GO:0090103

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Name cochlea morphogenesis
Categary Process
Go Slim No
Go Link GO:0090103
Unique Molecular Interactions 96
Total Molecular Interactions 115
Total Single Events 1112
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cochlea morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for cochlea morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
2 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
3 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99
4 INT53152 Rac1 Regulation of Scg2 1 0.03 0 0.9
5 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
6 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
7 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
8 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
9 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
10 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
11 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
12 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 0.42 0.21 0.48
13 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 0.38 0.21 0.48
14 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
15 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
16 INT131505 Rac1 Regulation of Gene_expression of Trpv1 1 0.55 0.39 0.42
17 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
18 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
19 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
20 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
21 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
22 INT330109 Binding of Racgap1 and Rac1 1 0.03 1.22 0.32
23 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
24 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
25 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
26 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
27 INT143973 Rac1 Positive_regulation of Vti1b 1 0.00 0.16 0.2
28 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
29 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
30 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
31 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18
32 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17
33 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
34 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
35 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
36 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
37 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
38 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
39 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
40 INT275157 Binding of Stat3 and Rac1 1 0.05 0.71 0.1
41 INT275158 Rac1 Positive_regulation of Stat3 1 0.07 0.72 0.1
42 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
43 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
44 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
45 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05
46 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
47 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
48 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
49 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
50 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
51 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
52 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
53 INT302640 Rac1 Regulation of Gene_expression of VEGFA 1 0.03 0 0
54 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
55 INT244839 Lbx1 Positive_regulation of Pax2 1 0.39 0 0
56 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
57 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
58 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
59 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
60 INT302641 Rac1 Regulation of TIE1 1 0.25 0.47 0
61 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
62 INT254847 Rac1 Positive_regulation of Fbrs 1 0.09 0.81 0
63 INT228112 Gene_expression of Chrm2 Positive_regulation of Positive_regulation of Rac1 1 0.14 0.26 0
64 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
65 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
66 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
67 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
68 INT334474 PGGT1B Regulation of Localization of Rac1 1 0.03 0.47 0
69 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0
70 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
71 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
72 INT302633 Rac1 Regulation of Cdc42ep2 1 0.01 0 0
73 INT297691 Binding of Fut1 and Pax2 1 0.03 0 0
74 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
75 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
76 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
77 INT213556 Binding of Eya1 and Six1 1 0.41 0.48 0
78 INT338184 Binding of PCa and HPN 1 0.02 0.79 0
79 INT257340 Binding of Cyba and Rac1 1 0.09 0.29 0
80 INT183721 HPN Positive_regulation of MYO7A 1 0.02 1.55 0
81 INT254850 Setd1a Negative_regulation of Rac1 1 0.00 0 0
82 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0
83 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cochlea morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in cochlea morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
2 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
3 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
4 INT27627 Binding of Rac1 41 0.41 22.88 13.68
5 INT95794 Gene_expression of GRHL3 9 0.68 5.57 9.9
6 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
7 INT127961 Transcription of GRHL3 1 0.45 4.34 8.17
8 INT127964 Regulation of Transcription of GRHL3 1 0.28 2.54 4.84
9 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
10 INT127962 Positive_regulation of GRHL3 3 0.32 2.67 3.69
11 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41
12 INT127963 Positive_regulation of Gene_expression of GRHL3 1 0.44 1.85 3.4
13 INT58475 Localization of Rac1 12 0.75 5.94 3.2
14 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33
15 INT108131 Localization of GRHL3 3 0.73 1.03 2.18
16 INT93764 Binding of GRHL3 3 0.36 1.79 2.07
17 INT24850 Regulation of GRHL3 4 0.45 0.32 1.9
18 INT117980 Regulation of Rac1 10 0.45 3.72 1.88
19 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
20 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
21 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21
22 INT98062 Regulation of Gene_expression of Rac1 4 0.39 1.41 1.21
23 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
24 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
25 INT93765 Negative_regulation of Binding of GRHL3 1 0.41 0.43 1.14
26 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13
27 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99
28 INT119674 Localization of GLI2 6 0.52 2.84 0.99
29 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
30 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
31 INT81211 Transcription of Rac1 4 0.54 1.05 0.89
