GO:0090331

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Name negative regulation of platelet aggregation
Categary Process
Go Slim No
Go Link GO:0090331
Unique Molecular Interactions 50
Total Molecular Interactions 55
Total Single Events 389
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of platelet aggregation. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of platelet aggregation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
2 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27
3 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07
4 INT85783 PRKG1 Regulation of Prkcg 1 0.09 0.38 0.9
5 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
6 INT150965 NT5C2 Positive_regulation of PRKG1 1 0.04 0.07 0.62
7 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
8 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
9 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
10 INT63512 Vip Positive_regulation of Localization of SERPINE2 1 0.63 1.84 0.5
11 INT296487 PRKG1 Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
12 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
13 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
14 INT85782 Rb1 Regulation of PRKG1 1 0.00 0.38 0.37
15 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
16 INT304536 Mknk1 Positive_regulation of PRKG1 1 0.03 0.53 0.3
17 INT109016 Negative_regulation of Prkg1 Negative_regulation of Positive_regulation of PRKG1 1 0.06 0.28 0.26
18 INT63510 SERPINE2 Positive_regulation of Localization of Vip 1 0.15 0.52 0.21
19 INT257231 PRKG1 Negative_regulation of Ltp 1 0.07 0.07 0.2
20 INT257233 PRKG1 Positive_regulation of Phosphorylation of Creb1 1 0.01 0.09 0.2
21 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
22 INT63511 F2 Negative_regulation of SERPINE2 1 0.15 0.97 0.16
23 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
24 INT304535 Mapk1 Positive_regulation of PRKG1 1 0.05 0.65 0.16
25 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14
26 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14
27 INT148174 Camk2a Positive_regulation of Positive_regulation of PRKG1 1 0.04 0 0.14
28 INT134400 Positive_regulation of PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.30 1.13 0.14
29 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
30 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
31 INT269335 PRKG1 Positive_regulation of Gene_expression of PRKCA 1 0.14 0 0.12
32 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
33 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
34 INT269327 PRKG1 Regulation of Localization of TMPO 1 0.02 0 0.08
35 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
36 INT269331 PRKG1 Regulation of ZAK 1 0.03 0 0.07
37 INT269329 Regulation of PRKG1 Regulation of ZAK 1 0.03 0 0.07
38 INT221251 PRKG1 Negative_regulation of Positive_regulation of Ptpn2 1 0.04 0.7 0.05
39 INT221253 PRKG1 Negative_regulation of Ros1 1 0.01 0.69 0.05
40 INT325586 Nppa Positive_regulation of Prkg1 1 0.28 0.16 0.03
41 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03
42 INT171248 Serpine2 Regulation of Gnrh1 1 0.21 0.07 0
43 INT269588 PRKG1 Positive_regulation of Phosphorylation of TMPO 1 0.11 0 0
44 INT171247 Serpine2 Regulation of Gene_expression of Gnrh1 1 0.21 0 0
45 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
46 INT269550 TMPO Positive_regulation of Phosphorylation of PRKG1 1 0.11 0 0
47 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
48 INT353316 Prkg1 Positive_regulation of Phosphorylation of PRKG1 1 0.00 0.06 0
49 INT291784 Binding of SERPINE2 and Gnat3 1 0.00 0.3 0
50 INT269558 Gene_expression of PRKG1 Positive_regulation of Phosphorylation of TMPO 1 0.11 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of platelet aggregation. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of platelet aggregation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89
