GO:0090090

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Name negative regulation of canonical Wnt receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0090090
Unique Molecular Interactions 703
Total Molecular Interactions 942
Total Single Events 7068
Pain Genes Associated 74

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of canonical Wnt receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of canonical Wnt receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38
2 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
3 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5
4 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
5 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
6 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
7 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11
8 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
9 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
10 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
11 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
12 INT61862 Slc3a1 Positive_regulation of Egr1 1 0.05 0 0.92
13 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
14 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88
15 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
16 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
17 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
18 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
19 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
20 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
21 INT12238 CCK Positive_regulation of CDH2 1 0.02 0 0.7
22 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
23 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
24 INT92026 Egr1 Positive_regulation of Fos 1 0.50 0.61 0.67
25 INT118568 Binding of Ddit3 and Atf6 1 0.33 0.85 0.66
26 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
27 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
28 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
29 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
30 INT5544 Ptpro Regulation of Syt17 1 0.05 0 0.6
31 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
32 INT239500 Binding of Aes and Atic 1 0.20 0.4 0.56
33 INT133854 Mcc Positive_regulation of Ngf 1 0.00 0.9 0.56
34 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
35 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
36 INT122107 Plbd2 Negative_regulation of Cdh2 1 0.03 0.42 0.5
37 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
38 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
39 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
40 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
41 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
42 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
43 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
44 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
45 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
46 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43
47 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
48 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
49 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
50 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
51 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
52 INT90722 Nr4a1 Positive_regulation of Egr1 1 0.20 0.48 0.35
53 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
54 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
55 INT90724 Egr3 Positive_regulation of Egr1 1 0.33 0.48 0.35
56 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
57 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35
58 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
59 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
60 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
61 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
62 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
63 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
64 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
65 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
66 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
67 INT74334 Penk Regulation of Transcription of Egr1 1 0.40 0.25 0.29
68 INT74336 Crh Regulation of Transcription of Egr1 1 0.49 0.24 0.28
69 INT147356 Egr1 Positive_regulation of Gene_expression of Btg1 1 0.14 1.56 0.28
70 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
71 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
72 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
73 INT147358 Egr1 Positive_regulation of Gene_expression of Gdf15 1 0.14 1.56 0.28
74 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
75 INT58182 Fos Regulation of Egr1 1 0.49 0.09 0.27
76 INT118860 MCC Positive_regulation of Phosphorylation of STAT3 1 0.01 0.1 0.27
77 INT147359 Positive_regulation of Pik3cd Positive_regulation of Egr1 1 0.09 1.51 0.27
78 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
79 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
80 INT130931 Sis Negative_regulation of Egr1 1 0.01 0.52 0.27
81 INT58176 Junb Regulation of Egr1 1 0.46 0.09 0.27
82 INT135947 MCC Regulation of GDF15 1 0.11 1.58 0.27
83 INT147360 Pik3cd Positive_regulation of Egr1 1 0.12 1.51 0.27
84 INT125521 EGR1 Regulation of GDF15 1 0.13 0.47 0.26
85 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
86 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
87 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
88 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24
89 INT130060 PPARG Positive_regulation of Positive_regulation of Egr1 1 0.22 0.46 0.24
90 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
91 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24
92 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
93 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
94 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
95 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
96 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
97 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
