GO:0090197

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Name positive regulation of chemokine secretion
Categary Process
Go Slim No
Go Link GO:0090197
Unique Molecular Interactions 119
Total Molecular Interactions 161
Total Single Events 970
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of chemokine secretion. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of chemokine secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
2 INT252858 C5 Negative_regulation of Positive_regulation of Trpa1 1 0.02 0.78 0.74
3 INT325267 Il33 Positive_regulation of Gene_expression of Il4 1 0.16 1.59 0.69
4 INT325263 Il33 Positive_regulation of Gene_expression of Il5 1 0.16 1.59 0.69
5 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
6 INT202160 Binding of ARSD and CSF1R 1 0.16 1.69 0.59
7 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54
8 INT54304 Il1rl1 Regulation of Regulation of Pdyn 1 0.04 0.23 0.54
9 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53
10 INT325259 Il33 Positive_regulation of Gene_expression of Spg21 1 0.07 1.23 0.53
11 INT325269 Il33 Positive_regulation of Spg21 1 0.05 1.11 0.48
12 INT329960 Binding of C5 and TRAF1 1 0.32 1.04 0.42
13 INT329958 Binding of C5 and STAT4 1 0.33 0.93 0.41
14 INT203140 Binding of C5ar1 and C5 1 0.39 0.81 0.38
15 INT164890 Binding of IL1RAP and IL33 1 0.09 0.2 0.36
16 INT164904 Binding of IL1A and IL33 1 0.39 0.19 0.35
17 INT320694 C5 Regulation of Gene_expression of Il2 1 0.03 2.15 0.34
18 INT320692 C5 Regulation of Gene_expression of Il12a 1 0.03 2.15 0.34
19 INT320693 C5 Regulation of Gene_expression of Il6 1 0.04 2.15 0.34
20 INT320696 C5 Regulation of Gene_expression of TNF 1 0.34 2.15 0.34
21 INT320691 C5 Regulation of Gene_expression of Il1 1 0.06 2.15 0.34
22 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34
23 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33
24 INT325266 Positive_regulation of Spg21 Positive_regulation of Il33 1 0.05 0.75 0.32
25 INT325265 Il33 Positive_regulation of Gene_expression of Ik 1 0.01 0.67 0.32
26 INT226512 Il1rl1 Positive_regulation of Jun 1 0.12 0.34 0.29
27 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
28 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
29 INT177978 Binding of CSF1R and SNRNP70 1 0.02 1.49 0.28
30 INT177977 RUNX1 Regulation of CSF1R 1 0.14 1 0.27
31 INT311046 Binding of CSF2 and IL33 1 0.00 1.86 0.26
32 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
33 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
34 INT290376 Binding of CSF1R and MEFV 1 0.29 0.31 0.24
35 INT328621 Gene_expression of Il1rl1 Positive_regulation of Cfp 1 0.00 0.06 0.23
36 INT325276 Il33 Positive_regulation of Gene_expression of TNF 1 0.04 0.82 0.23
37 INT332013 Hc Regulation of Binding of C3ar1 1 0.12 1.11 0.21
38 INT332016 C3ar1 Regulation of Binding of Hc 1 0.12 1.11 0.21
39 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
40 INT261759 Binding of Il13 and Il4ra 1 0.26 0.51 0.2
41 INT169567 IL33 Regulation of Pscs 1 0.03 0.46 0.19
42 INT164892 IL33 Regulation of Gene_expression of IL1RAP 1 0.06 0.2 0.18
43 INT63443 Binding of Pomc and Il1rl1 1 0.04 0.06 0.18
44 INT164908 Binding of IL1RAP and IL1RL1 1 0.08 0.1 0.18
45 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18
46 INT355566 IL1RL1 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17
47 INT302381 Il33 Regulation of Gene_expression of Il4 1 0.01 0.76 0.16
48 INT226527 Il1rl1 Positive_regulation of Gene_expression of IK 1 0.00 0.42 0.15
