GO:0071902

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Name positive regulation of protein serine/threonine kinase activity
Categary Process
Go Slim No
Go Link GO:0071902
Unique Molecular Interactions 343
Total Molecular Interactions 442
Total Single Events 3651
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
3 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
4 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
5 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
6 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
7 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
8 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
9 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
10 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
11 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
12 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
13 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67
14 INT311466 Binding of Acsl1 and Il1 1 0.00 2.46 0.63
15 INT311467 Binding of Crp and Acsl1 1 0.00 2.31 0.61
16 INT202160 Binding of ARSD and CSF1R 1 0.16 1.69 0.59
17 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
18 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
19 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
20 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
21 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
22 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
23 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
24 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
25 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54
26 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
27 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
28 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
29 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
30 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
31 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
32 INT313455 Binding of Ppp2ca and Syp 1 0.45 0.68 0.4
33 INT196828 Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.4
34 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
35 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
36 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
37 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
38 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
39 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
40 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
41 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
42 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
43 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
44 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
45 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
46 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
47 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
48 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31
49 INT339645 Binding of Cdk5r1 and Ebi3 1 0.01 0.78 0.31
50 INT235872 Phosphorylation of Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.31
51 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
52 INT235886 Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.3
53 INT196825 Prkaca Positive_regulation of Phosphorylation of Ppp2ca 1 0.20 0 0.29
54 INT328407 Nlrp1a Negative_regulation of Gene_expression of Snca 1 0.07 0.31 0.29
55 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
56 INT196831 Positive_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.29
57 INT298996 Il18 Positive_regulation of Gene_expression of Cdk5r1 1 0.03 1.65 0.29
58 INT328410 Nlrp1a Negative_regulation of Snca 1 0.07 0.31 0.29
59 INT196814 Negative_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.17 0 0.29
60 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
61 INT299011 Il18 Positive_regulation of Transcription of Cdk5r1 1 0.03 1.65 0.29
62 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
63 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
64 INT177978 Binding of CSF1R and SNRNP70 1 0.02 1.49 0.28
65 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
66 INT177977 RUNX1 Regulation of CSF1R 1 0.14 1 0.27
67 INT313446 Syp Regulation of Ppp2ca 1 0.58 0.62 0.26
68 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
69 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
70 INT290376 Binding of CSF1R and MEFV 1 0.29 0.31 0.24
71 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
72 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
73 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
74 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
75 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
76 INT34773 GH1 Regulation of IGF2 1 0.31 0.05 0.22
77 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
78 INT90280 Binding of Ppp1cc and Ppp2ca 1 0.34 0.22 0.22
79 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
80 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
81 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
82 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
83 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
84 INT326831 Cdk5r2 Positive_regulation of Binding of Cdk5r1 1 0.01 0.95 0.21
85 INT326834 Cdk5r2 Positive_regulation of Cdk5 1 0.02 0.96 0.21
86 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
87 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
88 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
89 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
90 INT221955 Binding of ELAVL1 and CDK5R1 1 0.01 0.93 0.19
91 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
92 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
93 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
94 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
95 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
96 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
97 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
98 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
99 INT313449 Siglec1 Regulation of Ppp2ca 1 0.03 0.61 0.17
