GO:0090037

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Name positive regulation of protein kinase C signaling cascade
Categary Process
Go Slim No
Go Link GO:0090037
Unique Molecular Interactions 680
Total Molecular Interactions 1205
Total Single Events 8743
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein kinase C signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of protein kinase C signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
3 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
4 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
5 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
6 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
7 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
8 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
9 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
10 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
11 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
12 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
13 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
14 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
15 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 0.00 1.8 1.42
16 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 1 0.08 0.65 1.35
17 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29
18 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
19 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
20 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
21 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
22 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
23 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
24 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
25 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
26 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05
27 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
28 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
29 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
30 INT140934 Binding of Cd40 and Ean5 1 0.09 1.03 0.98
31 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98
32 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95
33 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
34 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
35 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
36 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
37 INT116108 VEGFA Positive_regulation of SEC23IP 1 0.10 0.3 0.83
38 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
39 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
40 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
41 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
42 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
43 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
44 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
45 INT99335 Binding of Agrp and Mc1r 1 0.30 0 0.77
46 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
47 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
48 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
49 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
50 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
51 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
52 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
53 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
54 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
55 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
56 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
57 INT120036 VEGFA Positive_regulation of Prap1 1 0.00 1 0.7
58 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
59 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
60 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
61 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
62 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
63 INT167355 VEGFA Regulation of RYBP 1 0.01 0.53 0.68
64 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
65 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
66 INT168295 PROC Regulation of Gene_expression of VEGFA 2 0.00 1.6 0.67
67 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
68 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
69 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65
70 INT99170 Binding of Mc1r and Tyr 1 0.11 0.2 0.64
71 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63
72 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63
73 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
74 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62
75 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61
76 INT224731 Binding of VEGFA and Cia1 1 0.01 0.91 0.61
77 INT224733 Negative_regulation of Binding of VEGFA and Cia1 1 0.01 0.91 0.61
78 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
79 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
80 INT92998 Positive_regulation of SFTPA1 Positive_regulation of Localization of CD40 1 0.15 0.34 0.61
81 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6
82 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6
