GO:0080111

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Name DNA demethylation
Categary Process
Go Slim No
Go Link GO:0080111
Unique Molecular Interactions 43
Total Molecular Interactions 64
Total Single Events 615
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA demethylation. They are ordered first by their pain relevance and then by number of times they were reported for DNA demethylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
2 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
3 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 0.01 0.52 0.57
4 INT258338 Binding of Aicda and Cr2 1 0.24 1.35 0.51
5 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
6 INT179432 Binding of pcp and AICDA 1 0.03 3.51 0.43
7 INT128677 Positive_regulation of Binding of TET1 and Tet2 1 0.26 0.8 0.33
8 INT128678 Binding of TET1 and Tet2 1 0.19 0.8 0.33
9 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
10 INT258339 Binding of Aicda and Scara3 1 0.05 0.67 0.32
11 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
12 INT258343 Binding of Aicda and Kit 1 0.06 0.57 0.26
13 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
14 INT262640 Binding of HLA-DQA1 and AICDA 1 0.03 5.29 0.2
15 INT89763 Positive_regulation of APEX1 Positive_regulation of Positive_regulation of NR4A1 1 0.10 0.87 0.14
16 INT258344 Scara3 Positive_regulation of Gene_expression of Aicda 1 0.07 0.5 0.12
17 INT262653 Binding of AICDA and Lmx1a 1 0.00 3.18 0.1
18 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08
19 INT272774 Binding of Mc4r and Fto 1 0.30 0.66 0.08
20 INT262639 Binding of HLA-DOA and AICDA 1 0.01 2.85 0.07
21 INT262638 Binding of HLA-DQB1 and AICDA 1 0.03 1.34 0.06
22 INT262636 Binding of HLA-DRB1 and AICDA 1 0.09 1.35 0.06
23 INT292816 Binding of KCNJ11 and FTO 1 0.46 0.49 0.05
24 INT292815 Binding of CDC123 and FTO 1 0.50 0.48 0.05
25 INT321683 Binding of Aicda and Mapt 1 0.36 1.23 0.04
26 INT277243 Camk4 Regulation of Regulation of aicda 1 0.04 0.42 0.03
27 INT277223 Trib3 Regulation of Regulation of aicda 1 0.01 0.42 0.03
28 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 0.03 0.15 0.03
29 INT219791 Cttn Regulation of AICDA 1 0.21 0.42 0
30 INT292968 Fto Regulation of Gene_expression of Th 1 0.30 1.11 0
31 INT250555 Binding of APOBEC2 and CHDH 1 0.04 0.57 0
32 INT292970 Fto Regulation of Th 1 0.18 0.48 0
33 INT292969 Fto Regulation of Gene_expression of Arc 1 0.24 0.55 0
34 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0
35 INT262641 Binding of HLA-DRA and AICDA 1 0.04 0.53 0
36 INT292971 Arc Positive_regulation of Gene_expression of Fto 1 0.19 0.8 0
37 INT233118 Binding of SIRT2 and AICDA 1 0.00 0.21 0
38 INT219792 Hcls1 Regulation of AICDA 1 0.29 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA demethylation. They are ordered first by their pain relevance and then by number of times they were reported in DNA demethylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT258328 Gene_expression of Aicda 76 0.71 58.29 16.86
2 INT131808 Localization of Apex1 2 0.16 13.46 4.61
3 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84
4 INT258311 Positive_regulation of Gene_expression of Aicda 9 0.60 8.51 1.74
5 INT128670 Binding of TET1 10 0.42 3.96 1.63
6 INT258316 Binding of Aicda 1 0.30 2.24 1.08
7 INT258313 Positive_regulation of Aicda 6 0.46 2.14 0.85
8 INT258315 Negative_regulation of Gene_expression of Aicda 1 0.54 1.79 0.8
9 INT193203 Gene_expression of AICDA 30 0.58 3.54 0.78
10 INT258321 Regulation of Gene_expression of Aicda 1 0.42 1.47 0.75
11 INT9835 Binding of AICDA 29 0.47 6.76 0.66
12 INT253750 Positive_regulation of Gene_expression of Apex1 1 0.10 1.43 0.64
13 INT277232 Gene_expression of aicda 11 0.49 6.76 0.55