49 INT226507 Il1rl1 Positive_regulation of Gene_expression of Jun 1 0.13 0.2 0.15
50 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15
51 INT305371 Binding of IL1RL1 and MRI1 1 0.09 0.95 0.15
52 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15
53 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15
54 INT226516 Il1rl1 Positive_regulation of Phosphorylation of Jun 1 0.02 0.19 0.14
55 INT169562 PDGFD Positive_regulation of Gene_expression of IL33 1 0.03 0.35 0.13
56 INT325272 Il1rl1 Positive_regulation of Gene_expression of TNF 1 0.02 0.41 0.12
57 INT325268 Il1rl1 Positive_regulation of Gene_expression of Spg21 1 0.05 0.41 0.12
58 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
59 INT177980 CSF1R Regulation of PXN 1 0.07 0.48 0.11
60 INT309662 C5 Positive_regulation of Akt1 1 0.30 0.43 0.11
61 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 0.05 0 0.09
62 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08
63 INT41832 Binding of ALB and C5 1 0.41 0.07 0.08
64 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07
65 INT303997 IL1RL1 Positive_regulation of Lep 1 0.01 0.2 0.07
66 INT218511 Cfb Positive_regulation of C5 1 0.01 0.29 0.06
67 INT299703 ECB2 Negative_regulation of Binding of C5 1 0.00 0.39 0.06
68 INT325256 Chchd8 Regulation of Il1rl1 1 0.00 0.33 0.05
69 INT325255 Chchd8 Regulation of Il33 1 0.00 0.33 0.05
70 INT325261 Ralbp1 Positive_regulation of Gene_expression of Il33 1 0.01 0 0.05
71 INT320991 C5AR1 Regulation of C5 1 0.05 0 0.03
72 INT279698 Hc Regulation of Trpv1 1 0.01 0 0
73 INT164899 IL33 Positive_regulation of IFNG 1 0.25 0.05 0
74 INT285996 Binding of ACAT1 and IL1RL1 1 0.00 0 0
75 INT164907 IFNG Positive_regulation of Gene_expression of IL1RL1 1 0.31 0.11 0
76 INT299705 C5 Positive_regulation of Positive_regulation of C5AR1 1 0.03 0.1 0
77 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0
78 INT164895 IL33 Positive_regulation of Gene_expression of CCL2 1 0.16 0.05 0
79 INT164901 IL33 Positive_regulation of Gene_expression of CXCL10 1 0.16 0.05 0
80 INT218505 Binding of C5 and Cfb 1 0.01 0.29 0
81 INT164906 IL33 Positive_regulation of Gene_expression of IL4 1 0.43 0.05 0
82 INT164910 IL33 Positive_regulation of Gene_expression of CXCL1 1 0.12 0.05 0
83 INT164900 STAT6 Positive_regulation of Gene_expression of IL1RL1 1 0.42 0.06 0
84 INT279695 Hc Negative_regulation of Car2 1 0.02 0 0
85 INT276606 Binding of DBT and IL33 1 0.01 0 0
86 INT279696 Hc Negative_regulation of Trpv1 1 0.01 0 0
87 INT164891 STAT1 Positive_regulation of Gene_expression of IL1RL1 1 0.41 0.06 0
88 INT164911 Binding of IL1RL1 and ITS 1 0.48 0 0
89 INT218532 Binding of C5 and LCN1 1 0.06 0.49 0
90 INT279694 Hc Negative_regulation of Catsper1 1 0.05 0 0
91 INT164897 IL4 Positive_regulation of Gene_expression of IL1RL1 1 0.54 0.06 0
92 INT234306 Binding of Gria4 and Hc 1 0.01 0 0
93 INT325271 Positive_regulation of Il33 Regulation of Gene_expression of Il1rl1 1 0.22 0 0
94 INT164912 IL33 Positive_regulation of Gene_expression of IL8 1 0.45 0.05 0
95 INT164903 IL33 Positive_regulation of Gene_expression of CXCL2 1 0.12 0.05 0
96 INT164889 IL33 Positive_regulation of Gene_expression of IFNG 1 0.25 0.05 0
97 INT164909 IL33 Positive_regulation of Phosphorylation of NFKBIA 1 0.53 0.05 0
98 INT276608 Binding of UBE2S and IL33 1 0.00 0.32 0
99 INT164893 IL33 Positive_regulation of Gene_expression of IL6 1 0.46 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of chemokine secretion. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of chemokine secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