83 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
84 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
85 INT327339 Gtf3a Positive_regulation of VEGFA 1 0.00 2.34 0.58
86 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
87 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
88 INT304326 Ptger1 Positive_regulation of Gene_expression of VEGFA 1 0.19 1.37 0.57
89 INT92999 Binding of CD40 and VCAM1 1 0.39 0.33 0.57
90 INT66020 Binding of Mc1r and RBM25 1 0.00 0.42 0.57
91 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
92 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
93 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
94 INT194918 Csf2 Positive_regulation of Gene_expression of VEGFA 1 0.02 0.85 0.52
95 INT194919 Kitl Positive_regulation of Gene_expression of VEGFA 1 0.01 0.85 0.52
96 INT249600 IFNA1 Positive_regulation of Gene_expression of Cd40 1 0.49 1.13 0.52
97 INT127430 VEGFA Negative_regulation of Gene_expression of TIMP1 1 0.43 0.6 0.5
98 INT327332 VEGFA Positive_regulation of Gene_expression of Hgfac 1 0.00 2.02 0.49
99 INT288376 IL17A Regulation of VEGFA 1 0.00 1.16 0.49
100 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
101 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48
102 INT305547 VEGFA Positive_regulation of Gtf3a 2 0.00 1.83 0.48
103 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48
104 INT331928 Negative_regulation of Cpox Negative_regulation of VEGFA 1 0.01 0.97 0.47
105 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 0.02 0.2 0.47
106 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
107 INT93508 Binding of ASIP and Mc1r 1 0.02 0 0.47
108 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
109 INT224698 Il17a Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
110 INT224699 Il18 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
111 INT73831 Binding of Mc1r and Pld1 1 0.00 0.16 0.45
112 INT224451 Il1 Positive_regulation of Gene_expression of VEGFA 1 0.10 1.08 0.45
113 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45
114 INT288370 a Positive_regulation of Mc1r 1 0.39 0 0.44
115 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
116 INT224434 TNF Positive_regulation of VEGFA 1 0.10 2.04 0.44
117 INT311587 CXCL10 Regulation of Gene_expression of VEGFA 1 0.23 0.45 0.43
118 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43
119 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
120 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42
121 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42
122 INT153720 Binding of VEGFA and Pscs 1 0.32 3.12 0.41
123 INT295709 PTGER2 Regulation of VEGFA 1 0.01 1.61 0.41
124 INT189846 Binding of Cd40 and Churc1 1 0.01 0.73 0.41
125 INT304319 Ptger1 Positive_regulation of Gene_expression of Vegfa 1 0.37 1.19 0.39
126 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38
127 INT342623 Binding of VEGFA and Col18a1 1 0.02 1.15 0.37
128 INT342606 Binding of MMP14 and VEGFA 1 0.08 1.16 0.37
129 INT277353 VEGFA Regulation of Mtor 1 0.02 1.11 0.37
130 INT277355 VEGFA Regulation of Trerf1 1 0.08 1.17 0.37
131 INT277354 Gene_expression of VEGFA Regulation of Mtor 1 0.02 1.1 0.37
132 INT277352 Gene_expression of VEGFA Regulation of Trerf1 1 0.08 1.16 0.37
133 INT329449 IL17A Regulation of Gene_expression of Vegfa 1 0.28 0.63 0.36
134 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
135 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
136 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34
137 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34
138 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34
139 INT352232 VEGFA Negative_regulation of Vegfa 1 0.02 0.21 0.34
140 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
141 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
142 INT44654 Phc1 Negative_regulation of Adra1a 1 0.00 0.4 0.33
143 INT110691 Lta Positive_regulation of Gene_expression of VEGFA 1 0.24 0.48 0.33
144 INT295717 VEGFA Regulation of MMP9 1 0.01 0.98 0.33
145 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
146 INT329448 IL17A Positive_regulation of Gene_expression of Vegfa 1 0.45 0.59 0.32
147 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31
148 INT59326 Binding of Adra1a and Positive_regulation of Binding of Npy 1 0.44 0 0.31
149 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
150 INT210953 Binding of VEGFA and Csf2 1 0.00 0.47 0.3
151 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3
152 INT97543 Gtf3a Negative_regulation of Mc1r 1 0.05 0.15 0.3
153 INT97549 KITLG Negative_regulation of Mc1r 1 0.01 0.15 0.3
154 INT97546 Pomc Negative_regulation of Mc1r 1 0.40 0.15 0.3
155 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 0.02 0.88 0.29
156 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
157 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28
158 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28
159 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
160 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28
161 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27