14 INT272772 Gene_expression of Fto 2 0.76 3.76 0.52
15 INT68907 Regulation of AICDA 4 0.44 0.77 0.47
16 INT39931 Negative_regulation of TET1 1 0.37 0 0.44
17 INT182073 Binding of APEX1 4 0.12 1.72 0.32
18 INT219780 Positive_regulation of AICDA 23 0.49 2.27 0.29
19 INT233127 Positive_regulation of Gene_expression of AICDA 4 0.11 0.91 0.29
20 INT258320 Negative_regulation of Aicda 2 0.50 2.29 0.29
21 INT258329 Negative_regulation of Binding of Aicda 1 0.34 0.58 0.29
22 INT11327 Positive_regulation of TET1 1 0.67 0.23 0.27
23 INT227426 Positive_regulation of Apex1 2 0.08 1.98 0.23
24 INT258312 Localization of Aicda 4 0.64 0.88 0.2
25 INT253752 Negative_regulation of Localization of Apex1 1 0.08 1.26 0.2
26 INT89772 Positive_regulation of APEX1 4 0.21 2.29 0.19
27 INT179431 Localization of AICDA 9 0.78 2.34 0.16
28 INT182078 Gene_expression of APEX1 3 0.59 4.77 0.12
29 INT233119 Regulation of Gene_expression of AICDA 2 0.03 0.12 0.12
30 INT277234 Regulation of aicda 1 0.39 2.88 0.12
31 INT258319 Transcription of Aicda 1 0.55 0.28 0.11
32 INT236140 Negative_regulation of Fto 1 0.03 2.42 0.11
33 INT190501 Regulation of Apex1 1 0.12 0.32 0.1
34 INT258310 Positive_regulation of Localization of Aicda 1 0.40 0.19 0.1
35 INT273338 Protein_catabolism of Apex1 4 0.05 0.57 0.09
36 INT244340 Localization of TET1 1 0.61 0.33 0.08
37 INT272773 Binding of Fto 1 0.41 0.66 0.08
38 INT300138 Positive_regulation of FTO 2 0.36 2.64 0.07
39 INT298117 Binding of aicda 1 0.02 0.46 0.06
40 INT182080 Localization of APEX1 2 0.57 2.3 0.05
41 INT292953 Gene_expression of Fto 1 0.78 30.08 0.05
42 INT214043 Positive_regulation of Localization of APEX1 1 0.38 0.64 0.05
43 INT182079 Negative_regulation of APEX1 5 0.18 1.75 0
44 INT313942 Gene_expression of FTO 3 0.62 4.73 0
45 INT277114 Binding of FTO 3 0.34 3.93 0
46 INT233128 Regulation of Binding of AICDA 1 0.03 0 0
47 INT292960 Positive_regulation of Transcription of Fto 1 0.50 0.91 0
48 INT250575 Positive_regulation of APOBEC2 1 0.43 1.57 0
49 INT292954 Regulation of Fto 1 0.27 1.74 0
50 INT250573 Localization of APOBEC2 1 0.64 0.7 0
51 INT277235 Positive_regulation of Regulation of aicda 1 0.30 0.36 0
52 INT292963 Regulation of Gene_expression of Fto 1 0.62 5.12 0
53 INT250571 Binding of APOBEC2 1 0.31 1.21 0
54 INT277230 Negative_regulation of aicda 1 0.28 1.33 0
55 INT320479 Regulation of Localization of AICDA 1 0.19 0.08 0
56 INT182075 Negative_regulation of Positive_regulation of APEX1 1 0.13 0.63 0
57 INT292965 Negative_regulation of Gene_expression of Fto 1 0.59 5.69 0
58 INT292962 Positive_regulation of Gene_expression of Fto 1 0.70 9.41 0
59 INT277238 Localization of aicda 1 0.51 0.65 0
60 INT182072 Regulation of APEX1 1 0.08 0.76 0
61 INT292952 Transcription of Fto 1 0.72 2.21 0
62 INT292966 Negative_regulation of Fto 1 0.59 3.83 0
63 INT292955 Negative_regulation of Transcription of Fto 1 0.59 1.35 0
64 INT233123 Negative_regulation of AICDA 1 0.02 0 0
65 INT292956 Localization of Fto 1 0.65 0.45 0
66 INT313941 Positive_regulation of Gene_expression of FTO 1 0.36 1.4 0
67 INT250578 Gene_expression of APOBEC2 1 0.66 1.45 0
68 INT298109 Positive_regulation of Gene_expression of aicda 1 0.03 0 0
69 INT233122 Positive_regulation of Positive_regulation of AICDA 1 0.03 0 0
70 INT292964 Regulation of Negative_regulation of Fto 1 0.45 0.49 0
71 INT298108 Negative_regulation of Binding of aicda 1 0.02 0 0
72 INT214034 Positive_regulation of Gene_expression of APEX1 1 0.53 0.85 0
73 INT310100 Transcription of APEX1 1 0.09 0 0
74 INT292958 Positive_regulation of Fto 1 0.50 1.52 0
75 INT292959 Regulation of Localization of Fto 1 0.39 0.45 0
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