98 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
99 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
100 INT184162 Egr1 Positive_regulation of Transcription of Ptges2 1 0.08 0.42 0.22
101 INT220528 Ugt1a6b Positive_regulation of Cav1 1 0.01 1.31 0.22
102 INT184160 Binding of Egr1 and Ptges2 1 0.07 0.4 0.22
103 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
104 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
105 INT271853 Ngf Positive_regulation of Gene_expression of Egr1 1 0.53 1.36 0.21
106 INT259817 Ltp Positive_regulation of Egr1 1 0.03 0.28 0.2
107 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
108 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
109 INT121583 Negative_regulation of GSK3A Negative_regulation of Gene_expression of GDF15 1 0.11 0.49 0.2
110 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
111 INT259812 Gtf3a Regulation of Egr1 1 0.01 0.58 0.19
112 INT184159 Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
113 INT58178 Gtf3a Positive_regulation of Egr1 1 0.07 0.09 0.19
114 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
115 INT184161 Negative_regulation of Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
116 INT259814 Binding of Arc and Egr1 1 0.34 0.55 0.19
117 INT259813 Binding of Egr1 and Arc 1 0.32 0.55 0.19
118 INT149096 PITX2 Positive_regulation of Gene_expression of Egr1 1 0.01 1.23 0.19
119 INT58181 Gtf3a Positive_regulation of Gene_expression of Egr1 1 0.07 0.1 0.19
120 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
121 INT312090 EGR1 Regulation of Positive_regulation of PTGES 1 0.42 0.21 0.18
122 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
123 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18
124 INT318680 Binding of Cebpg and Ddit3 1 0.39 1.73 0.18
125 INT317895 Fos Regulation of Transcription of Egr1 1 0.41 1.03 0.17
126 INT317897 Egr1 Regulation of Transcription of Fosb 1 0.34 1.08 0.17
127 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
128 INT220520 Ugt1a6b Positive_regulation of Gene_expression of Cav1 1 0.01 0.81 0.17
129 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
130 INT130690 Gene_expression of HSPA5 Negative_regulation of Positive_regulation of DDIT3 1 0.21 0.58 0.17
131 INT295439 Binding of AES and IFNA1 1 0.25 0.46 0.17
132 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
133 INT317892 Egr1 Regulation of Transcription of Fos 1 0.41 1.03 0.17
134 INT312109 ELANE Positive_regulation of EGR1 1 0.15 0.23 0.16
135 INT312100 ELANE Positive_regulation of Binding of EGR1 1 0.16 0.23 0.16
136 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
137 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
138 INT146025 EGR1 Negative_regulation of Gene_expression of GDF15 1 0.28 0.81 0.15
139 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
140 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
141 INT312092 ELANE Positive_regulation of Gene_expression of EGR1 1 0.19 0.21 0.15
142 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
143 INT168806 Tlr4 Positive_regulation of Gene_expression of Egr1 1 0.18 0.3 0.15
144 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14
145 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14
146 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14
147 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14
148 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
149 INT115140 PPARG Positive_regulation of EGR1 1 0.36 0.45 0.13
150 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
151 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
152 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
153 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13
154 INT115141 TGM7 Positive_regulation of EGR1 1 0.26 0.44 0.13
155 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
156 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
157 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13
158 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
159 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
160 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12
161 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
162 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
163 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
164 INT147362 Mapk9 Positive_regulation of Ddit3 1 0.57 0.76 0.12
165 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
166 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
167 INT182481 Binding of Cav1 and Ighg2b 1 0.10 0 0.12
168 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
169 INT182482 Binding of Cav1 and Cxcl16 1 0.07 0 0.12
170 INT154803 Gene_expression of EGR1 Positive_regulation of Positive_regulation of GDF15 1 0.33 0.84 0.12
171 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
172 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
173 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11
174 INT334871 Binding of Mpz and Sox10 1 0.13 0 0.11
175 INT334862 Positive_regulation of Binding of Mpz and Sox10 1 0.17 0 0.11
176 INT245185 Binding of RRAD and TCF7L2 1 0.00 6.88 0.1
177 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
178 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
179 INT220517 Negative_regulation of Ugt1a6b Positive_regulation of Cav1 1 0.01 0.35 0.1
180 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
181 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1
182 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1
183 INT245182 Binding of SPINK1 and TCF7L2 1 0.39 2.05 0.1
184 INT262255 Binding of APC and F2R 1 0.05 3 0.1
185 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
186 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
187 INT165159 Gli1 Regulation of Penk 1 0.24 0.07 0.09
188 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
189 INT135948 MCC Regulation of Protein_catabolism of GDF15 1 0.09 0.77 0.09
190 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
191 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
192 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
