GO:0072659

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Name protein localization in plasma membrane
Categary Process
Go Slim No
Go Link GO:0072659
Unique Molecular Interactions 136
Total Molecular Interactions 205
Total Single Events 1460
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein localization in plasma membrane. They are ordered first by their pain relevance and then by number of times they were reported for protein localization in plasma membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
2 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
3 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
4 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
5 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
6 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
7 INT141963 Binding of CALCRL and RAMP1 2 0.43 0.81 0.78
8 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
9 INT142507 Binding of Calca and Ramp1 1 0.31 0.48 0.73
10 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
11 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
12 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
13 INT141964 Binding of ADM and RAMP1 1 0.30 2.63 0.47
14 INT138424 Binding of RAMP1 and Calca 1 0.01 0.08 0.47
15 INT194405 DCLK3 Positive_regulation of Gene_expression of RAMP1 1 0.16 0.09 0.43
16 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
17 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
18 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
19 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
20 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
21 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
22 INT138423 Binding of RAMP3 and Calca 1 0.01 0 0.32
23 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
24 INT119333 Binding of Ramp2 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
25 INT119332 Binding of Ramp3 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
26 INT194406 Binding of RAMP1 and RPL34P34 1 0.00 0 0.29
27 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28
28 INT233786 Binding of CALCR and SCT 1 0.05 0 0.27
29 INT274942 Binding of Dlg1 and Ephb6 1 0.05 0 0.25
30 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
31 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23
32 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22
33 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
34 INT194404 Binding of RAMP2 and DCLK3 1 0.07 0 0.22
35 INT356089 Positive_regulation of Binding of Tg and Rab11a 1 0.00 0.07 0.21
36 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21
37 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
38 INT356099 Binding of Tg and Rab11a 1 0.00 0.07 0.21
39 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
40 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
41 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2
42 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
43 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
44 INT23586 Binding of CALCR and KRIT1 1 0.40 0.97 0.19
45 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
46 INT172246 TAS2R14 Positive_regulation of Gene_expression of RAMP1 1 0.01 0.07 0.18
47 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
48 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
49 INT172251 CALCRL Positive_regulation of Gene_expression of RAMP1 1 0.04 0.07 0.17
50 INT256985 Binding of Dlg1 and Cd81 1 0.39 0.2 0.17
51 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15
52 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
53 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
54 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
55 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12
56 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
57 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
58 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
59 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12
60 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
61 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12
62 INT257467 Fat1 Regulation of Gene_expression of Adipoq 1 0.08 0.56 0.11
63 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1
64 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
65 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
66 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
67 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09
68 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
69 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08
70 INT257466 Psd Negative_regulation of Gene_expression of Adipoq 1 0.22 0.66 0.08
71 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