162 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27
163 INT103156 Tnf Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.94 0.27
164 INT287699 TNF Regulation of Binding of VEGFA 1 0.02 0.46 0.27
165 INT318551 Binding of VEGFA and Adamts1 1 0.13 1.13 0.27
166 INT285238 EGF Positive_regulation of VEGFA 1 0.01 1.55 0.27
167 INT248318 RETN Regulation of VEGFA 1 0.00 0.43 0.26
168 INT109538 Lox Negative_regulation of Transcription of VEGFA 1 0.30 0.69 0.26
169 INT260423 IFNA1 Positive_regulation of Gene_expression of VEGFA 1 0.01 1.28 0.26
170 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26
171 INT103152 TNF Positive_regulation of Positive_regulation of VEGFA 1 0.09 0.93 0.26
172 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26
173 INT126887 Protein_catabolism of SP4 Negative_regulation of Gene_expression of VEGFA 1 0.15 0.49 0.26
174 INT266803 Dlst Positive_regulation of VEGFA 1 0.01 0.96 0.25
175 INT109539 Lox Negative_regulation of VEGFA 1 0.40 0.68 0.25
176 INT145660 Zfp329 Positive_regulation of Gene_expression of VEGFA 1 0.00 0.51 0.25
177 INT241401 VEGFA Positive_regulation of Gene_expression of Gopc 1 0.11 0.85 0.25
178 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
179 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
180 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24
181 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24
182 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
183 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24
184 INT304323 VEGFA Positive_regulation of Gene_expression of Ptger2 1 0.27 0.16 0.23
185 INT118840 VEGFA Regulation of Positive_regulation of Mb 1 0.05 0.36 0.23
186 INT163403 VEGFA Positive_regulation of MMP2 1 0.52 0.13 0.23
187 INT323436 VEGFA Regulation of Kdr 1 0.03 0.77 0.23
188 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
189 INT304321 Ptger4 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.59 0.23
190 INT304324 VEGFA Positive_regulation of Gene_expression of Ptger4 1 0.27 0.16 0.23
191 INT245866 Binding of VEGFA and Fgf1 1 0.07 0.52 0.22
192 INT118838 Gene_expression of Vegfa Positive_regulation of Gene_expression of Mb 1 0.44 0.4 0.22
193 INT318189 MUC5AC Regulation of Gene_expression of VEGFA 1 0.21 1.17 0.22
194 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
195 INT137611 Crh Positive_regulation of Vegfa 1 0.43 0.49 0.21
196 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
197 INT137612 Crh Positive_regulation of Positive_regulation of Vegfa 1 0.43 0.43 0.21
198 INT114837 Il1b Negative_regulation of Vegfa 1 0.26 3.04 0.21
199 INT188696 Binding of Cd40 and Eae1 1 0.05 1.57 0.21
200 INT238001 Cxcl10 Positive_regulation of Gene_expression of Cd40 1 0.17 0.91 0.21

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein kinase C signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of protein kinase C signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
2 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
3 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
4 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
5 INT21737 Binding of MC1R 129 0.48 45.45 56.54
6 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
7 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
8 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
9 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
10 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
11 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
12 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7
13 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
14 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
15 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
16 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
17 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
18 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
19 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
20 INT133156 Binding of Cd40 77 0.48 45.92 13.77
21 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
22 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
23 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
24 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
25 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
26 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
27 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
28 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
29 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
30 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
31 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
32 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
33 INT93003 Binding of CD40 28 0.47 20.25 7.13
34 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63
35 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
36 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
37 INT335 Binding of Adra1a 16 0.36 6.16 6
38 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
39 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88
40 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78
41 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