2 INT76434 Negative_regulation of PRKG1 25 0.58 10.36 10.81
3 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56
4 INT116055 Phosphorylation of PRKG1 33 0.80 2.22 5.58
5 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56
6 INT76433 Regulation of PRKG1 13 0.34 4.27 4.57
7 INT89678 Positive_regulation of Gene_expression of PRKG1 15 0.70 5.99 3.84
8 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
9 INT109015 Positive_regulation of Positive_regulation of PRKG1 5 0.38 2.04 1.87
10 INT116056 Positive_regulation of Phosphorylation of PRKG1 8 0.33 0.27 1.37
11 INT156993 Localization of PRKG1 6 0.35 1.06 1.34
12 INT105865 Regulation of Gene_expression of PRKG1 4 0.12 1.82 1.15
13 INT154197 Positive_regulation of Prkg1 2 0.44 1.32 1.12
14 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
15 INT63508 Negative_regulation of SERPINE2 6 0.55 3.01 1.11
16 INT196276 Regulation of Phosphorylation of PRKG1 6 0.27 0 1.06
17 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
18 INT149575 Gene_expression of Prkg1 8 0.58 1.87 0.85
19 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
20 INT105864 Binding of PRKG1 2 0.36 0.42 0.83
21 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
22 INT59786 Binding of SERPINE2 4 0.32 2.98 0.79
23 INT112649 Negative_regulation of Serpine2 10 0.43 1.41 0.66
24 INT105866 Negative_regulation of Positive_regulation of PRKG1 3 0.12 0.98 0.64
25 INT63509 Localization of SERPINE2 1 0.75 2.37 0.62
26 INT69100 Regulation of Gene_expression of Serpine2 1 0.18 0 0.59
27 INT269380 Negative_regulation of Gene_expression of PRKG1 3 0.19 1.3 0.56
28 INT221225 Negative_regulation of Negative_regulation of PRKG1 1 0.08 0 0.51
29 INT120390 Phosphorylation of PRKCD 1 0.33 0.38 0.49
30 INT112651 Positive_regulation of Gene_expression of Serpine2 3 0.70 3.36 0.47
31 INT343948 Positive_regulation of SERPINE2 1 0.07 0.76 0.44
32 INT120394 Positive_regulation of PRKCD 2 0.26 1.58 0.41
33 INT149578 Localization of Prkg1 1 0.56 0.6 0.41
34 INT221221 Positive_regulation of Localization of PRKG1 2 0.09 0.11 0.37
35 INT154353 Positive_regulation of Phosphorylation of Prkg1 1 0.34 0.66 0.37
36 INT154352 Phosphorylation of Prkg1 1 0.46 0.66 0.37
37 INT120391 Negative_regulation of Localization of PRKCD 1 0.22 0 0.34
38 INT187790 Negative_regulation of Gene_expression of Serpine2 2 0.37 1.23 0.33
39 INT120398 Positive_regulation of Positive_regulation of PRKCD 1 0.26 0 0.33
40 INT171220 Regulation of Serpine2 3 0.20 0.1 0.28
41 INT263961 Binding of Prkg1 1 0.31 1.31 0.27
42 INT269368 Negative_regulation of Phosphorylation of PRKG1 3 0.20 0 0.25
43 INT283300 Transcription of Serpine2 1 0.06 0.67 0.25
44 INT304507 Regulation of Positive_regulation of PRKG1 1 0.03 0.47 0.23
45 INT263957 Positive_regulation of Binding of Prkg1 1 0.37 0.14 0.15
46 INT284593 Transcription of Prkg1 1 0.07 0 0.14
47 INT263960 Negative_regulation of Prkg1 1 0.32 0.44 0.12
48 INT209698 Gene_expression of PRKCD 1 0.33 1.78 0.12
49 INT171236 Localization of Serpine2 2 0.42 0.35 0.11
50 INT209688 Negative_regulation of Positive_regulation of PRKCD 1 0.18 1.1 0.08
51 INT243336 Negative_regulation of Negative_regulation of SERPINE2 1 0.04 0.21 0.07
52 INT171226 Positive_regulation of Serpine2 2 0.40 0.22 0.05
53 INT267192 Localization of Prkcd 1 0.78 0.96 0.03
54 INT267186 Positive_regulation of Localization of Prkcd 1 0.49 0.97 0.03
55 INT353315 Negative_regulation of Localization of PRKG1 1 0.03 0.1 0
56 INT230666 Regulation of Binding of Prkcd 1 0.44 0 0
57 INT263959 Negative_regulation of Positive_regulation of Prkg1 1 0.31 0.14 0
58 INT268026 Regulation of Negative_regulation of PRKG1 1 0.04 0 0
59 INT171229 Binding of Serpine2 1 0.22 0.06 0
60 INT230673 Binding of Prkcd 1 0.36 0 0
61 INT171227 Negative_regulation of Regulation of Serpine2 1 0.26 0 0
62 INT209686 Negative_regulation of Gene_expression of PRKCD 1 0.18 0 0
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