72 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
73 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
74 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
75 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07
76 INT222479 Binding of Ramp1 and Rxfp2 1 0.01 0 0.06
77 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06
78 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06
79 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
80 INT222559 Binding of Ramp3 and Ramp1 1 0.02 0 0.05
81 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
82 INT222485 Binding of Iapp and Ramp1 1 0.09 0 0.05
83 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05
84 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
85 INT236590 Binding of Adipoq and Ncoa2 1 0.15 0.2 0.03
86 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
87 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
88 INT236592 Positive_regulation of Binding of Adipoq and Ncoa2 1 0.19 0.2 0.03
89 INT227305 Zbp1 Regulation of Gene_expression of Adipoq 1 0.21 1.27 0
90 INT263726 Binding of Dlg1 and Dlg4 1 0.04 0 0
91 INT342387 Binding of CALCR and Car1 1 0.11 0.83 0
92 INT256988 Binding of Dlg1 and Rpe 1 0.06 0 0
93 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 0.08 0.12 0
94 INT263737 Binding of Dlg1 and Neto1 1 0.07 0 0
95 INT352516 Binding of POMT1 and Adipoq 1 0.01 0.4 0
96 INT204322 Binding of ADIPOQ and Positive_regulation of Gene_expression of PPARGC1A 1 0.30 0.07 0
97 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
98 INT140814 Adipoq Regulation of Retn 1 0.03 0.8 0
99 INT227302 Zbp1 Regulation of Transcription of Adipoq 1 0.09 1.27 0
100 INT342388 Binding of CALCR and Vdr 1 0.12 0.83 0
101 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
102 INT334894 Binding of CALCR and ARMC9 1 0.01 0.41 0
103 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0
104 INT350254 Slc12a6 Regulation of Gene_expression of Adipoq 1 0.02 0.63 0
105 INT197915 Des Positive_regulation of Adipoq 1 0.07 0 0
106 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0
107 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0
108 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0
109 INT109249 Calcrl Regulation of Ramp1 1 0.28 0.22 0
110 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0
111 INT342386 Binding of CALCR and Best1 1 0.01 0.96 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein localization in plasma membrane. They are ordered first by their pain relevance and then by number of times they were reported in protein localization in plasma membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
2 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
3 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
4 INT102448 Gene_expression of RAMP1 23 0.75 4.62 10.9
5 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
6 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
7 INT120200 Binding of RAMP1 6 0.47 0.72 6.16
8 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
9 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
10 INT109248 Gene_expression of Ramp1 8 0.72 2.45 4.69
11 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
12 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77
13 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
14 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
15 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
16 INT148934 Binding of Ramp1 4 0.36 0.94 2.89
17 INT142502 Gene_expression of Ramp1 5 0.67 2.23 2.72
18 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
19 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
20 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
21 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
22 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
23 INT103298 Binding of CALCR 5 0.47 6.03 2.15
24 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
25 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
26 INT194414 Positive_regulation of Gene_expression of RAMP1 4 0.60 0.57 1.89
27 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
28 INT141967 Gene_expression of RAMP3 4 0.69 3.35 1.69
29 INT148933 Localization of Ramp1 1 0.77 0.75 1.48
30 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
31 INT166595 Positive_regulation of Binding of RAMP1 2 0.45 0.18 1.36
32 INT142503 Positive_regulation of Gene_expression of Ramp1 1 0.43 0.83 1.26
33 INT23589 Positive_regulation of CALCR 9 0.67 6.73 1.25
34 INT161486 Regulation of Ramp1 2 0.61 1.64 1.16
35 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
36 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
37 INT194413 Positive_regulation of RAMP1 1 0.36 0.07 1.08
38 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