100 INT164790 Cdk5r1 Positive_regulation of Trib3 1 0.02 0.25 0.17
101 INT299001 Il18 Positive_regulation of Cdk5r1 1 0.03 0.36 0.17
102 INT116268 Binding of Myc and Acsl1 1 0.08 0.19 0.16
103 INT235883 Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
104 INT92580 IGF2 Positive_regulation of Gene_expression of PTGER2 1 0.07 0.43 0.15
105 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
106 INT92583 IGF2 Positive_regulation of Transcription of PTGER2 1 0.07 0.43 0.15
107 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
108 INT235879 Regulation of Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
109 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
110 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
111 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
112 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
113 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
114 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
115 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
116 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
117 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
118 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
119 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
120 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
121 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
122 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12
123 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
124 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
125 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
126 INT196827 Phosphorylation of Prkaca Positive_regulation of Ppp2ca 1 0.18 0 0.11
127 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
128 INT177980 CSF1R Regulation of PXN 1 0.07 0.48 0.11
129 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
130 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
131 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
132 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
133 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
134 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
135 INT196819 Prkaca Positive_regulation of Binding of Ppp2ca 1 0.20 0 0.11
136 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11
137 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
138 INT277657 Igfbp1 Negative_regulation of Negative_regulation of Igf1 1 0.02 0.26 0.1
139 INT161741 Gh1 Positive_regulation of Gene_expression of Igf1 1 0.35 0.55 0.1
140 INT328413 Binding of Snca and Nlrp1a 1 0.06 0.75 0.1
141 INT234626 IGFBP3 Regulation of IGF2 1 0.15 1.31 0.1
142 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
143 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
144 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
145 INT201748 Car2 Positive_regulation of Cdk5r1 1 0.00 0.67 0.09
146 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
147 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
148 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
149 INT354120 Binding of IGF2 and IGFBP5 1 0.01 0.45 0.09
150 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09
151 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
152 INT313430 Syp Positive_regulation of Ppp2ca 1 0.66 0.08 0.09
153 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
154 INT83270 Snca Regulation of Napepld 1 0.14 0 0.09
155 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
156 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
157 INT313447 Ppp2ca Regulation of Phosphorylation of Syp 1 0.43 0 0.08
158 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
159 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
160 INT301645 Binding of Alb and Slc27a1 1 0.02 0.38 0.08
161 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
162 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
163 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
164 INT301614 Binding of Slc27a1 and Cd36 1 0.09 0.38 0.08
165 INT313469 Ppp2ca Regulation of Phosphorylation of Siglec1 1 0.06 0 0.08
166 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
167 INT196810 Binding of Prkaca and Ppp2ca 1 0.14 0 0.07
168 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07
169 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
170 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07
171 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
172 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
173 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06
174 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
175 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
176 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
177 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06
178 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06
179 INT313463 Ppp2ca Regulation of Syp 1 0.43 0.6 0.06
180 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
181 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05
182 INT200889 Acsl1 Positive_regulation of Mapk14 1 0.01 0.09 0.05
183 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
184 INT200890 Acsl1 Positive_regulation of Mapk1 1 0.03 0.09 0.05
185 INT112282 Ntf3 Regulation of Igf1 1 0.07 0.14 0.05
186 INT206619 Mtpn Positive_regulation of Igf1 1 0.04 0.17 0.05
187 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05
188 INT198358 GH1 Regulation of Igf1 1 0.00 0.09 0.05
189 INT299302 Negative_regulation of RPTOR Regulation of AKT1 1 0.30 0.1 0.05
190 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
191 INT299304 RPTOR Regulation of AKT1 1 0.19 0.1 0.05
192 INT315986 Igf1 Positive_regulation of Pik3c3 1 0.00 0.48 0.05
193 INT335133 PPARA Positive_regulation of Slc27a1 1 0.10 0.14 0.04
194 INT184083 Positive_regulation of Gh Positive_regulation of Igf1 1 0.09 0.7 0.04
195 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
196 INT184115 Igf1 Positive_regulation of Gene_expression of Socs2 1 0.16 0.62 0.04
197 INT221952 UTS2R Regulation of Protein_catabolism of CDK5R1 1 0.10 0.3 0.04
198 INT326830 Cdk5r1 Positive_regulation of Positive_regulation of Cdk5 1 0.09 0.16 0.04