42 INT142607 Positive_regulation of Gene_expression of Cd40 41 0.62 13.85 5.51
43 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92
44 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9
45 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79
46 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56
47 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54
48 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22
49 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17
50 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91
51 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
52 INT140932 Binding of Cd40 1 0.44 4.19 3.6
53 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35
54 INT142606 Regulation of Gene_expression of Cd40 13 0.56 6.15 3.27
55 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25
56 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22
57 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1
58 INT137609 Localization of Vegfa 22 0.78 14.67 3.01
59 INT140929 Gene_expression of Cd40 9 0.72 8.76 2.88
60 INT61136 Localization of MC1R 8 0.75 2.8 2.85
61 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
62 INT43719 Positive_regulation of Vegfa 21 0.69 5.15 2.64
63 INT96151 Negative_regulation of Gene_expression of Cd40 20 0.58 6.06 2.58
64 INT113164 Regulation of Regulation of VEGFA 6 0.36 5.96 2.43
65 INT248297 Negative_regulation of Cd40 14 0.58 8.96 2.34
66 INT155045 Negative_regulation of Gene_expression of Mc1r 7 0.43 1.04 2.33
67 INT123528 Negative_regulation of Gene_expression of Vegfa 10 0.57 7.08 2.31
68 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28
69 INT15211 Localization of Adra1a 3 0.16 0 2.08
70 INT105247 Positive_regulation of Gene_expression of Vegfa 12 0.67 12.07 2.05
71 INT136818 Positive_regulation of Phosphorylation of VEGFA 4 0.46 0.81 2.02
72 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
73 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94
74 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92
75 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
76 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
77 INT162871 Localization of Mc1r 6 0.75 0.61 1.72
78 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7
79 INT12442 Localization of Vegfa 11 0.73 4.85 1.68
80 INT105248 Negative_regulation of Vegfa 8 0.47 6.19 1.61
81 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
82 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5
83 INT93001 Localization of CD40 4 0.78 1.97 1.45
84 INT93505 Positive_regulation of Positive_regulation of Mc1r 2 0.70 0.33 1.45
85 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41
86 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39
87 INT14803 Positive_regulation of Positive_regulation of Adra1a 4 0.35 0.49 1.36
88 INT188691 Negative_regulation of Binding of Cd40 3 0.42 2.49 1.31
89 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26
90 INT137607 Positive_regulation of Localization of Vegfa 7 0.49 3.72 1.18
91 INT188376 Negative_regulation of Gene_expression of Vegfa 5 0.30 5.29 1.18
92 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
93 INT189836 Regulation of Cd40 10 0.40 3.02 1.1
94 INT85626 Positive_regulation of Transcription of Mc1r 2 0.50 1.12 1.1
95 INT331103 Regulation of Transcription of Mc1r 1 0.61 1.1 1.09
96 INT106860 Regulation of Transcription of MC1R 1 0.45 0 1
97 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99
98 INT140930 Positive_regulation of Gene_expression of Cd40 4 0.64 3.26 0.99
99 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92
100 INT107474 Positive_regulation of Negative_regulation of Mc1r 1 0.61 0.41 0.89
101 INT211488 Regulation of Binding of VEGFA 5 0.43 3.72 0.83
102 INT125157 Negative_regulation of Gene_expression of Adra1a 1 0.18 0.54 0.8
103 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79
104 INT170603 Negative_regulation of Gene_expression of CD40 5 0.32 2.18 0.78
105 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78
106 INT143445 Protein_catabolism of VEGFA 12 0.85 4.14 0.72
107 INT12443 Regulation of Localization of Vegfa 2 0.20 0 0.72
108 INT289649 Regulation of Gene_expression of Flt4 1 0.21 0.66 0.72
109 INT5211 Localization of Cd40 6 0.78 1.75 0.71
110 INT153419 Regulation of Binding of MC1R 1 0.40 1.38 0.7
111 INT6734 Localization of Adra1a 3 0.31 0.25 0.67
112 INT340625 Protein_catabolism of Vegfa 1 0.05 1.61 0.64
113 INT97130 Negative_regulation of CD40 5 0.35 1.96 0.63
114 INT174868 Regulation of Negative_regulation of VEGFA 4 0.43 4.51 0.63
115 INT289655 Regulation of Flt4 1 0.29 0.63 0.6
116 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
117 INT269970 Positive_regulation of Positive_regulation of Cd40 2 0.50 1.79 0.57
118 INT181790 Gene_expression of FLT4 13 0.72 11.73 0.56
119 INT18657 Negative_regulation of Binding of Adra1a 2 0.43 0.17 0.56
120 INT174873 Regulation of Transcription of VEGFA 8 0.43 3.71 0.55
121 INT56708 Positive_regulation of Positive_regulation of Adra1a 1 0.25 0 0.55
122 INT188663 Regulation of Binding of Cd40 1 0.41 0.95 0.55
123 INT172964 Binding of Vegfa 14 0.47 10.62 0.53
