GO:0072537

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Name fibroblast activation
Categary Process
Go Slim No
Go Link GO:0072537
Unique Molecular Interactions 80
Total Molecular Interactions 99
Total Single Events 1018
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for fibroblast activation. They are ordered first by their pain relevance and then by number of times they were reported for fibroblast activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158302 Il23a Regulation of Gene_expression of Il17a 1 0.06 1.45 1.7
2 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24
3 INT209923 IL17A Negative_regulation of PPARA 1 0.14 2.46 0.99
4 INT346266 MTX1 Regulation of IL17A 1 0.08 1.33 0.89
5 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
6 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74
7 INT209048 Il3 Positive_regulation of Il17a 1 0.03 0.38 0.73
8 INT209052 Il2 Positive_regulation of Il17a 1 0.03 0.38 0.73
9 INT209034 Il4 Positive_regulation of Il17a 1 0.04 0.38 0.73
10 INT209039 Il6 Positive_regulation of Il17a 1 0.05 0.38 0.72
11 INT209028 Il12b Positive_regulation of Il17a 1 0.12 0.37 0.72
12 INT209044 Il10 Positive_regulation of Il17a 1 0.05 0.37 0.72
13 INT194618 Il17a Positive_regulation of Gene_expression of IL8 2 0.01 1.94 0.67
14 INT252290 Binding of Il17a and Positive_regulation of Gene_expression of Ccl20 1 0.06 0.54 0.66
15 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
16 INT209054 Il17a Positive_regulation of Gene_expression of Il6 1 0.10 0.45 0.65
17 INT209063 Slc11a1 Positive_regulation of Il17a 1 0.11 0.4 0.65
18 INT355881 Il17a Regulation of Gene_expression of Hand1 1 0.18 1.51 0.54
19 INT355878 Il17a Regulation of Eae1 1 0.06 1.52 0.54
20 INT355880 Il17a Regulation of Abi3 1 0.00 1.52 0.54
21 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53
22 INT163391 Il17a Positive_regulation of Gene_expression of Crp 1 0.02 0.6 0.51
23 INT349636 IL17A Positive_regulation of Gene_expression of IL4 1 0.06 1.28 0.5
24 INT288376 IL17A Regulation of VEGFA 1 0.00 1.16 0.49
25 INT293202 IK Regulation of Gene_expression of IL17A 1 0.00 0 0.48
26 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
27 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46
28 INT224698 Il17a Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
29 INT172149 IL17A Positive_regulation of Gene_expression of IL1B 1 0.01 0.5 0.43
30 INT172138 IL17A Positive_regulation of Gene_expression of TNF 1 0.07 0.5 0.43
31 INT186373 Il6 Positive_regulation of Gene_expression of Il17a 2 0.14 1.52 0.42
32 INT250328 Binding of TNF and Il17a 1 0.02 0.5 0.42
33 INT239042 Il17a Negative_regulation of Gene_expression of Il6 1 0.03 0.82 0.42
34 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41
35 INT155009 IL23A Positive_regulation of Gene_expression of IL17A 2 0.17 0.62 0.39
36 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39
37 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38
38 INT161517 Mpo Positive_regulation of Gene_expression of Il17a 1 0.22 1.42 0.36
39 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
40 INT329449 IL17A Regulation of Gene_expression of Vegfa 1 0.28 0.63 0.36
41 INT172004 IL17A Positive_regulation of Gene_expression of IL6 2 0.14 1.35 0.34
42 INT252289 Il17a Positive_regulation of Gene_expression of Il1 1 0.02 0.75 0.34
43 INT252295 Il17a Positive_regulation of Gene_expression of TNF 1 0.03 0.75 0.34
44 INT329448 IL17A Positive_regulation of Gene_expression of Vegfa 1 0.45 0.59 0.32
45 INT355984 PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31
46 INT355979 Negative_regulation of PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31
47 INT254221 Binding of Il17a and Il17ra 1 0.00 0.18 0.26
48 INT254203 Binding of Il17a and Hrec 1 0.00 0.19 0.26
49 INT254196 Binding of Il17a and Il17rc 1 0.01 0.18 0.26
50 INT254211 Binding of Il17ra and Hrec 1 0.00 0.19 0.26
51 INT335821 MIR146A Regulation of Gene_expression of Il17a 1 0.05 0.75 0.24
52 INT186391 TNF Positive_regulation of Gene_expression of Il17a 1 0.03 0.38 0.22
53 INT186358 Il1 Positive_regulation of Gene_expression of Il17a 1 0.02 0.38 0.22
54 INT318994 Il17a Regulation of Il23a 1 0.00 1.38 0.22
55 INT316538 Lvs Positive_regulation of Gene_expression of Il17a 1 0.30 1.3 0.21
56 INT285945 IL17A Regulation of IL6 1 0.13 1.22 0.2
57 INT181617 IL17A Positive_regulation of ISYNA1 1 0.01 0.27 0.2
