GO:0072341

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Name modified amino acid binding
Categary Function
Go Slim No
Go Link GO:0072341
Unique Molecular Interactions 50
Total Molecular Interactions 65
Total Single Events 287
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for modified amino acid binding. They are ordered first by their pain relevance and then by number of times they were reported for modified amino acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
2 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
3 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
4 INT103933 Cps1 Negative_regulation of Gene_expression of Cd69 1 0.03 0.25 0.93
5 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 0.02 0.25 0.93
6 INT14626 Binding of Dpep1 and Pax3 1 0.01 0 0.87
7 INT255324 Negative_regulation of Binding of Dpep1 and 2E 1 0.02 0 0.73
8 INT255325 Binding of Dpep1 and 2E 1 0.02 0 0.73
9 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
10 INT255319 Binding of Dpep1 and Kcnq2 1 0.01 0 0.6
11 INT255320 Binding of Dpep1 and Kcnq3 1 0.01 0 0.6
12 INT255326 Binding of Dpep1 and AIS 1 0.00 0 0.6
13 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
14 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
15 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 0.03 0.19 0.51
16 INT103932 Cps1 Negative_regulation of Gene_expression of Trav6-3 1 0.01 0.19 0.5
17 INT261498 CBS Positive_regulation of DSE 1 0.00 0 0.5
18 INT176010 Binding of MTHFR and ZNF677 1 0.00 0.7 0.5
19 INT103934 Cps1 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.2 0.49
20 INT280189 Binding of Cbs and P2rx3 1 0.01 1.03 0.47
21 INT280188 Binding of Cbs and Trpv1 1 0.26 1.03 0.47
22 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 0.01 0.13 0.47
23 INT103936 Cps1 Negative_regulation of Il2ra 1 0.02 0.07 0.46
24 INT103931 Cps1 Negative_regulation of Icam1 1 0.01 0.07 0.46
25 INT103935 Cps1 Negative_regulation of Cd69 1 0.03 0.07 0.46
26 INT326514 Sugt1 Negative_regulation of MTHFR 1 0.01 0.77 0.42
27 INT261499 CBS Positive_regulation of CNR1 1 0.01 0.48 0.35
28 INT280190 Cbs Regulation of Gene_expression of Hist1h1t 1 0.04 0.58 0.32
29 INT188789 Binding of pad and Mthfr 1 0.06 4.6 0.31
30 INT255322 Binding of Dpep1 and Csnk2b 1 0.01 0 0.29
31 INT255316 Csnk2b Regulation of Binding of Dpep1 1 0.01 0 0.22
32 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19
33 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15
34 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 0.05 0 0.09
35 INT220244 IL1B Regulation of Gene_expression of DPEP1 1 0.17 0 0.08
36 INT220241 IL1RN Regulation of Gene_expression of DPEP1 1 0.24 0 0.08
37 INT220238 IL1RN Regulation of Protein_catabolism of DPEP1 1 0.14 0 0.08
38 INT220247 IL1B Regulation of Protein_catabolism of DPEP1 1 0.10 0 0.08
39 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
40 INT245986 MTR Regulation of Mthfr 1 0.07 0.18 0.05
41 INT245981 Negative_regulation of TCN1 Regulation of Mthfr 1 0.03 0.18 0.05
42 INT27738 CBS Positive_regulation of EGF 1 0.33 0.85 0.05
43 INT245982 TCN1 Regulation of Mthfr 1 0.04 0.18 0.05
44 INT27737 CBS Positive_regulation of Positive_regulation of EGF 1 0.36 0.85 0.05
45 INT245974 Mtrr Regulation of Mthfr 1 0.07 0.18 0.05
46 INT245987 Binding of MTR and Mthfr 1 0.11 0.48 0.03
47 INT324836 Nox4 Regulation of Gene_expression of ROS1 1 0.01 0.13 0.03
48 INT324800 Binding of Tlr4 and Nox4 1 0.12 0.14 0.03
49 INT269062 Nox4 Negative_regulation of Localization of Cyba 1 0.17 0 0
