1 0.06 0.16 0.07
57 INT238165 Gene_expression of Sik1 1 0.05 0.2 0.07
58 INT299341 Positive_regulation of Phosphorylation of RPTOR 1 0.46 0.1 0.06
59 INT246770 Positive_regulation of Negative_regulation of Tsc2 1 0.20 1.91 0.05
60 INT299321 Positive_regulation of Gene_expression of RPTOR 1 0.46 0 0.05
61 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04
62 INT242338 Binding of TSC2 2 0.22 1.56 0.04
63 INT260911 Regulation of Phosphorylation of Zfp36 1 0.30 0.23 0.04
64 INT343553 Phosphorylation of PPP1R12A 1 0.17 0.16 0.04
65 INT271937 Positive_regulation of Binding of Tsc2 1 0.25 0 0.04
66 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03
67 INT238158 Phosphorylation of Sik1 1 0.06 0.69 0.03
68 INT238181 Binding of Sik1 1 0.04 0.18 0.03
69 INT238182 Positive_regulation of Localization of Sik1 1 0.04 0 0.03
70 INT238161 Positive_regulation of Phosphorylation of Sik1 1 0.04 0 0.03
71 INT246774 Positive_regulation of Tsc2 6 0.41 2.4 0
72 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0
73 INT228895 Binding of Tsc2 5 0.30 2.41 0
74 INT246755 Regulation of Tsc2 4 0.50 1.01 0
75 INT277405 Negative_regulation of Gene_expression of HDAC7 2 0.41 1.52 0
76 INT216011 Regulation of TSC2 2 0.26 3.31 0
77 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0
78 INT271944 Negative_regulation of Phosphorylation of Tsc2 2 0.30 0.42 0
79 INT260926 Regulation of Zfp36 2 0.21 0.47 0
80 INT246761 Positive_regulation of Gene_expression of Tsc2 2 0.41 1.17 0
81 INT246777 Regulation of Gene_expression of Tsc2 1 0.19 0 0
82 INT295842 Phosphorylation of Srpk2 1 0.38 0.42 0
83 INT295828 Positive_regulation of Gene_expression of Srpk2 1 0.32 1.93 0
84 INT246754 Negative_regulation of Binding of Tsc2 1 0.18 0.12 0
85 INT271905 Positive_regulation of Protein_catabolism of Tsc2 1 0.35 1.46 0
86 INT246747 Negative_regulation of Negative_regulation of Tsc2 1 0.18 0.56 0
87 INT271904 Localization of Tsc2 1 0.41 1.31 0
88 INT161736 Negative_regulation of Gene_expression of Arrb2 1 0.50 0 0
89 INT339999 Positive_regulation of Gene_expression of HDAC7 1 0.45 1.97 0
90 INT295853 Negative_regulation of Gene_expression of Srpk2 1 0.20 0 0
91 INT238166 Positive_regulation of Sik1 1 0.03 0.13 0
92 INT246780 Protein_catabolism of Tsc2 1 0.28 0.15 0
93 INT286549 Regulation of Tsc2 1 0.11 0.42 0
94 INT246752 Negative_regulation of Gene_expression of Tsc2 1 0.25 0.52 0
95 INT149645 Positive_regulation of Gene_expression of Zfp36 1 0.14 0 0
96 INT271940 Protein_catabolism of Tsc2 1 0.50 0.7 0
97 INT340003 Localization of HDAC7 1 0.67 1.61 0
98 INT246759 Positive_regulation of Phosphorylation of Tsc2 1 0.29 9.31 0
99 INT276884 Regulation of Phosphorylation of TSC2 1 0.25 0.21 0
100 INT238157 Positive_regulation of Gene_expression of Sik1 1 0.03 0 0
101 INT246751 Positive_regulation of Binding of Tsc2 1 0.21 0.15 0
102 INT295827 Gene_expression of Srpk2 1 0.36 1.25 0
103 INT149639 Gene_expression of Zfp36 1 0.22 0 0
104 INT277377 Phosphorylation of HDAC7 1 0.79 0.36 0
105 INT271909 Positive_regulation of Tsc2 1 0.25 0.06 0
106 INT277399 Binding of HDAC7 1 0.36 1.67 0
107 INT295821 Binding of Srpk2 1 0.22 0.75 0
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