32 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
33 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
34 INT330097 Positive_regulation of Positive_regulation of Rac1 1 0.37 2.47 0.86
35 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83
36 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82
37 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
38 INT264629 Localization of Rac1 8 0.72 5.7 0.79
39 INT104840 Binding of GLI2 6 0.08 1.89 0.72
40 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7
41 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
42 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
43 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
44 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57
45 INT16012 Binding of Rac1 17 0.37 6.9 0.53
46 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
47 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
48 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
49 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
50 INT81212 Negative_regulation of Transcription of Rac1 1 0.01 0 0.46
51 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43
52 INT87847 Regulation of Positive_regulation of Rac1 2 0.36 1.49 0.43
53 INT65606 Binding of TBX1 2 0.30 3.13 0.41
54 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
55 INT124986 Positive_regulation of Localization of Rac1 3 0.50 1.22 0.33
56 INT274626 Positive_regulation of Positive_regulation of GRHL3 1 0.22 0.67 0.32
57 INT112551 Protein_catabolism of Rac1 2 0.66 0.29 0.3
58 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
59 INT287931 Positive_regulation of Gene_expression of DVL1 2 0.09 0.08 0.29
60 INT116729 Regulation of Localization of Rac1 1 0.01 0.07 0.29
61 INT309354 Regulation of Pax2 1 0.10 0 0.29
62 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
63 INT269082 Gene_expression of TBX1 1 0.14 0.36 0.28
64 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
65 INT99682 Phosphorylation of Rac1 1 0.54 0.72 0.28
66 INT162873 Negative_regulation of Negative_regulation of Rac1 1 0.34 0.35 0.26
67 INT330090 Regulation of Negative_regulation of Rac1 1 0.36 0.53 0.25
68 INT306427 Localization of TBX1 1 0.20 1.08 0.23
69 INT330093 Negative_regulation of Positive_regulation of Rac1 1 0.34 0.88 0.23
70 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23
71 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
72 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
73 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
74 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
75 INT289128 Negative_regulation of Gene_expression of DVL1 1 0.07 0.31 0.17
76 INT289117 Negative_regulation of DVL1 1 0.07 0.31 0.17
77 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
78 INT168055 Regulation of Transcription of Rac1 1 0.36 0.34 0.16
79 INT133599 Positive_regulation of Binding of Rac1 2 0.40 0.4 0.15
80 INT330085 Regulation of Binding of Rac1 1 0.36 0.28 0.15
81 INT309352 Localization of Pax2 1 0.27 0 0.14
82 INT287922 Phosphorylation of DVL1 4 0.20 1.21 0.12
83 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
84 INT162568 Regulation of TBX1 3 0.35 1.54 0.11
85 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11
86 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
87 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
88 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
89 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
90 INT302613 Positive_regulation of Gene_expression of Rac1 14 0.67 3.7 0.08
91 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
92 INT183722 Gene_expression of HPN 3 0.37 1.63 0.08
93 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
94 INT334443 Positive_regulation of Positive_regulation of Rac1 1 0.33 1.1 0.08
95 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
96 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
97 INT287947 Binding of DVL1 3 0.10 0.95 0.06
98 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
99 INT302624 Negative_regulation of Gene_expression of Rac1 1 0.56 3.67 0.06
100 INT244741 Positive_regulation of Gene_expression of Pax2 1 0.38 0 0.06
101 INT308287 Positive_regulation of HPN 1 0.39 0.48 0.05
102 INT208924 Gene_expression of Eya1 1 0.34 0.33 0.05
103 INT323949 Negative_regulation of Positive_regulation of Rac1 1 0.23 0.53 0.05
104 INT334445 Regulation of Positive_regulation of Rac1 1 0.40 1.73 0.04
105 INT287920 Positive_regulation of DVL1 3 0.49 1.29 0.03
106 INT225365 Binding of Sox9 2 0.28 0.48 0.03
107 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
108 INT302611 Regulation of Gene_expression of Rac1 1 0.43 4.5 0.03
109 INT302615 Transcription of Rac1 5 0.66 1.1 0
110 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
111 INT245757 Localization of SOX9 4 0.62 0.8 0
112 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
113 INT287937 Positive_regulation of Positive_regulation of DVL1 2 0.12 0.52 0
114 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
115 INT334450 Regulation of Localization of Rac1 1 0.30 0.65 0
116 INT228095 Phosphorylation of Rac1 1 0.34 0.21 0
117 INT302609 Positive_regulation of Transcription of Rac1 1 0.48 0.27 0
118 INT300638 Transcription of DVL1 1 0.33 1.11 0
119 INT302631 Regulation of Transcription of Rac1 1 0.43 0.47 0
120 INT244782 Negative_regulation of Pax2 1 0.44 0 0
121 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
122 INT335880 Regulation of Wnt5a 1 0.32 0.07 0
123 INT291288 Binding of HPN 1 0.09 0.3 0
124 INT302621 Regulation of Negative_regulation of Rac1 1 0.43 0 0
125 INT211943 Transcription of Sox9 1 0.50 0.3 0
126 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
127 INT213510 Localization of Eya1 1 0.65 0 0
128 INT302627 Negative_regulation of Localization of Rac1 1 0.41 0.28 0
129 INT302620 Negative_regulation of Transcription of Rac1 1 0.41 0 0
130 INT322886 Transcription of Sox9 1 0.50 0.25 0
131 INT314739 Transcription of TBX1 1 0.32 0.8 0
132 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
133 INT334438 Positive_regulation of Localization of Rac1 1 0.33 2.37 0
134 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
135 INT308286 Negative_regulation of HPN 1 0.36 0.19 0
136 INT213525 Regulation of Localization of Eya1 1 0.39 0 0
137 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
138 INT207369 Transcription of GLI2 1 0.05 0.08 0
139 INT213529 Negative_regulation of Gene_expression of Pax2 1 0.37 0.23 0
140 INT254786 Positive_regulation of Negative_regulation of Rac1 1 0.26 0.95 0
141 INT162572 Positive_regulation of Gene_expression of Wnt5a 1 0.02 0.3 0
142 INT302614 Positive_regulation of Binding of Rac1 1 0.48 0.31 0
143 INT245765 Binding of SOX9 1 0.31 0.87 0
144 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
145 INT207714 Positive_regulation of Gene_expression of HPN 1 0.33 0.57 0
146 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
147 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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