39 INT223967 Regulation of Gene_expression of RAMP1 1 0.39 0.5 0.97
40 INT106746 Gene_expression of Mtap7 1 0.39 2.09 0.95
41 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
42 INT119324 Positive_regulation of Gene_expression of Ramp1 3 0.53 0.94 0.89
43 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
44 INT134654 Localization of CALCR 5 0.39 3.21 0.85
45 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
46 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
47 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
48 INT119331 Gene_expression of Ramp2 2 0.60 0.19 0.75
49 INT39820 Gene_expression of CALCR 16 0.37 4.96 0.74
50 INT23590 Regulation of CALCR 4 0.26 1.05 0.71
51 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
52 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
53 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
54 INT346182 Positive_regulation of Gene_expression of RAMP2 1 0.14 1.51 0.58
55 INT142504 Positive_regulation of Ramp1 1 0.46 0.66 0.55
56 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
57 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
58 INT119326 Positive_regulation of Ramp2 1 0.42 0.2 0.48
59 INT119327 Positive_regulation of Ramp3 1 0.45 0.19 0.48
60 INT119329 Positive_regulation of Ramp1 1 0.43 0.2 0.48
61 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
62 INT346192 Negative_regulation of RAMP2 1 0.12 0.92 0.42
63 INT98419 Positive_regulation of Mtap7 3 0.38 2.66 0.41
64 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
65 INT179491 Transcription of Adipoq 4 0.51 0.98 0.32
66 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3
67 INT119323 Binding of Ramp3 1 0.33 0.12 0.29
68 INT119325 Binding of Ramp2 1 0.33 0.12 0.29
69 INT319280 Positive_regulation of Dlg1 1 0.45 0.42 0.28
70 INT222653 Gene_expression of Ramp3 1 0.17 0 0.24
71 INT209224 Binding of Dlg1 3 0.13 0.22 0.23
72 INT253941 Positive_regulation of Localization of Adipoq 5 0.24 2.59 0.21
73 INT356070 Binding of Rab11a 1 0.01 0.07 0.21
74 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18
75 INT222647 Positive_regulation of Gene_expression of Ramp3 1 0.15 0 0.18
76 INT61468 Negative_regulation of CALCR 4 0.42 0.27 0.17
77 INT197872 Regulation of Regulation of Adipoq 3 0.35 1.11 0.17
78 INT191797 Negative_regulation of Gene_expression of CALCR 2 0.03 1.37 0.17
79 INT28026 Positive_regulation of Binding of Adipoq 1 0.27 0 0.17
80 INT137455 Protein_catabolism of ADIPOQ 1 0.66 0.25 0.17
81 INT228162 Negative_regulation of Localization of Adipoq 1 0.38 1.29 0.17
82 INT308978 Negative_regulation of Regulation of Adipoq 1 0.28 0.92 0.17
83 INT263001 Regulation of Gene_expression of ADIPOQ 5 0.45 3.77 0.16
84 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14
85 INT262999 Negative_regulation of Gene_expression of ADIPOQ 7 0.43 9.52 0.12
86 INT222603 Negative_regulation of Gene_expression of Ramp2 1 0.09 0 0.09
87 INT157267 Negative_regulation of Localization of Adipoq 1 0.24 0.94 0.09
88 INT327816 Regulation of Positive_regulation of ADIPOQ 1 0.04 1.2 0.09
89 INT256975 Binding of Dlg1 7 0.36 0 0.06
90 INT191796 Positive_regulation of Gene_expression of CALCR 2 0.06 1.74 0.05
91 INT353069 Positive_regulation of Positive_regulation of ADIPOQ 1 0.13 1.75 0.05
92 INT206890 Negative_regulation of Gene_expression of Ramp1 1 0.18 0.83 0.05
93 INT245905 Negative_regulation of Transcription of ADIPOQ 1 0.42 1.26 0.05
94 INT61469 Transcription of CALCR 3 0.43 1.37 0.04
95 INT228584 Phosphorylation of Adipoq 1 0.38 0.61 0.04
96 INT251940 Positive_regulation of Transcription of ADIPOQ 1 0.01 0 0.04
97 INT222576 Regulation of Gene_expression of Ramp1 1 0.09 0 0.04
98 INT222643 Regulation of Gene_expression of Ramp3 1 0.14 0 0.04
99 INT213679 Positive_regulation of Transcription of CALCR 1 0.30 1.37 0.04
100 INT240621 Negative_regulation of Localization of ADIPOQ 1 0.39 0.64 0.03
101 INT222622 Negative_regulation of Gene_expression of Ramp3 1 0.10 0 0.03
102 INT256961 Regulation of Gene_expression of Dlg1 1 0.33 0 0
103 INT94755 Binding of Mtap7 1 0.31 0 0
104 INT256978 Positive_regulation of Dlg1 1 0.34 0 0
105 INT256952 Localization of Dlg1 1 0.55 0 0
106 INT257464 Negative_regulation of Transcription of Adipoq 1 0.41 0.45 0
107 INT263530 Negative_regulation of Positive_regulation of ADIPOQ 1 0.31 1.43 0
108 INT193864 Regulation of Rab11a 1 0.00 0 0
109 INT227262 Regulation of Transcription of Adipoq 1 0.35 0.47 0
110 INT286250 Positive_regulation of RAMP2 1 0.33 0.5 0
111 INT92060 Localization of Mtap7 1 0.22 0.07 0
112 INT256974 Gene_expression of Dlg1 1 0.50 0.08 0
113 INT92061 Phosphorylation of Mtap7 1 0.20 0.07 0
114 INT263679 Transcription of Dlg1 1 0.12 0.07 0
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