GO:0090080

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Name positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0090080
Unique Molecular Interactions 34
Total Molecular Interactions 45
Total Single Events 359
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
2 INT335027 Binding of Vdr and Fgf23 1 0.24 0.34 0.29
3 INT9717 Binding of Egf and Fgfr1 1 0.15 0 0.22
4 INT335021 Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.53 1.49 0.21
5 INT335025 Gm7647 Positive_regulation of Gene_expression of Fgf21 1 0.01 0.29 0.21
6 INT335020 Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.62 0.82 0.18
7 INT335018 Vdr Positive_regulation of Gene_expression of Fgf23 1 0.44 0.36 0.17
8 INT335026 Positive_regulation of Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.45 0.2 0.13
9 INT335024 Positive_regulation of Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.39 0.19 0.13
10 INT228501 Binding of AAVS1 and Fgfr1 1 0.01 0.57 0.07
11 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
12 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
13 INT335017 Fgf23 Positive_regulation of Fgfr1 1 0.23 0.59 0.04
14 INT335016 Fgf23 Negative_regulation of Gene_expression of Slc34a3 1 0.03 0.63 0.03
15 INT316598 Pth Regulation of Fgf23 1 0.10 0.28 0.03
16 INT205611 Gm6668 Negative_regulation of Fgfr1 1 0.01 1.59 0
17 INT265753 Binding of FLT1 and KL 1 0.18 0 0
18 INT335013 Fgf21 Positive_regulation of Localization of Ins1 1 0.06 0.58 0
19 INT352793 Binding of APOC1 and FGF21 1 0.01 2.76 0
20 INT265759 KL Positive_regulation of Binding of VEGFA 1 0.25 0.14 0
21 INT265747 Binding of KLKB1 and KL 1 0.02 0 0
22 INT335012 Fgf21 Positive_regulation of Gene_expression of Ins1 1 0.06 0.57 0
23 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0
24 INT352795 Binding of INS and FGF21 1 0.05 2.03 0
25 INT266839 Fgf23 Negative_regulation of Slc34a1 1 0.21 0.88 0
26 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0
27 INT335019 Fgf23 Positive_regulation of Phosphorylation of Mapk1 1 0.08 0.45 0
28 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0
29 INT352794 Binding of APOB and FGF21 1 0.01 1.98 0
30 INT266838 Fgf23 Regulation of Slc34a1 1 0.13 0.3 0
31 INT265769 GOPC Positive_regulation of Gene_expression of KL 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109391 Gene_expression of Fgfr1 7 0.56 1.78 3.67
2 INT119218 Positive_regulation of Fgfr1 4 0.58 1.11 3.05
3 INT314554 Gene_expression of Fgf21 3 0.74 7.97 2.48
4 INT332832 Positive_regulation of Gene_expression of Fgf21 2 0.66 3.18 1.29
5 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04
6 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85
7 INT130797 Gene_expression of Fgf23 6 0.66 4.73 0.77
8 INT118469 Gene_expression of Fgfr3 5 0.72 6.98 0.75
9 INT166537 Localization of Fgfr1 5 0.40 2.69 0.69
10 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66
11 INT146775 Phosphorylation of Fgfr1 1 0.53 0.8 0.62
12 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57
13 INT146776 Transcription of Fgfr1 1 0.45 0.67 0.49
14 INT146777 Regulation of Transcription of Fgfr1 1 0.23 0.67 0.49
15 INT188371 Regulation of Localization of Fgfr1 1 0.10 1.02 0.43
16 INT150948 Positive_regulation of Gene_expression of Fgfr1 3 0.15 3.19 0.32
17 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29
18 INT130799 Localization of Fgf23 2 0.63 1.94 0.28
19 INT180696 Positive_regulation of Gene_expression of Fgfr1 1 0.32 0.08 0.28
20 INT157409 Negative_regulation of Fgf23 3 0.50 3.21 0.27
21 INT285474 Negative_regulation of Gene_expression of Fgfr1 2 0.40 2.15 0.24
22 INT188373 Positive_regulation of Localization of Fgfr1 1 0.19 1.09 0.21