199 INT206620 Gh1 Positive_regulation of Igf1 1 0.25 0.17 0.04
200 INT221953 UTS2R Positive_regulation of Gene_expression of CDK5R1 1 0.16 0.23 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
3 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
4 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
5 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
6 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
7 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
8 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
9 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
10 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
11 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1
12 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
13 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
14 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
15 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
16 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
17 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
18 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
19 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
20 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
21 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
22 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
23 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
24 INT151032 Localization of Igf1 49 0.76 26.32 5.71
25 INT152433 Binding of CSF1R 6 0.33 10.97 5.54
26 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
27 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2
28 INT123594 Negative_regulation of Snca 19 0.59 4.43 4.59
29 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56
30 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
31 INT196782 Positive_regulation of Ppp2ca 32 0.61 1.89 4.33
32 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
33 INT49360 Localization of Igf1 22 0.76 6.96 4.26
34 INT109219 Negative_regulation of Cdk5r1 5 0.43 1.22 4.25
35 INT90277 Negative_regulation of Ppp2ca 15 0.41 4.04 4.02
36 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
37 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81
38 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
39 INT25709 Negative_regulation of Igf2 11 0.56 9.38 3.76
40 INT75869 Gene_expression of Acsl1 24 0.45 27.76 3.66
41 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
42 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
43 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
44 INT196779 Phosphorylation of Ppp2ca 28 0.72 1.86 3.25
45 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
46 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
47 INT123595 Regulation of Snca 7 0.62 4.3 3.06
48 INT177993 Localization of CSF1R 4 0.73 7.49 2.94
49 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78
50 INT201632 Positive_regulation of Cdk5r1 20 0.40 21.6 2.75
51 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74
52 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
53 INT299340 Negative_regulation of RPTOR 1 0.53 1.68 2.6
54 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
55 INT66544 Binding of Igf1 23 0.46 8.33 2.44
56 INT9327 Localization of Igf2 8 0.80 5.07 2.36
57 INT101603 Positive_regulation of Cdk5r1 4 0.56 1.12 2.35
58 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31
59 INT86184 Negative_regulation of Acsl1 10 0.34 20.45 2.23
60 INT57132 Positive_regulation of Igf2 9 0.50 5.15 2.22
61 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
62 INT90272 Gene_expression of Ppp2ca 18 0.68 4.69 2.08
63 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03
64 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
65 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
66 INT127125 Localization of Snca 6 0.81 8.24 1.88
67 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
68 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74
69 INT101599 Gene_expression of Cdk5r1 5 0.63 1.27 1.68
70 INT299331 Positive_regulation of RPTOR 1 0.63 0.9 1.62
71 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
72 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
73 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
74 INT101601 Regulation of Cdk5r1 3 0.50 1.2 1.46
75 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
76 INT201271 Phosphorylation of Snca 3 0.82 4.22 1.45
77 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
78 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
79 INT124247 Negative_regulation of Gene_expression of Snca 12 0.59 3.87 1.39
80 INT144805 Regulation of Negative_regulation of Ppp2ca 1 0.28 0.24 1.38
81 INT90491 Binding of Igf1 25 0.44 9.75 1.36
82 INT114969 Gene_expression of CDK5R1 3 0.75 11.24 1.33
83 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
84 INT55619 Binding of Acsl1 8 0.31 9.91 1.22
85 INT202161 Negative_regulation of CSF1R 3 0.31 3.36 1.22
86 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21
87 INT9324 Negative_regulation of Gene_expression of Igf2 6 0.50 5.12 1.2
88 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19
89 INT299333 Gene_expression of RPTOR 1 0.61 0.25 1.18
90 INT25710 Regulation of Igf2 6 0.62 3.1 1.17
91 INT196785 Regulation of Ppp2ca 5 0.54 2.1 1.17
92 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
93 INT138783 Positive_regulation of Gene_expression of Cdk5r1 2 0.38 0.68 1.15
94 INT110394 Regulation of CSF1R 3 0.38 2.49 1.12
95 INT203890 Positive_regulation of Gene_expression of Cdk5r1 9 0.40 9.13 1.11
96 INT151753 Transcription of Snca 6 0.69 1.99 1.11
97 INT299342 Regulation of RPTOR 1 0.41 1.06 1.1
98 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07
99 INT292945 Positive_regulation of Positive_regulation of Snca 4 0.69 2.42 1.05
100 INT20470 Positive_regulation of Acsl1 5 0.40 3.76 1.03
101 INT286344 Positive_regulation of Gene_expression of Snca 1 0.41 2.84 1.03
102 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
103 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
104 INT109221 Positive_regulation of Negative_regulation of Cdk5r1 1 0.37 0.15 0.95