2 INT11855 Positive_regulation of Gene_expression of Il1rl1 19 0.69 12.22 14.57
3 INT65638 Negative_regulation of Gene_expression of Il1rl1 12 0.58 7.86 11.7
4 INT226402 Gene_expression of Il33 60 0.77 23.82 8.67
5 INT87432 Regulation of Gene_expression of Il1rl1 6 0.58 4.5 6.62
6 INT152433 Binding of CSF1R 6 0.33 10.97 5.54
7 INT6507 Binding of C5 23 0.48 15.35 3.91
8 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81
9 INT69904 Binding of Hc 11 0.35 7.79 3.69
10 INT107074 Gene_expression of C5 14 0.75 9.87 3.64
11 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63
12 INT15299 Gene_expression of IL1RL1 37 0.69 10.09 3.43
13 INT164920 Gene_expression of IL33 22 0.76 13.63 3.16
14 INT177993 Localization of CSF1R 4 0.73 7.49 2.94
15 INT145774 Positive_regulation of C5 7 0.67 4.88 2.79
16 INT64147 Gene_expression of C5 15 0.60 16.8 2.78
17 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74
18 INT121683 Gene_expression of Hc 23 0.75 7.15 2.7
19 INT45014 Regulation of IL1RL1 12 0.14 1.87 2.67
20 INT52601 Positive_regulation of Il1rl1 12 0.66 1.34 2.22
21 INT325254 Positive_regulation of Il33 19 0.69 6.56 2.09
22 INT25286 Localization of IL1RL1 7 0.56 3.17 2.07
23 INT135961 Positive_regulation of Hc 8 0.67 3.67 1.87
24 INT325244 Localization of Il33 1 0.80 4.17 1.8
25 INT26426 Localization of C5 5 0.78 3.87 1.61
26 INT212790 Regulation of C5 6 0.24 6.04 1.59
27 INT28681 Gene_expression of Il1rl1 4 0.55 3.04 1.46
28 INT202161 Negative_regulation of CSF1R 3 0.31 3.36 1.22
29 INT107942 Positive_regulation of C5 9 0.50 6.86 1.19
30 INT110394 Regulation of CSF1R 3 0.38 2.49 1.12
31 INT28493 Positive_regulation of IL1RL1 10 0.47 3.44 1.11
32 INT145773 Positive_regulation of Localization of C5 1 0.49 1.15 1.06
33 INT7552 Negative_regulation of IL1RL1 12 0.42 1.68 0.87
34 INT63442 Localization of Il1rl1 2 0.12 0.05 0.87
35 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86
36 INT184351 Localization of Hc 2 0.20 2.33 0.83
37 INT325230 Positive_regulation of Gene_expression of Il33 1 0.50 1.47 0.83
38 INT269693 Regulation of Negative_regulation of Hc 1 0.00 0.09 0.83
39 INT329967 Positive_regulation of Gene_expression of C5 1 0.42 1.63 0.81
40 INT112386 Positive_regulation of Gene_expression of IL1RL1 4 0.47 2.72 0.77
41 INT28682 Negative_regulation of Gene_expression of Il1rl1 2 0.42 0.31 0.75
42 INT204929 Binding of IL33 18 0.08 4.74 0.7
43 INT121684 Positive_regulation of Gene_expression of Hc 3 0.67 1.56 0.69
44 INT161201 Localization of C5 2 0.75 0.93 0.69
45 INT226421 Regulation of Il33 2 0.45 2.7 0.68
46 INT252856 Positive_regulation of Positive_regulation of C5 1 0.02 0.95 0.67
47 INT164916 Binding of IL1RL1 9 0.33 1.84 0.66
48 INT157225 Negative_regulation of Gene_expression of Hc 2 0.12 1.12 0.66
49 INT203146 Protein_catabolism of C5 1 0.64 1.62 0.64
50 INT166437 Binding of C5 4 0.36 3.28 0.63
51 INT226403 Regulation of Gene_expression of Il33 2 0.61 1.94 0.63
52 INT202163 Negative_regulation of Localization of CSF1R 1 0.31 1.76 0.63
53 INT184367 Protein_catabolism of Hc 4 0.26 2.66 0.6
54 INT273000 Localization of IL33 5 0.45 1.77 0.56
55 INT82749 Negative_regulation of Gene_expression of IL1RL1 4 0.40 2 0.52
56 INT85081 Protein_catabolism of C5 5 0.19 1.34 0.5
57 INT273003 Positive_regulation of IL33 4 0.26 3.27 0.49
58 INT178000 Positive_regulation of Gene_expression of CSF1R 1 0.46 0.85 0.46
59 INT325251 Positive_regulation of Localization of Il33 1 0.69 1.03 0.45
60 INT290389 Positive_regulation of Binding of CSF1R 1 0.25 1.14 0.4
