GO:0090179

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Name planar cell polarity pathway involved in neural tube closure
Categary Process
Go Slim No
Go Link GO:0090179
Unique Molecular Interactions 20
Total Molecular Interactions 31
Total Single Events 195
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for planar cell polarity pathway involved in neural tube closure. They are ordered first by their pain relevance and then by number of times they were reported for planar cell polarity pathway involved in neural tube closure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
2 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99
3 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
4 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
5 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
6 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
7 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
8 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
9 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
10 INT347124 Binding of FZD1 and Lrp1 1 0.11 0.24 0
11 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
12 INT233520 Tlr4 Positive_regulation of Fzd1 1 0.03 0.09 0
13 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
14 INT242165 Wnt2 Positive_regulation of Gene_expression of Fzd1 1 0.15 0.26 0
15 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
16 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
17 INT242166 Fzd1 Positive_regulation of Positive_regulation of Wnt2 1 0.13 0.24 0
18 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
19 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for planar cell polarity pathway involved in neural tube closure. They are ordered first by their pain relevance and then by number of times they were reported in planar cell polarity pathway involved in neural tube closure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95794 Gene_expression of GRHL3 9 0.68 5.57 9.9
2 INT127961 Transcription of GRHL3 1 0.45 4.34 8.17
3 INT127964 Regulation of Transcription of GRHL3 1 0.28 2.54 4.84
4 INT127962 Positive_regulation of GRHL3 3 0.32 2.67 3.69
5 INT127963 Positive_regulation of Gene_expression of GRHL3 1 0.44 1.85 3.4
6 INT108131 Localization of GRHL3 3 0.73 1.03 2.18
7 INT93764 Binding of GRHL3 3 0.36 1.79 2.07
8 INT24850 Regulation of GRHL3 4 0.45 0.32 1.9
9 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
10 INT93765 Negative_regulation of Binding of GRHL3 1 0.41 0.43 1.14
11 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
12 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83
13 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
14 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
15 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
16 INT274626 Positive_regulation of Positive_regulation of GRHL3 1 0.22 0.67 0.32
17 INT287931 Positive_regulation of Gene_expression of DVL1 2 0.09 0.08 0.29
18 INT242141 Gene_expression of Fzd1 1 0.21 2.5 0.21
19 INT289128 Negative_regulation of Gene_expression of DVL1 1 0.07 0.31 0.17
20 INT289117 Negative_regulation of DVL1 1 0.07 0.31 0.17
21 INT287922 Phosphorylation of DVL1 4 0.20 1.21 0.12
22 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
23 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
24 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
25 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
26 INT233462 Regulation of Fzd1 1 0.45 0.33 0.08
27 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
28 INT287947 Binding of DVL1 3 0.10 0.95 0.06
29 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
30 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
31 INT287920 Positive_regulation of DVL1 3 0.49 1.29 0.03
32 INT347119 Localization of FZD1 1 0.68 0.16 0.03
33 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
34 INT287937 Positive_regulation of Positive_regulation of DVL1 2 0.12 0.52 0
35 INT300638 Transcription of DVL1 1 0.33 1.11 0
36 INT335880 Regulation of Wnt5a 1 0.32 0.07 0
37 INT315189 Binding of SFRP1 1 0.15 2.96 0
38 INT242143 Regulation of Gene_expression of Fzd1 1 0.14 0.25 0
39 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
40 INT233478 Negative_regulation of Fzd1 1 0.31 0.09 0
41 INT201624 Regulation of FZD1 1 0.01 0 0
42 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
43 INT162572 Positive_regulation of Gene_expression of Wnt5a 1 0.02 0.3 0
44 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
45 INT242126 Positive_regulation of Fzd1 1 0.16 0.25 0
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