193 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
194 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
195 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
196 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
197 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
198 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
199 INT111432 TMPRSS15 Positive_regulation of Positive_regulation of MCC 1 0.02 0.16 0.08
200 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of canonical Wnt receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of canonical Wnt receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
2 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
3 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
4 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95
5 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45
6 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
7 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
8 INT158070 Localization of Aes 23 0.65 19.93 10.9
9 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16
10 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89
11 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41
12 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18
13 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
14 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
15 INT150422 Positive_regulation of Aes 24 0.43 15.63 8
16 INT6055 Transcription of Egr1 47 0.69 3.61 7.68
17 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17
18 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
19 INT47707 Negative_regulation of Egr1 9 0.41 0.17 7.03
20 INT264641 Binding of AES 25 0.42 18.56 6.98
21 INT52180 Binding of Aes 38 0.42 23.16 6.7
22 INT73022 Positive_regulation of Gene_expression of EGR1 21 0.69 10.61 6.5
23 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38
24 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
25 INT188844 Gene_expression of AES 44 0.58 33.94 5.85
26 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
27 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
28 INT47704 Regulation of Egr1 17 0.60 2.43 5.18
29 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13
30 INT201130 Localization of AES 31 0.63 25.45 5.12
31 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1
32 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
33 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01
34 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
35 INT57376 Transcription of EGR1 20 0.69 12.94 4.84
36 INT51944 Positive_regulation of Transcription of Egr1 12 0.49 1.96 4.72
37 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
38 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45
39 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
40 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32
41 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
42 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25
43 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
44 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
45 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
46 INT63121 Binding of APC 29 0.41 23.02 3.8
47 INT123502 Binding of Egr1 11 0.35 6.7 3.77
48 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
49 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
50 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5
51 INT142483 Positive_regulation of Gene_expression of DDIT3 15 0.67 11.39 3.47
52 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39
53 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22
54 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
55 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
56 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
57 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
58 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48
59 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
60 INT98634 Positive_regulation of Positive_regulation of EGR1 9 0.68 3.43 2.47
61 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41
62 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39
63 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
64 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
65 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
66 INT15243 Regulation of Egr1 19 0.61 7.6 2.13
67 INT139403 Positive_regulation of Mcc 3 0.45 1.64 2.11
68 INT80599 Regulation of Positive_regulation of Egr1 3 0.28 0.46 2.09
69 INT248325 Positive_regulation of Localization of Aes 4 0.26 1.88 2.07
70 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
71 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
72 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
73 INT141166 Positive_regulation of Gene_expression of Ddit3 15 0.56 10.32 1.92
74 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87
75 INT73023 Binding of EGR1 7 0.48 4.23 1.86
76 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
77 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
78 INT275875 Negative_regulation of Localization of Aes 2 0.19 3.87 1.8
79 INT280889 Gene_expression of Sox10 19 0.72 3.45 1.78
80 INT57375 Regulation of EGR1 5 0.40 1.94 1.78
81 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
82 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76
83 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75
84 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
85 INT3818 Regulation of Apc 13 0.39 12.52 1.68
86 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
87 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
88 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
89 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
90 INT57877 Negative_regulation of Positive_regulation of Egr1 4 0.42 1.63 1.57
91 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
92 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
93 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
94 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
95 INT140245 Binding of Gli3 3 0.36 2.65 1.46
96 INT53003 Positive_regulation of Positive_regulation of Egr1 6 0.64 2.36 1.44
