GO:0090307

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Name spindle assembly involved in mitosis
Categary Process
Go Slim No
Go Link GO:0090307
Unique Molecular Interactions 76
Total Molecular Interactions 109
Total Single Events 542
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for spindle assembly involved in mitosis. They are ordered first by their pain relevance and then by number of times they were reported for spindle assembly involved in mitosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
2 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
3 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
4 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
5 INT193029 CHRM2 Positive_regulation of RHOA 1 0.01 0.12 0.24
6 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
7 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
8 INT269561 TMPO Positive_regulation of RHOA 1 0.22 0 0.23
9 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
10 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
11 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
12 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
13 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
14 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
15 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
16 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
17 INT269572 MAPKAP1 Positive_regulation of RHOA 1 0.06 0 0.13
18 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
19 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
20 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
21 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
22 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
23 INT269593 MAPKAP1 Positive_regulation of Positive_regulation of RHOA 1 0.06 0 0.09
24 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
25 INT236531 Binding of Cacna1f and Flna 1 0.08 0 0.07
26 INT159851 Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.06
27 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
28 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
29 INT326384 Slc9a3r2 Positive_regulation of Positive_regulation of Rhoa 1 0.03 0.16 0.05
30 INT120572 Positive_regulation of Binding of Egfr and Cltc 1 0.38 1.21 0.05
31 INT120568 Binding of Egfr and Cltc 1 0.28 1.21 0.05
32 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
33 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03
34 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
35 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
36 INT326383 Binding of Rhoa and Gopc 2 0.04 0.89 0
37 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
38 INT269586 Negative_regulation of TMPO Positive_regulation of RHOA 1 0.14 0 0
39 INT295704 Positive_regulation of Binding of RHOA and Racgap1 1 0.15 0.16 0
40 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0
41 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
42 INT334472 Gopc Regulation of Positive_regulation of Rhoa 1 0.02 0.3 0
43 INT338018 Binding of AR and Flna 1 0.11 0.33 0
44 INT269547 PTGIR Regulation of Phosphorylation of RHOA 1 0.02 0 0
45 INT295706 PTGER2 Regulation of Regulation of RHOA 1 0.01 0.61 0
46 INT254851 C3 Negative_regulation of Rhoa 1 0.06 0 0
47 INT254848 Tgfb1 Negative_regulation of Rhoa 1 0.02 0 0
48 INT342432 Binding of Rhoa and Positive_regulation of Atp9a 1 0.20 0 0
49 INT334469 Gopc Regulation of Localization of Rhoa 1 0.02 0.3 0
50 INT269549 Regulation of GOPC Positive_regulation of RHOA 1 0.09 0 0
51 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0
52 INT254854 Positive_regulation of C3 Negative_regulation of Rhoa 1 0.05 0 0
53 INT269581 PTGIR Regulation of RHOA 1 0.02 0 0
54 INT295714 PTGER2 Positive_regulation of RHOA 1 0.01 0.34 0
55 INT334473 PGGT1B Regulation of Localization of Rhoa 1 0.04 0.47 0
56 INT269571 Positive_regulation of GOPC Positive_regulation of RHOA 1 0.10 0 0
57 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
58 INT254865 Rhoa Positive_regulation of Fbrs 1 0.08 0.81 0
59 INT269555 GOPC Positive_regulation of RHOA 1 0.10 0 0
60 INT254864 Rhoa Positive_regulation of Egfl7 1 0.02 0.82 0
61 INT322843 Positive_regulation of PIK3CD Positive_regulation of Positive_regulation of RHOA 1 0.03 0 0
62 INT338021 Binding of Flna and Regulation of Transcription of AR 1 0.14 0.33 0
63 INT269564 MAPKAP1 Regulation of Positive_regulation of RHOA 1 0.03 0 0
64 INT269590 Positive_regulation of TMPO Positive_regulation of RHOA 1 0.16 0 0
65 INT269583 TMPO Positive_regulation of Gene_expression of RHOA 1 0.16 0.14 0
66 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
67 INT269574 Regulation of TMPO Positive_regulation of RHOA 1 0.20 0 0
68 INT295703 Binding of RHOA and Racgap1 1 0.11 0.16 0
69 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
70 INT269576 Negative_regulation of GOPC Positive_regulation of RHOA 1 0.08 0 0
71 INT180125 Rhoa Positive_regulation of Rock1 1 0.14 0 0
72 INT344318 PDPN Positive_regulation of Positive_regulation of RHOA 1 0.11 0.92 0
73 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