61 INT325250 Regulation of Positive_regulation of Il33 2 0.45 1.16 0.39
62 INT273005 Negative_regulation of IL33 4 0.07 2.4 0.38
63 INT80742 Regulation of Il1rl1 1 0.08 0.09 0.37
64 INT325234 Negative_regulation of Il33 1 0.43 0.67 0.37
65 INT164919 Transcription of IL1RL1 2 0.64 2.74 0.35
66 INT27059 Negative_regulation of C5 2 0.42 1.87 0.35
67 INT325231 Negative_regulation of Negative_regulation of Il33 1 0.43 0.67 0.34
68 INT177994 Negative_regulation of Phosphorylation of CSF1R 1 0.39 1 0.34
69 INT207775 Negative_regulation of Gene_expression of C5 4 0.42 2.08 0.33
70 INT177999 Phosphorylation of CSF1R 1 0.75 0.99 0.33
71 INT226389 Localization of Il1rl1 2 0.53 0.93 0.31
72 INT319433 Positive_regulation of Localization of IL1RL1 1 0.35 1.39 0.26
73 INT226397 Positive_regulation of Il1rl1 2 0.31 1.04 0.25
74 INT290388 Regulation of Gene_expression of CSF1R 1 0.24 0.84 0.25
75 INT135960 Regulation of Hc 2 0.44 1.28 0.21
76 INT261747 Gene_expression of Il4ra 1 0.22 0.58 0.21
77 INT261749 Binding of Il4ra 1 0.26 0.51 0.2
78 INT238246 Regulation of Gene_expression of C5 1 0.12 0 0.19
79 INT212788 Regulation of Regulation of C5 1 0.24 0.48 0.18
80 INT212789 Negative_regulation of Gene_expression of C5 2 0.38 1.04 0.17
81 INT325238 Negative_regulation of Il1rl1 1 0.27 0.55 0.17
82 INT325246 Regulation of Localization of Il33 1 0.27 0.23 0.16
83 INT325252 Positive_regulation of Gene_expression of Il1rl1 1 0.36 0.43 0.15
84 INT125712 Regulation of C5 1 0.07 0.07 0.15
85 INT309647 Regulation of Positive_regulation of C5 1 0.44 0.46 0.15
86 INT319410 Positive_regulation of Transcription of IL1RL1 1 0.48 1.49 0.14
87 INT169566 Positive_regulation of Gene_expression of IL33 1 0.41 0.38 0.14
88 INT325249 Binding of Il33 1 0.37 0.72 0.13
89 INT319432 Positive_regulation of Localization of IL33 1 0.26 1.02 0.13
90 INT116052 Phosphorylation of Il1rl1 1 0.05 0.1 0.13
91 INT164918 Regulation of Gene_expression of IL33 2 0.44 1.09 0.12
92 INT196112 Transcription of Hc 1 0.17 0.08 0.11
93 INT169564 Negative_regulation of Gene_expression of IL33 1 0.38 0.3 0.11
94 INT25287 Negative_regulation of Localization of IL1RL1 1 0.04 0 0.09
95 INT72901 Negative_regulation of Il1rl1 2 0.27 0.59 0.06
96 INT211317 Positive_regulation of Positive_regulation of IL1RL1 1 0.25 0.09 0.04
97 INT325253 Negative_regulation of Positive_regulation of Il33 1 0.42 0 0.03
98 INT325247 Negative_regulation of Gene_expression of Il33 1 0.42 0 0.03
99 INT135962 Regulation of Gene_expression of Hc 2 0.60 0.71 0
100 INT325237 Transcription of Il33 1 0.68 0.15 0
101 INT325243 Regulation of Gene_expression of Il1rl1 1 0.44 0 0
102 INT299681 Negative_regulation of Positive_regulation of C5 1 0.12 0.17 0
103 INT279442 Negative_regulation of Protein_catabolism of Hc 1 0.04 0 0
104 INT299674 Regulation of Gene_expression of C5 1 0.13 0.18 0
105 INT276617 Negative_regulation of Localization of IL33 1 0.03 0.28 0
106 INT286002 Negative_regulation of Binding of IL1RL1 1 0.02 0 0
107 INT218474 Negative_regulation of Binding of C5 1 0.06 0.53 0
108 INT193363 Regulation of Binding of IL1RL1 1 0.02 0 0
109 INT325235 Transcription of Il1rl1 1 0.49 0.15 0
110 INT218534 Negative_regulation of Binding of C5 1 0.41 0.23 0
111 INT325245 Positive_regulation of Localization of Il1rl1 1 0.31 0 0
112 INT255262 Transcription of C5 1 0.42 3 0
113 INT279469 Negative_regulation of Binding of Hc 1 0.05 0 0
114 INT164914 Regulation of Gene_expression of IL1RL1 1 0.40 0.09 0
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