97 INT254298 Protein_catabolism of AES 6 0.55 9.79 1.43
98 INT98635 Negative_regulation of Gene_expression of EGR1 5 0.58 2.2 1.42
99 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42
100 INT271464 Transcription of Ptpro 1 0.02 0.95 1.4
101 INT21523 Positive_regulation of Ctnnd1 1 0.27 0.35 1.4
102 INT220177 Binding of Apc 21 0.37 15.34 1.37
103 INT65121 Negative_regulation of Ptpro 1 0.02 0.97 1.36
104 INT141344 Transcription of Egr1 11 0.70 5.59 1.34
105 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
106 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
107 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
108 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
109 INT128160 Regulation of DDIT3 3 0.57 2.45 1.29
110 INT141862 Binding of Cav1 11 0.36 1.32 1.25
111 INT203099 Negative_regulation of Aes 3 0.25 0.82 1.25
112 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24
113 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
114 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21
115 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
116 INT116144 Positive_regulation of Positive_regulation of Ddit3 2 0.41 2.95 1.2
117 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
118 INT110780 Localization of Notch1 2 0.06 0.47 1.19
119 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
120 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
121 INT242414 Regulation of Aes 5 0.23 1.82 1.16
122 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
123 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
124 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
125 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
126 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
127 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
128 INT98633 Negative_regulation of Transcription of EGR1 3 0.43 0.79 1.11
129 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
130 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
131 INT165338 Binding of Dkk1 4 0.37 3.64 1.04
132 INT123503 Positive_regulation of Binding of Egr1 3 0.13 2.34 1.04
133 INT133842 Binding of SOX10 3 0.38 5.79 1.02
134 INT152407 Negative_regulation of Gene_expression of DDIT3 3 0.40 0.87 1.02
135 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
136 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
137 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
138 INT122106 Localization of Cdh2 3 0.69 0.95 1
139 INT152408 Binding of DDIT3 3 0.35 2.06 1
140 INT123501 Negative_regulation of Binding of Egr1 2 0.12 2.04 0.99
141 INT78210 Gene_expression of MCC 7 0.65 1.8 0.98
142 INT51947 Regulation of Transcription of Egr1 2 0.59 0.15 0.96
143 INT136613 Negative_regulation of Cav1 2 0.57 2.28 0.96
144 INT116140 Localization of Ddit3 2 0.57 1.94 0.96
145 INT6833 Binding of Notch1 4 0.36 0.05 0.94
146 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
147 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
148 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
149 INT76807 Binding of MCC 4 0.36 0.54 0.92
150 INT243533 Positive_regulation of SOX10 1 0.35 3.93 0.92
151 INT98638 Positive_regulation of Transcription of EGR1 3 0.49 2.83 0.91
152 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
153 INT242134 Localization of Apc 8 0.74 4.83 0.88
154 INT141442 Negative_regulation of Phosphorylation of Cav1 1 0.59 0.94 0.87
155 INT229278 Positive_regulation of Cby1 5 0.67 8.07 0.85
156 INT239497 Binding of Aes 8 0.29 3.61 0.84
157 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83
158 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
159 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
160 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
161 INT133841 Gene_expression of SOX10 18 0.67 9.96 0.8
162 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
163 INT111437 Positive_regulation of MCC 3 0.05 1.48 0.79
164 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78
165 INT130057 Positive_regulation of CAV1 12 0.65 8.96 0.77
166 INT188251 Localization of DKK1 6 0.50 3.26 0.77
167 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
168 INT242131 Localization of Dkk1 5 0.79 6 0.76
169 INT239496 Gene_expression of Aes 4 0.52 1.45 0.76
170 INT98636 Negative_regulation of Positive_regulation of EGR1 3 0.58 2.21 0.73
171 INT112088 Regulation of Cav1 2 0.44 0.51 0.73
172 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73
173 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72
174 INT57062 Regulation of APC 24 0.58 14.3 0.7
175 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
176 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
177 INT6050 Localization of Egr1 4 0.68 0.53 0.7
178 INT318666 Negative_regulation of Ddit3 1 0.56 6.86 0.7
179 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
180 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
181 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
182 INT153667 Localization of CAV1 15 0.76 11.92 0.68
183 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
184 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
185 INT118564 Regulation of Gene_expression of Ddit3 1 0.55 0.89 0.68
186 INT335876 Negative_regulation of Sost 11 0.51 6.77 0.67
187 INT141341 Binding of Egr1 5 0.48 2.65 0.67
188 INT8718 Regulation of Mcc 1 0.19 0.52 0.66
189 INT318667 Negative_regulation of Gene_expression of Ddit3 6 0.56 3.16 0.65
190 INT40698 Positive_regulation of Aes 3 0.32 3.84 0.65
191 INT102686 Phosphorylation of Egr1 3 0.59 2.57 0.64
192 INT133089 Negative_regulation of MCC 3 0.41 0.72 0.64
193 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
194 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
195 INT122104 Regulation of Localization of Cdh2 1 0.23 0.51 0.62
196 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
197 INT86700 Regulation of Cav1 7 0.54 0.92 0.61
198 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
199 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
200 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
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