GO:0072001

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Name renal system development
Categary Process
Go Slim No
Go Link GO:0072001
Unique Molecular Interactions 94
Total Molecular Interactions 143
Total Single Events 662
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for renal system development. They are ordered first by their pain relevance and then by number of times they were reported for renal system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
2 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
3 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
4 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
5 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
6 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
7 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
8 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
9 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
10 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
11 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
12 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
13 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
14 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1 0.48 1.49 0.11
15 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
16 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
17 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
18 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
19 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08
20 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
21 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08
22 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
23 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
24 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
25 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
26 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
27 INT233280 Binding of PBX1 and Emx2 1 0.19 0.68 0
28 INT233273 Binding of Emx2 and Tbca 1 0.01 0.34 0
29 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
30 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
31 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
32 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
33 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
34 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
35 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
36 INT244839 Lbx1 Positive_regulation of Pax2 1 0.39 0 0
37 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
38 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
39 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
40 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
41 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
42 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
43 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
44 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
45 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
46 INT269940 Binding of Sox17 and Scn4a 1 0.17 0.15 0
47 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
48 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
49 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
50 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
51 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
52 INT269928 Binding of Sox17 and Mgst1 1 0.12 0 0
53 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
54 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
55 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
56 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0
57 INT269950 Sox17 Negative_regulation of Gene_expression of Cdkn2b 1 0.27 0.24 0
58 INT244857 Lbx1 Positive_regulation of Lhx1 1 0.37 0 0
59 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
60 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
61 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
62 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
63 INT269947 Sox17 Positive_regulation of Gene_expression of Atxn1 1 0.08 0 0
64 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
65 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
66 INT233271 Binding of Emx2 and Hoxa10 1 0.13 0.36 0
67 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
68 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
69 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
70 INT269934 Sox17 Regulation of Gopc 1 0.12 0 0
71 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
72 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
73 INT269951 Binding of Sox17 and Gopc 1 0.11 0 0
74 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
75 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
76 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
77 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
78 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
79 INT297691 Binding of Fut1 and Pax2 1 0.03 0 0
80 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
81 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
82 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
83 INT213556 Binding of Eya1 and Six1 1 0.41 0.48 0
84 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
85 INT269918 Binding of Scn5a and Sox17 1 0.18 0.15 0
86 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
87 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
88 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
89 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
90 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for renal system development. They are ordered first by their pain relevance and then by number of times they were reported in renal system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
2 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
3 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
4 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
5 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
6 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
7 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
8 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
9 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
10 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
11 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
12 INT116008 Binding of Gata3 2 0.34 1.37 1.41
13 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
14 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
15 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
16 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
17 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
18 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
19 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
20 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
21 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
22 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
23 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
24 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
25 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
26 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
27 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
28 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
29 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
30 INT182677 Gene_expression of Emx2 11 0.78 2.14 0.59
31 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
32 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
33 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
34 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
35 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
36 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
37 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
38 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
39 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
40 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
41 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
42 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
43 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
44 INT309354 Regulation of Pax2 1 0.10 0 0.29
45 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
46 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28
47 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
48 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
49 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
50 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
51 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
52 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
53 INT140639 Gene_expression of FOXF1 3 0.52 0.89 0.22
54 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
55 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
56 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
57 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
58 INT185427 Negative_regulation of Lhx1 4 0.42 3.48 0.17
59 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
60 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
61 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
62 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
63 INT309352 Localization of Pax2 1 0.27 0 0.14
64 INT249096 Regulation of FOXF1 1 0.19 0.28 0.14
65 INT253190 Localization of Shh 2 0.77 1.06 0.13
66 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
67 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
68 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
69 INT197449 Negative_regulation of Emx2 1 0.51 0.2 0.12
70 INT213448 Localization of FOXF1 1 0.58 0.15 0.1
71 INT287912 Localization of BMP4 1 0.18 1.13 0.1
72 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
73 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
74 INT213440 Negative_regulation of FOXF1 1 0.33 0.14 0.08
75 INT197443 Positive_regulation of Gene_expression of Emx2 1 0.47 0.1 0.08
76 INT205973 Binding of SHH 3 0.35 1.03 0.07
77 INT256862 Regulation of Shh 1 0.25 0 0.07
78 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
79 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
80 INT345344 Regulation of SMO 1 0.23 1.07 0.06
81 INT244741 Positive_regulation of Gene_expression of Pax2 1 0.38 0 0.06
82 INT262772 Binding of SMO 1 0.27 0.59 0.05
83 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
84 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
85 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
86 INT262777 Localization of SMO 1 0.59 0.6 0.04
87 INT185429 Regulation of Lhx1 1 0.12 1.33 0.04
88 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
89 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
90 INT310486 Transcription of Emx2 1 0.32 0 0.03
91 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
92 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
93 INT253181 Transcription of Shh 1 0.68 0.54 0.03
94 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
95 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
96 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
97 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
98 INT196027 Binding of Bmp4 2 0.13 0.97 0
99 INT142119 Regulation of Bmp4 2 0.58 0.29 0
100 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
101 INT200864 Positive_regulation of Sox17 2 0.50 0.07 0
102 INT269903 Localization of Sox17 1 0.75 0.07 0
103 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
104 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
105 INT185426 Binding of Lhx1 1 0.36 1.96 0
106 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
107 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
108 INT269907 Positive_regulation of Localization of Sox17 1 0.50 0.2 0
109 INT244782 Negative_regulation of Pax2 1 0.44 0 0
110 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
111 INT269904 Regulation of Sox17 1 0.45 0 0
112 INT339667 Localization of Bmp4 1 0.38 0.27 0
113 INT269876 Binding of Sox17 1 0.48 0.72 0
114 INT260089 Localization of PTCH1 1 0.70 0.37 0
115 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
116 INT233225 Regulation of Gene_expression of Emx2 1 0.23 0.09 0
117 INT269885 Negative_regulation of Sox17 1 0.42 0.32 0
118 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
119 INT269891 Positive_regulation of Gene_expression of Sox17 1 0.69 0.4 0
120 INT269878 Negative_regulation of Gene_expression of Sox17 1 0.42 0 0
121 INT269892 Transcription of Sox17 1 0.71 0 0
122 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
123 INT213529 Negative_regulation of Gene_expression of Pax2 1 0.37 0.23 0
124 INT290929 Binding of Shh 1 0.31 0.1 0
125 INT269898 Positive_regulation of Binding of Sox17 1 0.44 0 0
126 INT351554 Negative_regulation of Gene_expression of BMP4 1 0.26 0 0
127 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
128 INT269869 Gene_expression of Sox17 1 0.77 2.48 0
129 INT269882 Regulation of Gene_expression of Sox17 1 0.61 0.14 0
130 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
131 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
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