105 INT90278 Localization of Ppp2ca 4 0.66 1.12 0.94
106 INT151752 Positive_regulation of Transcription of Snca 2 0.50 0.99 0.92
107 INT124246 Binding of Snca 10 0.37 6.53 0.9
108 INT34779 Regulation of IGF2 7 0.38 4.34 0.9
109 INT196754 Binding of Ppp2ca 5 0.37 0.42 0.89
110 INT170742 Positive_regulation of Acsl1 6 0.44 6.98 0.86
111 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
112 INT311464 Negative_regulation of Binding of Acsl1 1 0.03 2.71 0.83
113 INT299350 Phosphorylation of RPTOR 1 0.75 0.26 0.82
114 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
115 INT77663 Positive_regulation of CDK5R1 3 0.67 0.43 0.79
116 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
117 INT58245 Regulation of Localization of Igf2 1 0.62 1.27 0.78
118 INT190781 Binding of Acsl1 6 0.36 9.12 0.76
119 INT273220 Positive_regulation of Positive_regulation of Cdk5r1 4 0.40 5.3 0.75
120 INT230901 Regulation of Acsl1 2 0.03 1.65 0.75
121 INT114608 Negative_regulation of Transcription of Acsl1 1 0.27 0.48 0.75
122 INT114609 Transcription of Acsl1 1 0.45 0.47 0.74
123 INT196753 Negative_regulation of Phosphorylation of Ppp2ca 3 0.37 0.52 0.7
124 INT196742 Positive_regulation of Positive_regulation of Ppp2ca 4 0.44 0.05 0.68
125 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
126 INT134472 Binding of Cdk5r1 4 0.26 4.25 0.65
127 INT337755 Protein_catabolism of Acsl1 1 0.21 0.72 0.65
128 INT77662 Regulation of CDK5R1 2 0.60 1.93 0.63
129 INT202163 Negative_regulation of Localization of CSF1R 1 0.31 1.76 0.63
130 INT296253 Negative_regulation of Gene_expression of Ppp2ca 3 0.41 1.71 0.62
131 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
132 INT221978 Regulation of Gene_expression of CDK5R1 1 0.59 5.08 0.61
133 INT196765 Positive_regulation of Gene_expression of Ppp2ca 4 0.44 1.05 0.6
134 INT34778 Localization of IGF2 5 0.62 4.78 0.59
135 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
136 INT220662 Gene_expression of Camk1 3 0.66 3.17 0.58
137 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
138 INT277644 Negative_regulation of Localization of Igf2 1 0.02 0.69 0.56
139 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
140 INT273230 Negative_regulation of Cdk5r1 1 0.25 4.48 0.53
141 INT114450 Gene_expression of Camk1 4 0.03 1.17 0.52
142 INT170739 Gene_expression of Acsl1 8 0.65 7.02 0.5
143 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
144 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
145 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
146 INT178000 Positive_regulation of Gene_expression of CSF1R 1 0.46 0.85 0.46
147 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
148 INT70893 Positive_regulation of Gene_expression of IGF2 5 0.67 6.13 0.44
149 INT201636 Protein_catabolism of Cdk5r1 3 0.18 2.79 0.44
150 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
151 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
152 INT114447 Negative_regulation of Regulation of Camk1 1 0.00 0.72 0.43
153 INT114453 Regulation of Camk1 1 0.01 0.72 0.43
154 INT148264 Transcription of SNCA 1 0.40 0.25 0.42
155 INT9328 Regulation of Gene_expression of Igf2 1 0.39 0.91 0.42
156 INT326821 Positive_regulation of Protein_catabolism of Cdk5r1 1 0.13 1.9 0.41
157 INT290389 Positive_regulation of Binding of CSF1R 1 0.25 1.14 0.4
158 INT199340 Localization of Igf2 4 0.75 4.47 0.39
159 INT134473 Binding of Cdk5r2 2 0.19 1.34 0.39
160 INT343972 Negative_regulation of Binding of SNCA 1 0.36 0.2 0.39
161 INT170737 Localization of Acsl1 5 0.20 3.51 0.38
162 INT48617 Negative_regulation of IGF2 4 0.25 0.22 0.36
163 INT169628 Binding of SNCA 4 0.47 3.53 0.36
164 INT147014 Localization of Acsl1 3 0.60 2.35 0.36
165 INT311465 Positive_regulation of Localization of Acsl1 1 0.04 1.63 0.36
166 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
167 INT57131 Negative_regulation of Positive_regulation of Igf2 1 0.36 0.67 0.35
168 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
169 INT177994 Negative_regulation of Phosphorylation of CSF1R 1 0.39 1 0.34
170 INT177999 Phosphorylation of CSF1R 1 0.75 0.99 0.33
171 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
172 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
173 INT199358 Negative_regulation of Gene_expression of Igf2 3 0.43 4.48 0.3
174 INT247937 Localization of Cdk5r1 3 0.41 1.21 0.3
175 INT343973 Localization of SNCA 1 0.63 0.07 0.3
176 INT114448 Regulation of Gene_expression of Camk1 1 0.01 0.52 0.3
177 INT202435 Transcription of IGF2 3 0.58 2.44 0.29
178 INT9329 Transcription of Igf2 2 0.58 1.28 0.29
179 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
180 INT298974 Transcription of Cdk5r1 1 0.04 1.64 0.28
181 INT290388 Regulation of Gene_expression of CSF1R 1 0.24 0.84 0.25
182 INT273216 Negative_regulation of Gene_expression of Cdk5r1 1 0.25 1.73 0.25
183 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
184 INT215027 Regulation of Localization of Igf2 1 0.07 1.71 0.24
185 INT142052 Binding of Snca 4 0.47 1.02 0.22
186 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
187 INT196761 Regulation of Positive_regulation of Ppp2ca 2 0.40 0.05 0.22
188 INT114452 Regulation of Regulation of Camk1 1 0.00 0.38 0.22
189 INT227795 Negative_regulation of Acsl1 3 0.21 3.05 0.21
190 INT196763 Positive_regulation of Regulation of Ppp2ca 1 0.30 0 0.21
191 INT292944 Regulation of Positive_regulation of Snca 1 0.45 0.36 0.21
192 INT196759 Negative_regulation of Negative_regulation of Ppp2ca 2 0.30 0.17 0.2
193 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
194 INT326823 Positive_regulation of Localization of Cdk5r1 1 0.09 0.9 0.2
195 INT311462 Positive_regulation of Gene_expression of Acsl1 1 0.04 2.13 0.2
196 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
197 INT257418 Negative_regulation of Transcription of Snca 1 0.43 0.93 0.19
198 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
199 INT134469 Positive_regulation of Binding of Cdk5r1 1 0.35 0.4 0.18
200 INT134471 Positive_regulation of Binding of Cdk5r2 1 0.28 0.4 0.18
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