23 INT173515 Negative_regulation of Transcription of Fgfr1 1 0.06 0.92 0.21
24 INT303539 Binding of Fgfr1 3 0.45 0.96 0.2
25 INT130798 Positive_regulation of Gene_expression of Fgf23 2 0.59 1.12 0.2
26 INT173503 Transcription of Fgfr1 1 0.08 0.92 0.2
27 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15
28 INT334998 Positive_regulation of Fgf21 1 0.66 4.8 0.14
29 INT352803 Positive_regulation of FGF21 1 0.66 18.41 0.14
30 INT295974 Regulation of Fgf23 1 0.07 2.3 0.11
31 INT188374 Negative_regulation of Fgfr1 1 0.22 0.68 0.1
32 INT158294 Regulation of KL 1 0.37 1.06 0.09
33 INT334999 Regulation of Fgf21 1 0.43 2.33 0.09
34 INT250851 Binding of Fgfr1 1 0.10 0.19 0.08
35 INT250839 Binding of Fgfr3 1 0.16 0.19 0.08
36 INT266826 Binding of Fgf23 1 0.32 1.26 0.07
37 INT138616 Binding of KL 2 0.32 1.96 0.06
38 INT188372 Negative_regulation of Localization of Fgfr1 1 0.22 0.66 0.06
39 INT352801 Gene_expression of FGF21 1 0.73 22.78 0.05
40 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04
41 INT316595 Transcription of Fgf23 1 0.61 0.44 0.04
42 INT316589 Negative_regulation of Transcription of Fgf23 1 0.50 0.44 0.04
43 INT303538 Positive_regulation of Fgfr1 3 0.65 0.92 0.03
44 INT303544 Positive_regulation of Negative_regulation of Fgfr1 1 0.47 1.07 0.03
45 INT335006 Negative_regulation of Gene_expression of Fgf21 1 0.41 1.33 0.03
46 INT335007 Protein_catabolism of Fgf23 1 0.59 1.28 0.03
47 INT334980 Negative_regulation of Fgf21 1 0.41 2.31 0.03
48 INT316588 Positive_regulation of Fgf23 1 0.43 0.29 0.03
49 INT303536 Localization of Fgfr1 1 0.70 0.28 0.03
50 INT207842 Gene_expression of KL 3 0.34 2.88 0
51 INT207843 Positive_regulation of Gene_expression of KL 2 0.26 1.1 0
52 INT276327 Positive_regulation of Gene_expression of Fgfr3 2 0.43 1.83 0
53 INT352804 Binding of FGF21 1 0.40 5.56 0
54 INT310246 Positive_regulation of Positive_regulation of Fgfr1 1 0.31 0 0
55 INT150308 Protein_catabolism of Fgf23 1 0.75 0.05 0
56 INT352796 Positive_regulation of Positive_regulation of FGF21 1 0.47 3.26 0
57 INT243057 Positive_regulation of Fgfr3 1 0.46 0.79 0
58 INT334982 Phosphorylation of Fgf23 1 0.73 1.21 0
59 INT335003 Negative_regulation of Localization of Fgf23 1 0.39 2.37 0
60 INT303553 Regulation of Gene_expression of Fgfr3 1 0.25 0.3 0
61 INT334997 Localization of Fgf23 1 0.72 3.56 0
62 INT265796 Positive_regulation of Positive_regulation of KL 1 0.26 0 0
63 INT352799 Negative_regulation of FGF21 1 0.40 0.97 0
64 INT352805 Positive_regulation of Gene_expression of FGF21 1 0.47 4.89 0
65 INT243058 Positive_regulation of Positive_regulation of Fgfr3 1 0.46 0.8 0
66 INT266824 Regulation of Positive_regulation of Fgf23 1 0.27 1.22 0
67 INT265810 Positive_regulation of KL 1 0.35 1.04 0
68 INT352797 Regulation of Positive_regulation of FGF21 1 0.26 1.45 0
69 INT334988 Localization of Fgf21 1 0.71 0.08 0
70 INT352802 Regulation of FGF21 1 0.58 4.21 0
71 INT352798 Negative_regulation of Localization of FGF21 1 0.40 0.97 0
72 INT334991 Positive_regulation of Positive_regulation of Fgf23 1 0.39 1.5 0
73 INT150307 Positive_regulation of Protein_catabolism of Fgf23 1 0.52 0.11 0
74 INT266825 Positive_regulation of Regulation of Fgf23 1 0.46 0.25 0
75 INT334993 Negative_regulation of Gene_expression of Fgf23 1 0.38 4.1 0
76 INT334984 Regulation of Gene_expression of Fgf21 1 0.43 0.67 0
77 INT180708 Regulation of Fgfr1 1 0.09 0 0
78 INT352800 Localization of FGF21 1 0.71 0.97 0
79 INT188240 Transcription of KL 1 0.54 1.88 0
80 INT301359 Positive_regulation of Fgfr3 1 0.19 0.64 0
81 INT301357 Negative_regulation of Positive_regulation of Fgfr3 1 0.16 0.35 0
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