74 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
75 INT236529 Binding of Om and Flna 1 0.00 0.09 0
76 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for spindle assembly involved in mitosis. They are ordered first by their pain relevance and then by number of times they were reported in spindle assembly involved in mitosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
2 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
3 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
4 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
5 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
6 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
7 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
8 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
9 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
10 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
11 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
12 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
13 INT85348 Localization of RHOA 12 0.59 4.81 1.83
14 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
15 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28
16 INT128176 Regulation of RHOA 13 0.44 4.35 1.26
17 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
18 INT136817 Negative_regulation of Positive_regulation of RHOA 8 0.57 0 1.04
19 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
20 INT131824 Negative_regulation of RHOA 10 0.57 2.9 0.92
21 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
22 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
23 INT173338 Positive_regulation of Localization of RHOA 2 0.14 1.52 0.76
24 INT85347 Negative_regulation of Localization of RHOA 1 0.31 0 0.74
25 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
26 INT316940 Positive_regulation of Phosphorylation of Rhoa 1 0.41 0.41 0.58
27 INT316931 Phosphorylation of Rhoa 1 0.48 0.41 0.57
28 INT160777 Transcription of CHEK2 1 0.52 1.03 0.57
29 INT140368 Positive_regulation of Positive_regulation of Rhoa 3 0.69 0.2 0.56
30 INT180420 Negative_regulation of Gene_expression of Rhoa 3 0.37 1.65 0.55
31 INT180422 Regulation of Gene_expression of Rhoa 2 0.39 0.6 0.55
32 INT140373 Binding of Rhoa 3 0.48 0.28 0.45
33 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37
34 INT183879 Binding of RHOA 6 0.34 2.1 0.31
35 INT131822 Positive_regulation of Positive_regulation of RHOA 2 0.45 0.33 0.29
36 INT140371 Positive_regulation of Negative_regulation of Rhoa 1 0.46 0 0.26
37 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25
38 INT109859 Localization of Rhoa 3 0.54 1.09 0.24
39 INT289343 Regulation of Gene_expression of Rhoa 1 0.13 0.28 0.23
40 INT140365 Negative_regulation of Protein_catabolism of Rhoa 1 0.43 0 0.23
41 INT140358 Negative_regulation of Positive_regulation of Rhoa 1 0.43 0 0.23
42 INT289342 Negative_regulation of Gene_expression of Rhoa 1 0.20 0.28 0.23
43 INT289353 Positive_regulation of Gene_expression of Rhoa 1 0.23 0.28 0.23
44 INT180415 Regulation of Rhoa 7 0.53 3.92 0.22
45 INT140359 Positive_regulation of Protein_catabolism of Rhoa 1 0.69 0 0.22
46 INT140369 Protein_catabolism of Rhoa 1 0.99 0 0.22
47 INT180418 Binding of Rhoa 16 0.32 7.05 0.2
48 INT140361 Regulation of Positive_regulation of Rhoa 1 0.45 0 0.17
49 INT345415 Positive_regulation of Cltc 1 0.11 1.06 0.17
50 INT211717 Gene_expression of CHEK2 13 0.37 2.13 0.1
51 INT269666 Regulation of Gene_expression of RHOA 1 0.32 0.38 0.1
52 INT282407 Transcription of Rhoa 1 0.15 0.52 0.1
53 INT252551 Phosphorylation of CHEK2 4 0.48 4.73 0.08
54 INT252552 Positive_regulation of Phosphorylation of CHEK2 1 0.23 0.26 0.08
55 INT109862 Negative_regulation of Localization of Rhoa 1 0.33 0.37 0.08
56 INT139362 Negative_regulation of CHEK2 2 0.35 1.66 0.06
57 INT139364 Negative_regulation of Negative_regulation of CHEK2 1 0.26 1.67 0.06
58 INT126629 Negative_regulation of Transcription of Rhoa 1 0.33 0 0.05
59 INT180419 Regulation of Positive_regulation of Rhoa 2 0.39 0.9 0.04
60 INT269659 Negative_regulation of Gene_expression of RHOA 1 0.42 0.26 0.04
61 INT126630 Transcription of Rhoa 1 0.54 0 0.04
62 INT236523 Binding of Flna 3 0.30 0.45 0.03
63 INT276544 Gene_expression of Flna 3 0.63 1.97 0
64 INT295675 Protein_catabolism of RHOA 2 0.24 0.21 0
65 INT276523 Negative_regulation of Gene_expression of Flna 2 0.48 0.8 0
66 INT252553 Positive_regulation of Positive_regulation of CHEK2 1 0.17 0 0
67 INT322860 Regulation of Protein_catabolism of RHOA 1 0.08 0 0
68 INT269608 Regulation of Positive_regulation of RHOA 1 0.32 0.06 0
69 INT212954 Positive_regulation of Negative_regulation of Rhoa 1 0.19 1.18 0
70 INT191647 Regulation of Regulation of Rhoa 1 0.13 0.32 0
71 INT269627 Regulation of Phosphorylation of RHOA 1 0.32 0 0
72 INT269597 Negative_regulation of Phosphorylation of RHOA 1 0.31 0 0
73 INT221708 Binding of CHEK2 1 0.01 0 0
74 INT269624 Positive_regulation of Phosphorylation of RHOA 1 0.36 0 0
75 INT334441 Regulation of Localization of Rhoa 1 0.33 0.88 0
76 INT337958 Localization of Flna 1 0.61 0.43 0
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