50 INT269067 Nox4 Negative_regulation of Localization of Ncf1 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for modified amino acid binding. They are ordered first by their pain relevance and then by number of times they were reported in modified amino acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34
2 INT261511 Localization of CBS 1 0.02 5.06 7.27
3 INT138833 Binding of MTHFR 12 0.46 16.08 6.4
4 INT121954 Binding of Mthfr 17 0.44 13.47 4.66
5 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44
6 INT280193 Positive_regulation of Gene_expression of Cbs 1 0.69 6.59 3.81
7 INT14625 Binding of Dpep1 2 0.02 0 3.36
8 INT109448 Negative_regulation of MTHFR 8 0.58 7.62 3.11
9 INT138652 Negative_regulation of Mthfr 13 0.54 7.3 2.88
10 INT124063 Gene_expression of MTHFR 9 0.65 6.22 2.67
11 INT124417 Gene_expression of Mthfr 8 0.60 8.65 2.53
12 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26
13 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09
14 INT142049 Regulation of Mthfr 6 0.41 4.73 2
15 INT38043 Gene_expression of Cps1 6 0.56 0.82 1.46
16 INT34626 Binding of Cbs 2 0.37 3.27 1.27
17 INT144645 Localization of Cbs 2 0.64 1.02 1.22
18 INT22353 Positive_regulation of Cps1 6 0.17 0.98 1.14
19 INT176609 Gene_expression of Dpep1 8 0.03 2.37 1.07
20 INT123536 Positive_regulation of MTHFR 7 0.57 4.74 1
21 INT4971 Regulation of Cbs 2 0.44 1.66 1
22 INT77856 Binding of Cps1 6 0.30 2.32 0.95
23 INT220249 Gene_expression of DPEP1 1 0.40 0.99 0.95
24 INT255304 Regulation of Binding of Dpep1 1 0.02 0 0.95
25 INT261514 Positive_regulation of Localization of CBS 1 0.01 0.67 0.91
26 INT202190 Gene_expression of CBS 7 0.32 4.19 0.88
27 INT46483 Localization of Dpep1 4 0.06 1.58 0.88
28 INT152474 Phosphorylation of Cps1 1 0.06 0 0.78
29 INT280194 Regulation of Gene_expression of Cbs 1 0.61 1.54 0.73
30 INT157186 Regulation of Cps1 4 0.22 0.54 0.67
31 INT155639 Regulation of Negative_regulation of Mthfr 1 0.56 0.76 0.66
32 INT176013 Negative_regulation of Binding of MTHFR 2 0.42 1.18 0.63
33 INT153699 Regulation of MTHFR 2 0.45 1.54 0.63
34 INT255306 Positive_regulation of Dpep1 1 0.02 0 0.61
35 INT261508 Negative_regulation of CBS 1 0.01 0.39 0.61
36 INT253325 Positive_regulation of Negative_regulation of MTHFR 2 0.44 1.22 0.49
37 INT255308 Negative_regulation of Binding of Dpep1 1 0.02 0 0.46
38 INT220254 Positive_regulation of Gene_expression of DPEP1 1 0.22 0.56 0.44
39 INT199078 Gene_expression of Nox4 3 0.59 3.83 0.41
40 INT261515 Positive_regulation of CBS 2 0.47 2.63 0.41
41 INT188788 Negative_regulation of Gene_expression of Mthfr 2 0.33 1.3 0.39
42 INT111345 Negative_regulation of Cbs 2 0.30 2.82 0.36
43 INT259859 Regulation of CBS 1 0.01 1.26 0.34
44 INT227514 Regulation of Dpep1 1 0.02 0.06 0.3
45 INT259857 Regulation of Gene_expression of CBS 1 0.01 1.07 0.27
46 INT176012 Localization of MTHFR 1 0.74 0.38 0.24
47 INT69801 Positive_regulation of DPEP1 3 0.49 0.89 0.23
48 INT138653 Positive_regulation of Negative_regulation of Mthfr 1 0.45 0.53 0.2
49 INT38044 Regulation of Gene_expression of Cps1 1 0.38 0 0.19
50 INT220251 Regulation of DPEP1 1 0.12 0.33 0.15
51 INT259858 Protein_catabolism of CBS 1 0.03 1.46 0.14
52 INT220259 Protein_catabolism of DPEP1 1 0.34 0 0.11
53 INT253327 Negative_regulation of Positive_regulation of MTHFR 1 0.41 1.17 0.09
54 INT69802 Binding of DPEP1 1 0.02 0 0.09
55 INT220263 Negative_regulation of DPEP1 1 0.22 0.28 0.09
56 INT270815 Localization of DPEP1 1 0.06 0.08 0.07
57 INT270819 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
58 INT143346 Localization of Mthfr 2 0.54 0.4 0.04
59 INT220258 Negative_regulation of Gene_expression of DPEP1 1 0.22 0 0.03
60 INT142048 Transcription of Mthfr 1 0.51 0.18 0
61 INT169661 Localization of Cps1 1 0.62 0.09 0
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