124 INT13738 Negative_regulation of Positive_regulation of Adra1a 3 0.29 0.08 0.52
125 INT134629 Positive_regulation of Gene_expression of Flt4 3 0.32 2.13 0.52
126 INT21090 Regulation of Negative_regulation of Adra1a 1 0.18 0.35 0.52
127 INT105677 Binding of Vegfa 7 0.37 5.22 0.51
128 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51
129 INT113978 Positive_regulation of Localization of MC1R 1 0.24 1.2 0.51
130 INT311966 Positive_regulation of Cd40 2 0.50 1.46 0.49
131 INT238502 Regulation of CD40 6 0.28 3.7 0.44
132 INT247568 Negative_regulation of Negative_regulation of VEGFA 5 0.41 5.35 0.43
133 INT268877 Regulation of Gene_expression of Vegfa 2 0.58 4.73 0.42
134 INT152023 Regulation of Vegfa 4 0.52 3.99 0.41
135 INT43720 Regulation of Positive_regulation of Vegfa 1 0.03 0.41 0.41
136 INT216992 Regulation of Binding of CD40 1 0.13 0.06 0.41
137 INT43722 Positive_regulation of Regulation of Vegfa 1 0.06 0.41 0.41
138 INT66593 Regulation of Gene_expression of Adra1a 2 0.05 0 0.39
139 INT129849 Positive_regulation of Localization of Vegfa 1 0.46 0.35 0.39
140 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37
141 INT211706 Negative_regulation of Localization of Mc1r 1 0.42 0 0.37
142 INT102164 Positive_regulation of Binding of Adra1a 1 0.35 0.19 0.37
143 INT34162 Regulation of Regulation of Adra1a 1 0.02 0 0.36
144 INT188680 Positive_regulation of Binding of Cd40 1 0.46 1.33 0.32
145 INT44623 Positive_regulation of Regulation of Adra1a 1 0.04 0.64 0.29
146 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29
147 INT176333 Transcription of Cd40 1 0.52 0.8 0.28
148 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28
149 INT196006 Regulation of FLT4 2 0.25 2.24 0.27
150 INT224619 Regulation of Positive_regulation of Vegfa 1 0.05 0.57 0.27
151 INT5213 Regulation of Localization of Cd40 1 0.26 0 0.27
152 INT224638 Positive_regulation of Positive_regulation of Vegfa 1 0.06 0.57 0.27
153 INT148796 Regulation of Phosphorylation of VEGFA 3 0.35 1.66 0.26
154 INT109537 Transcription of Vegfa 2 0.44 1.32 0.26
155 INT42351 Regulation of Positive_regulation of Adra1a 1 0.01 0 0.26
156 INT217002 Positive_regulation of Localization of CD40 1 0.14 0 0.26
157 INT118118 Positive_regulation of Binding of Adra1a 1 0.18 0.3 0.26
158 INT311985 Regulation of Positive_regulation of Cd40 1 0.45 0.64 0.24
159 INT122590 Transcription of Adra1a 1 0.03 0.73 0.24
160 INT137608 Regulation of Localization of Vegfa 1 0.25 0.56 0.24
161 INT206159 Negative_regulation of Regulation of VEGFA 3 0.24 2.38 0.2
162 INT39288 Regulation of Binding of Adra1a 1 0.20 0.35 0.2
163 INT288358 Positive_regulation of Binding of Mc1r 1 0.41 0 0.19
164 INT197104 Positive_regulation of Gene_expression of FLT4 1 0.56 3.45 0.19
165 INT197102 Localization of FLT4 4 0.65 2.89 0.17
166 INT31927 Positive_regulation of Localization of Adra1a 1 0.10 0.17 0.16
167 INT252316 Regulation of Regulation of Cd40 2 0.24 0.71 0.15
168 INT238504 Positive_regulation of Positive_regulation of CD40 2 0.36 3.03 0.15
169 INT197103 Binding of FLT4 2 0.29 3.08 0.14
170 INT234680 Localization of Cd40 1 0.18 0.16 0.14
171 INT302444 Negative_regulation of Binding of Vegfa 2 0.57 4.08 0.12
172 INT246872 Negative_regulation of Localization of Vegfa 2 0.41 2.16 0.12
173 INT289653 Negative_regulation of Transcription of Flt4 1 0.20 0.62 0.12
174 INT289652 Transcription of Flt4 1 0.34 0.62 0.12
175 INT260740 Negative_regulation of Localization of Vegfa 1 0.10 0.19 0.12
176 INT170592 Regulation of Gene_expression of CD40 4 0.17 0 0.11
177 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
178 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
179 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
180 INT184511 Positive_regulation of Negative_regulation of VEGFA 5 0.46 2.86 0.09
181 INT288014 Negative_regulation of Positive_regulation of CD40 1 0.17 0.63 0.09
182 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
183 INT196007 Positive_regulation of FLT4 2 0.56 5.44 0.08
184 INT247569 Positive_regulation of Regulation of VEGFA 6 0.48 4.15 0.07
185 INT311981 Regulation of Protein_catabolism of Cd40 1 0.45 0.31 0.07
186 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
187 INT311983 Protein_catabolism of Cd40 1 0.88 0.31 0.07
188 INT85629 Regulation of Regulation of Mc1r 1 0.34 0.39 0.07
189 INT275162 Negative_regulation of Gene_expression of Cd40 1 0.14 1.23 0.06
190 INT197101 Positive_regulation of Localization of FLT4 1 0.38 0.77 0.06
191 INT320783 Binding of Flt4 2 0.26 0.98 0.05
192 INT125793 Protein_catabolism of Adra1a 1 0.39 0.24 0.05
193 INT294427 Regulation of Gene_expression of Vegfa 2 0.44 2.4 0.04
194 INT211878 Transcription of CD40 2 0.35 2.01 0.03
195 INT295840 Positive_regulation of Regulation of Vegfa 1 0.12 0 0.03
196 INT319335 Transcription of FLT4 1 0.18 0.99 0.03
197 INT337233 Positive_regulation of Binding of CD40 1 0.26 0.6 0.03
198 INT112325 Transcription of Vegfa 2 0.41 1.11 0
199 INT143447 Regulation of Protein_catabolism of VEGFA 1 0.27 0.15 0
200 INT347528 Negative_regulation of Flt4 1 0.29 0.13 0
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