58 INT231622 Pax3 Positive_regulation of Il17a 1 0.03 1.01 0.19
59 INT184458 Il17a Positive_regulation of Transcription of Adamts1 1 0.05 0.87 0.18
60 INT296036 IL6 Positive_regulation of IL17A 1 0.04 0.05 0.17
61 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17
62 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16
63 INT296079 IL17A Negative_regulation of Positive_regulation of Gtf3a 1 0.00 0.77 0.13
64 INT296040 IL17A Regulation of TH1L 1 0.07 0.7 0.12
65 INT285948 IL17A Regulation of Gene_expression of TERT 1 0.00 0.58 0.11
66 INT183797 IL17A Positive_regulation of Positive_regulation of MMP2 1 0.03 0.24 0.1
67 INT183796 IL17A Positive_regulation of MMP9 1 0.28 0.24 0.1
68 INT183795 IL17A Positive_regulation of Positive_regulation of MMP9 1 0.30 0.24 0.1
69 INT265212 Cd28 Negative_regulation of Gene_expression of Il17a 1 0.10 0 0.09
70 INT316539 Il17a Positive_regulation of Gene_expression of Lvs 1 0.22 1.02 0.08
71 INT265221 Binding of Cd28 and Positive_regulation of Gene_expression of Il17a 1 0.15 0.09 0.08
72 INT285947 IL6 Regulation of IL17A 1 0.08 0.44 0.05
73 INT231621 Il6 Positive_regulation of Positive_regulation of Il17a 1 0.15 0.19 0.04
74 INT285936 IL17A Positive_regulation of Gene_expression of POU5F1 1 0.10 0.34 0.04
75 INT316496 Il17a Positive_regulation of VEGFA 1 0.11 0.65 0.03
76 INT160567 Il22 Positive_regulation of Il17a 1 0.01 0 0
77 INT285949 IL6 Positive_regulation of Gene_expression of IL17A 1 0.14 0.23 0
78 INT160566 Positive_regulation of Il22 Positive_regulation of Il17a 1 0.01 0 0
79 INT265216 Cd28 Positive_regulation of Gene_expression of Il17a 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for fibroblast activation. They are ordered first by their pain relevance and then by number of times they were reported in fibroblast activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06
2 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33
3 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87
4 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82
5 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82
6 INT160563 Localization of Il17a 34 0.74 26.53 10.24
7 INT140338 Negative_regulation of Gene_expression of Il17a 34 0.46 23.82 9.87
8 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15
9 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43
10 INT115947 Regulation of Il17a 17 0.37 14.26 5.97
11 INT173584 Localization of IL17A 14 0.74 10.83 5.19
12 INT235510 Binding of Il17a 14 0.34 10.67 3.99
13 INT155011 Negative_regulation of IL17A 8 0.54 6.43 3.64
14 INT135408 Transcription of Il17a 8 0.64 10.7 3.39
15 INT183809 Regulation of IL17A 11 0.25 6.6 2.37
16 INT239025 Regulation of Gene_expression of Il17a 9 0.42 7.18 2.09
17 INT183808 Regulation of Gene_expression of IL17A 6 0.42 4.12 2.01
18 INT155012 Negative_regulation of Gene_expression of IL17A 11 0.36 8.64 1.94
19 INT184235 Positive_regulation of Localization of Il17a 4 0.35 4.26 1.89
20 INT236349 Positive_regulation of Positive_regulation of Il17a 7 0.46 5.96 1.67
21 INT250894 Positive_regulation of Localization of IL17A 5 0.46 2.49 1.19
22 INT203119 Positive_regulation of Positive_regulation of IL17A 2 0.46 1.12 0.76
23 INT204771 Negative_regulation of Transcription of Il17a 2 0.39 2.31 0.63
24 INT353931 Positive_regulation of Negative_regulation of Il17a 1 0.35 0.9 0.44
25 INT183815 Binding of IL17A 5 0.34 1.33 0.4
26 INT209016 Positive_regulation of Il17ra 1 0.03 0.59 0.35
27 INT254261 Negative_regulation of Binding of Il17a 1 0.06 1 0.31
28 INT183812 Negative_regulation of Positive_regulation of IL17A 1 0.36 0.08 0.31
29 INT300537 Positive_regulation of Regulation of Il17a 1 0.39 1.74 0.29
30 INT204774 Positive_regulation of Transcription of Il17a 1 0.12 1.08 0.29
31 INT316529 Protein_catabolism of Il17a 2 0.82 2.21 0.26
32 INT220840 Phosphorylation of Il17a 2 0.75 1.24 0.23
33 INT237157 Negative_regulation of Localization of Il17a 1 0.14 0 0.22
34 INT183811 Transcription of IL17A 3 0.58 0.11 0.2
35 INT296062 Positive_regulation of Transcription of IL17A 1 0.15 0.11 0.2
36 INT329445 Negative_regulation of Localization of IL17A 1 0.39 0.6 0.13
37 INT316534 Regulation of Positive_regulation of Il17a 1 0.42 0.99 0.08
38 INT346125 Regulation of Binding of Il17a 1 0.35 0.22 0.07
39 INT285951 Negative_regulation of Binding of IL17A 1 0.18 0.1 0
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